Review: taking Flexeril and Doxycycline hyclate together


Summary

Drug interactions are reported among people who take Flexeril and Doxycycline hyclate together. This review analyzes the effectiveness and drug interactions between Flexeril and Doxycycline hyclate. It is created by eHealthMe based on reports of 421 people who take the same drugs from FDA and social media, and is updated regularly.

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Flexeril

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 18,602 users)

Doxycycline Hyclate

Doxycycline hyclate has active ingredients of doxycycline hyclate. It is often used in acne. (latest outcomes from Doxycycline hyclate 2,759 users)

On Aug, 19, 2016

421 people who take Flexeril, Doxycycline Hyclate are studied.


Number of reports submitted per year:

Flexeril and Doxycycline hyclate drug interactions.

Drug effectiveness over time:

Flexeril:
  • < 1 month: 33.0% - (1 of 3 people)
  • 1 - 6 months: 0.0% - (0 of 3 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 1 people)
  • 2 - 5 years: 0.0% - (0 of 1 people)
  • 5 - 10 years: 66.0% - (2 of 3 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)
Doxycycline Hyclate:
  • < 1 month: 33.0% - (1 of 3 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 0.0% - (0 of 2 people)
  • 1 - 2 years: 0.0% - (0 of 1 people)
  • 2 - 5 years: 0.0% - (0 of 2 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Flexeril:
  • female: 37.0% - (3 of 8 people)
  • male: 0.0% - (0 of 3 people)
Doxycycline Hyclate:
  • female: 0.0% - (0 of 6 people)
  • male: 33.0% - (1 of 3 people)

Drug effectiveness by age:

Flexeril:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 40.0% - (2 of 5 people)
  • 40-49: 33.0% - (1 of 3 people)
  • 50-59: 0.0% - (0 of 1 people)
  • 60+: 0.0% - (0 of 0 people)
Doxycycline Hyclate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 0.0% - (0 of 5 people)
  • 40-49: 0.0% - (0 of 2 people)
  • 50-59: 100.0% - (1 of 1 people)
  • 60+: 0.0% - (0 of 0 people)

Most common drug interactions over time *:

< 1 month:
  • chest pain
  • cellulitis
  • angioedema
  • hypertension
  • impaired gastric emptying
  • pain
  • cardiac failure
  • dizziness
  • migraine
  • multi-organ failure
1 - 6 months:
  • abdominal pain upper
  • cholecystitis chronic
  • cholelithiasis
  • anxiety disorder due to a general medical condition
  • blood creatine phosphokinase increased
  • constipation aggravated
  • dehydration
  • difficulty breathing
  • fatigue
  • non-cardiac chest pain
1 - 2 years:
  • abnormal behaviour
  • arthralgia
  • back pain
  • depression
  • fatigue
  • joint swelling
  • memory impairment
  • oedema
  • pain
  • recurring skin boils
2 - 5 years:
  • depression
  • suicide attempt
  • anxiety
  • abnormal dreams
  • aggression
  • bipolar disorder
  • daydreaming
  • intentional overdose
  • irritability
  • loss of consciousness
5 - 10 years:
  • deep vein thrombosis
  • dyspnoea
  • pain in extremity
  • cellulitis staphylococcal
  • oedema peripheral
  • pulmonary embolism
  • depression
  • injury
  • pain
  • daydreaming
not specified:
  • pain
  • anxiety
  • back pain
  • fatigue
  • nausea
  • dyspnoea
  • hypertension
  • depression
  • diarrhoea
  • neuropathy peripheral

Most common drug interactions by gender *:

female:
  • pain
  • fatigue
  • anxiety
  • nausea
  • depression
  • back pain
  • dyspnoea
  • arthralgia
  • asthenia
  • hypertension
male:
  • pain
  • diarrhoea
  • anxiety
  • pyrexia
  • dizziness
  • anaemia
  • musculoskeletal pain
  • neuropathy peripheral
  • dyspnoea
  • decreased interest

Most common drug interactions by age *:

0-1:
  • activities of daily living impaired
  • anhedonia
  • anxiety
  • balance disorder
  • bronchitis
  • extrapyramidal disorder
  • injury
  • muscle spasms
  • myoclonus
  • neuropathy peripheral
10-19:
  • anxiety
  • injury
  • pain
  • anhedonia
  • cerebrovascular accident
  • chest pain
  • deep vein thrombosis
  • embolism arterial
  • fear of disease
  • gallbladder disorder
20-29:
  • cholecystitis chronic
  • cholelithiasis
  • abdominal pain upper
  • nausea
  • biliary dyskinesia
  • gallbladder disorder
  • pulmonary embolism
  • pain
  • abdominal pain
  • anxiety
30-39:
  • emotional distress
  • dyspnoea
  • fatigue
  • pain
  • anxiety
  • hyperhidrosis
  • nausea
  • back pain
  • injury
  • myalgia
40-49:
  • depression
  • pain
  • arthralgia
  • back pain
  • nausea
  • anxiety
  • alopecia
  • asthenia
  • dyskinesia
  • diarrhoea
50-59:
  • anxiety
  • pain
  • nausea
  • insomnia
  • fatigue
  • headache
  • oedema peripheral
  • myalgia
  • chest pain
  • diarrhoea
60+:
  • pain
  • anxiety
  • dyspnoea
  • anaemia
  • osteoarthritis
  • pyrexia
  • back pain
  • asthenia
  • fatigue
  • headache

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Doxycycline hyclate (doxycycline hyclate) is often used to treat acne. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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