Review: taking Flexeril and Lyrica together


Summary

Drug interactions are reported among people who take Flexeril and Lyrica together. This review analyzes the effectiveness and drug interactions between Flexeril and Lyrica. It is created by eHealthMe based on reports of 3,533 people who take the same drugs from FDA and social media, and is updated regularly.

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Flexeril

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 24,055 users)

Lyrica

Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. (latest outcomes from Lyrica 121,583 users)

On Sep, 16, 2016

3,533 people who take Flexeril, Lyrica are studied.


Number of reports submitted per year:

Flexeril and Lyrica drug interactions.

Drug effectiveness over time:

Flexeril:
  • < 1 month: 10.0% - (1 of 10 people)
  • 1 - 6 months: 8.0% - (1 of 12 people)
  • 6 - 12 months: 16.0% - (2 of 12 people)
  • 1 - 2 years: 33.0% - (4 of 12 people)
  • 2 - 5 years: 36.0% - (12 of 33 people)
  • 5 - 10 years: 21.0% - (3 of 14 people)
  • 10+ years: 33.0% - (2 of 6 people)
  • not specified: 50.0% - (1 of 2 people)
Lyrica:
  • < 1 month: 16.0% - (2 of 12 people)
  • 1 - 6 months: 20.0% - (5 of 24 people)
  • 6 - 12 months: 12.0% - (1 of 8 people)
  • 1 - 2 years: 35.0% - (7 of 20 people)
  • 2 - 5 years: 34.0% - (9 of 26 people)
  • 5 - 10 years: 50.0% - (6 of 12 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Flexeril:
  • female: 25.0% - (22 of 86 people)
  • male: 26.0% - (4 of 15 people)
Lyrica:
  • female: 30.0% - (27 of 88 people)
  • male: 20.0% - (3 of 15 people)

Drug effectiveness by age:

Flexeril:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (1 of 1 people)
  • 20-29: 0.0% - (0 of 12 people)
  • 30-39: 40.0% - (12 of 30 people)
  • 40-49: 28.0% - (8 of 28 people)
  • 50-59: 14.0% - (3 of 21 people)
  • 60+: 22.0% - (2 of 9 people)
Lyrica:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 7.0% - (1 of 13 people)
  • 30-39: 38.0% - (12 of 31 people)
  • 40-49: 37.0% - (10 of 27 people)
  • 50-59: 22.0% - (5 of 22 people)
  • 60+: 22.0% - (2 of 9 people)

Most common drug interactions over time *:

< 1 month:
  • dizziness
  • drug ineffective
  • pain
  • somnolence
  • vision blurred
  • nausea
  • dry mouth
  • dyspnoea
  • oedema peripheral
  • insomnia
1 - 6 months:
  • pain
  • weight increased
  • anxiety
  • drug ineffective
  • depression
  • dizziness
  • insomnia
  • back pain
  • nausea
  • feeling abnormal
6 - 12 months:
  • blood pressure diastolic decreased
  • blood pressure systolic decreased
  • brain scan abnormal
  • breathing - rapid and deep
  • chest pain
  • heart murmurs
  • heart rate decreased
  • left ventricular dysfunction
  • muscle fatigue
  • syncope
1 - 2 years:
  • pain
  • drug ineffective
  • fatigue
  • depression
  • malaise
  • headache
  • nausea
  • anxiety
  • insomnia
  • burning sensation
2 - 5 years:
  • pain
  • depression
  • weight increased
  • anxiety
  • drug ineffective
  • chest pain
  • feeling abnormal
  • insomnia
  • malaise
  • withdrawal syndrome
5 - 10 years:
  • pain
  • depression
  • fatigue
  • irritability
  • memory impairment
  • tremor
  • vision blurred
  • blood cholesterol increased
  • feeling abnormal
  • muscle twitching
10+ years:
  • back pain
  • mouth dry aggravated
  • muscle twitching
  • pain
  • seizure
  • abdominal pain
  • abdominal pain lower
  • anxiety aggravated
  • arrhythmia
  • asthenia
not specified:
  • pain
  • drug ineffective
  • nausea
  • fatigue
  • arthralgia
  • weight increased
  • anxiety
  • back pain
  • depression
  • fall

Most common drug interactions by gender *:

female:
  • pain
  • drug ineffective
  • weight increased
  • nausea
  • fatigue
  • arthralgia
  • anxiety
  • fall
  • depression
  • back pain
male:
  • pain
  • drug ineffective
  • depression
  • anxiety
  • dyspnoea
  • nausea
  • fatigue
  • back pain
  • neuropathy peripheral
  • dizziness

Most common drug interactions by age *:

0-1:
  • death
  • foetal exposure during pregnancy
10-19:
  • convulsion
  • drug ineffective
  • dyspnoea
  • hypoaesthesia
  • hypokinesia
  • musculoskeletal pain
  • musculoskeletal stiffness
  • abdominal pain upper
  • agitation
  • alanine aminotransferase increased
20-29:
  • pain in extremity
  • pulmonary embolism
  • depression
  • back pain
  • hypoaesthesia
  • nausea
  • pain
  • feeling abnormal
  • chest pain
  • insomnia
30-39:
  • pain
  • drug ineffective
  • depression
  • weight increased
  • nausea
  • abdominal pain upper
  • vomiting
  • arthralgia
  • fatigue
  • completed suicide
40-49:
  • pain
  • drug ineffective
  • weight increased
  • depression
  • arthralgia
  • fatigue
  • nausea
  • anxiety
  • headache
  • muscle spasms
50-59:
  • pain
  • fatigue
  • drug ineffective
  • nausea
  • anxiety
  • weight increased
  • back pain
  • fall
  • arthralgia
  • depression
60+:
  • pain
  • dyspnoea
  • fall
  • nausea
  • anxiety
  • arthralgia
  • dizziness
  • pain in extremity
  • back pain
  • diarrhoea

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Lyrica (pregabalin) is often used to treat fibromyalgia. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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