Review: taking Lexapro and Depakote together


Summary

Drug interactions are reported among people who take Lexapro and Depakote together. This review analyzes the effectiveness and drug interactions between Lexapro and Depakote. It is created by eHealthMe based on reports of 1,547 people who take the same drugs from FDA and social media, and is updated regularly.

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Lexapro

Lexapro has active ingredients of escitalopram oxalate. It is often used in depression. (latest outcomes from Lexapro 52,596 users)

Depakote

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from Depakote 38,406 users)

On Sep, 16, 2016

1,547 people who take Lexapro, Depakote are studied.


Number of reports submitted per year:

Lexapro and Depakote drug interactions.

Drug effectiveness over time:

Lexapro:
  • < 1 month: 0.0% - (0 of 4 people)
  • 1 - 6 months: 11.0% - (1 of 9 people)
  • 6 - 12 months: 25.0% - (2 of 8 people)
  • 1 - 2 years: 42.0% - (3 of 7 people)
  • 2 - 5 years: 25.0% - (3 of 12 people)
  • 5 - 10 years: 50.0% - (1 of 2 people)
  • 10+ years: 83.0% - (5 of 6 people)
  • not specified: 0.0% - (0 of 1 people)
Depakote:
  • < 1 month: 40.0% - (4 of 10 people)
  • 1 - 6 months: 20.0% - (2 of 10 people)
  • 6 - 12 months: 50.0% - (2 of 4 people)
  • 1 - 2 years: 60.0% - (3 of 5 people)
  • 2 - 5 years: 50.0% - (5 of 10 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 57.0% - (4 of 7 people)
  • not specified: 100.0% - (1 of 1 people)

Drug effectiveness by gender:

Lexapro:
  • female: 36.0% - (12 of 33 people)
  • male: 18.0% - (3 of 16 people)
Depakote:
  • female: 41.0% - (13 of 31 people)
  • male: 52.0% - (9 of 17 people)

Drug effectiveness by age:

Lexapro:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 20.0% - (1 of 5 people)
  • 20-29: 28.0% - (2 of 7 people)
  • 30-39: 42.0% - (6 of 14 people)
  • 40-49: 16.0% - (2 of 12 people)
  • 50-59: 33.0% - (2 of 6 people)
  • 60+: 40.0% - (2 of 5 people)
Depakote:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 20.0% - (1 of 5 people)
  • 20-29: 66.0% - (6 of 9 people)
  • 30-39: 58.0% - (7 of 12 people)
  • 40-49: 36.0% - (4 of 11 people)
  • 50-59: 16.0% - (1 of 6 people)
  • 60+: 60.0% - (3 of 5 people)

Most common drug interactions over time *:

< 1 month:
  • dyspnoea
  • suicide attempt
  • eosinophilic pneumonia
  • convulsion
  • intentional overdose
  • suicidal ideation
  • benign breast neoplasm
  • breast cyst
  • somnolence
  • cerebrovascular accident
1 - 6 months:
  • depression
  • pancreatitis
  • type 2 diabetes mellitus
  • alopecia
  • blood cholesterol increased
  • dehydration
  • type 1 diabetes mellitus
  • vomiting
  • anxiety
  • convulsion
6 - 12 months:
  • weight increased
  • pain in extremity
  • anxiety
  • chest pain
  • depression
  • failure to thrive
  • fatigue
  • fatigue - chronic
  • major depression
  • overdose
1 - 2 years:
  • type 2 diabetes mellitus
  • obesity
  • diabetes mellitus
  • weight increased
  • neuropathy peripheral
  • overdose
  • hyperglycaemia
  • blood cholesterol increased
  • breast mass
  • cardiac disorder
2 - 5 years:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • pain
  • diabetic neuropathy
  • somnolence
  • trismus
  • convulsion
  • hypoglycaemia
  • nausea
  • anxiety
5 - 10 years:
  • somnolence
  • suicidal ideation
  • depression
  • mental impairment
  • diabetes mellitus
  • neuropathy peripheral
  • abasia
  • back pain
  • dementia
  • dysarthria
10+ years:
  • weight increased
  • obesity
  • breast mass
  • perirectal abscess
  • somnolence
  • thrombosis
  • type 2 diabetes mellitus
  • depression
  • headache
  • abdominal discomfort
not specified:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • weight increased
  • depression
  • fatigue
  • suicidal ideation
  • nausea
  • tremor
  • anxiety
  • diarrhoea

Most common drug interactions by gender *:

female:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • depression
  • nausea
  • weight increased
  • headache
  • blood cholesterol increased
  • suicidal ideation
  • fatigue
  • dizziness
male:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • anxiety
  • fatigue
  • weight increased
  • tremor
  • depression
  • drug ineffective
  • suicidal ideation
  • diarrhoea

Most common drug interactions by age *:

0-1:
  • abdominal pain
  • abscess
  • anaemia
  • clostridium difficile colitis
  • colitis ulcerative
  • constipation
  • dehydration
  • depression
  • drug exposure during pregnancy
  • foetal exposure during pregnancy
2-9:
  • somnolence
  • anticonvulsant drug level increased
  • blood glucose
  • disorientation
  • dizziness
  • drug toxicity
  • fall
  • haematocrit
  • headache
  • lymphocyte count increased
10-19:
  • diarrhoea
  • vomiting
  • dizziness
  • aggression
  • suicidal ideation
  • weight increased
  • abdominal pain
  • diabetes mellitus
  • hyperhidrosis
  • anxiety
20-29:
  • diabetes mellitus
  • dyspnoea
  • insomnia
  • type 2 diabetes mellitus
  • weight increased
  • abdominal pain
  • fatigue
  • suicidal ideation
  • dizziness
  • suicide attempt
30-39:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • obesity
  • blood cholesterol increased
  • weight increased
  • blood triglycerides increased
  • diabetes mellitus inadequate control
  • suicidal ideation
  • depression
  • hyperlipidaemia
40-49:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • blood cholesterol increased
  • nausea
  • neuropathy peripheral
  • diabetic neuropathy
  • convulsion
  • back pain
  • gastrooesophageal reflux disease
  • anxiety
50-59:
  • depression
  • diabetes mellitus
  • type 2 diabetes mellitus
  • somnolence
  • fatigue
  • pain
  • dizziness
  • insomnia
  • anxiety
  • tremor
60+:
  • suicidal ideation
  • diarrhoea
  • depression
  • decreased appetite
  • dry mouth
  • fall
  • tremor
  • drug ineffective
  • muscle twitching
  • weight decreased

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Lexapro (escitalopram oxalate) is often used to treat depression. Depakote (divalproex sodium) is often used to treat bipolar disorder. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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