Review: taking Flexeril and Methotrexate together


Summary

Drug interactions are reported among people who take Flexeril and Methotrexate together. This review analyzes the effectiveness and drug interactions between Flexeril and Methotrexate. It is created by eHealthMe based on reports of 1,211 people who take the same drugs from FDA and social media, and is updated regularly.

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Flexeril

Flexeril has active ingredients of cyclobenzaprine. It is often used in muscle spasms. (latest outcomes from Flexeril 16,144 users)

Methotrexate

Methotrexate has active ingredients of methotrexate. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 129,243 users)

On Jul, 20, 2016

1,211 people who take Flexeril, Methotrexate are studied.


Number of reports submitted per year:

Flexeril and Methotrexate drug interactions.

Drug effectiveness over time:

Flexeril:
  • < 1 month: 25.0% - (1 of 4 people)
  • 1 - 6 months: 0.0% - (0 of 3 people)
  • 6 - 12 months: 0.0% - (0 of 3 people)
  • 1 - 2 years: 66.0% - (2 of 3 people)
  • 2 - 5 years: 33.0% - (2 of 6 people)
  • 5 - 10 years: 83.0% - (5 of 6 people)
  • 10+ years: 83.0% - (5 of 6 people)
  • not specified: 0.0% - (0 of 0 people)
Methotrexate:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 4 people)
  • 6 - 12 months: 0.0% - (0 of 2 people)
  • 1 - 2 years: 50.0% - (1 of 2 people)
  • 2 - 5 years: 27.0% - (3 of 11 people)
  • 5 - 10 years: 0.0% - (0 of 2 people)
  • 10+ years: 50.0% - (5 of 10 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Flexeril:
  • female: 56.0% - (14 of 25 people)
  • male: 16.0% - (1 of 6 people)
Methotrexate:
  • female: 20.0% - (5 of 25 people)
  • male: 66.0% - (4 of 6 people)

Drug effectiveness by age:

Flexeril:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 16.0% - (1 of 6 people)
  • 40-49: 60.0% - (6 of 10 people)
  • 50-59: 58.0% - (7 of 12 people)
  • 60+: 33.0% - (1 of 3 people)
Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 40.0% - (2 of 5 people)
  • 40-49: 20.0% - (2 of 10 people)
  • 50-59: 30.0% - (4 of 13 people)
  • 60+: 33.0% - (1 of 3 people)

Most common drug interactions over time *:

< 1 month:
  • abdominal pain
  • acute lymphocytic leukaemia recurrent
  • muscle spasms
  • retching
  • stomatitis
  • vomiting
  • cellulitis
  • non-hodgkin's lymphoma
  • death
  • lower respiratory tract infection fungal
1 - 6 months:
  • pneumonia
  • cellulitis
  • decreased appetite
  • jaundice
  • nausea
  • vomiting
  • anaemia
  • arthralgia
  • blood pressure abnormal
  • bone pain
6 - 12 months:
  • cellulitis
  • abdominal pain lower
  • abdominal pain upper
  • actinic keratosis
  • back injury
  • blood cholesterol increased
  • blood pressure increased
  • blood triglycerides increased
  • brain stem haemorrhage
  • bronchial hyperreactivity
1 - 2 years:
  • osteonecrosis
  • abdominal pain lower
  • abdominal pain upper
  • back injury
  • blood cholesterol increased
  • blood pressure increased
  • blood triglycerides increased
  • bronchial hyperreactivity
  • bronchitis
  • bursitis
2 - 5 years:
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • blood amylase increased
  • colitis collagenous
  • dehydration
  • diarrhoea
  • diplegia
  • drug ineffective
  • headaches
  • hypoglycaemia
5 - 10 years:
  • hypoglycaemia
  • rash
  • shortness of breath
  • aggression
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • blood lactate dehydrogenase increased
  • calcium deficiency
  • confusional state
  • deep vein thrombosis
10+ years:
  • blurred vision
  • excessive skin
  • nausea
  • osteonecrosis
  • pneumonia
  • rheumatoid arthritis
  • sepsis
  • anaemia
  • arthralgia
  • arthritis
not specified:
  • pain
  • fatigue
  • arthralgia
  • nausea
  • oedema peripheral
  • pain in extremity
  • abdominal pain
  • diarrhoea
  • fall
  • back pain

Most common drug interactions by gender *:

female:
  • pain
  • fatigue
  • arthralgia
  • nausea
  • oedema peripheral
  • fall
  • diarrhoea
  • abdominal pain
  • anaemia
  • osteoarthritis
male:
  • arthralgia
  • pain
  • oedema peripheral
  • muscle spasms
  • nausea
  • chest pain
  • fatigue
  • vomiting
  • drug ineffective
  • pain in extremity

Most common drug interactions by age *:

10-19:
  • asthma aggravated
  • dysarthria
  • hypoaesthesia
  • rheumatoid arthritis aggravated
  • tremor
  • vertigo
  • vision blurred
  • autoimmune deficiency syndrome
  • blood urea increased
  • loss of consciousness
20-29:
  • headache
  • nausea
  • acute lymphocytic leukaemia recurrent
  • rheumatoid arthritis
  • dyspnoea
  • gallbladder disorder
  • tachycardia
  • abdominal discomfort
  • abortion spontaneous
  • back pain
30-39:
  • pain
  • drug ineffective
  • arthralgia
  • nausea
  • pneumonia
  • vomiting
  • injection site haemorrhage
  • asthenia
  • chest pain
  • cough
40-49:
  • arthralgia
  • nausea
  • pain
  • injection site pain
  • oedema peripheral
  • vomiting
  • rheumatoid arthritis
  • headache
  • muscle spasms
  • weight decreased
50-59:
  • fatigue
  • pain
  • abdominal pain
  • diarrhoea
  • oedema peripheral
  • nausea
  • bone pain
  • swelling
  • osteoarthritis
  • arthralgia
60+:
  • arthralgia
  • fatigue
  • pain
  • anaemia
  • dyspnoea
  • pain in extremity
  • fall
  • deep vein thrombosis
  • oedema peripheral
  • chest pain

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Flexeril (cyclobenzaprine) is often used to treat muscle spasms. Methotrexate (methotrexate) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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