Review: taking Loratadine and Benadryl together


Summary

Drug interactions are reported among people who take Loratadine and Benadryl together. This review analyzes the effectiveness and drug interactions between Loratadine and Benadryl. It is created by eHealthMe based on reports of 1,247 people who take the same drugs from FDA and social media, and is updated regularly.

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Loratadine

Loratadine has active ingredients of loratadine. It is often used in hypersensitivity. (latest outcomes from Loratadine 10,554 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 28,893 users)

On Jul, 28, 2016

1,247 people who take Loratadine, Benadryl are studied.


Number of reports submitted per year:

Loratadine and Benadryl drug interactions.

Drug effectiveness over time:

Loratadine:
  • < 1 month: 19.0% - (4 of 21 people)
  • 1 - 6 months: 20.0% - (3 of 15 people)
  • 6 - 12 months: 11.0% - (1 of 9 people)
  • 1 - 2 years: 27.0% - (3 of 11 people)
  • 2 - 5 years: 45.0% - (5 of 11 people)
  • 5 - 10 years: 33.0% - (3 of 9 people)
  • 10+ years: 20.0% - (1 of 5 people)
  • not specified: 0.0% - (0 of 1 people)
Benadryl:
  • < 1 month: 48.0% - (12 of 25 people)
  • 1 - 6 months: 33.0% - (6 of 18 people)
  • 6 - 12 months: 33.0% - (1 of 3 people)
  • 1 - 2 years: 42.0% - (3 of 7 people)
  • 2 - 5 years: 50.0% - (4 of 8 people)
  • 5 - 10 years: 36.0% - (4 of 11 people)
  • 10+ years: 0.0% - (0 of 5 people)
  • not specified: 0.0% - (0 of 2 people)

Drug effectiveness by gender:

Loratadine:
  • female: 24.0% - (13 of 54 people)
  • male: 25.0% - (7 of 28 people)
Benadryl:
  • female: 32.0% - (17 of 52 people)
  • male: 48.0% - (13 of 27 people)

Drug effectiveness by age:

Loratadine:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 50.0% - (2 of 4 people)
  • 10-19: 20.0% - (1 of 5 people)
  • 20-29: 11.0% - (2 of 18 people)
  • 30-39: 50.0% - (6 of 12 people)
  • 40-49: 19.0% - (4 of 21 people)
  • 50-59: 23.0% - (3 of 13 people)
  • 60+: 22.0% - (2 of 9 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 66.0% - (2 of 3 people)
  • 10-19: 66.0% - (4 of 6 people)
  • 20-29: 44.0% - (8 of 18 people)
  • 30-39: 30.0% - (3 of 10 people)
  • 40-49: 38.0% - (8 of 21 people)
  • 50-59: 23.0% - (3 of 13 people)
  • 60+: 25.0% - (2 of 8 people)

Most common drug interactions over time *:

< 1 month:
  • cardiac failure congestive
  • loss of consciousness
  • blood pressure increased
  • dizziness
  • myocardial infarction
  • aortic stenosis
  • hypotension
  • agranulocytosis
  • bronchitis
  • convulsion
1 - 6 months:
  • antepartum haemorrhage
  • bronchitis
  • fall
  • premature separation of placenta
  • skeletal injury
  • upper respiratory tract infection
  • viral infection
  • cold-stimulus headache
  • constipation
  • conversion disorder
6 - 12 months:
  • pneumonia
  • respiratory syncytial virus infection
  • anxiety
  • cold-stimulus headache
  • autoimmune disorder
  • bladder diverticulum
  • crohn's disease
  • death
  • dehydration
  • demyelination
1 - 2 years:
  • anxiety
  • back pain
  • neck pain
  • bladder irritation
  • eosinophilic pneumonia
  • bone loss
  • death
  • respiratory arrest
2 - 5 years:
  • fatigue
  • acid reflux
  • alopecia
  • asthma
  • balance disorder
  • body temperature fluctuation
  • chest pain
  • cough
  • decreased appetite
  • decreased interest
5 - 10 years:
  • arrhythmias
  • supraventricular tachycardia
  • adjustment disorder with mixed anxiety and depressed mood
  • anxiety
  • asthma
  • body temperature fluctuation
  • bone loss
  • death
  • depression suicidal
  • dizziness
10+ years:
  • ear pain
  • eye floaters
  • eyes - sensitive to light
  • headache - tension
  • menstruation - painful
  • pain
  • acne
  • alopecia
  • balance disorder
  • colitis
not specified:
  • nausea
  • pain
  • dyspnoea
  • fatigue
  • depression
  • headache
  • arthralgia
  • vomiting
  • pyrexia
  • chest pain

Most common drug interactions by gender *:

female:
  • nausea
  • pain
  • depression
  • fatigue
  • arthralgia
  • dyspnoea
  • anxiety
  • headache
  • oedema peripheral
  • chest pain
male:
  • nausea
  • vomiting
  • pyrexia
  • dyspnoea
  • fatigue
  • rash
  • cough
  • headache
  • dizziness
  • blood pressure increased

Most common drug interactions by age *:

0-1:
  • aggression
  • convulsion
  • agitation
  • foaming at mouth
  • tardive dyskinesia
  • chest pain
  • constipation
  • drug ineffective
  • hyperkinetic syndrome
  • mydriasis
2-9:
  • vomiting
  • sinusitis
  • cough
  • arrhythmia
  • headache
  • heart rate increased
  • respiratory tract infection
  • sudden death
  • unresponsive to stimuli
  • nausea
10-19:
  • headache
  • hypotension
  • pneumonitis
  • fatigue
  • pyrexia
  • acute respiratory distress syndrome
  • blood bilirubin increased
  • nausea
  • agitation
  • cough
20-29:
  • cerebral haemorrhage
  • cerebral infarction
  • convulsion
  • pain
  • transverse sinus thrombosis
  • blood pressure increased
  • loss of consciousness
  • nausea
  • abdominal pain
  • abdominal pain upper
30-39:
  • fall
  • bronchitis
  • depression
  • obesity
  • anaemia
  • arthralgia
  • blood cholesterol increased
  • contusion
  • joint swelling
  • abdominal pain
40-49:
  • pain
  • nausea
  • dyspnoea
  • depression
  • vomiting
  • fatigue
  • anxiety
  • back pain
  • arthralgia
  • headache
50-59:
  • nausea
  • chest pain
  • oedema peripheral
  • anxiety
  • headache
  • pain in extremity
  • fall
  • pain
  • diarrhoea
  • injury
60+:
  • nausea
  • cardiac failure congestive
  • dizziness
  • asthenia
  • drug ineffective
  • fatigue
  • vomiting
  • diarrhoea
  • myalgia
  • pyrexia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Loratadine (loratadine) is often used to treat hypersensitivity. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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