Review: taking Flexeril and Methotrexate together


Summary

Drug interactions are reported among people who take Flexeril and Methotrexate together. This review analyzes the effectiveness and drug interactions between Flexeril and Methotrexate. It is created by eHealthMe based on reports of 2,503 people who take the same drugs from FDA and social media, and is updated regularly.

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Flexeril

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 24,055 users)

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 205,730 users)

On Sep, 17, 2016

2,503 people who take Flexeril, Methotrexate are studied.


Number of reports submitted per year:

Flexeril and Methotrexate drug interactions.

Drug effectiveness over time:

Flexeril:
  • < 1 month: 25.0% - (1 of 4 people)
  • 1 - 6 months: 0.0% - (0 of 3 people)
  • 6 - 12 months: 0.0% - (0 of 3 people)
  • 1 - 2 years: 66.0% - (2 of 3 people)
  • 2 - 5 years: 40.0% - (2 of 5 people)
  • 5 - 10 years: 80.0% - (4 of 5 people)
  • 10+ years: 83.0% - (5 of 6 people)
  • not specified: 0.0% - (0 of 0 people)
Methotrexate:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 4 people)
  • 6 - 12 months: 0.0% - (0 of 2 people)
  • 1 - 2 years: 50.0% - (1 of 2 people)
  • 2 - 5 years: 27.0% - (3 of 11 people)
  • 5 - 10 years: 0.0% - (0 of 2 people)
  • 10+ years: 50.0% - (4 of 8 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Flexeril:
  • female: 56.0% - (13 of 23 people)
  • male: 16.0% - (1 of 6 people)
Methotrexate:
  • female: 17.0% - (4 of 23 people)
  • male: 66.0% - (4 of 6 people)

Drug effectiveness by age:

Flexeril:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 16.0% - (1 of 6 people)
  • 40-49: 55.0% - (5 of 9 people)
  • 50-59: 63.0% - (7 of 11 people)
  • 60+: 33.0% - (1 of 3 people)
Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 40.0% - (2 of 5 people)
  • 40-49: 22.0% - (2 of 9 people)
  • 50-59: 25.0% - (3 of 12 people)
  • 60+: 33.0% - (1 of 3 people)

Most common drug interactions over time *:

< 1 month:
  • muscle spasms
  • vomiting
  • abdominal pain
  • acute lymphocytic leukaemia recurrent
  • retching
  • stomatitis
  • cellulitis
  • non-hodgkin's lymphoma
  • arthralgia
  • death
1 - 6 months:
  • pneumonia
  • respiratory failure
  • cellulitis
  • decreased appetite
  • jaundice
  • nausea
  • pain
  • vomiting
  • anaemia
  • arthralgia
6 - 12 months:
  • cataract
  • abdominal pain
  • bronchitis
  • cellulitis
  • cystitis
  • depression
  • feeling abnormal
  • herpes zoster
  • hyperhidrosis
  • influenza
1 - 2 years:
  • cataract
  • multiple fractures
  • nasopharyngitis
  • osteonecrosis
  • osteopenia
  • osteoporosis
  • abdominal pain lower
  • abdominal pain upper
  • asthenia
  • back injury
2 - 5 years:
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • blood amylase increased
  • colitis collagenous
  • dehydration
  • diarrhoea
  • diplegia
  • drug ineffective
  • headaches
  • hypoglycaemia
5 - 10 years:
  • hypoglycaemia
  • deep vein thrombosis
  • mental disorder
  • rash
  • shortness of breath
  • aggression
  • alanine aminotransferase increased
  • amenorrhoea
  • aspartate aminotransferase increased
  • blood lactate dehydrogenase increased
10+ years:
  • arthralgia
  • pneumonia
  • fibromyalgia
  • sepsis
  • abnormal loss of weight
  • blurred vision
  • deep vein thrombosis
  • excessive skin
  • gastrooesophageal reflux disease
  • hypothyroidism
not specified:
  • arthralgia
  • pain
  • fatigue
  • injection site pain
  • nausea
  • headache
  • pain in extremity
  • drug ineffective
  • fall
  • dyspnoea

Most common drug interactions by gender *:

female:
  • pain
  • arthralgia
  • fatigue
  • injection site pain
  • nausea
  • headache
  • pain in extremity
  • drug ineffective
  • dyspnoea
  • fall
male:
  • arthralgia
  • pain
  • fatigue
  • drug ineffective
  • nausea
  • pain in extremity
  • chest pain
  • injection site pain
  • diarrhoea
  • abdominal pain

Most common drug interactions by age *:

2-9:
  • scar
  • vomiting
  • acute sinusitis
  • anaemia
  • angiopathy
  • anhedonia
  • anxiety
  • aortic arteriosclerosis
  • arthropathy
  • asthenia
10-19:
  • asthma aggravated
  • dysarthria
  • dyspnoea
  • hypoaesthesia
  • pruritus
  • rheumatoid arthritis aggravated
  • tremor
  • vertigo
  • vision blurred
  • autoimmune deficiency syndrome
20-29:
  • headache
  • diabetic ketoacidosis
  • joint swelling
  • pain in extremity
  • drug withdrawal syndrome
  • gastroenteritis
  • oedema peripheral
  • upper respiratory tract infection
  • nausea
  • rheumatoid arthritis
30-39:
  • pain
  • arthralgia
  • nausea
  • dyspnoea
  • injection site pain
  • fatigue
  • cough
  • diarrhoea
  • vomiting
  • drug ineffective
40-49:
  • injection site pain
  • arthralgia
  • pain
  • headache
  • fatigue
  • nausea
  • rheumatoid arthritis
  • vomiting
  • drug ineffective
  • muscle spasms
50-59:
  • pain
  • arthralgia
  • fatigue
  • nausea
  • abdominal pain
  • injection site pain
  • diarrhoea
  • headache
  • sinusitis
  • pain in extremity
60+:
  • arthralgia
  • pain
  • fatigue
  • pain in extremity
  • fall
  • dyspnoea
  • back pain
  • nausea
  • anaemia
  • hypertension

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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