Review: taking Lamotrigine and Benadryl together


Summary

Drug interactions are reported among people who take Lamotrigine and Benadryl together. This review analyzes the effectiveness and drug interactions between Lamotrigine and Benadryl. It is created by eHealthMe based on reports of 876 people who take the same drugs from FDA and social media, and is updated regularly.

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Lamotrigine

Lamotrigine has active ingredients of lamotrigine. It is often used in epilepsy. (latest outcomes from Lamotrigine 26,630 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 43,259 users)

On Sep, 15, 2016

876 people who take Lamotrigine, Benadryl are studied.


Number of reports submitted per year:

Lamotrigine and Benadryl drug interactions.

Drug effectiveness over time:

Lamotrigine:
  • < 1 month: 16.0% - (1 of 6 people)
  • 1 - 6 months: 7.0% - (1 of 13 people)
  • 6 - 12 months: 0.0% - (0 of 3 people)
  • 1 - 2 years: 33.0% - (3 of 9 people)
  • 2 - 5 years: 50.0% - (7 of 14 people)
  • 5 - 10 years: 85.0% - (6 of 7 people)
  • 10+ years: 33.0% - (1 of 3 people)
  • not specified: 100.0% - (1 of 1 people)
Benadryl:
  • < 1 month: 37.0% - (6 of 16 people)
  • 1 - 6 months: 44.0% - (4 of 9 people)
  • 6 - 12 months: 57.0% - (4 of 7 people)
  • 1 - 2 years: 18.0% - (2 of 11 people)
  • 2 - 5 years: 50.0% - (2 of 4 people)
  • 5 - 10 years: 33.0% - (1 of 3 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 66.0% - (2 of 3 people)

Drug effectiveness by gender:

Lamotrigine:
  • female: 31.0% - (14 of 45 people)
  • male: 54.0% - (6 of 11 people)
Benadryl:
  • female: 38.0% - (17 of 44 people)
  • male: 44.0% - (4 of 9 people)

Drug effectiveness by age:

Lamotrigine:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 5 people)
  • 20-29: 11.0% - (1 of 9 people)
  • 30-39: 40.0% - (6 of 15 people)
  • 40-49: 35.0% - (6 of 17 people)
  • 50-59: 85.0% - (6 of 7 people)
  • 60+: 33.0% - (1 of 3 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 4 people)
  • 20-29: 14.0% - (1 of 7 people)
  • 30-39: 40.0% - (6 of 15 people)
  • 40-49: 47.0% - (8 of 17 people)
  • 50-59: 57.0% - (4 of 7 people)
  • 60+: 66.0% - (2 of 3 people)

Most common drug interactions over time *:

< 1 month:
  • blood bilirubin increased
  • engraftment syndrome
  • rash
  • renal failure acute
  • pyrexia
  • fatigue
  • insomnia
  • stevens-johnson syndrome
  • back pain
  • pain
1 - 6 months:
  • rash
  • urticaria
  • asthenia
  • depression
  • disorientation
  • dizziness
  • dystonia
  • gait disturbance
  • muscle twitching
  • pruritus
6 - 12 months:
  • rash
  • depression
  • diarrhoea
  • feeling abnormal
  • hallucination, visual
  • pruritus
  • blister
  • bone loss
  • pain
  • rash pustular
1 - 2 years:
  • dizziness
  • diabetes mellitus
  • headache
  • numbness and tingling
  • oxygen saturation decreased
  • type 2 diabetes mellitus
  • agitation
  • anhedonia
  • arthritis
  • cystitis
2 - 5 years:
  • abdominal discomfort
  • abdominal pain
  • abdominal pain upper
  • aggression aggravated
  • agitation aggravated
  • anger
  • arthritis
  • biliary dyskinesia
  • breast enlargement
  • breast pain
5 - 10 years:
  • asthma
  • depression
  • drowsiness
  • dizziness
  • headache
  • numbness and tingling
  • oxygen saturation decreased
  • rash pustular
  • angioedema
  • anxiety
10+ years:
  • confusion
  • forgetfulness
  • lower blood pressure
not specified:
  • completed suicide
  • depression
  • pain
  • rash
  • nausea
  • convulsion
  • headache
  • pruritus
  • vomiting
  • fatigue

Most common drug interactions by gender *:

female:
  • rash
  • depression
  • pain
  • completed suicide
  • pruritus
  • nausea
  • headache
  • insomnia
  • convulsion
  • fatigue
male:
  • drug abuse
  • completed suicide
  • rash
  • weight increased
  • gait disturbance
  • pneumonia
  • headache
  • vomiting
  • dyspnoea
  • mania

Most common drug interactions by age *:

0-1:
  • dehydration
  • foetal exposure during pregnancy
  • hypotonia
  • hypotonia neonatal
  • jaundice
2-9:
  • abnormal behaviour
  • petit mal epilepsy
  • respiratory tract infection
  • seizure
10-19:
  • completed suicide
  • suicidal ideation
  • weight increased
  • akathisia
  • agitation
  • mania
  • pyrexia
  • dyspepsia
  • gait disturbance
  • pneumonia
20-29:
  • completed suicide
  • rash
  • cardio-respiratory arrest
  • convulsion
  • feeling abnormal
  • diarrhoea
  • abdominal pain
  • depression
  • dizziness
  • nausea
30-39:
  • completed suicide
  • headache
  • drug abuse
  • vomiting
  • convulsion
  • rash
  • loss of consciousness
  • dizziness
  • nausea
  • nightmare
40-49:
  • rash
  • pruritus
  • fatigue
  • dizziness
  • depression
  • headache
  • pain
  • nausea
  • coma
  • insomnia
50-59:
  • completed suicide
  • pain
  • depression
  • fall
  • cardio-respiratory arrest
  • fatigue
  • death
  • rash
  • weight decreased
  • drug abuse
60+:
  • back pain
  • headache
  • pain in extremity
  • pyrexia
  • anxiety
  • convulsion
  • confusional state
  • loss of consciousness
  • pneumonia
  • swelling

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Lamotrigine (lamotrigine) is often used to treat epilepsy. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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