Review: taking Loratadine and Benadryl together


Summary

Drug interactions are reported among people who take Loratadine and Benadryl together. This review analyzes the effectiveness and drug interactions between Loratadine and Benadryl. It is created by eHealthMe based on reports of 1,591 people who take the same drugs from FDA and social media, and is updated regularly.

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Loratadine

Loratadine has active ingredients of loratadine. It is often used in hypersensitivity. (latest outcomes from Loratadine 12,984 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 33,627 users)

On Aug, 29, 2016

1,591 people who take Loratadine, Benadryl are studied.


Number of reports submitted per year:

Loratadine and Benadryl drug interactions.

Drug effectiveness over time:

Loratadine:
  • < 1 month: 20.0% - (4 of 20 people)
  • 1 - 6 months: 25.0% - (3 of 12 people)
  • 6 - 12 months: 14.0% - (1 of 7 people)
  • 1 - 2 years: 30.0% - (3 of 10 people)
  • 2 - 5 years: 55.0% - (5 of 9 people)
  • 5 - 10 years: 33.0% - (3 of 9 people)
  • 10+ years: 33.0% - (1 of 3 people)
  • not specified: 0.0% - (0 of 1 people)
Benadryl:
  • < 1 month: 47.0% - (11 of 23 people)
  • 1 - 6 months: 46.0% - (6 of 13 people)
  • 6 - 12 months: 33.0% - (1 of 3 people)
  • 1 - 2 years: 50.0% - (3 of 6 people)
  • 2 - 5 years: 50.0% - (4 of 8 people)
  • 5 - 10 years: 44.0% - (4 of 9 people)
  • 10+ years: 0.0% - (0 of 2 people)
  • not specified: 0.0% - (0 of 2 people)

Drug effectiveness by gender:

Loratadine:
  • female: 27.0% - (13 of 47 people)
  • male: 29.0% - (7 of 24 people)
Benadryl:
  • female: 37.0% - (17 of 45 people)
  • male: 57.0% - (12 of 21 people)

Drug effectiveness by age:

Loratadine:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 50.0% - (2 of 4 people)
  • 10-19: 20.0% - (1 of 5 people)
  • 20-29: 13.0% - (2 of 15 people)
  • 30-39: 54.0% - (6 of 11 people)
  • 40-49: 23.0% - (4 of 17 people)
  • 50-59: 25.0% - (3 of 12 people)
  • 60+: 28.0% - (2 of 7 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 66.0% - (2 of 3 people)
  • 10-19: 66.0% - (4 of 6 people)
  • 20-29: 53.0% - (8 of 15 people)
  • 30-39: 30.0% - (3 of 10 people)
  • 40-49: 50.0% - (7 of 14 people)
  • 50-59: 25.0% - (3 of 12 people)
  • 60+: 33.0% - (2 of 6 people)

Most common drug interactions over time *:

< 1 month:
  • cardiac failure congestive
  • thrombocytopenia
  • myocardial infarction
  • aortic stenosis
  • dizziness
  • loss of consciousness
  • pneumonia
  • febrile neutropenia
  • dehydration
  • vomiting
1 - 6 months:
  • antepartum haemorrhage
  • bronchitis
  • fall
  • premature separation of placenta
  • skeletal injury
  • upper respiratory tract infection
  • viral infection
  • cold-stimulus headache
  • constipation
  • conversion disorder
6 - 12 months:
  • anxiety
  • pneumonia
  • respiratory syncytial virus infection
  • cold-stimulus headache
  • crohn's disease
  • dyspepsia
  • insomnia
  • nausea
  • pyrexia
  • urinary tract infection
1 - 2 years:
  • anxiety
  • back pain
  • neck pain
  • bladder irritation
  • eosinophilic pneumonia
  • nephrogenic systemic fibrosis
  • bone loss
  • death
  • gait disturbance
  • head discomfort
2 - 5 years:
  • acid reflux
  • asthma
  • body temperature fluctuation
  • chest pain
  • dizziness
  • drowsiness
  • drug effect decreased
  • fatigue
  • gynaecomastia
  • headache
5 - 10 years:
  • arrhythmias
  • supraventricular tachycardia
  • adjustment disorder with mixed anxiety and depressed mood
  • anxiety
  • asthma
  • body temperature fluctuation
  • bone loss
  • death
  • depression suicidal
  • dizziness
10+ years:
  • ear pain
  • eye floaters
  • eyes - sensitive to light
  • headache - tension
  • menstruation - painful
  • pain
  • acne
  • colitis
  • constipation
  • esophageal spasm
not specified:
  • nausea
  • pain
  • dyspnoea
  • fatigue
  • depression
  • headache
  • vomiting
  • arthralgia
  • pyrexia
  • drug ineffective

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • dyspnoea
  • depression
  • fatigue
  • headache
  • anxiety
  • arthralgia
  • pain in extremity
  • fall
male:
  • nausea
  • vomiting
  • pyrexia
  • dyspnoea
  • pain
  • fatigue
  • headache
  • rash
  • dizziness
  • cough

Most common drug interactions by age *:

0-1:
  • aggression
  • convulsion
  • accidental overdose
  • agitation
  • foaming at mouth
  • tardive dyskinesia
  • cardiac murmur
  • chest pain
  • cleft lip and palate
  • constipation
2-9:
  • vomiting
  • sinusitis
  • cough
  • diarrhoea
  • arrhythmia
  • drug ineffective
  • headache
  • heart rate increased
  • respiratory tract infection
  • sudden death
10-19:
  • headache
  • pain
  • fatigue
  • pyrexia
  • hypotension
  • pneumonitis
  • nausea
  • acute respiratory distress syndrome
  • blood bilirubin increased
  • convulsion
20-29:
  • pain
  • cerebral haemorrhage
  • cerebral infarction
  • convulsion
  • transverse sinus thrombosis
  • blood pressure increased
  • completed suicide
  • loss of consciousness
  • nausea
  • anxiety
30-39:
  • fall
  • bronchitis
  • depression
  • abdominal pain
  • obesity
  • anaemia
  • arthralgia
  • blood cholesterol increased
  • contusion
  • joint swelling
40-49:
  • pain
  • nausea
  • dyspnoea
  • fatigue
  • depression
  • arthralgia
  • vomiting
  • back pain
  • headache
  • anxiety
50-59:
  • nausea
  • chest pain
  • anxiety
  • pain
  • headache
  • oedema peripheral
  • diarrhoea
  • depression
  • fall
  • injury
60+:
  • nausea
  • dizziness
  • asthenia
  • diarrhoea
  • fatigue
  • dyspnoea
  • vomiting
  • drug ineffective
  • headache
  • cardiac failure congestive

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Loratadine (loratadine) is often used to treat hypersensitivity. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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