Review: taking Flexeril and Tramadol together


Summary

Drug interactions are reported among people who take Flexeril and Tramadol together. This review analyzes the effectiveness and drug interactions between Flexeril and Tramadol. It is created by eHealthMe based on reports of 2,770 people who take the same drugs from FDA and social media, and is updated regularly.

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Flexeril

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 16,144 users)

Tramadol

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 42,204 users)

On Jul, 24, 2016

2,770 people who take Flexeril, Tramadol are studied.


Number of reports submitted per year:

Flexeril and Tramadol drug interactions.

Drug effectiveness over time:

Flexeril:
  • < 1 month: 18.0% - (7 of 37 people)
  • 1 - 6 months: 7.0% - (3 of 40 people)
  • 6 - 12 months: 25.0% - (6 of 24 people)
  • 1 - 2 years: 31.0% - (13 of 41 people)
  • 2 - 5 years: 27.0% - (16 of 58 people)
  • 5 - 10 years: 31.0% - (5 of 16 people)
  • 10+ years: 83.0% - (10 of 12 people)
  • not specified: 40.0% - (2 of 5 people)
Tramadol:
  • < 1 month: 20.0% - (7 of 34 people)
  • 1 - 6 months: 20.0% - (8 of 39 people)
  • 6 - 12 months: 3.0% - (1 of 27 people)
  • 1 - 2 years: 17.0% - (6 of 34 people)
  • 2 - 5 years: 30.0% - (20 of 66 people)
  • 5 - 10 years: 39.0% - (15 of 38 people)
  • 10+ years: 50.0% - (4 of 8 people)
  • not specified: 16.0% - (1 of 6 people)

Drug effectiveness by gender:

Flexeril:
  • female: 26.0% - (47 of 178 people)
  • male: 27.0% - (15 of 55 people)
Tramadol:
  • female: 24.0% - (48 of 193 people)
  • male: 23.0% - (14 of 59 people)

Drug effectiveness by age:

Flexeril:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 20.0% - (6 of 29 people)
  • 30-39: 30.0% - (22 of 73 people)
  • 40-49: 17.0% - (12 of 67 people)
  • 50-59: 21.0% - (8 of 38 people)
  • 60+: 56.0% - (14 of 25 people)
Tramadol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 22.0% - (7 of 31 people)
  • 30-39: 23.0% - (17 of 72 people)
  • 40-49: 15.0% - (12 of 78 people)
  • 50-59: 30.0% - (14 of 46 people)
  • 60+: 50.0% - (12 of 24 people)

Most common drug interactions over time *:

< 1 month:
  • completed suicide
  • myocardial infarction
  • anxiety
  • nausea
  • dyspnoea
  • deep vein thrombosis
  • heart rate increased
  • myalgia
  • vision blurred
  • actinic keratosis
1 - 6 months:
  • pain
  • seizure anoxic
  • high blood pressure
  • atonic seizures
  • heartburn
  • skin rash
  • tonic seizures
  • anxiety
  • frequent headaches
  • paraesthesia
6 - 12 months:
  • acute myocardial infarction
  • anxiety
  • therapeutic response decreased
  • blood pressure diastolic decreased
  • blood pressure systolic decreased
  • brain scan abnormal
  • breathing - rapid and deep
  • chest pain
  • heart murmurs
  • heart rate decreased
1 - 2 years:
  • frequent headaches
  • depression
  • insomnia
  • blurred vision
  • heart palpitations
  • skin burning sensation
  • abnormal behaviour
  • anxiety
  • constipation
  • flushing
2 - 5 years:
  • depression
  • anxiety
  • memory impairment
  • cognitive deterioration
  • suicidal ideation
  • blood pressure diastolic decreased
  • blood pressure systolic decreased
  • brain scan abnormal
  • breathing - rapid and deep
  • chest pain
5 - 10 years:
  • confusion
  • fatigue
  • memory impairment
  • pain
  • apraxia
  • depression
  • mood swings
  • muscle twitching
  • nausea
  • tremor
10+ years:
  • tinnitus
  • abnormal dreams
  • anxiety
  • depression
  • dizziness
  • dry mouth
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • eye floaters
  • heart pounding
  • heart racing
not specified:
  • pain
  • nausea
  • back pain
  • anxiety
  • depression
  • arthralgia
  • fatigue
  • headache
  • fall
  • pain in extremity

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • fatigue
  • arthralgia
  • headache
  • anxiety
  • back pain
  • depression
  • fall
  • dyspnoea
male:
  • anxiety
  • back pain
  • depression
  • pain
  • pain in extremity
  • nausea
  • dyspnoea
  • insomnia
  • headache
  • fatigue

Most common drug interactions by age *:

0-1:
  • death
  • foetal exposure during pregnancy
  • accidental drug intake by child
  • apnoea
  • cardio-respiratory arrest
  • coma
  • convulsion
  • diabetes mellitus
  • lethargy
2-9:
  • accidental drug intake by child
  • lethargy
  • multiple drug overdose accidental
  • somnolence
10-19:
  • pain
  • deep vein thrombosis
  • cholecystitis chronic
  • abdominal pain upper
  • pulmonary embolism
  • pulmonary thrombosis
  • cholelithiasis
  • diarrhoea
  • drug toxicity
  • gallbladder disorder
20-29:
  • pain
  • convulsion
  • injury
  • dizziness
  • nausea
  • deep vein thrombosis
  • insomnia
  • loss of consciousness
  • hypersensitivity
  • multiple drug overdose
30-39:
  • pain
  • depression
  • headache
  • nausea
  • anxiety
  • arthralgia
  • dyspnoea
  • dizziness
  • drug dependence
  • multiple drug overdose
40-49:
  • pain
  • depression
  • back pain
  • nausea
  • arthralgia
  • anxiety
  • fatigue
  • chest pain
  • dyspnoea
  • pain in extremity
50-59:
  • pain
  • nausea
  • headache
  • anxiety
  • fatigue
  • fall
  • arthralgia
  • diarrhoea
  • back pain
  • cough
60+:
  • back pain
  • pain in extremity
  • fall
  • pain
  • osteoarthritis
  • dyspnoea
  • fatigue
  • headache
  • osteonecrosis of jaw
  • anaemia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Tramadol (tramadol hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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