Review: taking Isoniazid and Rifampin together


Summary

Drug interactions are reported among people who take Isoniazid and Rifampin together. This review analyzes the effectiveness and drug interactions between Isoniazid and Rifampin. It is created by eHealthMe based on reports of 1,425 people who take the same drugs from FDA and social media, and is updated regularly.

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Isoniazid

Isoniazid has active ingredients of isoniazid. It is often used in tuberculosis. (latest outcomes from Isoniazid 10,069 users)

Rifampin

Rifampin has active ingredients of rifampin. It is often used in tuberculosis. (latest outcomes from Rifampin 3,220 users)

On Sep, 16, 2016

1,425 people who take Isoniazid, Rifampin are studied.


Number of reports submitted per year:

Isoniazid and Rifampin drug interactions.

Drug effectiveness over time:

Isoniazid:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 44.0% - (4 of 9 people)
  • 6 - 12 months: 100.0% - (3 of 3 people)
  • 1 - 2 years: 100.0% - (1 of 1 people)
  • 2 - 5 years: 0.0% - (0 of 0 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)
Rifampin:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 44.0% - (4 of 9 people)
  • 6 - 12 months: 100.0% - (3 of 3 people)
  • 1 - 2 years: 100.0% - (1 of 1 people)
  • 2 - 5 years: 0.0% - (0 of 0 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Isoniazid:
  • female: 77.0% - (7 of 9 people)
  • male: 25.0% - (1 of 4 people)
Rifampin:
  • female: 77.0% - (7 of 9 people)
  • male: 25.0% - (1 of 4 people)

Drug effectiveness by age:

Isoniazid:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 75.0% - (3 of 4 people)
  • 30-39: 50.0% - (2 of 4 people)
  • 40-49: 100.0% - (2 of 2 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 50.0% - (1 of 2 people)
Rifampin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 75.0% - (3 of 4 people)
  • 30-39: 50.0% - (2 of 4 people)
  • 40-49: 100.0% - (2 of 2 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 50.0% - (1 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • pyrexia
  • renal failure acute
  • cytolytic hepatitis
  • hepatitis
  • hepatitis fulminant
  • cholestasis
  • headache
  • hepatic encephalopathy
  • liver disorder
  • multi-organ failure
1 - 6 months:
  • pyrexia
  • hepatitis fulminant
  • cytolytic hepatitis
  • neutropenia
  • drug eruption
  • leukopenia
  • renal failure acute
  • eosinophilia
  • anaemia
  • dyspnoea
6 - 12 months:
  • convulsion
  • ocular icterus
  • deafness
  • hypoacusis
  • optic neuropathy
  • pruritus
  • blood alkaline phosphatase increased
  • cerebral toxoplasmosis
  • cholangitis
  • cholestasis
1 - 2 years:
  • acne
  • blood cholesterol
  • thrombocytopenia
  • disturbance in attention
  • hypothermia
  • lung disorder
  • mental disorder
  • pulmonary thrombosis
  • renal failure chronic
  • respiratory distress
2 - 5 years:
  • disturbance in attention
  • paraesthesia
  • mental disorder
  • somnolence
  • cerebral ischaemia
  • diplopia
  • drug eruption
  • dysarthria
  • fatigue
  • meningism
5 - 10 years:
  • stevens johnson syndrome
not specified:
  • pyrexia
  • renal failure acute
  • tuberculosis
  • weight decreased
  • vomiting
  • nausea
  • thrombocytopenia
  • hepatotoxicity
  • aspartate aminotransferase increased
  • alanine aminotransferase increased

Most common drug interactions by gender *:

female:
  • pyrexia
  • tuberculosis
  • hepatitis fulminant
  • nausea
  • hepatic encephalopathy
  • alanine aminotransferase increased
  • hepatotoxicity
  • vomiting
  • weight decreased
  • aspartate aminotransferase increased
male:
  • pyrexia
  • renal failure acute
  • dyspnoea
  • thrombocytopenia
  • neutropenia
  • weight decreased
  • liver disorder
  • drug eruption
  • aspartate aminotransferase increased
  • vomiting

Most common drug interactions by age *:

0-1:
  • foetal exposure during pregnancy
  • trisomy 21
  • foetal growth restriction
  • immune reconstitution syndrome
  • premature baby
  • pyrexia
  • acute hepatic failure
  • bovine tuberculosis
  • brain oedema
  • coagulopathy
2-9:
  • drug resistance
  • disease progression
  • hemiparesis
  • hydrocephalus
  • paradoxical drug reaction
  • pyrexia
  • acute hepatic failure
  • hepatitis
  • pulmonary tuberculosis
  • acinetobacter infection
10-19:
  • pyrexia
  • acute hepatic failure
  • renal failure acute
  • drug level increased
  • eosinophilia
  • lymphadenopathy
  • paradoxical drug reaction
  • thrombocytopenia
  • acute respiratory distress syndrome
  • cough
20-29:
  • pyrexia
  • aspartate aminotransferase increased
  • nausea
  • hepatic failure
  • hepatotoxicity
  • alanine aminotransferase increased
  • immune reconstitution syndrome
  • blood creatine phosphokinase increased
  • hepatic necrosis
  • weight decreased
30-39:
  • pyrexia
  • renal failure acute
  • hepatitis fulminant
  • tuberculosis
  • immune reconstitution syndrome
  • deep vein thrombosis
  • general physical health deterioration
  • dyspnoea
  • lymphadenopathy
  • pulmonary embolism
40-49:
  • pyrexia
  • vomiting
  • pulmonary tuberculosis
  • hepatitis fulminant
  • anaemia
  • diarrhoea
  • death
  • aspartate aminotransferase increased
  • dyspnoea
  • hepatic encephalopathy
50-59:
  • pyrexia
  • renal failure acute
  • drug eruption
  • leukopenia
  • weight decreased
  • neutropenia
  • chest pain
  • stevens-johnson syndrome
  • convulsion
  • disseminated tuberculosis
60+:
  • pyrexia
  • liver disorder
  • thrombocytopenia
  • renal failure acute
  • liver function tests nos abnormal
  • hepatic failure
  • nausea
  • vomiting
  • weight decreased
  • cholestasis

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Isoniazid (isoniazid) is often used to treat tuberculosis. Rifampin (rifampin) is often used to treat tuberculosis. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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