Review: taking Enbrel and Plaquenil together


Summary

Drug interactions are reported among people who take Enbrel and Plaquenil together. This review analyzes the effectiveness and drug interactions between Enbrel and Plaquenil. It is created by eHealthMe based on reports of 11,153 people who take the same drugs from FDA and social media, and is updated regularly.

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Enbrel

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. (latest outcomes from Enbrel 361,641 users)

Plaquenil

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in rheumatoid arthritis. (latest outcomes from Plaquenil 26,922 users)

On Sep, 19, 2016

11,153 people who take Enbrel, Plaquenil are studied.


Number of reports submitted per year:

Enbrel and Plaquenil drug interactions.

Drug effectiveness over time:

Enbrel:
  • < 1 month: 50.0% - (3 of 6 people)
  • 1 - 6 months: 41.0% - (5 of 12 people)
  • 6 - 12 months: 71.0% - (5 of 7 people)
  • 1 - 2 years: 100.0% - (4 of 4 people)
  • 2 - 5 years: 37.0% - (3 of 8 people)
  • 5 - 10 years: 57.0% - (4 of 7 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Plaquenil:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 50.0% - (3 of 6 people)
  • 6 - 12 months: 20.0% - (1 of 5 people)
  • 1 - 2 years: 28.0% - (2 of 7 people)
  • 2 - 5 years: 6.0% - (1 of 15 people)
  • 5 - 10 years: 25.0% - (1 of 4 people)
  • 10+ years: 25.0% - (1 of 4 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Enbrel:
  • female: 55.0% - (21 of 38 people)
  • male: 57.0% - (4 of 7 people)
Plaquenil:
  • female: 20.0% - (7 of 35 people)
  • male: 33.0% - (2 of 6 people)

Drug effectiveness by age:

Enbrel:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 66.0% - (6 of 9 people)
  • 40-49: 57.0% - (8 of 14 people)
  • 50-59: 46.0% - (7 of 15 people)
  • 60+: 60.0% - (3 of 5 people)
Plaquenil:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 25.0% - (2 of 8 people)
  • 40-49: 23.0% - (3 of 13 people)
  • 50-59: 21.0% - (3 of 14 people)
  • 60+: 20.0% - (1 of 5 people)

Most common drug interactions over time *:

< 1 month:
  • injection site erythema
  • injection site reaction
  • fatigue
  • arthralgia
  • headache
  • injection site pruritus
  • rheumatoid arthritis
  • hypersensitivity
  • nausea
  • injection site swelling
1 - 6 months:
  • drug ineffective
  • pain
  • injection site erythema
  • arthralgia
  • rheumatoid arthritis
  • injection site pain
  • headache
  • pain in extremity
  • nausea
  • injection site pruritus
6 - 12 months:
  • drug ineffective
  • injection site erythema
  • arthralgia
  • joint swelling
  • rheumatoid arthritis
  • fatigue
  • gait disturbance
  • pain
  • nausea
  • cough
1 - 2 years:
  • rheumatoid arthritis
  • drug ineffective
  • pain in extremity
  • pain
  • pneumonia
  • arthralgia
  • fatigue
  • nausea
  • paraesthesia
  • headache
2 - 5 years:
  • rheumatoid arthritis
  • drug ineffective
  • arthralgia
  • pain
  • joint swelling
  • fatigue
  • infection
  • cough
  • malaise
  • headache
5 - 10 years:
  • rheumatoid arthritis
  • drug ineffective
  • arthralgia
  • pain
  • fatigue
  • nausea
  • joint swelling
  • pain in extremity
  • interstitial lung disease
  • fall
10+ years:
  • rheumatoid arthritis
  • pneumonia
  • arthralgia
  • drug ineffective
  • alopecia
  • lung neoplasm
  • lymphadenopathy
  • nasopharyngitis
  • nausea
  • pain in extremity
not specified:
  • injection site pain
  • rheumatoid arthritis
  • drug ineffective
  • injection site erythema
  • arthralgia
  • pain
  • fatigue
  • nausea
  • headache
  • injection site pruritus

Most common drug interactions by gender *:

female:
  • injection site pain
  • rheumatoid arthritis
  • drug ineffective
  • arthralgia
  • injection site erythema
  • fatigue
  • pain
  • nausea
  • headache
  • pain in extremity
male:
  • rheumatoid arthritis
  • drug ineffective
  • arthralgia
  • pain
  • joint swelling
  • injection site pain
  • fatigue
  • pain in extremity
  • cough
  • pyrexia

Most common drug interactions by age *:

0-1:
  • adrenal insufficiency
  • antibody test positive
  • arthritis
  • body height below normal
  • bone density decreased
  • c-reactive protein increased
  • diarrhoea
  • dizziness
  • drug ineffective
  • drug intolerance
2-9:
  • psoriasis
  • nausea
  • diarrhoea
  • dizziness
  • drug ineffective
  • mobility decreased
  • septic shock
  • vomiting
  • activities of daily living impaired
  • adrenal insufficiency
10-19:
  • injection site pain
  • injection site erythema
  • nausea
  • injection site pruritus
  • injection site reaction
  • injection site swelling
  • injection site warmth
  • drug ineffective
  • clostridial infection
  • hospitalisation
20-29:
  • injection site swelling
  • injection site erythema
  • drug ineffective
  • injection site pain
  • injection site reaction
  • nausea
  • vomiting
  • vaginal haemorrhage
  • injection site urticaria
  • pelvic pain
30-39:
  • injection site erythema
  • injection site pain
  • injection site pruritus
  • rheumatoid arthritis
  • injection site swelling
  • injection site reaction
  • injection site haemorrhage
  • pain
  • arthralgia
  • fatigue
40-49:
  • injection site erythema
  • injection site pain
  • rheumatoid arthritis
  • drug ineffective
  • arthralgia
  • fatigue
  • nausea
  • headache
  • pain
  • injection site swelling
50-59:
  • rheumatoid arthritis
  • injection site pain
  • arthralgia
  • drug ineffective
  • pain
  • injection site erythema
  • fatigue
  • headache
  • nausea
  • pain in extremity
60+:
  • drug ineffective
  • rheumatoid arthritis
  • arthralgia
  • pain
  • fatigue
  • injection site pain
  • pain in extremity
  • injection site erythema
  • joint swelling
  • nausea

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Enbrel (etanercept) is often used to treat rheumatoid arthritis. Plaquenil (hydroxychloroquine sulfate) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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