Review: taking Keppra and Benadryl together


Summary

Drug interactions are reported among people who take Keppra and Benadryl together. This review analyzes the effectiveness and drug interactions between Keppra and Benadryl. It is created by eHealthMe based on reports of 281 people who take the same drugs from FDA and social media, and is updated regularly.

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Keppra

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. (latest outcomes from Keppra 20,775 users)

Benadryl

Benadryl has active ingredients of diphenhydramine. It is often used in hypersensitivity. (latest outcomes from Benadryl 29,241 users)

On Jul, 20, 2016

281 people who take Keppra, Benadryl are studied.


Number of reports submitted per year:

Keppra and Benadryl drug interactions.

Drug effectiveness over time:

Keppra:
  • < 1 month: 33.0% - (1 of 3 people)
  • 1 - 6 months: 0.0% - (0 of 2 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 60.0% - (3 of 5 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)
Benadryl:
  • < 1 month: 0.0% - (0 of 3 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 1 people)
  • 2 - 5 years: 0.0% - (0 of 0 people)
  • 5 - 10 years: 33.0% - (1 of 3 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Keppra:
  • female: 50.0% - (3 of 6 people)
  • male: 40.0% - (2 of 5 people)
Benadryl:
  • female: 0.0% - (0 of 4 people)
  • male: 25.0% - (1 of 4 people)

Drug effectiveness by age:

Keppra:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 2 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 100.0% - (2 of 2 people)
  • 30-39: 0.0% - (0 of 2 people)
  • 40-49: 100.0% - (3 of 3 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 0.0% - (0 of 0 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 2 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 100.0% - (1 of 1 people)
  • 30-39: 0.0% - (0 of 2 people)
  • 40-49: 0.0% - (0 of 1 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 0.0% - (0 of 0 people)

Most common drug interactions over time *:

< 1 month:
  • engraftment syndrome
  • acute graft versus host disease in liver
  • blood lactate dehydrogenase increased
  • haemoglobinuria
  • insomnia
  • mental status changes
  • oral herpes
  • osteomyelitis
  • renal failure acute
  • blood bilirubin increased
1 - 6 months:
  • toxic epidermal necrolysis
  • seizure anoxic
6 - 12 months:
  • dizziness
1 - 2 years:
  • metabolic acidosis
  • metabolic alkalosis
2 - 5 years:
  • metabolic acidosis
  • metabolic alkalosis
5 - 10 years:
  • dizziness
not specified:
  • convulsion
  • nausea
  • headache
  • vomiting
  • diarrhoea
  • anaemia
  • pneumonia
  • pyrexia
  • dyspnoea
  • tremor

Most common drug interactions by gender *:

female:
  • convulsion
  • nausea
  • headache
  • asthenia
  • vomiting
  • depression
  • diarrhoea
  • anxiety
  • dizziness
  • pain in extremity
male:
  • convulsion
  • renal failure acute
  • dyspnoea
  • anaemia
  • blood bilirubin increased
  • mental status changes
  • neutropenia
  • vomiting
  • pneumonia
  • thrombocytopenia

Most common drug interactions by age *:

2-9:
  • dehydration
  • bacillus infection
  • diarrhoea haemorrhagic
  • disease progression
  • gastrointestinal mucosal exfoliation
  • haematochezia
  • haemoglobin decreased
  • hypokalaemia
  • pneumatosis intestinalis
  • seizure anoxic
10-19:
  • blood bilirubin increased
  • engraftment syndrome
  • renal failure acute
  • headache
  • convulsion
  • acute graft versus host disease in liver
  • alanine aminotransferase increased
  • blood alkaline phosphatase increased
  • fall
  • nervous system disorder
20-29:
  • headache
  • vomiting
  • diarrhoea
  • nausea
  • cerebrovascular accident
  • dyspepsia
  • gestational diabetes
  • malaise
  • pregnancy
  • subarachnoid haemorrhage
30-39:
  • convulsion
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • blood bilirubin increased
  • blood creatine phosphokinase increased
  • blood glucose increased
  • blood triglycerides increased
  • brain oedema
  • deep vein thrombosis
  • gamma-glutamyltransferase increased
40-49:
  • fatigue
  • nausea
  • pneumonia
  • convulsion
  • fall
  • loss of consciousness
  • dyspnoea
  • constipation
  • deep vein thrombosis
  • gastrooesophageal reflux disease
50-59:
  • nausea
  • pyrexia
  • convulsion
  • dizziness
  • hypersensitivity
  • oesophageal infection
  • oxygen saturation decreased
  • tremor
  • anaemia
  • dyspnoea
60+:
  • convulsion
  • anaemia
  • mental status changes
  • nausea
  • loss of consciousness
  • unresponsive to stimuli
  • anxiety
  • asthenia
  • delirium
  • pneumonia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Keppra (levetiracetam) is often used to treat epilepsy. Benadryl (diphenhydramine) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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