Review: taking Flexeril and Zanaflex together


Summary

Drug interactions are reported among people who take Flexeril and Zanaflex together. This review analyzes the effectiveness and drug interactions between Flexeril and Zanaflex. It is created by eHealthMe based on reports of 659 people who take the same drugs from FDA and social media, and is updated regularly.

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Flexeril

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 18,602 users)

Zanaflex

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. (latest outcomes from Zanaflex 8,038 users)

On Aug, 21, 2016

659 people who take Flexeril, Zanaflex are studied.


Number of reports submitted per year:

Flexeril and Zanaflex drug interactions.

Drug effectiveness over time:

Flexeril:
  • < 1 month: 18.0% - (2 of 11 people)
  • 1 - 6 months: 25.0% - (2 of 8 people)
  • 6 - 12 months: 0.0% - (0 of 3 people)
  • 1 - 2 years: 60.0% - (3 of 5 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 100.0% - (2 of 2 people)
  • 10+ years: 66.0% - (2 of 3 people)
  • not specified: 0.0% - (0 of 0 people)
Zanaflex:
  • < 1 month: 27.0% - (3 of 11 people)
  • 1 - 6 months: 30.0% - (3 of 10 people)
  • 6 - 12 months: 50.0% - (1 of 2 people)
  • 1 - 2 years: 50.0% - (2 of 4 people)
  • 2 - 5 years: 50.0% - (2 of 4 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Flexeril:
  • female: 40.0% - (8 of 20 people)
  • male: 30.0% - (4 of 13 people)
Zanaflex:
  • female: 23.0% - (5 of 21 people)
  • male: 53.0% - (7 of 13 people)

Drug effectiveness by age:

Flexeril:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 20.0% - (1 of 5 people)
  • 30-39: 40.0% - (4 of 10 people)
  • 40-49: 16.0% - (1 of 6 people)
  • 50-59: 40.0% - (4 of 10 people)
  • 60+: 100.0% - (2 of 2 people)
Zanaflex:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 40.0% - (2 of 5 people)
  • 30-39: 10.0% - (1 of 10 people)
  • 40-49: 50.0% - (3 of 6 people)
  • 50-59: 45.0% - (5 of 11 people)
  • 60+: 50.0% - (1 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • breast cancer
  • dizziness
  • fatigue
  • epilepsy
  • memory impairment
  • swelling of the ankles - feet - legs
  • vision blurred
  • weight gain
  • alanine aminotransferase increased
  • albumin globulin ratio decreased
1 - 6 months:
  • anxiety
  • depression
  • emotional distress
  • fear
  • anhedonia
  • injury
  • obsessive-compulsive disorder
  • pain
  • pathological gambling
  • back pain
6 - 12 months:
  • anxiety
  • emotional distress
  • pain
  • vision blurred
  • arthralgia
  • bile duct obstruction
  • coordination abnormal
  • cushingoid
  • dehydration
  • disorientation
1 - 2 years:
  • anxiety
  • depression
  • completed suicide
  • deep vein thrombosis
  • emotional distress
  • fatigue
  • hair loss
  • intentional overdose
  • lightheadedness - dizzy
  • memory loss
2 - 5 years:
  • anxiety
  • completed suicide
  • depression
  • fatigue
  • hair loss
  • intentional overdose
  • lightheadedness - dizzy
  • memory loss
  • mental disorder
  • sleepy
5 - 10 years:
  • depression
  • dyspnoea
  • emotional distress
  • myocardial infarction
  • pain in extremity
  • pulmonary embolism
  • back disorder
  • blood cholesterol increased
  • anxiety
  • deep vein thrombosis
10+ years:
  • complicated migraine
  • hypokalaemia
  • sleep disorder due to general medical condition, insomnia type
  • vein distended
  • joint pain
  • joint swelling
  • pain in fingers
  • stiffness in a joint
not specified:
  • pain
  • depression
  • anxiety
  • arthralgia
  • nausea
  • headache
  • back pain
  • dyspnoea
  • asthenia
  • emotional distress

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • headache
  • depression
  • nausea
  • chest pain
  • arthralgia
  • insomnia
  • dyspnoea
  • asthenia
male:
  • depression
  • pain
  • anxiety
  • arthralgia
  • emotional distress
  • back pain
  • hypoaesthesia
  • injury
  • drug dependence
  • dyspnoea

Most common drug interactions by age *:

10-19:
  • anxiety
  • cough
  • depression
  • drug dependence
  • drug ineffective
  • drug withdrawal syndrome
  • nausea
  • pain
  • pyrexia
  • chills
20-29:
  • pulmonary embolism
  • deep vein thrombosis
  • dizziness
  • hypoaesthesia
  • cold sweat
  • muscle spasms
  • myoclonic jerks
  • pain
  • sinus tachycardia
  • arthralgia
30-39:
  • arthralgia
  • anxiety
  • pain in extremity
  • pain
  • depression
  • hypertension
  • lymphadenopathy
  • vision blurred
  • drug withdrawal syndrome
  • nausea
40-49:
  • pain
  • depression
  • headache
  • anxiety
  • emotional distress
  • chest pain
  • nausea
  • drug dependence
  • insomnia
  • fall
50-59:
  • pain
  • anxiety
  • depression
  • arthralgia
  • dyspnoea
  • back pain
  • osteonecrosis of jaw
  • sciatica
  • emotional distress
  • intervertebral disc degeneration
60+:
  • pain
  • muscle spasms
  • anaemia
  • osteoarthritis
  • pneumonia
  • musculoskeletal pain
  • asthenia
  • deep vein thrombosis
  • dyspnoea
  • fall

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Zanaflex (tizanidine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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