Review: taking Elavil and Benadryl together


Summary

Drug interactions are reported among people who take Elavil and Benadryl together. This review analyzes the effectiveness and drug interactions between Elavil and Benadryl. It is created by eHealthMe based on reports of 1,727 people who take the same drugs from FDA and social media, and is updated regularly.

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Elavil

Elavil has active ingredients of amitriptyline hydrochloride. It is often used in depression. (latest outcomes from Elavil 14,316 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 43,259 users)

On Sep, 24, 2016

1,727 people who take Elavil, Benadryl are studied.


Number of reports submitted per year:

Elavil and Benadryl drug interactions.

Drug effectiveness over time:

Elavil:
  • < 1 month: 0.0% - (0 of 10 people)
  • 1 - 6 months: 40.0% - (2 of 5 people)
  • 6 - 12 months: 0.0% - (0 of 2 people)
  • 1 - 2 years: 0.0% - (0 of 6 people)
  • 2 - 5 years: 50.0% - (1 of 2 people)
  • 5 - 10 years: 100.0% - (2 of 2 people)
  • 10+ years: 40.0% - (2 of 5 people)
  • not specified: 0.0% - (0 of 0 people)
Benadryl:
  • < 1 month: 28.0% - (2 of 7 people)
  • 1 - 6 months: 0.0% - (0 of 3 people)
  • 6 - 12 months: 33.0% - (1 of 3 people)
  • 1 - 2 years: 66.0% - (2 of 3 people)
  • 2 - 5 years: 12.0% - (1 of 8 people)
  • 5 - 10 years: 0.0% - (0 of 4 people)
  • 10+ years: 25.0% - (1 of 4 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Elavil:
  • female: 21.0% - (5 of 23 people)
  • male: 22.0% - (2 of 9 people)
Benadryl:
  • female: 26.0% - (6 of 23 people)
  • male: 11.0% - (1 of 9 people)

Drug effectiveness by age:

Elavil:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 9.0% - (1 of 11 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 37.0% - (3 of 8 people)
  • 50-59: 25.0% - (1 of 4 people)
  • 60+: 16.0% - (1 of 6 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 40.0% - (4 of 10 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 0.0% - (0 of 8 people)
  • 50-59: 20.0% - (1 of 5 people)
  • 60+: 16.0% - (1 of 6 people)

Most common drug interactions over time *:

< 1 month:
  • pain
  • hyperbilirubinaemia
  • malaise
  • nausea
  • drug ineffective
  • headache
  • abdominal pain
  • anxiety
  • diarrhoea
  • confusional state
1 - 6 months:
  • dyspnoea
  • endometrial cancer stage ii
  • dizziness
  • chest pressure sensation
  • cough
  • drug ineffective
  • headache
  • hives
  • muscle spasms
  • neck pain
6 - 12 months:
  • vomiting
  • back pain
  • cardiomegaly
  • choledochal cyst
  • cyanosis neonatal
  • death
  • drug ineffective
  • nausea
  • neonatal respiratory distress syndrome
  • pneumonia
1 - 2 years:
  • dizziness
  • hyponatraemia
  • nausea
  • pain
  • vomiting
  • alopecia
  • atelectasis
  • balance disorder
  • cartilage injury
  • cough
2 - 5 years:
  • vertigo positional
  • dizziness
  • arthralgia
  • hyponatraemia
  • nausea
  • vomiting
  • atelectasis
  • blue vision
  • constipation
  • contusion
5 - 10 years:
  • vertigo positional
  • anasarca
  • dyspnea
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • hyperhidrosis
  • hypoparathyroidism
  • lack of strength, muscle weakness, weakness
  • nausea and vomiting
  • polyneuropathy
  • primary hypothyroidism
10+ years:
  • hyperhidrosis
  • anasarca
  • dyspnea
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • hypoparathyroidism
  • lack of strength, muscle weakness, weakness
  • nausea and vomiting
  • polyneuropathy
  • primary hypothyroidism
  • restless legs syndrome
not specified:
  • pain
  • nausea
  • anxiety
  • pain in extremity
  • arthralgia
  • headache
  • dyspnoea
  • vomiting
  • fatigue
  • dizziness

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • pain in extremity
  • anxiety
  • pyrexia
  • dyspnoea
  • fatigue
  • dizziness
  • vomiting
  • arthralgia
male:
  • pain
  • anxiety
  • nausea
  • headache
  • arthralgia
  • depression
  • back pain
  • vomiting
  • dyspnoea
  • asthenia

Most common drug interactions by age *:

0-1:
  • brain oedema
  • bronchopneumonia
  • death
  • foetal exposure during pregnancy
  • pulse absent
  • unresponsive to stimuli
  • vomiting
  • abdominal compartment syndrome
  • ascites
  • blood lactic acid increased
2-9:
  • viral infection
  • pyrexia
  • cough
  • drug administration error
  • ear disorder
  • headache
  • middle ear effusion
  • oropharyngeal pain
  • pneumonia
10-19:
  • pain
  • paraesthesia
  • muscle spasms
  • nausea
  • pain in extremity
  • abdominal pain
  • myalgia
  • nephrogenic systemic fibrosis
  • dizziness
  • cardiac arrest
20-29:
  • pain
  • abdominal pain upper
  • diarrhoea
  • vomiting
  • nausea
  • migraine
  • sickle cell anaemia with crisis
  • back pain
  • cholecystitis chronic
  • dyspnoea
30-39:
  • pain
  • vomiting
  • nausea
  • diarrhoea
  • back pain
  • drug abuse
  • fatigue
  • arthralgia
  • headache
  • dyspnoea
40-49:
  • pain
  • headache
  • nausea
  • drug abuse
  • anxiety
  • back pain
  • pain in extremity
  • vomiting
  • arthralgia
  • asthenia
50-59:
  • pain
  • pyrexia
  • pain in extremity
  • anxiety
  • nausea
  • dizziness
  • chest pain
  • fall
  • dyspnoea
  • insomnia
60+:
  • pain
  • anxiety
  • nausea
  • dyspnoea
  • fatigue
  • fall
  • arthralgia
  • vomiting
  • asthenia
  • diarrhoea

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Elavil (amitriptyline hydrochloride) is often used to treat depression. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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