Review: taking Gabapentin and Benadryl together


Summary

Drug interactions are reported among people who take Gabapentin and Benadryl together. This review analyzes the effectiveness and drug interactions between Gabapentin and Benadryl. It is created by eHealthMe based on reports of 1,951 people who take the same drugs from FDA and social media, and is updated regularly.

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Gabapentin

Gabapentin has active ingredients of gabapentin. It is often used in pain. (latest outcomes from Gabapentin 38,775 users)

Benadryl

Benadryl has active ingredients of diphenhydramine. It is often used in hypersensitivity. (latest outcomes from Benadryl 29,241 users)

On Jul, 20, 2016

1,951 people who take Gabapentin, Benadryl are studied.


Number of reports submitted per year:

Gabapentin and Benadryl drug interactions.

Drug effectiveness over time:

Gabapentin:
  • < 1 month: 40.0% - (2 of 5 people)
  • 1 - 6 months: 25.0% - (3 of 12 people)
  • 6 - 12 months: 28.0% - (2 of 7 people)
  • 1 - 2 years: 37.0% - (6 of 16 people)
  • 2 - 5 years: 33.0% - (5 of 15 people)
  • 5 - 10 years: 80.0% - (4 of 5 people)
  • 10+ years: 50.0% - (3 of 6 people)
  • not specified: 0.0% - (0 of 2 people)
Benadryl:
  • < 1 month: 13.0% - (2 of 15 people)
  • 1 - 6 months: 36.0% - (4 of 11 people)
  • 6 - 12 months: 100.0% - (5 of 5 people)
  • 1 - 2 years: 42.0% - (3 of 7 people)
  • 2 - 5 years: 71.0% - (5 of 7 people)
  • 5 - 10 years: 77.0% - (7 of 9 people)
  • 10+ years: 87.0% - (7 of 8 people)
  • not specified: 50.0% - (1 of 2 people)

Drug effectiveness by gender:

Gabapentin:
  • female: 36.0% - (18 of 49 people)
  • male: 36.0% - (7 of 19 people)
Benadryl:
  • female: 58.0% - (28 of 48 people)
  • male: 37.0% - (6 of 16 people)

Drug effectiveness by age:

Gabapentin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 33.0% - (2 of 6 people)
  • 30-39: 25.0% - (3 of 12 people)
  • 40-49: 20.0% - (3 of 15 people)
  • 50-59: 65.0% - (13 of 20 people)
  • 60+: 26.0% - (4 of 15 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 28.0% - (2 of 7 people)
  • 30-39: 75.0% - (9 of 12 people)
  • 40-49: 42.0% - (6 of 14 people)
  • 50-59: 64.0% - (11 of 17 people)
  • 60+: 42.0% - (6 of 14 people)

Most common drug interactions over time *:

< 1 month:
  • pain in extremity
  • fatigue
  • dehydration
  • hypotension
  • aspartate aminotransferase increased
  • deep vein thrombosis
  • alanine aminotransferase increased
  • anaemia
  • alopecia
  • anorexia
1 - 6 months:
  • neck pain
  • pneumonitis
  • respiratory failure
  • acute respiratory distress syndrome
  • blood bilirubin increased
  • duodenal ulcer perforation
  • hypernatraemia
  • hypotension
  • interstitial lung disease
  • pneumonia respiratory syncytial viral
6 - 12 months:
  • appendicitis
  • blood cholesterol increased
  • cardiac failure congestive
  • dehydration
  • diabetes mellitus inadequate control
  • diabetic foot
  • diabetic neuropathy
  • erythema
  • fabry's disease
  • foot fracture
1 - 2 years:
  • neck pain
  • coma
  • drug ineffective
  • hepatic failure
  • suicide attempt
  • acid reflux
  • allergy to animal
  • allergy to chemicals
  • allergy to plants
  • amnesia
2 - 5 years:
  • amnesia
  • blood creatinine increased
  • coma
  • confusional state
  • drug ineffective
  • hepatic failure
  • hypoglycaemia
  • multiple drug overdose
  • oliguria
  • suicide attempt
5 - 10 years:
  • drug ineffective
  • sleep disorder
  • alopecia
  • arthritis
  • bronchitis chronic
  • convulsion
  • emotional disorder
  • excessive thirst
  • feeling abnormal
  • haemorrhoids
10+ years:
  • ataxia
  • myoclonus
  • blurred vision
  • cervical spine pain
  • chronic hepatitis
  • double vision
  • fasciculations of muscle
  • hyperlipidemia
  • loss of sensation, numbness and tingling, paresthesias, sensory loss, tingling and numbness
  • myoclonic epilepsy
not specified:
  • pain
  • anxiety
  • arthralgia
  • nausea
  • back pain
  • pain in extremity
  • dyspnoea
  • anaemia
  • osteonecrosis of jaw
  • vomiting

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • arthralgia
  • dyspnoea
  • nausea
  • pain in extremity
  • back pain
  • anaemia
  • osteonecrosis of jaw
  • vomiting
male:
  • pain
  • anxiety
  • nausea
  • pain in extremity
  • depression
  • arthralgia
  • back pain
  • headache
  • vomiting
  • anaemia

Most common drug interactions by age *:

0-1:
  • orthostatic hypotension
  • chest pain
  • nephrolithiasis
  • pericardial effusion
  • pulmonary hypertension
  • sepsis
  • stillbirth
  • type 2 diabetes mellitus
  • umbilical cord around neck
  • urinary tract infection
2-9:
  • contusion
  • diarrhoea haemorrhagic
  • gastrointestinal mucosal exfoliation
  • haematochezia
  • malignant neoplasm progression
  • neuroblastoma
  • pneumatosis intestinalis
  • ulcer haemorrhage
10-19:
  • pain
  • hypotension
  • nephrogenic systemic fibrosis
  • pain in extremity
  • cardiac arrest
  • pyrexia
  • acute respiratory distress syndrome
  • blood bilirubin increased
  • hypernatraemia
  • malaise
20-29:
  • pain
  • dyspnoea
  • nausea
  • lung disorder
  • pyrexia
  • lymphadenopathy
  • tachycardia
  • arthralgia
  • depression
  • dizziness
30-39:
  • headache
  • pain
  • vomiting
  • anxiety
  • diarrhoea
  • pyrexia
  • paraesthesia
  • hallucination
  • back pain
  • dyspnoea
40-49:
  • pain
  • anxiety
  • back pain
  • diarrhoea
  • headache
  • pain in extremity
  • anaemia
  • nausea
  • arthralgia
  • fatigue
50-59:
  • pain
  • anxiety
  • pain in extremity
  • arthralgia
  • injury
  • nausea
  • hypoaesthesia
  • osteoarthritis
  • dyspnoea
  • emotional distress
60+:
  • fall
  • fatigue
  • pain
  • anaemia
  • pain in extremity
  • osteoarthritis
  • dyspnoea
  • nausea
  • back pain
  • osteonecrosis of jaw

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Gabapentin (gabapentin) is often used to treat pain. Benadryl (diphenhydramine) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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