Review: taking Flexeril and Effexor xr together


Summary

Drug interactions are reported among people who take Flexeril and Effexor xr together. This review analyzes the effectiveness and drug interactions between Flexeril and Effexor xr. It is created by eHealthMe based on reports of 1,477 people who take the same drugs from FDA and social media, and is updated regularly.

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Flexeril

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 16,098 users)

Effexor Xr

Effexor xr has active ingredients of venlafaxine hydrochloride. It is often used in depression. (latest outcomes from Effexor xr 21,658 users)

On Jul, 28, 2016

1,477 people who take Flexeril, Effexor Xr are studied.


Number of reports submitted per year:

Flexeril and Effexor xr drug interactions.

Drug effectiveness over time:

Flexeril:
  • < 1 month: 7.0% - (1 of 14 people)
  • 1 - 6 months: 33.0% - (4 of 12 people)
  • 6 - 12 months: 0.0% - (0 of 13 people)
  • 1 - 2 years: 25.0% - (4 of 16 people)
  • 2 - 5 years: 29.0% - (5 of 17 people)
  • 5 - 10 years: 33.0% - (2 of 6 people)
  • 10+ years: 60.0% - (3 of 5 people)
  • not specified: 0.0% - (0 of 0 people)
Effexor Xr:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 38.0% - (5 of 13 people)
  • 6 - 12 months: 25.0% - (2 of 8 people)
  • 1 - 2 years: 20.0% - (2 of 10 people)
  • 2 - 5 years: 37.0% - (6 of 16 people)
  • 5 - 10 years: 50.0% - (17 of 34 people)
  • 10+ years: 100.0% - (8 of 8 people)
  • not specified: 100.0% - (1 of 1 people)

Drug effectiveness by gender:

Flexeril:
  • female: 22.0% - (17 of 74 people)
  • male: 22.0% - (2 of 9 people)
Effexor Xr:
  • female: 46.0% - (37 of 80 people)
  • male: 36.0% - (4 of 11 people)

Drug effectiveness by age:

Flexeril:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 22.0% - (2 of 9 people)
  • 30-39: 33.0% - (4 of 12 people)
  • 40-49: 14.0% - (6 of 41 people)
  • 50-59: 31.0% - (5 of 16 people)
  • 60+: 40.0% - (2 of 5 people)
Effexor Xr:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 7 people)
  • 30-39: 47.0% - (8 of 17 people)
  • 40-49: 58.0% - (25 of 43 people)
  • 50-59: 31.0% - (6 of 19 people)
  • 60+: 40.0% - (2 of 5 people)

Most common drug interactions over time *:

< 1 month:
  • acute myocardial infarction
  • completed suicide
  • confusional state
  • abnormal behaviour
  • delirium
  • insomnia
  • respiratory failure
  • suicide attempt
  • unresponsive to stimuli
  • intentional overdose
1 - 6 months:
  • gastrooesophageal reflux disease
  • pain
  • nausea
  • atrial septal defect
  • bronchomalacia
  • cardiac failure congestive
  • cardiomegaly
  • coarctation of the aorta
  • laryngomalacia
  • pectus carinatum
6 - 12 months:
  • anxiety
  • arthropathy
  • cerebral cyst
  • depression
  • oral herpes
  • osteonecrosis
  • temporomandibular joint syndrome
  • vertigo
  • wound
  • aphthous stomatitis
1 - 2 years:
  • anxiety
  • depression
  • arthropathy
  • cerebral cyst
  • oral herpes
  • osteonecrosis
  • temporomandibular joint syndrome
  • vertigo
  • wound
  • aphthous stomatitis
2 - 5 years:
  • anxiety
  • depression
  • suicidal ideation
  • aggression
  • insomnia
  • hot flush
  • panic attack
  • drug withdrawal syndrome
  • homicidal ideation
  • memory impairment
5 - 10 years:
  • anxiety
  • nausea
  • constipation
  • arterial thrombosis
  • cyanosis
  • dehydration
  • dizziness (excl vertigo)
  • drug hypersensitivity
  • emotional distress
  • epistaxis
10+ years:
  • abnormal behaviour
  • anxiety
  • depression
  • intentional overdose
  • suicide attempt
  • aggression
  • agitation
  • anger
  • anxiety aggravated
  • arrhythmia
not specified:
  • pain
  • anxiety
  • back pain
  • depression
  • fall
  • dyspnoea
  • fatigue
  • headache
  • nausea
  • arthralgia

Most common drug interactions by gender *:

female:
  • anxiety
  • pain
  • fatigue
  • depression
  • fall
  • dyspnoea
  • back pain
  • nausea
  • headache
  • arthralgia
male:
  • back pain
  • depression
  • pain
  • anxiety
  • insomnia
  • constipation
  • pyrexia
  • arthralgia
  • fall
  • neuropathy peripheral

Most common drug interactions by age *:

0-1:
  • diabetes mellitus
  • gastritis
  • pancreatitis
10-19:
  • anxiety
  • depression
  • nausea
  • cough
  • drug dependence
  • drug ineffective
  • drug withdrawal syndrome
  • pain
  • pyrexia
  • chills
20-29:
  • cholelithiasis
  • depression
  • nausea
  • anxiety
  • suicidal ideation
  • back pain
  • drug withdrawal syndrome
  • dehydration
  • pain
  • pyrexia
30-39:
  • diabetes mellitus
  • arthralgia
  • pulmonary embolism
  • oedema peripheral
  • pain in extremity
  • back pain
  • hypoaesthesia
  • depression
  • type 2 diabetes mellitus
  • anxiety
40-49:
  • pain
  • anxiety
  • depression
  • chest pain
  • nausea
  • headache
  • dyspnoea
  • back pain
  • pain in extremity
  • fatigue
50-59:
  • pain
  • anxiety
  • dyspnoea
  • neuropathy peripheral
  • hypertension
  • fatigue
  • back pain
  • headache
  • depression
  • fall
60+:
  • fall
  • fatigue
  • back pain
  • anxiety
  • dyspnoea
  • osteonecrosis of jaw
  • arthralgia
  • chest pain
  • pain
  • headache

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Effexor xr (venlafaxine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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