Review: taking Flexeril and Synthroid together


Summary

Drug interactions are reported among people who take Flexeril and Synthroid together. This review analyzes the effectiveness and drug interactions between Flexeril and Synthroid. It is created by eHealthMe based on reports of 3,746 people who take the same drugs from FDA and social media, and is updated regularly.

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Flexeril

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 18,602 users)

Synthroid

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. (latest outcomes from Synthroid 104,321 users)

On Aug, 19, 2016

3,746 people who take Flexeril, Synthroid are studied.


Number of reports submitted per year:

Flexeril and Synthroid drug interactions.

Drug effectiveness over time:

Flexeril:
  • < 1 month: 30.0% - (8 of 26 people)
  • 1 - 6 months: 15.0% - (3 of 20 people)
  • 6 - 12 months: 26.0% - (4 of 15 people)
  • 1 - 2 years: 23.0% - (5 of 21 people)
  • 2 - 5 years: 26.0% - (9 of 34 people)
  • 5 - 10 years: 18.0% - (4 of 22 people)
  • 10+ years: 29.0% - (5 of 17 people)
  • not specified: 100.0% - (1 of 1 people)
Synthroid:
  • < 1 month: 0.0% - (0 of 2 people)
  • 1 - 6 months: 37.0% - (3 of 8 people)
  • 6 - 12 months: 30.0% - (3 of 10 people)
  • 1 - 2 years: 58.0% - (7 of 12 people)
  • 2 - 5 years: 56.0% - (14 of 25 people)
  • 5 - 10 years: 66.0% - (26 of 39 people)
  • 10+ years: 63.0% - (36 of 57 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Flexeril:
  • female: 24.0% - (36 of 146 people)
  • male: 30.0% - (3 of 10 people)
Synthroid:
  • female: 58.0% - (83 of 143 people)
  • male: 60.0% - (6 of 10 people)

Drug effectiveness by age:

Flexeril:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 11.0% - (1 of 9 people)
  • 30-39: 20.0% - (6 of 29 people)
  • 40-49: 23.0% - (11 of 47 people)
  • 50-59: 26.0% - (11 of 42 people)
  • 60+: 34.0% - (10 of 29 people)
Synthroid:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 77.0% - (7 of 9 people)
  • 30-39: 48.0% - (13 of 27 people)
  • 40-49: 60.0% - (27 of 45 people)
  • 50-59: 50.0% - (21 of 42 people)
  • 60+: 70.0% - (21 of 30 people)

Most common drug interactions over time *:

< 1 month:
  • anxiety
  • febrile neutropenia
  • nausea
  • pneumonia
  • headache
  • hypokalaemia
  • diarrhoea
  • dizziness
  • insomnia
  • myalgia
1 - 6 months:
  • headache
  • pain
  • pain exacerbated
  • emotional distress
  • abdominal pain
  • anxiety
  • deep vein thrombosis
  • hypothyroidism
  • injury
  • chronic back pain
6 - 12 months:
  • lightheadedness - fainting
  • nervousness
  • shortness of breath
  • swelling of the ankles - feet - legs
  • nausea
  • anxiety
  • febrile neutropenia
  • migraine
  • neutropenia
  • pain exacerbated
1 - 2 years:
  • anxiety
  • pain
  • pain exacerbated
  • chronic back pain
  • closed head injury
  • depression
  • gluten intolerance
  • headache
  • nausea
  • cholecystitis chronic
2 - 5 years:
  • nervousness
  • shortness of breath
  • lightheadedness - fainting
  • swelling of the ankles - feet - legs
  • depression
  • anxiety
  • cardiac failure congestive
  • memory impairment
  • pain
  • stuffy nose
5 - 10 years:
  • heart rate increased
  • anxiety aggravated
  • insomnia
  • depression
  • fatigue
  • anxiety
  • headache
  • cerebrovascular accident
  • numbness and tingling
  • abdominal pain aggravated
10+ years:
  • insomnia
  • anxiety aggravated
  • heart rate increased
  • anxiety
  • deep vein thrombosis
  • pulmonary embolism
  • impaired driving ability
  • mobility decreased
  • pain
  • post thrombotic syndrome
not specified:
  • pain
  • nausea
  • dyspnoea
  • fatigue
  • fall
  • arthralgia
  • back pain
  • anxiety
  • oedema peripheral
  • depression

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • fatigue
  • anxiety
  • dyspnoea
  • arthralgia
  • back pain
  • fall
  • oedema peripheral
  • depression
male:
  • nausea
  • pain
  • fall
  • oedema peripheral
  • depression
  • vomiting
  • back pain
  • pneumonia
  • diarrhoea
  • asthenia

Most common drug interactions by age *:

10-19:
  • nausea
  • acidosis
  • constipation
  • face oedema
  • insomnia
  • lymphadenopathy
  • viral infection
  • weight decreased
  • ammonia increased
  • carbon dioxide increased
20-29:
  • pain
  • pulmonary embolism
  • injury
  • deep vein thrombosis
  • anxiety
  • emotional distress
  • headache
  • cerebral thrombosis
  • dyspnoea
  • gallbladder disorder
30-39:
  • pain
  • anxiety
  • pulmonary embolism
  • injury
  • nausea
  • deep vein thrombosis
  • depression
  • dyspnoea
  • fatigue
  • insomnia
40-49:
  • nausea
  • pain
  • fatigue
  • dizziness
  • anxiety
  • vomiting
  • back pain
  • headache
  • deep vein thrombosis
  • pain in extremity
50-59:
  • pain
  • nausea
  • arthralgia
  • depression
  • fatigue
  • hypoaesthesia
  • anxiety
  • dyspnoea
  • fall
  • chest pain
60+:
  • fall
  • pain
  • oedema peripheral
  • back pain
  • dyspnoea
  • asthenia
  • fatigue
  • arthralgia
  • pneumonia
  • nausea

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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