Review: taking Keppra and Benadryl together


Summary

Drug interactions are reported among people who take Keppra and Benadryl together. This review analyzes the effectiveness and drug interactions between Keppra and Benadryl. It is created by eHealthMe based on reports of 603 people who take the same drugs from FDA and social media, and is updated regularly.

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Keppra

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. (latest outcomes from Keppra 36,047 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 43,259 users)

On Sep, 16, 2016

603 people who take Keppra, Benadryl are studied.


Number of reports submitted per year:

Keppra and Benadryl drug interactions.

Drug effectiveness over time:

Keppra:
  • < 1 month: 33.0% - (1 of 3 people)
  • 1 - 6 months: 0.0% - (0 of 2 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 50.0% - (1 of 2 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)
Benadryl:
  • < 1 month: 0.0% - (0 of 3 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 0.0% - (0 of 0 people)
  • 5 - 10 years: 50.0% - (1 of 2 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Keppra:
  • female: 25.0% - (1 of 4 people)
  • male: 50.0% - (2 of 4 people)
Benadryl:
  • female: 0.0% - (0 of 3 people)
  • male: 33.0% - (1 of 3 people)

Drug effectiveness by age:

Keppra:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 2 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 100.0% - (2 of 2 people)
  • 30-39: 0.0% - (0 of 2 people)
  • 40-49: 100.0% - (1 of 1 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 0.0% - (0 of 0 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 2 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 100.0% - (1 of 1 people)
  • 30-39: 0.0% - (0 of 2 people)
  • 40-49: 0.0% - (0 of 0 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 0.0% - (0 of 0 people)

Most common drug interactions over time *:

< 1 month:
  • renal failure acute
  • blood bilirubin increased
  • fatigue
  • engraftment syndrome
  • insomnia
  • pyrexia
  • osteomyelitis
  • blood lactate dehydrogenase increased
  • haemoglobinuria
  • oral herpes
1 - 6 months:
  • acute respiratory failure
  • haemorrhage intracranial
  • hypotension
  • disease progression
  • convulsion
  • failure to thrive
  • pneumonia streptococcal
  • sepsis
  • seizure
  • overdose
6 - 12 months:
  • coronary artery disease
  • disease progression
  • dizziness
  • fatigue
  • glioblastoma
  • haemorrhagic stroke
  • heart rate irregular
  • ischaemic stroke
  • laboratory test abnormal
  • platelet count decreased
1 - 2 years:
  • metabolic acidosis
  • metabolic alkalosis
  • vomiting
  • abdominal discomfort
  • abdominal pain upper
  • aspartate aminotransferase increased
  • asthenia
  • body temperature decreased
  • diarrhoea
  • disease progression
2 - 5 years:
  • meningitis aseptic
  • metabolic acidosis
  • metabolic alkalosis
  • pruritus
  • alopecia
  • autoimmune disorder
  • convulsion
  • headache
  • heart rate increased
  • infusion site vesicles
5 - 10 years:
  • contusion
  • convulsion
  • dizziness
  • fall
not specified:
  • convulsion
  • headache
  • nausea
  • diarrhoea
  • vomiting
  • fatigue
  • pyrexia
  • dyspnoea
  • pneumonia
  • anaemia

Most common drug interactions by gender *:

female:
  • headache
  • nausea
  • convulsion
  • vomiting
  • fatigue
  • diarrhoea
  • pyrexia
  • asthenia
  • pain
  • rash
male:
  • convulsion
  • diarrhoea
  • fatigue
  • pyrexia
  • dyspnoea
  • anaemia
  • hypotension
  • vomiting
  • pneumonia
  • constipation

Most common drug interactions by age *:

0-1:
  • constipation
  • decreased appetite
  • diabetes insipidus
  • hyponatraemia
  • muscle spasms
  • myoclonic epilepsy
  • pain
  • hypernatraemia
  • tachycardia
  • vomiting
2-9:
  • dehydration
  • seizure
  • convulsion
  • pyrexia
  • anaemia
  • irritability
  • vomiting
  • constipation
  • diarrhoea
  • fatigue
10-19:
  • convulsion
  • blood bilirubin increased
  • hypotension
  • acute respiratory failure
  • engraftment syndrome
  • haemorrhage intracranial
  • renal failure acute
  • headache
  • failure to thrive
  • pneumonia streptococcal
20-29:
  • headache
  • convulsion
  • nausea
  • vomiting
  • diarrhoea
  • cerebrovascular accident
  • dyspepsia
  • gestational diabetes
  • malaise
  • pregnancy
30-39:
  • convulsion
  • fatigue
  • dyspnoea
  • vomiting
  • deep vein thrombosis
  • nausea
  • death
  • headache
  • insomnia
  • rash
40-49:
  • fatigue
  • diarrhoea
  • weight decreased
  • fall
  • pain
  • dyspnoea
  • nausea
  • pruritus
  • headache
  • disease progression
50-59:
  • headache
  • nausea
  • convulsion
  • pyrexia
  • fatigue
  • fall
  • insomnia
  • seizure
  • amnesia
  • diarrhoea
60+:
  • convulsion
  • nausea
  • mental status changes
  • pyrexia
  • anaemia
  • asthenia
  • cellulitis
  • pneumonia
  • diarrhoea
  • loss of consciousness

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Keppra (levetiracetam) is often used to treat epilepsy. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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