Review: taking Lamotrigine and Benadryl together


Summary

Drug interactions are reported among people who take Lamotrigine and Benadryl together. This review analyzes the effectiveness and drug interactions between Lamotrigine and Benadryl. It is created by eHealthMe based on reports of 477 people who take the same drugs from FDA and social media, and is updated regularly.

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Lamotrigine

Lamotrigine has active ingredients of lamotrigine. It is often used in epilepsy. (latest outcomes from Lamotrigine 15,506 users)

Benadryl

Benadryl has active ingredients of diphenhydramine. It is often used in hypersensitivity. (latest outcomes from Benadryl 29,241 users)

On Jul, 20, 2016

477 people who take Lamotrigine, Benadryl are studied.


Number of reports submitted per year:

Lamotrigine and Benadryl drug interactions.

Drug effectiveness over time:

Lamotrigine:
  • < 1 month: 14.0% - (1 of 7 people)
  • 1 - 6 months: 7.0% - (1 of 14 people)
  • 6 - 12 months: 0.0% - (0 of 3 people)
  • 1 - 2 years: 33.0% - (3 of 9 people)
  • 2 - 5 years: 41.0% - (7 of 17 people)
  • 5 - 10 years: 77.0% - (7 of 9 people)
  • 10+ years: 33.0% - (1 of 3 people)
  • not specified: 100.0% - (3 of 3 people)
Benadryl:
  • < 1 month: 38.0% - (7 of 18 people)
  • 1 - 6 months: 44.0% - (4 of 9 people)
  • 6 - 12 months: 62.0% - (5 of 8 people)
  • 1 - 2 years: 13.0% - (2 of 15 people)
  • 2 - 5 years: 50.0% - (2 of 4 people)
  • 5 - 10 years: 33.0% - (1 of 3 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 80.0% - (4 of 5 people)

Drug effectiveness by gender:

Lamotrigine:
  • female: 30.0% - (16 of 53 people)
  • male: 58.0% - (7 of 12 people)
Benadryl:
  • female: 38.0% - (20 of 52 people)
  • male: 50.0% - (5 of 10 people)

Drug effectiveness by age:

Lamotrigine:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 5 people)
  • 20-29: 11.0% - (1 of 9 people)
  • 30-39: 37.0% - (6 of 16 people)
  • 40-49: 28.0% - (6 of 21 people)
  • 50-59: 90.0% - (9 of 10 people)
  • 60+: 25.0% - (1 of 4 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 4 people)
  • 20-29: 14.0% - (1 of 7 people)
  • 30-39: 37.0% - (6 of 16 people)
  • 40-49: 42.0% - (9 of 21 people)
  • 50-59: 70.0% - (7 of 10 people)
  • 60+: 50.0% - (2 of 4 people)

Most common drug interactions over time *:

< 1 month:
  • blood bilirubin increased
  • engraftment syndrome
  • renal failure acute
  • rash
  • acute graft versus host disease in liver
  • insomnia
  • pain
  • respiratory failure
  • pyrexia
  • sensory disturbance
1 - 6 months:
  • rash
  • urticaria
  • asthenia
  • depression
  • dizziness
  • dystonia
  • muscle twitching
  • pruritus
  • vision blurred
  • abasia
6 - 12 months:
  • rash
  • depression
  • feeling abnormal
  • hallucination, visual
  • pruritus
  • blister
  • bone loss
  • diarrhoea
  • pain
  • rash pustular
1 - 2 years:
  • dizziness
  • diabetes mellitus
  • headache
  • numbness and tingling
  • oxygen saturation decreased
  • type 2 diabetes mellitus
  • agitation
  • anhedonia
  • arthritis
  • cystitis
2 - 5 years:
  • abdominal discomfort
  • abdominal pain
  • abdominal pain upper
  • aggression aggravated
  • agitation aggravated
  • anger
  • arthritis
  • biliary dyskinesia
  • breast enlargement
  • breast pain
5 - 10 years:
  • hives
  • implant site bruising
  • petechiae
  • dizziness
  • headache
  • numbness and tingling
  • oxygen saturation decreased
  • rash pustular
  • drowsiness
  • heart rate irregular
10+ years:
  • confusion
  • forgetfulness
  • lower blood pressure
not specified:
  • rash
  • nausea
  • convulsion
  • depression
  • headache
  • confusional state
  • tremor
  • pain
  • vomiting
  • pruritus

Most common drug interactions by gender *:

female:
  • rash
  • nausea
  • pruritus
  • headache
  • pain
  • depression
  • convulsion
  • confusional state
  • tremor
  • pyrexia
male:
  • weight increased
  • rash
  • completed suicide
  • pneumonia
  • vomiting
  • agitation
  • dyspepsia
  • gait disturbance
  • incontinence
  • mania

Most common drug interactions by age *:

2-9:
  • petit mal epilepsy
10-19:
  • suicidal ideation
  • weight increased
  • akathisia
  • blood bilirubin increased
  • engraftment syndrome
  • pyrexia
  • renal failure acute
  • agitation
  • dyspepsia
  • gait disturbance
20-29:
  • rash
  • completed suicide
  • diarrhoea
  • feeling abnormal
  • abdominal pain
  • depression
  • convulsion
  • nausea
  • urticaria
  • dizziness
30-39:
  • convulsion
  • loss of consciousness
  • rash
  • headache
  • vomiting
  • dizziness
  • type 2 diabetes mellitus
  • agitation
  • amnesia
  • completed suicide
40-49:
  • rash
  • pruritus
  • headache
  • coma
  • mental disorder
  • nausea
  • completed suicide
  • confusional state
  • dizziness
  • tremor
50-59:
  • depression
  • meningitis aseptic
  • rash
  • mood swings
  • pain
  • fall
  • tremor
  • weight increased
  • weight decreased
  • fatigue
60+:
  • swelling
  • confusional state
  • delirium
  • pyrexia
  • anxiety
  • back pain
  • conjunctivitis
  • depression
  • dry mouth
  • headache

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Lamotrigine (lamotrigine) is often used to treat epilepsy. Benadryl (diphenhydramine) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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