Review: taking Doxycycline and Synthroid together


Summary

Drug interactions are reported among people who take Doxycycline and Synthroid together. This review analyzes the effectiveness and drug interactions between Doxycycline and Synthroid. It is created by eHealthMe based on reports of 1,177 people who take the same drugs from FDA and social media, and is updated regularly.

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Doxycycline

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. (latest outcomes from Doxycycline 16,465 users)

Synthroid

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. (latest outcomes from Synthroid 107,543 users)

On Aug, 27, 2016

1,177 people who take Doxycycline, Synthroid are studied.


Number of reports submitted per year:

Doxycycline and Synthroid drug interactions.

Drug effectiveness over time:

Doxycycline:
  • < 1 month: 40.0% - (4 of 10 people)
  • 1 - 6 months: 33.0% - (3 of 9 people)
  • 6 - 12 months: 50.0% - (2 of 4 people)
  • 1 - 2 years: 25.0% - (1 of 4 people)
  • 2 - 5 years: 0.0% - (0 of 2 people)
  • 5 - 10 years: 0.0% - (0 of 2 people)
  • 10+ years: 100.0% - (2 of 2 people)
  • not specified: 0.0% - (0 of 0 people)
Synthroid:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 25.0% - (1 of 4 people)
  • 6 - 12 months: 25.0% - (2 of 8 people)
  • 1 - 2 years: 28.0% - (2 of 7 people)
  • 2 - 5 years: 66.0% - (4 of 6 people)
  • 5 - 10 years: 33.0% - (1 of 3 people)
  • 10+ years: 70.0% - (12 of 17 people)
  • not specified: 100.0% - (1 of 1 people)

Drug effectiveness by gender:

Doxycycline:
  • female: 33.0% - (10 of 30 people)
  • male: 66.0% - (2 of 3 people)
Synthroid:
  • female: 51.0% - (21 of 41 people)
  • male: 33.0% - (2 of 6 people)

Drug effectiveness by age:

Doxycycline:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 60.0% - (3 of 5 people)
  • 30-39: 0.0% - (0 of 6 people)
  • 40-49: 20.0% - (1 of 5 people)
  • 50-59: 37.0% - (3 of 8 people)
  • 60+: 62.0% - (5 of 8 people)
Synthroid:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 37.0% - (3 of 8 people)
  • 30-39: 22.0% - (2 of 9 people)
  • 40-49: 57.0% - (4 of 7 people)
  • 50-59: 63.0% - (7 of 11 people)
  • 60+: 63.0% - (7 of 11 people)

Most common drug interactions over time *:

< 1 month:
  • nausea
  • migraine with aura
  • migraine without aura
  • visual disturbance
  • dizziness
  • liver function test abnormal
  • asthma
  • asthenia
  • hair - oily
  • menstrual cycle prolonged
1 - 6 months:
  • chest pain
  • oesophagitis
  • back pain
  • cardiac failure congestive
  • chronic obstructive pulmonary disease
  • coronary arterial stent insertion
  • death
  • heart rate irregular
  • heart valve calcification
  • heart valve incompetence
6 - 12 months:
  • deep vein thrombosis
  • emotional distress
  • oedema peripheral
  • pain in extremity
  • hypoacusis
  • loss of consciousness
  • nausea
  • tremor aggravated
  • vision blurred
  • acne
1 - 2 years:
  • diarrhoea
  • nausea
  • abdominal pain
  • abdominal pain lower
  • anxiety
  • bone pain
  • burning sensation
  • cerebellar infarction
  • cerebral infarction
  • cerebrovascular accident
2 - 5 years:
  • depression
  • myalgia
  • anxiety
  • arthralgia
  • dizziness
  • dyspnoea
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • fatigue
  • nausea
  • abdominal pain
5 - 10 years:
  • anxiety
  • convulsion
  • discomfort
  • fractured coccyx
  • fractured sacrum
  • loss of consciousness
  • lumbar vertebral fracture
  • muscle spasms
  • pain
  • abdominal pain
10+ years:
  • metallic taste
  • nervousness
  • hair loss
  • itching
  • lymph node pain
  • petechiae
  • deep vein thrombosis
  • dry eye syndrome
  • dyspnoea
  • fatigue
not specified:
  • pain
  • nausea
  • anxiety
  • fall
  • depression
  • dyspnoea
  • back pain
  • pain in extremity
  • fatigue
  • gastrooesophageal reflux disease

Most common drug interactions by gender *:

female:
  • nausea
  • pain
  • fatigue
  • anxiety
  • dyspnoea
  • depression
  • vomiting
  • dizziness
  • diarrhoea
  • arthralgia
male:
  • dyspnoea
  • pain
  • asthenia
  • fall
  • nausea
  • anxiety
  • vomiting
  • cardiac failure congestive
  • death
  • multiple injuries

Most common drug interactions by age *:

10-19:
  • juvenile myoclonic epilepsy
  • antiendomysial antibody positive
  • contusion
  • diabetes mellitus
  • diabetic ketoacidosis
  • dizziness
  • granulocytopenia
  • lacrimation increased
  • leukopenia
  • rhabdomyolysis
20-29:
  • migraine with aura
  • migraine without aura
  • visual disturbance
  • deep vein thrombosis
  • blood thyroid stimulating hormone increased
  • emotional distress
  • asthma
  • hair - oily
  • menstrual cycle prolonged
  • oily skin
30-39:
  • nausea
  • constipation
  • dizziness
  • hypoaesthesia
  • vomiting
  • dehydration
  • insomnia
  • neck pain
  • pain
  • epistaxis
40-49:
  • nausea
  • gastrooesophageal reflux disease
  • fatigue
  • pain
  • pyrexia
  • back pain
  • depression
  • chest pain
  • decreased appetite
  • hypothyroidism
50-59:
  • anxiety
  • pain
  • hypothyroidism
  • gastrooesophageal reflux disease
  • fatigue
  • arthralgia
  • back pain
  • dizziness
  • dyspnoea
  • nausea
60+:
  • pain
  • dyspnoea
  • fall
  • diarrhoea
  • fatigue
  • anaemia
  • arthralgia
  • asthenia
  • nausea
  • vomiting

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Doxycycline (doxycycline hyclate) is often used to treat acne. Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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