Review: taking Flexeril and Cymbalta together


Summary

Drug interactions are reported among people who take Flexeril and Cymbalta together. This review analyzes the effectiveness and drug interactions between Flexeril and Cymbalta. It is created by eHealthMe based on reports of 1,701 people who take the same drugs from FDA and social media, and is updated regularly.

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Flexeril

Flexeril has active ingredients of cyclobenzaprine. It is often used in muscle spasms. (latest outcomes from Flexeril 16,144 users)

Cymbalta

Cymbalta has active ingredients of duloxetine. It is often used in depression. (latest outcomes from Cymbalta 48,473 users)

On Jul, 20, 2016

1,701 people who take Flexeril, Cymbalta are studied.


Number of reports submitted per year:

Flexeril and Cymbalta drug interactions.

Drug effectiveness over time:

Flexeril:
  • < 1 month: 20.0% - (5 of 25 people)
  • 1 - 6 months: 24.0% - (7 of 29 people)
  • 6 - 12 months: 30.0% - (6 of 20 people)
  • 1 - 2 years: 16.0% - (4 of 25 people)
  • 2 - 5 years: 34.0% - (17 of 50 people)
  • 5 - 10 years: 21.0% - (6 of 28 people)
  • 10+ years: 57.0% - (4 of 7 people)
  • not specified: 33.0% - (1 of 3 people)
Cymbalta:
  • < 1 month: 25.0% - (5 of 20 people)
  • 1 - 6 months: 23.0% - (12 of 51 people)
  • 6 - 12 months: 27.0% - (5 of 18 people)
  • 1 - 2 years: 38.0% - (12 of 31 people)
  • 2 - 5 years: 28.0% - (17 of 59 people)
  • 5 - 10 years: 25.0% - (2 of 8 people)
  • 10+ years: 62.0% - (5 of 8 people)
  • not specified: 50.0% - (1 of 2 people)

Drug effectiveness by gender:

Flexeril:
  • female: 27.0% - (41 of 150 people)
  • male: 24.0% - (9 of 37 people)
Cymbalta:
  • female: 32.0% - (52 of 160 people)
  • male: 18.0% - (7 of 37 people)

Drug effectiveness by age:

Flexeril:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 26.0% - (4 of 15 people)
  • 30-39: 29.0% - (14 of 48 people)
  • 40-49: 16.0% - (11 of 66 people)
  • 50-59: 36.0% - (17 of 46 people)
  • 60+: 33.0% - (4 of 12 people)
Cymbalta:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 35.0% - (6 of 17 people)
  • 30-39: 23.0% - (11 of 47 people)
  • 40-49: 22.0% - (15 of 66 people)
  • 50-59: 40.0% - (21 of 52 people)
  • 60+: 40.0% - (6 of 15 people)

Most common drug interactions over time *:

< 1 month:
  • aspartate aminotransferase increased
  • alanine aminotransferase increased
  • blood bilirubin increased
  • blood creatine phosphokinase increased
  • feeling abnormal
  • headache
  • international normalised ratio increased
  • nausea
  • renal failure acute
  • depression
1 - 6 months:
  • anxiety
  • depression
  • dizziness
  • hypersensitivity
  • pneumonia
  • alanine aminotransferase increased
  • bile duct stenosis
  • cellulitis
  • chronic hepatitis
  • dry mouth
6 - 12 months:
  • anxiety
  • depression
  • arthropathy
  • cerebral cyst
  • oral herpes
  • osteonecrosis
  • temporomandibular joint syndrome
  • vertigo
  • wound
  • aphthous stomatitis
1 - 2 years:
  • nausea
  • bile duct stenosis
  • chronic hepatitis
  • hepatic cirrhosis
  • pancreatic duct stenosis
  • sphincter of oddi dysfunction
  • acute respiratory failure
  • cardiac disorder
  • cardiomyopathy
  • convulsion
2 - 5 years:
  • depression
  • anxiety
  • degenerative joint disease
  • anxiety disorder due to a general medical condition
  • back injury
  • lumbar spinal stenosis
  • major depressive disorder
  • muscle twitching
  • fatigue
  • insomnia
5 - 10 years:
  • degenerative joint disease
  • anxiety disorder due to a general medical condition
  • back injury
  • lumbar spinal stenosis
  • major depressive disorder
  • hyperhidrosis
  • fatigue
  • muscle twitching
  • tremor
  • apraxia
10+ years:
  • colon adenoma
  • cystitis
  • femur fracture
  • gastrointestinal disorder
  • hypothyroidism
  • low turnover osteopathy
  • lymphoedema
  • menopausal symptoms
  • osteoporosis
  • ovarian cyst
not specified:
  • pain
  • nausea
  • depression
  • fatigue
  • anxiety
  • arthralgia
  • weight increased
  • insomnia
  • dyspnoea
  • headache

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • depression
  • anxiety
  • fatigue
  • arthralgia
  • weight increased
  • insomnia
  • headache
  • dyspnoea
male:
  • depression
  • anxiety
  • pain
  • fatigue
  • nausea
  • suicidal ideation
  • chest pain
  • neuropathy peripheral
  • diabetes mellitus
  • headache

Most common drug interactions by age *:

0-1:
  • abortion induced
  • congenital central nervous system anomaly
  • congenital hydrocephalus
  • maternal drugs affecting foetus
  • meningomyelocele
  • neural tube defect
  • spina bifida
  • talipes
  • blood cholesterol increased
  • obesity
10-19:
  • cholecystitis chronic
  • gallbladder disorder
  • pain
  • pancreatitis
  • sphincter of oddi dysfunction
  • abdominal distension
  • anxiety
  • biliary dyskinesia
  • constipation
  • depression
20-29:
  • diabetes mellitus
  • convulsion
  • type 2 diabetes mellitus
  • pulmonary embolism
  • depression
  • suicidal ideation
  • anxiety
  • death
  • injury
  • pain
30-39:
  • weight increased
  • nausea
  • fatigue
  • headache
  • type 2 diabetes mellitus
  • depression
  • dyspnoea
  • vomiting
  • arthralgia
  • abdominal pain
40-49:
  • pain
  • nausea
  • depression
  • anxiety
  • fatigue
  • back pain
  • asthenia
  • diabetes mellitus
  • diarrhoea
  • arthralgia
50-59:
  • pain
  • nausea
  • arthralgia
  • depression
  • anxiety
  • fatigue
  • insomnia
  • headache
  • weight increased
  • constipation
60+:
  • pain
  • anxiety
  • depression
  • fatigue
  • fall
  • neuropathy peripheral
  • hypertension
  • dizziness
  • pneumonia
  • anaemia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Flexeril (cyclobenzaprine) is often used to treat muscle spasms. Cymbalta (duloxetine) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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