Review: taking Elavil and Benadryl together


Summary

Drug interactions are reported among people who take Elavil and Benadryl together. This review analyzes the effectiveness and drug interactions between Elavil and Benadryl. It is created by eHealthMe based on reports of 1,206 people who take the same drugs from FDA and social media, and is updated regularly.

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Elavil

Elavil has active ingredients of amitriptyline hydrochloride. It is often used in depression. (latest outcomes from Elavil 12,508 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 32,636 users)

On Aug, 22, 2016

1,206 people who take Elavil, Benadryl are studied.


Number of reports submitted per year:

Elavil and Benadryl drug interactions.

Drug effectiveness over time:

Elavil:
  • < 1 month: 0.0% - (0 of 10 people)
  • 1 - 6 months: 40.0% - (2 of 5 people)
  • 6 - 12 months: 0.0% - (0 of 2 people)
  • 1 - 2 years: 0.0% - (0 of 6 people)
  • 2 - 5 years: 50.0% - (1 of 2 people)
  • 5 - 10 years: 100.0% - (2 of 2 people)
  • 10+ years: 40.0% - (2 of 5 people)
  • not specified: 0.0% - (0 of 0 people)
Benadryl:
  • < 1 month: 28.0% - (2 of 7 people)
  • 1 - 6 months: 0.0% - (0 of 3 people)
  • 6 - 12 months: 33.0% - (1 of 3 people)
  • 1 - 2 years: 66.0% - (2 of 3 people)
  • 2 - 5 years: 12.0% - (1 of 8 people)
  • 5 - 10 years: 0.0% - (0 of 4 people)
  • 10+ years: 25.0% - (1 of 4 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Elavil:
  • female: 21.0% - (5 of 23 people)
  • male: 22.0% - (2 of 9 people)
Benadryl:
  • female: 26.0% - (6 of 23 people)
  • male: 11.0% - (1 of 9 people)

Drug effectiveness by age:

Elavil:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 9.0% - (1 of 11 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 37.0% - (3 of 8 people)
  • 50-59: 25.0% - (1 of 4 people)
  • 60+: 16.0% - (1 of 6 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 40.0% - (4 of 10 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 0.0% - (0 of 8 people)
  • 50-59: 20.0% - (1 of 5 people)
  • 60+: 16.0% - (1 of 6 people)

Most common drug interactions over time *:

< 1 month:
  • hyperbilirubinaemia
  • pain
  • anxiety
  • malaise
  • nausea
  • drug ineffective
  • drug withdrawal syndrome
  • dyspnoea
  • headache
  • pulmonary embolism
1 - 6 months:
  • endometrial cancer stage ii
  • chest pressure sensation
  • headache
  • hives
  • muscle spasms
  • neck pain
  • neck swelling
  • dyspnoea
  • endometrial cancer
  • endometrial cancer stage i
6 - 12 months:
  • cardiomegaly
  • choledochal cyst
  • cyanosis neonatal
  • death
  • neonatal respiratory distress syndrome
  • pulmonary artery atresia
  • pulmonary valve stenosis
  • tricuspid valve incompetence
  • ventricular septal defect
  • back pain
1 - 2 years:
  • alopecia
  • balance disorder
  • cough
  • decreased appetite
  • decreased interest
  • depression aggravated
  • diarrhoea
  • dizziness postural
  • dry mouth
  • dry throat
2 - 5 years:
  • vertigo positional
  • arthralgia
  • blue vision
  • diastolic dysfunction
  • dizziness
  • drug effect decreased
  • dry mouth
  • flushing
  • hallucination
  • headache
5 - 10 years:
  • vertigo positional
  • anasarca
  • dyspnea
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • hyperhidrosis
  • hypoparathyroidism
  • lack of strength, muscle weakness, weakness
  • nausea and vomiting
  • polyneuropathy
  • primary hypothyroidism
10+ years:
  • anasarca
  • dyspnea
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • hyperhidrosis
  • hypoparathyroidism
  • lack of strength, muscle weakness, weakness
  • nausea and vomiting
  • polyneuropathy
  • primary hypothyroidism
  • restless legs syndrome
not specified:
  • pain
  • anxiety
  • nausea
  • pain in extremity
  • dyspnoea
  • arthralgia
  • vomiting
  • depression
  • pyrexia
  • headache

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • pain in extremity
  • dyspnoea
  • pyrexia
  • nausea
  • arthralgia
  • pain in jaw
  • vomiting
  • diarrhoea
male:
  • pain
  • anxiety
  • nausea
  • headache
  • depression
  • back pain
  • vomiting
  • dyspnoea
  • arthralgia
  • asthenia

Most common drug interactions by age *:

0-1:
  • abdominal compartment syndrome
  • ascites
  • blood lactic acid increased
  • cholecystitis
  • cholelithiasis
  • coagulopathy
  • duodenal perforation
  • electroencephalogram abnormal
  • enterococcal infection
  • fluid retention
2-9:
  • cough
  • ear disorder
  • headache
  • middle ear effusion
  • oropharyngeal pain
  • pneumonia
10-19:
  • pain in extremity
  • pain
  • paraesthesia
  • muscle spasms
  • nephrogenic systemic fibrosis
  • nausea
  • cardiac arrest
  • platelet count decreased
  • abdominal pain
  • crohn's disease
20-29:
  • abdominal pain upper
  • nausea
  • pain
  • vomiting
  • diarrhoea
  • sickle cell anaemia with crisis
  • convulsion
  • migraine
  • pain in extremity
  • back pain
30-39:
  • vomiting
  • diarrhoea
  • drug abuse
  • pain
  • back pain
  • fatigue
  • nausea
  • dyspnoea
  • pyrexia
  • anxiety
40-49:
  • headache
  • pain
  • anxiety
  • nausea
  • pain in extremity
  • back pain
  • asthenia
  • fall
  • arthralgia
  • depression
50-59:
  • pain
  • anxiety
  • pyrexia
  • chest pain
  • pain in extremity
  • bone disorder
  • pain in jaw
  • insomnia
  • fall
  • hypoaesthesia
60+:
  • anxiety
  • dyspnoea
  • pain
  • nausea
  • depression
  • fall
  • anaemia
  • fatigue
  • pyrexia
  • diarrhoea

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Elavil (amitriptyline hydrochloride) is often used to treat depression. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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