Review: taking Flexeril and Melatonin together


Summary

Drug interactions are reported among people who take Flexeril and Melatonin together. This review analyzes the effectiveness and drug interactions between Flexeril and Melatonin. It is created by eHealthMe based on reports of 309 people who take the same drugs from FDA and social media, and is updated regularly.

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Flexeril

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 24,055 users)

Melatonin

Melatonin has active ingredients of melatonin. It is often used in insomnia. (latest outcomes from Melatonin 8,403 users)

On Sep, 16, 2016

309 people who take Flexeril, Melatonin are studied.


Number of reports submitted per year:

Flexeril and Melatonin drug interactions.

Drug effectiveness over time:

Flexeril:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 50.0% - (2 of 4 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 40.0% - (2 of 5 people)
  • 2 - 5 years: 75.0% - (3 of 4 people)
  • 5 - 10 years: 0.0% - (0 of 2 people)
  • 10+ years: 0.0% - (0 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Melatonin:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 14.0% - (1 of 7 people)
  • 6 - 12 months: 66.0% - (2 of 3 people)
  • 1 - 2 years: 25.0% - (1 of 4 people)
  • 2 - 5 years: 0.0% - (0 of 2 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Flexeril:
  • female: 41.0% - (5 of 12 people)
  • male: 40.0% - (2 of 5 people)
Melatonin:
  • female: 30.0% - (4 of 13 people)
  • male: 0.0% - (0 of 3 people)

Drug effectiveness by age:

Flexeril:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 20.0% - (1 of 5 people)
  • 40-49: 50.0% - (3 of 6 people)
  • 50-59: 100.0% - (2 of 2 people)
  • 60+: 0.0% - (0 of 2 people)
Melatonin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 3 people)
  • 30-39: 25.0% - (1 of 4 people)
  • 40-49: 16.0% - (1 of 6 people)
  • 50-59: 100.0% - (1 of 1 people)
  • 60+: 50.0% - (1 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • behcet's syndrome
  • cataplexy
  • chest pain
  • depression
  • diarrhoea
  • drug ineffective
  • dystonia
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • language disorder - expressive
  • melanosis coli
1 - 6 months:
  • nausea
  • diarrhea
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • insomnia
  • abdominal pain
  • back pain
  • cataplexy
  • dystonia
  • fatigue - chronic
  • fracture
6 - 12 months:
  • diarrhea
  • gastritis haemorrhagic
  • insomnia
  • knee pain
  • nausea
  • pain - back
  • pain in jaw
1 - 2 years:
  • restless legs syndrome
  • abdominal pain
  • back pain
  • diarrhea
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • fatigue - chronic
  • headaches
  • high blood pressure
  • insomnia
  • nausea
2 - 5 years:
  • candidiasis
  • food allergy
  • food intolerance
  • viral infection
  • fracture
5 - 10 years:
  • candidiasis
  • food allergy
  • food intolerance
10+ years:
  • vaginal sloughing
not specified:
  • pain
  • fatigue
  • depression
  • drug ineffective
  • insomnia
  • diarrhoea
  • nausea
  • pain in extremity
  • back pain
  • fall

Most common drug interactions by gender *:

female:
  • drug ineffective
  • pain
  • fatigue
  • insomnia
  • nausea
  • depression
  • arthralgia
  • fall
  • muscle spasms
  • back pain
male:
  • pain
  • diarrhoea
  • pain in extremity
  • depression
  • fatigue
  • anxiety
  • nephrolithiasis
  • back pain
  • anaemia
  • osteomyelitis

Most common drug interactions by age *:

0-1:
  • herpes zoster
10-19:
  • viral infection
  • non-alcoholic steatohepatitis
  • weight increased
  • hyporesponsive to stimuli
  • intentional overdose
  • agitation
  • alanine aminotransferase increased
  • aphasia
  • appetite disorder
  • aspartate aminotransferase increased
20-29:
  • insomnia
  • back pain
  • nausea
  • abdominal pain
  • bipolar i disorder
  • blood cholesterol increased
  • chronic obstructive pulmonary disease
  • depression
  • fatigue
  • gastrooesophageal reflux disease
30-39:
  • pain
  • arthralgia
  • blood creatinine increased
  • depression
  • pruritus
  • rash
  • accident at work
  • anger
  • candidiasis
  • cervicobrachial syndrome
40-49:
  • fatigue
  • pain
  • depression
  • anxiety
  • tooth infection
  • back pain
  • cellulitis
  • abdominal neoplasm
  • anaemia
  • b-cell lymphoma recurrent
50-59:
  • drug ineffective
  • pain
  • muscle spasms
  • depression
  • fatigue
  • insomnia
  • back pain
  • diarrhoea
  • pain in extremity
  • abdominal pain
60+:
  • drug ineffective
  • myocardial infarction
  • nausea
  • weight decreased
  • fall
  • fatigue
  • pneumonia
  • muscle spasms
  • cough
  • insomnia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Melatonin (melatonin) is often used to treat insomnia. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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