Review: taking Flexeril and Tramadol together


Summary

Drug interactions are reported among people who take Flexeril and Tramadol together. This review analyzes the effectiveness and drug interactions between Flexeril and Tramadol. It is created by eHealthMe based on reports of 5,181 people who take the same drugs from FDA and social media, and is updated regularly.

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Flexeril

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 24,056 users)

Tramadol

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 73,716 users)

On Sep, 16, 2016

5,181 people who take Flexeril, Tramadol are studied.


Number of reports submitted per year:

Flexeril and Tramadol drug interactions.

Drug effectiveness over time:

Flexeril:
  • < 1 month: 20.0% - (7 of 35 people)
  • 1 - 6 months: 6.0% - (2 of 32 people)
  • 6 - 12 months: 20.0% - (3 of 15 people)
  • 1 - 2 years: 33.0% - (12 of 36 people)
  • 2 - 5 years: 33.0% - (14 of 42 people)
  • 5 - 10 years: 21.0% - (3 of 14 people)
  • 10+ years: 75.0% - (6 of 8 people)
  • not specified: 40.0% - (2 of 5 people)
Tramadol:
  • < 1 month: 21.0% - (7 of 33 people)
  • 1 - 6 months: 18.0% - (6 of 32 people)
  • 6 - 12 months: 5.0% - (1 of 19 people)
  • 1 - 2 years: 18.0% - (6 of 33 people)
  • 2 - 5 years: 35.0% - (16 of 45 people)
  • 5 - 10 years: 40.0% - (8 of 20 people)
  • 10+ years: 50.0% - (4 of 8 people)
  • not specified: 20.0% - (1 of 5 people)

Drug effectiveness by gender:

Flexeril:
  • female: 26.0% - (38 of 141 people)
  • male: 23.0% - (11 of 46 people)
Tramadol:
  • female: 25.0% - (38 of 147 people)
  • male: 22.0% - (11 of 48 people)

Drug effectiveness by age:

Flexeril:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 22.0% - (6 of 27 people)
  • 30-39: 29.0% - (16 of 55 people)
  • 40-49: 21.0% - (11 of 52 people)
  • 50-59: 21.0% - (7 of 32 people)
  • 60+: 45.0% - (9 of 20 people)
Tramadol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 20.0% - (6 of 29 people)
  • 30-39: 21.0% - (12 of 55 people)
  • 40-49: 21.0% - (11 of 52 people)
  • 50-59: 30.0% - (12 of 39 people)
  • 60+: 42.0% - (8 of 19 people)

Most common drug interactions over time *:

< 1 month:
  • anxiety
  • completed suicide
  • deep vein thrombosis
  • myocardial infarction
  • pain
  • myalgia
  • nausea
  • dizziness
  • pulmonary mass
  • alanine aminotransferase increased
1 - 6 months:
  • pain
  • headache
  • injury
  • seizure anoxic
  • anxiety
  • high blood pressure
  • atonic seizures
  • heartburn
  • paraesthesia
  • skin rash
6 - 12 months:
  • acute myocardial infarction
  • depression
  • anxiety
  • therapeutic response decreased
  • blood pressure diastolic decreased
  • blood pressure systolic decreased
  • brain scan abnormal
  • breathing - rapid and deep
  • chest pain
  • heart murmurs
1 - 2 years:
  • pain
  • depression
  • frequent headaches
  • deep vein thrombosis
  • headache
  • insomnia
  • anxiety
  • blurred vision
  • hallucination
  • heart palpitations
2 - 5 years:
  • depression
  • anxiety
  • memory impairment
  • cognitive deterioration
  • suicidal ideation
  • blood pressure diastolic decreased
  • blood pressure systolic decreased
  • brain scan abnormal
  • breathing - rapid and deep
  • chest pain
5 - 10 years:
  • pain
  • confusion
  • fatigue
  • memory impairment
  • anxiety
  • apraxia
  • depression
  • mood swings
  • muscle twitching
  • nausea
10+ years:
  • tinnitus
  • abnormal dreams
  • anxiety
  • depression
  • dizziness
  • dry mouth
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • eye floaters
  • heart pounding
  • heart racing
not specified:
  • pain
  • nausea
  • fatigue
  • arthralgia
  • headache
  • depression
  • back pain
  • anxiety
  • fall
  • dyspnoea

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • fatigue
  • headache
  • arthralgia
  • anxiety
  • depression
  • back pain
  • fall
  • dyspnoea
male:
  • pain
  • depression
  • fall
  • dyspnoea
  • back pain
  • drug abuse
  • nausea
  • fatigue
  • pain in extremity
  • anxiety

Most common drug interactions by age *:

0-1:
  • foetal exposure during pregnancy
  • death
  • abdominal distension
  • abdominal pain upper
  • accidental drug intake by child
  • apnoea
  • asthenia
  • atrial septal defect
  • cardio-respiratory arrest
  • coma
2-9:
  • abdominal pain upper
  • dyspnoea
  • emotional disorder
  • hyperkalaemia
  • pyrexia
  • rash
  • somnolence
  • splenic infarction
  • tardive dyskinesia
  • thrombotic thrombocytopenic purpura
10-19:
  • pain
  • deep vein thrombosis
  • cholecystitis chronic
  • drug ineffective
  • anxiety
  • injury
  • pulmonary embolism
  • nausea
  • gallbladder disorder
  • abdominal pain upper
20-29:
  • pain
  • injury
  • pulmonary embolism
  • deep vein thrombosis
  • anxiety
  • drug abuse
  • fatigue
  • nausea
  • emotional distress
  • dizziness
30-39:
  • pain
  • depression
  • completed suicide
  • drug abuse
  • anxiety
  • headache
  • nausea
  • arthralgia
  • dizziness
  • fatigue
40-49:
  • pain
  • depression
  • back pain
  • nausea
  • arthralgia
  • fatigue
  • anxiety
  • dyspnoea
  • chest pain
  • pain in extremity
50-59:
  • pain
  • nausea
  • headache
  • fall
  • arthralgia
  • fatigue
  • anxiety
  • depression
  • back pain
  • diarrhoea
60+:
  • pain
  • fall
  • dyspnoea
  • back pain
  • fatigue
  • pain in extremity
  • headache
  • arthralgia
  • anaemia
  • osteoarthritis

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Tramadol (tramadol hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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