Review: taking Elavil and Savella together


Summary

Drug interactions are reported among people who take Elavil and Savella together. This review analyzes the effectiveness and drug interactions between Elavil and Savella. It is created by eHealthMe based on reports of 219 people who take the same drugs from FDA and social media, and is updated regularly.

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Elavil

Elavil has active ingredients of amitriptyline hydrochloride. It is often used in depression. (latest outcomes from Elavil 14,316 users)

Savella

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. (latest outcomes from Savella 4,721 users)

On Sep, 17, 2016

219 people who take Elavil, Savella are studied.


Number of reports submitted per year:

Elavil and Savella drug interactions.

Drug effectiveness over time:

Elavil:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 2 people)
  • 6 - 12 months: 50.0% - (2 of 4 people)
  • 1 - 2 years: 50.0% - (1 of 2 people)
  • 2 - 5 years: 0.0% - (0 of 2 people)
  • 5 - 10 years: 0.0% - (0 of 1 people)
  • 10+ years: 60.0% - (3 of 5 people)
  • not specified: 0.0% - (0 of 0 people)
Savella:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 37.0% - (3 of 8 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 66.0% - (2 of 3 people)
  • 2 - 5 years: 0.0% - (0 of 2 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Elavil:
  • female: 33.0% - (5 of 15 people)
  • male: 100.0% - (1 of 1 people)
Savella:
  • female: 38.0% - (5 of 13 people)
  • male: 0.0% - (0 of 2 people)

Drug effectiveness by age:

Elavil:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 33.0% - (1 of 3 people)
  • 30-39: 50.0% - (1 of 2 people)
  • 40-49: 0.0% - (0 of 1 people)
  • 50-59: 40.0% - (4 of 10 people)
  • 60+: 0.0% - (0 of 0 people)
Savella:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (2 of 4 people)
  • 30-39: 0.0% - (0 of 1 people)
  • 40-49: 0.0% - (0 of 0 people)
  • 50-59: 30.0% - (3 of 10 people)
  • 60+: 0.0% - (0 of 0 people)

Most common drug interactions over time *:

< 1 month:
  • mental status changes
  • dyspnoea
  • nausea
  • decreased appetite
  • heart rate increased
  • palpitations
  • blood glucose increased
  • fatigue
  • anaphylactic shock
  • asthenia
1 - 6 months:
  • activities of daily living impaired
  • feeling abnormal
  • asthenia
  • depression
  • nausea
  • pain
  • palpitations
  • somnolence
  • abdominal discomfort
  • abnormal behaviour
6 - 12 months:
  • mental status changes
  • aggression
  • alexia
  • blood pressure increased
  • confusional state
  • depression aggravated
  • drug ineffective
  • hallucination, visual
  • sweating - excessive
  • weight gain
1 - 2 years:
  • migraine
  • back pain - low
  • facet joint syndrome
  • fibromyalgia
  • gerd
  • myofascial pain syndrome
  • anxiety aggravated
  • cognitive deterioration
  • confusion
  • depression aggravated
2 - 5 years:
  • abdominal bloating
  • abdominal pain
  • back pain - low
  • blood urine
  • constipation aggravated
  • facet joint syndrome
  • fibromyalgia
  • gerd
  • migraine
  • mood swings
10+ years:
  • anxiety aggravated
  • cognitive deterioration
  • confusion
  • depression aggravated
  • discolored teeth
  • dry eyes aggravated
  • eagles syndrome
  • job change
  • memory impairment
  • migraine
not specified:
  • nausea
  • pain
  • dizziness
  • fall
  • tremor
  • drug ineffective
  • sinusitis
  • arthralgia
  • insomnia
  • back pain

Most common drug interactions by gender *:

female:
  • nausea
  • pain
  • dizziness
  • fall
  • asthenia
  • insomnia
  • migraine
  • mental status changes
  • depression
  • drug ineffective
male:
  • arthralgia
  • international normalised ratio increased
  • joint injury
  • nasal cyst
  • sinusitis
  • tremor
  • drug abuse
  • serotonin syndrome
  • stevens-johnson syndrome
  • abdominal discomfort

Most common drug interactions by age *:

20-29:
  • migraine
  • back pain - low
  • facet joint syndrome
  • fibromyalgia
  • gerd
  • myofascial pain syndrome
  • decreased appetite
  • depression
  • nausea
  • poor quality sleep
30-39:
  • abnormal loss of weight
  • drug ineffective
  • depression
  • suicidal ideation
  • back pain
  • dysuria
  • feeling hot
  • pyrexia
  • urinary tract infection
  • vaginal haemorrhage
40-49:
  • pain
  • injection site pain
  • diarrhoea
  • anaphylactic shock
  • dermatitis exfoliative
  • migraine
  • adverse drug reaction
  • abdominal distension
  • fall
  • fungal infection
50-59:
  • nausea
  • dizziness
  • asthenia
  • sinusitis
  • tremor
  • constipation
  • fall
  • injection site discolouration
  • psoriasis
  • syncope
60+:
  • mental status changes
  • insomnia
  • nausea
  • confusional state
  • pain
  • headache
  • intervertebral disc degeneration
  • memory impairment
  • musculoskeletal stiffness
  • myofascial pain syndrome

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Elavil (amitriptyline hydrochloride) is often used to treat depression. Savella (milnacipran hydrochloride) is often used to treat fibromyalgia. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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