Review: taking Flexeril and Melatonin together


Summary

Drug interactions are reported among people who take Flexeril and Melatonin together. This review analyzes the effectiveness and drug interactions between Flexeril and Melatonin. It is created by eHealthMe based on reports of 154 people who take the same drugs from FDA and social media, and is updated regularly.

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Flexeril

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 19,420 users)

Melatonin

Melatonin has active ingredients of melatonin. It is often used in insomnia. (latest outcomes from Melatonin 4,547 users)

On Aug, 26, 2016

154 people who take Flexeril, Melatonin are studied.


Number of reports submitted per year:

Flexeril and Melatonin drug interactions.

Drug effectiveness over time:

Flexeril:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 50.0% - (2 of 4 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 40.0% - (2 of 5 people)
  • 2 - 5 years: 75.0% - (3 of 4 people)
  • 5 - 10 years: 0.0% - (0 of 2 people)
  • 10+ years: 0.0% - (0 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Melatonin:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 14.0% - (1 of 7 people)
  • 6 - 12 months: 66.0% - (2 of 3 people)
  • 1 - 2 years: 25.0% - (1 of 4 people)
  • 2 - 5 years: 0.0% - (0 of 2 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Flexeril:
  • female: 41.0% - (5 of 12 people)
  • male: 40.0% - (2 of 5 people)
Melatonin:
  • female: 30.0% - (4 of 13 people)
  • male: 0.0% - (0 of 3 people)

Drug effectiveness by age:

Flexeril:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 20.0% - (1 of 5 people)
  • 40-49: 50.0% - (3 of 6 people)
  • 50-59: 100.0% - (2 of 2 people)
  • 60+: 0.0% - (0 of 2 people)
Melatonin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 3 people)
  • 30-39: 25.0% - (1 of 4 people)
  • 40-49: 16.0% - (1 of 6 people)
  • 50-59: 100.0% - (1 of 1 people)
  • 60+: 50.0% - (1 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • cataplexy
  • dystonia
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • language disorder - expressive
  • musculoskeletal pain
  • musculoskeletal stiffness
  • neuropathy - peripheral
  • numbness and tingling
  • orthostatic hypotension
  • pain - joints
1 - 6 months:
  • nausea
  • diarrhea
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • insomnia
  • abdominal pain
  • back pain
  • cataplexy
  • dystonia
  • fatigue - chronic
  • fracture
6 - 12 months:
  • diarrhea
  • insomnia
  • knee pain
  • nausea
  • pain - back
  • pain in jaw
1 - 2 years:
  • abdominal pain
  • back pain
  • diarrhea
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • fatigue - chronic
  • headaches
  • high blood pressure
  • insomnia
  • nausea
  • restless legs syndrome
2 - 5 years:
  • candidiasis
  • food allergy
  • food intolerance
  • fracture
5 - 10 years:
  • candidiasis
  • food allergy
  • food intolerance
10+ years:
  • vaginal sloughing
not specified:
  • pain
  • depression
  • fatigue
  • diarrhoea
  • back pain
  • anxiety
  • drug ineffective
  • injury
  • insomnia
  • nausea

Most common drug interactions by gender *:

female:
  • drug ineffective
  • pain
  • insomnia
  • nausea
  • fatigue
  • depression
  • abdominal pain
  • dyspnoea
  • back pain
  • feeling abnormal
male:
  • pain
  • diarrhoea
  • anxiety
  • depression
  • fatigue
  • pain in extremity
  • abdominal neoplasm
  • anaemia
  • b-cell lymphoma recurrent
  • back pain

Most common drug interactions by age *:

10-19:
  • deep vein thrombosis
  • jugular vein thrombosis
  • psoriatic arthropathy
  • pulmonary embolism
  • thrombophlebitis superficial
  • viral infection
20-29:
  • insomnia
  • back pain
  • abdominal pain
  • bipolar i disorder
  • blood cholesterol increased
  • chronic obstructive pulmonary disease
  • depression
  • gastrooesophageal reflux disease
  • hypothyroidism
  • irritable bowel syndrome
30-39:
  • pain
  • accident at work
  • anger
  • arthralgia
  • blood creatinine increased
  • candidiasis
  • cervicobrachial syndrome
  • depression
  • feeling abnormal
  • food allergy
40-49:
  • fatigue
  • pain
  • depression
  • anxiety
  • back pain
  • cellulitis
  • tooth infection
  • abdominal neoplasm
  • anaemia
  • b-cell lymphoma recurrent
50-59:
  • drug ineffective
  • pain
  • abdominal pain
  • diarrhoea
  • dyspnoea
  • fall
  • fatigue
  • paraesthesia
  • white blood cell count decreased
  • abdominal pain upper
60+:
  • depression
  • diarrhoea
  • muscle spasms
  • type 2 diabetes mellitus
  • drug ineffective
  • asthma
  • chronic obstructive pulmonary disease
  • fall
  • fatigue
  • gait disturbance

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Melatonin (melatonin) is often used to treat insomnia. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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