Flexeril and Cymbalta drug interactions - from FDA reports


Summary

Drug interactions are reported among people who take Flexeril and Cymbalta together. This review analyzes the effectiveness and drug interactions between Flexeril and Cymbalta. It is created by eHealthMe based on reports of 3,347 people who take the same drugs from FDA, and is updated regularly.

What to expect?

If you take Flexeril and Cymbalta, find out what symptoms you could have in 1 year or longer.

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Flexeril

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 24,897 users)

Cymbalta

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. (latest outcomes from Cymbalta 92,197 users)

On Feb, 08, 2017

3,347 people who take Flexeril, Cymbalta are studied.


Number of reports submitted per year:

Flexeril and Cymbalta drug interactions.

Most common drug interactions over time *:

< 1 month:
  • dizziness
  • nausea
  • pain
  • aspartate aminotransferase increased
  • alanine aminotransferase increased
  • drug withdrawal syndrome
  • headache
  • anxiety
  • fatigue
  • insomnia
1 - 6 months:
  • dizziness
  • anxiety
  • pain
  • headache
  • depression
  • drug withdrawal syndrome
  • serotonin syndrome
  • weight increased
  • erectile dysfunction
  • neutropenia
6 - 12 months:
  • anxiety
  • depression
  • arthropathy
  • cerebral cyst
  • oral herpes
  • osteonecrosis
  • temporomandibular joint syndrome
  • vertigo
  • wound
  • aphthous stomatitis
1 - 2 years:
  • dizziness
  • nausea
  • anxiety
  • pain
  • vomiting
  • drug withdrawal syndrome
  • fatigue
  • hypertension
  • diarrhoea
  • fibromyalgia
2 - 5 years:
  • anxiety
  • depression
  • insomnia
  • pain
  • weight increased
  • headache
  • psychotic disorder
  • drug withdrawal syndrome
  • fibromyalgia
  • weight decreased
5 - 10 years:
  • cholecystitis chronic
  • gallbladder disorder
  • pain
  • pancreatitis
  • sphincter of oddi dysfunction
  • blood pressure increased
  • mania
  • acne
  • arthralgia
  • bronchitis
10+ years:
  • colon adenoma
  • cystitis
  • femur fracture
  • gastrointestinal disorder
  • hypothyroidism
  • low turnover osteopathy
  • lymphoedema
  • menopausal symptoms
  • osteoporosis
  • ovarian cyst
not specified:
  • pain
  • nausea
  • fatigue
  • depression
  • arthralgia
  • anxiety
  • headache
  • drug ineffective
  • insomnia
  • dizziness

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • fatigue
  • depression
  • anxiety
  • arthralgia
  • drug ineffective
  • headache
  • insomnia
  • dizziness
male:
  • depression
  • pain
  • fatigue
  • nausea
  • anxiety
  • headache
  • pain in extremity
  • arthralgia
  • dizziness
  • drug ineffective

Most common drug interactions by age *:

0-1:
  • abortion induced
  • congenital central nervous system anomaly
  • congenital hydrocephalus
  • maternal drugs affecting foetus
  • meningomyelocele
  • neural tube defect
  • spina bifida
  • talipes
  • blood cholesterol increased
  • obesity
10-19:
  • pain
  • cholecystitis chronic
  • gallbladder disorder
  • pancreatitis
  • sphincter of oddi dysfunction
  • fatigue
  • vomiting
  • blood glucose decreased
  • drug ineffective
  • haemorrhage
20-29:
  • pulmonary embolism
  • insomnia
  • pain
  • dizziness
  • diabetes mellitus
  • injury
  • depression
  • anxiety
  • convulsion
  • deep vein thrombosis
30-39:
  • nausea
  • completed suicide
  • pain
  • headache
  • fatigue
  • vomiting
  • depression
  • dyspnoea
  • dizziness
  • abdominal pain
40-49:
  • pain
  • nausea
  • fatigue
  • depression
  • arthralgia
  • anxiety
  • drug ineffective
  • diarrhoea
  • gait disturbance
  • headache
50-59:
  • pain
  • nausea
  • depression
  • arthralgia
  • fatigue
  • headache
  • insomnia
  • anxiety
  • fall
  • dizziness
60+:
  • pain
  • fatigue
  • anxiety
  • fall
  • dizziness
  • nausea
  • pneumonia
  • depression
  • hypertension
  • diarrhoea

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Flexeril and Cymbalta?

Interactions between Flexeril and drugs from A to Z

a b c d e f g h i j k l m n o p q r s t u v w x y z

Interactions between Cymbalta and drugs from A to Z

a b c d e f g h i j k l m n o p q r s t u v w x y z

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Cymbalta (duloxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:

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