Review: taking Excedrin and Benzonatate together


Drug interactions are reported among people who take Excedrin and Benzonatate together. This review analyzes the effectiveness and drug interactions between Excedrin and Benzonatate. It is created by eHealthMe based on reports of 24 people who take the same drugs from FDA and social media, and is updated regularly.

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Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. (latest outcomes from Excedrin 8,156 users)


Benzonatate has active ingredients of benzonatate. It is often used in cough. (latest outcomes from Benzonatate 1,939 users)

On Jul, 20, 2016

24 people who take Excedrin, Benzonatate are studied.

Number of reports submitted per year:

Excedrin and Benzonatate drug interactions.

Most common drug interactions by gender *:

  • depression
  • stress
  • cleft lip
  • cleft palate
  • pulmonary embolism
  • deep vein thrombosis
  • throat irritation
  • eustachian tube dysfunction
  • femoral anteversion
  • hearing impaired

Most common drug interactions by age *:

  • depression
  • stress
  • weight decreased
  • deep vein thrombosis
  • pulmonary embolism
  • chest pain
  • diabetes mellitus
  • diabetes mellitus inadequate control
  • diabetic nephropathy
  • diarrhoea
  • dyspnoea
  • glucose tolerance impaired
  • hyperhidrosis
  • throat irritation
  • chest discomfort
  • nasal discomfort
  • anxiety
  • cataract
  • confusional state
  • dyspnoea
  • fall
  • mental status changes
  • pain

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Excedrin (acetaminophen; aspirin; caffeine) is often used to treat headache. Benzonatate (benzonatate) is often used to treat cough. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.