Review: taking Lamictal and Keppra xr together


Summary

Drug interactions are reported among people who take Lamictal and Keppra xr together. This review analyzes the effectiveness and drug interactions between Lamictal and Keppra xr. It is created by eHealthMe based on reports of 3,516 people who take the same drugs from FDA and social media, and is updated regularly.

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Lamictal

Lamictal has active ingredients of lamotrigine. It is often used in bipolar disorder. (latest outcomes from Lamictal 40,254 users)

Keppra Xr

Keppra xr has active ingredients of levetiracetam. It is often used in epilepsy. (latest outcomes from Keppra xr 431 users)

On Jul, 20, 2016

3,516 people who take Lamictal, Keppra Xr are studied.


Number of reports submitted per year:

Lamictal and Keppra xr drug interactions.

Drug effectiveness over time:

Lamictal:
  • < 1 month: 25.0% - (1 of 4 people)
  • 1 - 6 months: 50.0% - (5 of 10 people)
  • 6 - 12 months: 37.0% - (3 of 8 people)
  • 1 - 2 years: 44.0% - (12 of 27 people)
  • 2 - 5 years: 46.0% - (21 of 45 people)
  • 5 - 10 years: 55.0% - (16 of 29 people)
  • 10+ years: 56.0% - (14 of 25 people)
  • not specified: 33.0% - (1 of 3 people)
Keppra Xr:
  • < 1 month: 37.0% - (3 of 8 people)
  • 1 - 6 months: 66.0% - (8 of 12 people)
  • 6 - 12 months: 50.0% - (6 of 12 people)
  • 1 - 2 years: 37.0% - (9 of 24 people)
  • 2 - 5 years: 53.0% - (23 of 43 people)
  • 5 - 10 years: 68.0% - (20 of 29 people)
  • 10+ years: 65.0% - (15 of 23 people)
  • not specified: 33.0% - (1 of 3 people)

Drug effectiveness by gender:

Lamictal:
  • female: 44.0% - (47 of 106 people)
  • male: 57.0% - (26 of 45 people)
Keppra Xr:
  • female: 54.0% - (57 of 104 people)
  • male: 56.0% - (28 of 50 people)

Drug effectiveness by age:

Lamictal:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 50.0% - (2 of 4 people)
  • 10-19: 28.0% - (2 of 7 people)
  • 20-29: 42.0% - (17 of 40 people)
  • 30-39: 53.0% - (23 of 43 people)
  • 40-49: 36.0% - (7 of 19 people)
  • 50-59: 59.0% - (16 of 27 people)
  • 60+: 54.0% - (6 of 11 people)
Keppra Xr:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 50.0% - (2 of 4 people)
  • 10-19: 42.0% - (3 of 7 people)
  • 20-29: 48.0% - (19 of 39 people)
  • 30-39: 59.0% - (26 of 44 people)
  • 40-49: 55.0% - (10 of 18 people)
  • 50-59: 67.0% - (19 of 28 people)
  • 60+: 42.0% - (6 of 14 people)

Most common drug interactions over time *:

< 1 month:
  • rash
  • pyrexia
  • convulsion
  • status epilepticus
  • grand mal convulsion
  • stevens-johnson syndrome
  • fatigue
  • pruritus
  • tonsillar hypertrophy
  • vomiting
1 - 6 months:
  • convulsion
  • headache
  • pyrexia
  • depression
  • grand mal convulsion
  • thrombocytopenia
  • confusional state
  • dizziness
  • drug exposure during pregnancy
  • drug toxicity
6 - 12 months:
  • pyrexia
  • drug exposure during pregnancy
  • insomnia
  • irritability
  • diarrhoea
  • cough
  • ammonia increased
  • atrial septal defect
  • autonomic nervous system imbalance
  • constipation
1 - 2 years:
  • insomnia
  • constipation
  • diarrhoea
  • pyrexia
  • ammonia increased
  • atrial septal defect
  • autonomic nervous system imbalance
  • cough
  • crying
  • cyanosis
2 - 5 years:
  • convulsion
  • aggression
  • mood altered
  • thermal burn
  • rhabdomyolysis
  • acute hepatic failure
  • pruritus
  • rash
  • thrombocytopenia
  • dizziness
5 - 10 years:
  • rash
  • complex partial seizures
  • epilepsy
  • thirst
  • tremor
  • abnormal behaviour
  • agitation
  • balance disorder
  • bronchial obstruction
  • chest pain
10+ years:
  • seizure - grand mal
  • seizure - petit mal
  • inflammation
  • vicodin overdose
  • aches - leg
  • angiopathy
  • arthritis
  • blood creatinine increased
  • burning eyes
  • clumsiness
not specified:
  • convulsion
  • drug exposure during pregnancy
  • grand mal convulsion
  • fatigue
  • dizziness
  • drug ineffective
  • depression
  • epilepsy
  • nausea
  • headache

Most common drug interactions by gender *:

female:
  • convulsion
  • drug exposure during pregnancy
  • grand mal convulsion
  • fatigue
  • dizziness
  • drug ineffective
  • headache
  • nausea
  • rash
  • depression
male:
  • convulsion
  • fatigue
  • grand mal convulsion
  • pyrexia
  • fall
  • status epilepticus
  • depression
  • rash
  • aggression
  • insomnia

Most common drug interactions by age *:

0-1:
  • maternal drugs affecting foetus
  • drug exposure during pregnancy
  • ventricular septal defect
  • foetal exposure during pregnancy
  • maternal exposure during pregnancy
  • eyelid ptosis congenital
  • congenital hydronephrosis
  • foot deformity
  • oxygen saturation decreased
  • bradycardia neonatal
2-9:
  • convulsion
  • aggression
  • rash
  • abnormal behaviour
  • drug ineffective
  • thrombocytopenia
  • encephalopathy
  • hyperpyrexia
  • metabolic acidosis
  • cognitive disorder
10-19:
  • convulsion
  • grand mal convulsion
  • depression
  • aggression
  • fatigue
  • thrombocytopenia
  • rash
  • epilepsy
  • stevens-johnson syndrome
  • abnormal behaviour
20-29:
  • convulsion
  • drug exposure during pregnancy
  • grand mal convulsion
  • nausea
  • fatigue
  • vomiting
  • drug ineffective
  • epilepsy
  • pregnancy
  • speech disorder
30-39:
  • convulsion
  • drug exposure during pregnancy
  • epilepsy
  • nausea
  • depression
  • grand mal convulsion
  • dizziness
  • headache
  • fatigue
  • rash
40-49:
  • convulsion
  • drug ineffective
  • dizziness
  • headache
  • fatigue
  • grand mal convulsion
  • rash
  • somnolence
  • status epilepticus
  • nausea
50-59:
  • convulsion
  • fatigue
  • headache
  • urinary tract infection
  • asthenia
  • grand mal convulsion
  • confusional state
  • somnolence
  • epilepsy
  • depression
60+:
  • convulsion
  • dizziness
  • confusional state
  • asthenia
  • nausea
  • fall
  • fatigue
  • rash
  • depression
  • pneumonia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Lamictal (lamotrigine) is often used to treat bipolar disorder. Keppra xr (levetiracetam) is often used to treat epilepsy. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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