Review: taking Gabapentin and Benadryl together


Summary

Drug interactions are reported among people who take Gabapentin and Benadryl together. This review analyzes the effectiveness and drug interactions between Gabapentin and Benadryl. It is created by eHealthMe based on reports of 3,986 people who take the same drugs from FDA and social media, and is updated regularly.

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Gabapentin

Gabapentin has active ingredients of gabapentin. It is often used in pain. (latest outcomes from Gabapentin 83,499 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 43,259 users)

On Sep, 16, 2016

3,986 people who take Gabapentin, Benadryl are studied.


Number of reports submitted per year:

Gabapentin and Benadryl drug interactions.

Drug effectiveness over time:

Gabapentin:
  • < 1 month: 40.0% - (2 of 5 people)
  • 1 - 6 months: 30.0% - (3 of 10 people)
  • 6 - 12 months: 33.0% - (2 of 6 people)
  • 1 - 2 years: 40.0% - (4 of 10 people)
  • 2 - 5 years: 25.0% - (3 of 12 people)
  • 5 - 10 years: 80.0% - (4 of 5 people)
  • 10+ years: 50.0% - (2 of 4 people)
  • not specified: 0.0% - (0 of 2 people)
Benadryl:
  • < 1 month: 15.0% - (2 of 13 people)
  • 1 - 6 months: 28.0% - (2 of 7 people)
  • 6 - 12 months: 100.0% - (4 of 4 people)
  • 1 - 2 years: 42.0% - (3 of 7 people)
  • 2 - 5 years: 66.0% - (4 of 6 people)
  • 5 - 10 years: 71.0% - (5 of 7 people)
  • 10+ years: 83.0% - (5 of 6 people)
  • not specified: 50.0% - (1 of 2 people)

Drug effectiveness by gender:

Gabapentin:
  • female: 33.0% - (13 of 39 people)
  • male: 46.0% - (7 of 15 people)
Benadryl:
  • female: 52.0% - (20 of 38 people)
  • male: 42.0% - (6 of 14 people)

Drug effectiveness by age:

Gabapentin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 33.0% - (2 of 6 people)
  • 30-39: 30.0% - (3 of 10 people)
  • 40-49: 30.0% - (3 of 10 people)
  • 50-59: 61.0% - (8 of 13 people)
  • 60+: 26.0% - (4 of 15 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 28.0% - (2 of 7 people)
  • 30-39: 70.0% - (7 of 10 people)
  • 40-49: 40.0% - (4 of 10 people)
  • 50-59: 63.0% - (7 of 11 people)
  • 60+: 42.0% - (6 of 14 people)

Most common drug interactions over time *:

< 1 month:
  • nausea
  • vomiting
  • pain in extremity
  • fatigue
  • anaemia
  • diarrhoea
  • deep vein thrombosis
  • hypotension
  • dehydration
  • drug ineffective
1 - 6 months:
  • headache
  • nausea
  • anxiety
  • hypoaesthesia
  • neuropathy peripheral
  • pain
  • arthralgia
  • bone pain
  • deep vein thrombosis
  • drug ineffective
6 - 12 months:
  • vanishing twin syndrome
  • feeding disorder neonatal
  • microcephaly
  • respiratory disorder neonatal
  • small for dates baby
  • temperature regulation disorder
  • foetal exposure during pregnancy
  • maternal exposure during pregnancy
  • foetal growth restriction
  • anaemia
1 - 2 years:
  • neck pain
  • drug ineffective
  • anaemia
  • coma
  • hepatic failure
  • nausea
  • neutropenia
  • suicide attempt
  • acid reflux
  • allergy to animal
2 - 5 years:
  • blood creatinine increased
  • amnesia
  • coma
  • confusional state
  • drug ineffective
  • hepatic failure
  • hypoglycaemia
  • multiple drug overdose
  • nausea
  • oliguria
5 - 10 years:
  • drug ineffective
  • sleep disorder
  • alopecia
  • arthritis
  • bronchitis chronic
  • convulsion
  • emotional disorder
  • excessive thirst
  • feeling abnormal
  • haemorrhoids
10+ years:
  • ataxia
  • myoclonus
  • blurred vision
  • cervical spine pain
  • chronic hepatitis
  • depression
  • double vision
  • drug ineffective
  • fasciculations of muscle
  • hyperlipidemia
not specified:
  • pain
  • nausea
  • dyspnoea
  • anxiety
  • arthralgia
  • fatigue
  • headache
  • pain in extremity
  • diarrhoea
  • vomiting

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • dyspnoea
  • arthralgia
  • fatigue
  • pain in extremity
  • diarrhoea
  • anxiety
  • vomiting
  • headache
male:
  • pain
  • anxiety
  • nausea
  • headache
  • fatigue
  • vomiting
  • arthralgia
  • pain in extremity
  • dyspnoea
  • diarrhoea

Most common drug interactions by age *:

0-1:
  • feeding disorder neonatal
  • microcephaly
  • respiratory disorder neonatal
  • small for dates baby
  • temperature regulation disorder
  • foetal exposure during pregnancy
  • foetal growth restriction
  • muscle disorder
  • orthostatic hypotension
  • chest pain
2-9:
  • pyrexia
  • abnormal behaviour
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • blood creatinine increased
  • blood lactate dehydrogenase increased
  • c-reactive protein increased
  • catheter site erythema
  • contusion
  • dermatitis
10-19:
  • pain
  • nausea
  • paraesthesia
  • pain in extremity
  • vomiting
  • diarrhoea
  • dehydration
  • muscle spasms
  • pyrexia
  • headache
20-29:
  • pain
  • headache
  • depression
  • pyrexia
  • anxiety
  • dyspnoea
  • back pain
  • nausea
  • arthralgia
  • dizziness
30-39:
  • vomiting
  • headache
  • pain
  • diarrhoea
  • anxiety
  • nausea
  • pyrexia
  • fatigue
  • dyspnoea
  • depression
40-49:
  • pain
  • diarrhoea
  • headache
  • anxiety
  • nausea
  • fatigue
  • back pain
  • arthralgia
  • vomiting
  • pain in extremity
50-59:
  • pain
  • nausea
  • arthralgia
  • anxiety
  • pain in extremity
  • dyspnoea
  • fall
  • hypoaesthesia
  • injury
  • vomiting
60+:
  • fatigue
  • pain
  • nausea
  • fall
  • dyspnoea
  • pain in extremity
  • anaemia
  • headache
  • arthralgia
  • asthenia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Gabapentin (gabapentin) is often used to treat pain. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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