Review: taking Losartan and Spironolactone together


Summary

Drug interactions are reported among people who take Losartan and Spironolactone together. This review analyzes the effectiveness and drug interactions between Losartan and Spironolactone. It is created by eHealthMe based on reports of 2,236 people who take the same drugs from FDA and social media, and is updated regularly.

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Losartan

Losartan has active ingredients of losartan potassium. It is often used in high blood pressure. (latest outcomes from Losartan 25,155 users)

Spironolactone

Spironolactone has active ingredients of spironolactone. It is often used in high blood pressure. (latest outcomes from Spironolactone 30,620 users)

On Aug, 26, 2016

2,236 people who take Losartan, Spironolactone are studied.


Number of reports submitted per year:

Losartan and Spironolactone drug interactions.

Drug effectiveness over time:

Losartan:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 62.0% - (5 of 8 people)
  • 6 - 12 months: 0.0% - (0 of 2 people)
  • 1 - 2 years: 40.0% - (2 of 5 people)
  • 2 - 5 years: 14.0% - (1 of 7 people)
  • 5 - 10 years: 57.0% - (4 of 7 people)
  • 10+ years: 66.0% - (2 of 3 people)
  • not specified: 0.0% - (0 of 0 people)
Spironolactone:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 50.0% - (3 of 6 people)
  • 6 - 12 months: 50.0% - (2 of 4 people)
  • 1 - 2 years: 33.0% - (2 of 6 people)
  • 2 - 5 years: 0.0% - (0 of 6 people)
  • 5 - 10 years: 50.0% - (2 of 4 people)
  • 10+ years: 100.0% - (2 of 2 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Losartan:
  • female: 44.0% - (8 of 18 people)
  • male: 42.0% - (6 of 14 people)
Spironolactone:
  • female: 47.0% - (8 of 17 people)
  • male: 25.0% - (3 of 12 people)

Drug effectiveness by age:

Losartan:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 0.0% - (0 of 1 people)
  • 40-49: 100.0% - (5 of 5 people)
  • 50-59: 60.0% - (3 of 5 people)
  • 60+: 30.0% - (6 of 20 people)
Spironolactone:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 0.0% - (0 of 1 people)
  • 40-49: 75.0% - (3 of 4 people)
  • 50-59: 25.0% - (1 of 4 people)
  • 60+: 36.0% - (7 of 19 people)

Most common drug interactions over time *:

< 1 month:
  • hyperkalaemia
  • renal failure acute
  • blood creatinine increased
  • nephrotic syndrome
  • blood urea increased
  • cardiac arrest
  • renal failure chronic
  • hypotension
  • international normalised ratio increased
  • metabolic encephalopathy
1 - 6 months:
  • hyperkalaemia
  • renal failure acute
  • anaemia
  • blood urea increased
  • dizziness
  • blood creatinine increased
  • fatigue
  • cardiac arrest
  • cold sweat
  • purpura
6 - 12 months:
  • hyperkalaemia
  • asthenia
  • urinary tract infection
  • general physical health deterioration
  • renal failure acute
  • anorexia
  • sepsis
  • blood potassium decreased
  • bronchiectasis
  • dehydration
1 - 2 years:
  • acid reflux
  • allergies
  • gouty arthritis
  • high blood pressure
  • anaemia
  • cardiac failure
  • chest pain
  • international normalised ratio increased
  • death
  • dehydration
2 - 5 years:
  • hyperkalaemia
  • hyponatraemia
  • dementia
  • palpitations
  • renal failure acute
  • cardiac failure
  • ascites
  • breath sounds abnormal
  • cardiac arrest
  • cardiogenic shock
5 - 10 years:
  • anaemia
  • eczema
  • sensitivity of teeth
  • xerosis
  • blood immunoglobulin e increased
  • cardiac disorder
  • eosinophil count increased
  • eosinophilic pneumonia
  • eye swelling
  • interstitial lung disease
10+ years:
  • bradycardia
  • electrolyte imbalance
  • hyperkalaemia
  • syncope
  • electrocardiogram t wave abnormal
  • nodal rhythm
  • presyncope
  • blood potassium increased
  • electrocardiogram t wave peaked
  • memory impairment
not specified:
  • dyspnoea
  • fatigue
  • cardiac failure congestive
  • pain
  • dizziness
  • asthenia
  • anxiety
  • nausea
  • hypertension
  • anaemia

Most common drug interactions by gender *:

female:
  • dyspnoea
  • fatigue
  • pain
  • dizziness
  • hypertension
  • asthenia
  • cardiac failure congestive
  • diarrhoea
  • pneumonia
  • nausea
male:
  • dyspnoea
  • chest pain
  • cardiac failure congestive
  • pain
  • anxiety
  • anaemia
  • fatigue
  • dizziness
  • cough
  • asthenia

Most common drug interactions by age *:

0-1:
  • pulmonary embolism
  • proteinuria
  • haemolytic uraemic syndrome
  • blood pressure decreased
  • nephrotic syndrome
  • renal failure acute
  • oliguria
  • rhabdomyolysis
  • thrombocytopenia
2-9:
  • pyrexia
  • renal failure acute
  • blood pressure systolic decreased
  • cyanosis
  • hypotension
  • pharyngitis streptococcal
  • appendicitis
  • blood chloride decreased
  • blood creatinine decreased
  • blood potassium increased
10-19:
  • blood alkaline phosphatase increased
  • blood lactate dehydrogenase increased
  • blood urea increased
  • dyspnoea
  • hypogammaglobulinaemia
  • lung infiltration
  • pulmonary haemorrhage
  • pyrexia
  • renal failure acute
  • aspartate aminotransferase increased
20-29:
  • excessive eye blinking
  • headache
  • nausea
  • pain - foot
  • tiredness
  • vaginal itching
  • anaemia
  • asthenia
  • asthma
  • blood count abnormal
30-39:
  • cardiac failure congestive
  • abdominal distension
  • anxiety
  • weight increased
  • pain
  • cough
  • feeling abnormal
  • fatigue
  • anhedonia
  • injury
40-49:
  • abdominal distension
  • oedema peripheral
  • fatigue
  • pain
  • chest pain
  • dizziness
  • back pain
  • fall
  • nasopharyngitis
  • anxiety
50-59:
  • dyspnoea
  • cardiac failure congestive
  • pain
  • fatigue
  • anxiety
  • back pain
  • cardiac arrest
  • vomiting
  • diarrhoea
  • dizziness
60+:
  • dyspnoea
  • asthenia
  • dizziness
  • pain
  • atrial fibrillation
  • cardiac failure congestive
  • anaemia
  • pneumonia
  • fatigue
  • hyperkalaemia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Losartan (losartan potassium) is often used to treat high blood pressure. Spironolactone (spironolactone) is often used to treat high blood pressure. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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