Review: taking Flexeril and Methotrexate together


Summary

Drug interactions are reported among people who take Flexeril and Methotrexate together. This review analyzes the effectiveness and drug interactions between Flexeril and Methotrexate. It is created by eHealthMe based on reports of 1,809 people who take the same drugs from FDA and social media, and is updated regularly.

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Flexeril

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 19,420 users)

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 160,929 users)

On Aug, 26, 2016

1,809 people who take Flexeril, Methotrexate are studied.


Number of reports submitted per year:

Flexeril and Methotrexate drug interactions.

Drug effectiveness over time:

Flexeril:
  • < 1 month: 25.0% - (1 of 4 people)
  • 1 - 6 months: 0.0% - (0 of 3 people)
  • 6 - 12 months: 0.0% - (0 of 3 people)
  • 1 - 2 years: 66.0% - (2 of 3 people)
  • 2 - 5 years: 40.0% - (2 of 5 people)
  • 5 - 10 years: 80.0% - (4 of 5 people)
  • 10+ years: 83.0% - (5 of 6 people)
  • not specified: 0.0% - (0 of 0 people)
Methotrexate:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 4 people)
  • 6 - 12 months: 0.0% - (0 of 2 people)
  • 1 - 2 years: 50.0% - (1 of 2 people)
  • 2 - 5 years: 27.0% - (3 of 11 people)
  • 5 - 10 years: 0.0% - (0 of 2 people)
  • 10+ years: 50.0% - (4 of 8 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Flexeril:
  • female: 56.0% - (13 of 23 people)
  • male: 16.0% - (1 of 6 people)
Methotrexate:
  • female: 17.0% - (4 of 23 people)
  • male: 66.0% - (4 of 6 people)

Drug effectiveness by age:

Flexeril:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 16.0% - (1 of 6 people)
  • 40-49: 55.0% - (5 of 9 people)
  • 50-59: 63.0% - (7 of 11 people)
  • 60+: 33.0% - (1 of 3 people)
Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 40.0% - (2 of 5 people)
  • 40-49: 22.0% - (2 of 9 people)
  • 50-59: 25.0% - (3 of 12 people)
  • 60+: 33.0% - (1 of 3 people)

Most common drug interactions over time *:

< 1 month:
  • muscle spasms
  • vomiting
  • abdominal pain
  • acute lymphocytic leukaemia recurrent
  • retching
  • stomatitis
  • cellulitis
  • non-hodgkin's lymphoma
  • death
  • lower respiratory tract infection fungal
1 - 6 months:
  • pneumonia
  • respiratory failure
  • cellulitis
  • decreased appetite
  • jaundice
  • nausea
  • vomiting
  • anaemia
  • arthralgia
  • arthropathy
6 - 12 months:
  • cellulitis
  • abdominal pain lower
  • abdominal pain upper
  • abortion spontaneous
  • abscess
  • actinic keratosis
  • back injury
  • blood cholesterol increased
  • blood pressure increased
  • blood triglycerides increased
1 - 2 years:
  • cataract
  • nasopharyngitis
  • osteonecrosis
  • abdominal pain lower
  • abdominal pain upper
  • back injury
  • blood cholesterol increased
  • blood pressure increased
  • blood triglycerides increased
  • bronchial hyperreactivity
2 - 5 years:
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • blood amylase increased
  • colitis collagenous
  • dehydration
  • diarrhoea
  • diplegia
  • drug ineffective
  • headaches
  • hypoglycaemia
5 - 10 years:
  • hypoglycaemia
  • rash
  • shortness of breath
  • aggression
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • blood lactate dehydrogenase increased
  • calcium deficiency
  • confusional state
  • deep vein thrombosis
10+ years:
  • blurred vision
  • excessive skin
  • nausea
  • osteonecrosis
  • pneumonia
  • rheumatoid arthritis
  • sepsis
  • anaemia
  • arthralgia
  • arthritis
not specified:
  • pain
  • arthralgia
  • fatigue
  • injection site pain
  • nausea
  • pain in extremity
  • headache
  • oedema peripheral
  • dyspnoea
  • fall

Most common drug interactions by gender *:

female:
  • pain
  • arthralgia
  • fatigue
  • injection site pain
  • nausea
  • headache
  • pain in extremity
  • dyspnoea
  • oedema peripheral
  • fall
male:
  • arthralgia
  • pain
  • nausea
  • pain in extremity
  • chest pain
  • fatigue
  • oedema peripheral
  • vomiting
  • muscle spasms
  • injection site pain

Most common drug interactions by age *:

2-9:
  • scar
  • vomiting
  • acute sinusitis
  • anaemia
  • angiopathy
  • anhedonia
  • anxiety
  • aortic arteriosclerosis
  • arthropathy
  • asthenia
10-19:
  • asthma aggravated
  • dysarthria
  • dyspnoea
  • hypoaesthesia
  • pruritus
  • rheumatoid arthritis aggravated
  • tremor
  • vertigo
  • vision blurred
  • autoimmune deficiency syndrome
20-29:
  • headache
  • diabetic ketoacidosis
  • joint swelling
  • nausea
  • pain in extremity
  • acute lymphocytic leukaemia recurrent
  • drug withdrawal syndrome
  • gastroenteritis
  • oedema peripheral
  • rheumatoid arthritis
30-39:
  • pain
  • arthralgia
  • injection site pain
  • nausea
  • injection site swelling
  • drug ineffective
  • pneumonia
  • asthenia
  • cough
  • dyspnoea
40-49:
  • injection site pain
  • pain
  • arthralgia
  • headache
  • nausea
  • rheumatoid arthritis
  • oedema peripheral
  • vomiting
  • pyrexia
  • sinusitis
50-59:
  • pain
  • fatigue
  • arthralgia
  • abdominal pain
  • nausea
  • diarrhoea
  • oedema peripheral
  • headache
  • injection site pain
  • pain in extremity
60+:
  • pain
  • arthralgia
  • fatigue
  • pain in extremity
  • fall
  • dyspnoea
  • anaemia
  • hypertension
  • oedema peripheral
  • pneumonia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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