Review: taking Lamictal and Keppra xr together


Summary

Drug interactions are reported among people who take Lamictal and Keppra xr together. This review analyzes the effectiveness and drug interactions between Lamictal and Keppra xr. It is created by eHealthMe based on reports of 4,490 people who take the same drugs from FDA and social media, and is updated regularly.

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Lamictal

Lamictal has active ingredients of lamotrigine. It is often used in bipolar disorder. (latest outcomes from Lamictal 44,187 users)

Keppra Xr

Keppra xr has active ingredients of levetiracetam. It is often used in convulsion. (latest outcomes from Keppra xr 587 users)

On Aug, 19, 2016

4,490 people who take Lamictal, Keppra Xr are studied.


Number of reports submitted per year:

Lamictal and Keppra xr drug interactions.

Drug effectiveness over time:

Lamictal:
  • < 1 month: 25.0% - (1 of 4 people)
  • 1 - 6 months: 50.0% - (5 of 10 people)
  • 6 - 12 months: 33.0% - (2 of 6 people)
  • 1 - 2 years: 50.0% - (9 of 18 people)
  • 2 - 5 years: 45.0% - (17 of 37 people)
  • 5 - 10 years: 55.0% - (16 of 29 people)
  • 10+ years: 55.0% - (11 of 20 people)
  • not specified: 33.0% - (1 of 3 people)
Keppra Xr:
  • < 1 month: 40.0% - (2 of 5 people)
  • 1 - 6 months: 63.0% - (7 of 11 people)
  • 6 - 12 months: 62.0% - (5 of 8 people)
  • 1 - 2 years: 29.0% - (5 of 17 people)
  • 2 - 5 years: 57.0% - (22 of 38 people)
  • 5 - 10 years: 73.0% - (19 of 26 people)
  • 10+ years: 57.0% - (11 of 19 people)
  • not specified: 33.0% - (1 of 3 people)

Drug effectiveness by gender:

Lamictal:
  • female: 44.0% - (40 of 90 people)
  • male: 59.0% - (22 of 37 people)
Keppra Xr:
  • female: 56.0% - (50 of 88 people)
  • male: 56.0% - (22 of 39 people)

Drug effectiveness by age:

Lamictal:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 33.0% - (1 of 3 people)
  • 10-19: 40.0% - (2 of 5 people)
  • 20-29: 44.0% - (15 of 34 people)
  • 30-39: 51.0% - (19 of 37 people)
  • 40-49: 43.0% - (7 of 16 people)
  • 50-59: 56.0% - (13 of 23 people)
  • 60+: 55.0% - (5 of 9 people)
Keppra Xr:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 33.0% - (1 of 3 people)
  • 10-19: 60.0% - (3 of 5 people)
  • 20-29: 51.0% - (18 of 35 people)
  • 30-39: 59.0% - (22 of 37 people)
  • 40-49: 64.0% - (9 of 14 people)
  • 50-59: 60.0% - (14 of 23 people)
  • 60+: 50.0% - (5 of 10 people)

Most common drug interactions over time *:

< 1 month:
  • convulsion
  • rash
  • pyrexia
  • drug eruption
  • grand mal convulsion
  • erythema
  • erythema multiforme
  • status epilepticus
  • conjunctivitis
  • stevens-johnson syndrome
1 - 6 months:
  • convulsion
  • pyrexia
  • headache
  • rash
  • grand mal convulsion
  • maternal drugs affecting foetus
  • depression
  • cleft lip and palate
  • limb malformation
  • microcephaly
6 - 12 months:
  • foetal exposure during pregnancy
  • atrial septal defect
  • pyrexia
  • drug exposure during pregnancy
  • insomnia
  • neonatal respiratory distress syndrome
  • irritability
  • convulsion
  • diarrhoea
  • cough
1 - 2 years:
  • insomnia
  • constipation
  • pyrexia
  • diarrhoea
  • road traffic accident
  • ammonia increased
  • atrial septal defect
  • autonomic nervous system imbalance
  • cough
  • crying
2 - 5 years:
  • convulsion
  • aggression
  • mood altered
  • thermal burn
  • rhabdomyolysis
  • acute hepatic failure
  • pruritus
  • rash
  • thrombocytopenia
  • dizziness
5 - 10 years:
  • convulsion
  • tremor
  • alopecia
  • diabetes mellitus
  • pancreatitis
  • weight decreased
  • aggression
  • chest pain
  • rash
  • speech disorder
10+ years:
  • seizure - grand mal
  • seizure - petit mal
  • inflammation
  • vicodin overdose
  • aches - leg
  • angiopathy
  • arthritis
  • blood creatinine increased
  • burning eyes
  • clumsiness
not specified:
  • convulsion
  • drug ineffective
  • grand mal convulsion
  • drug exposure during pregnancy
  • fatigue
  • dizziness
  • epilepsy
  • depression
  • headache
  • nausea

Most common drug interactions by gender *:

female:
  • convulsion
  • drug ineffective
  • grand mal convulsion
  • drug exposure during pregnancy
  • dizziness
  • pregnancy
  • headache
  • fatigue
  • nausea
  • epilepsy
male:
  • convulsion
  • fatigue
  • grand mal convulsion
  • drug ineffective
  • pyrexia
  • status epilepticus
  • fall
  • aggression
  • rash
  • depression

Most common drug interactions by age *:

0-1:
  • foetal exposure during pregnancy
  • maternal drugs affecting foetus
  • drug exposure during pregnancy
  • ventricular septal defect
  • convulsion
  • hypoglycaemia
  • hypoglycaemia neonatal
  • maternal exposure during pregnancy
  • oxygen saturation decreased
  • atrial septal defect
2-9:
  • convulsion
  • aggression
  • status epilepticus
  • rash
  • abnormal behaviour
  • drug ineffective
  • lethargy
  • thrombocytopenia
  • somnolence
  • encephalopathy
10-19:
  • convulsion
  • grand mal convulsion
  • depression
  • epilepsy
  • aggression
  • fatigue
  • rash
  • thrombocytopenia
  • memory impairment
  • status epilepticus
20-29:
  • convulsion
  • grand mal convulsion
  • drug exposure during pregnancy
  • nausea
  • drug ineffective
  • vomiting
  • fatigue
  • epilepsy
  • pregnancy
  • dizziness
30-39:
  • convulsion
  • epilepsy
  • drug exposure during pregnancy
  • grand mal convulsion
  • drug ineffective
  • nausea
  • fatigue
  • dizziness
  • headache
  • depression
40-49:
  • convulsion
  • drug ineffective
  • dizziness
  • headache
  • grand mal convulsion
  • fatigue
  • rash
  • somnolence
  • status epilepticus
  • speech disorder
50-59:
  • convulsion
  • headache
  • epilepsy
  • fatigue
  • urinary tract infection
  • dizziness
  • grand mal convulsion
  • asthenia
  • confusional state
  • somnolence
60+:
  • convulsion
  • confusional state
  • dizziness
  • fall
  • nausea
  • drug ineffective
  • depression
  • asthenia
  • rash
  • fatigue

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Lamictal (lamotrigine) is often used to treat bipolar disorder. Keppra xr (levetiracetam) is often used to treat convulsion. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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