Review: taking Klonopin and Aldactone together


Summary

Drug interactions are reported among people who take Klonopin and Aldactone together. This review analyzes the effectiveness and drug interactions between Klonopin and Aldactone. It is created by eHealthMe based on reports of 1,496 people who take the same drugs from FDA and social media, and is updated regularly.

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Klonopin

Klonopin has active ingredients of clonazepam. It is often used in stress and anxiety. (latest outcomes from Klonopin 41,671 users)

Aldactone

Aldactone has active ingredients of spironolactone. It is often used in high blood pressure. (latest outcomes from Aldactone 28,199 users)

On Sep, 25, 2016

1,496 people who take Klonopin, Aldactone are studied.


Number of reports submitted per year:

Klonopin and Aldactone drug interactions.

Drug effectiveness over time:

Klonopin:
  • < 1 month: 50.0% - (1 of 2 people)
  • 1 - 6 months: 33.0% - (1 of 3 people)
  • 6 - 12 months: 33.0% - (1 of 3 people)
  • 1 - 2 years: 28.0% - (2 of 7 people)
  • 2 - 5 years: 28.0% - (2 of 7 people)
  • 5 - 10 years: 33.0% - (1 of 3 people)
  • 10+ years: 0.0% - (0 of 4 people)
  • not specified: 0.0% - (0 of 0 people)
Aldactone:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 50.0% - (1 of 2 people)
  • 6 - 12 months: 60.0% - (3 of 5 people)
  • 1 - 2 years: 28.0% - (2 of 7 people)
  • 2 - 5 years: 60.0% - (3 of 5 people)
  • 5 - 10 years: 50.0% - (2 of 4 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Klonopin:
  • female: 32.0% - (8 of 25 people)
  • male: 0.0% - (0 of 4 people)
Aldactone:
  • female: 45.0% - (10 of 22 people)
  • male: 50.0% - (2 of 4 people)

Drug effectiveness by age:

Klonopin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 33.0% - (2 of 6 people)
  • 30-39: 20.0% - (1 of 5 people)
  • 40-49: 16.0% - (1 of 6 people)
  • 50-59: 22.0% - (2 of 9 people)
  • 60+: 66.0% - (2 of 3 people)
Aldactone:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (3 of 6 people)
  • 30-39: 100.0% - (4 of 4 people)
  • 40-49: 16.0% - (1 of 6 people)
  • 50-59: 14.0% - (1 of 7 people)
  • 60+: 100.0% - (3 of 3 people)

Most common drug interactions over time *:

< 1 month:
  • pain
  • renal failure acute
  • blood osmolarity decreased
  • dysgeusia
  • erythema
  • face oedema
  • hyponatraemia
  • inappropriate antidiuretic hormone secretion
  • oral mucosal discolouration
  • oropharyngeal swelling
1 - 6 months:
  • renal failure acute
  • cardiac arrest
  • dyspnoea
  • fall
  • anxiety
  • hyperkalaemia
  • malaise
  • pulmonary embolism
  • pyrexia
  • abdominal pain upper
6 - 12 months:
  • hepatic cirrhosis
  • ascites
  • blood pressure increased
  • portal hypertension
  • varices oesophageal
  • anaemia
  • blood creatinine increased
  • blood phosphorus increased
  • blood sodium decreased
  • cardiomegaly
1 - 2 years:
  • dyspnoea
  • asthenia
  • chest pain
  • death
  • depressed mood
  • headache
  • high blood pressure
  • hypertension
  • injury
  • leukopenia
2 - 5 years:
  • pain
  • osteomyelitis
  • arrhythmia
  • acquired oesophageal web
  • blindness unilateral
  • cataract
  • cellulitis
  • dermatitis
  • eyelid ptosis
  • gastrooesophageal reflux disease
5 - 10 years:
  • anxiety
  • back injury
  • depression
  • face injury
  • fall
  • mouth injury
  • osteomyelitis
  • osteonecrosis
  • road traffic accident
  • spinal cord disorder
10+ years:
  • depression
  • accommodation disorder
  • agitated depression
  • anxiety
  • dry mouth
  • dry skin
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • foetal methotrexate syndrome
  • hair loss
  • hallucinations
not specified:
  • pain
  • fall
  • depression
  • anxiety
  • cardiac failure congestive
  • dyspnoea
  • nausea
  • dizziness
  • oedema peripheral
  • fatigue

Most common drug interactions by gender *:

female:
  • nausea
  • dyspnoea
  • pain
  • cardiac failure congestive
  • anxiety
  • fall
  • dizziness
  • chest pain
  • fatigue
  • vomiting
male:
  • pain
  • fall
  • depression
  • cellulitis
  • oedema peripheral
  • anxiety
  • osteoarthritis
  • ankle fracture
  • cardiac failure congestive
  • atrial fibrillation

Most common drug interactions by age *:

0-1:
  • neonatal disorder
  • upper respiratory tract infection
  • viral infection
2-9:
  • anxiety
  • death
  • fear
  • injury
  • multi-organ failure
  • pain
  • renal failure
  • renal impairment
  • emotional distress
  • renal injury
10-19:
  • blood culture positive
  • catheter site haemorrhage
  • catheter site infection
  • chest pain
  • cytokine release syndrome
  • disease progression
  • febrile neutropenia
  • fluid overload
  • hyperglycaemia
  • pulmonary arterial hypertension
20-29:
  • bronchitis
  • cardiac failure congestive
  • cholecystitis
  • influenza like illness
  • urinary tract infection
  • atrial fibrillation
  • insomnia
  • intracardiac thrombus
  • presyncope
  • tuberculin test positive
30-39:
  • anxiety
  • nausea
  • asthenia
  • dizziness
  • mucosal inflammation
  • pneumonia
  • dyspnoea
  • injury
  • chest discomfort
  • pain
40-49:
  • pain
  • diabetes mellitus
  • anxiety
  • back pain
  • nausea
  • depression
  • diarrhoea
  • fatigue
  • oedema
  • drug ineffective
50-59:
  • fall
  • depression
  • pain
  • cellulitis
  • osteoarthritis
  • osteoporosis
  • ankle fracture
  • lower limb fracture
  • drug ineffective
  • dyspnoea
60+:
  • fall
  • dizziness
  • pain
  • cardiac failure congestive
  • dyspnoea
  • oedema peripheral
  • anxiety
  • nausea
  • atrial fibrillation
  • arthralgia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Klonopin (clonazepam) is often used to treat stress and anxiety. Aldactone (spironolactone) is often used to treat high blood pressure. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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