Losartan and Spironolactone drug interactions - from FDA reports


Summary

Drug interactions are reported among people who take Losartan and Spironolactone together. This review analyzes the effectiveness and drug interactions between Losartan and Spironolactone. It is created by eHealthMe based on reports of 3,404 people who take the same drugs from FDA, and is updated regularly.

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Losartan

Losartan has active ingredients of losartan potassium. It is often used in high blood pressure. (latest outcomes from Losartan 49,085 users)

Spironolactone

Spironolactone has active ingredients of spironolactone. It is often used in acne. (latest outcomes from Spironolactone 43,287 users)

On Feb, 03, 2017

3,404 people who take Losartan, Spironolactone are studied.


Number of reports submitted per year:

Losartan and Spironolactone drug interactions.

Most common drug interactions over time *:

< 1 month:
  • hyperkalaemia
  • renal failure acute
  • blood creatinine increased
  • nephrotic syndrome
  • blood urea increased
  • cardiac arrest
  • renal failure chronic
  • cardiac failure
  • hypotension
  • international normalised ratio increased
1 - 6 months:
  • hyperkalaemia
  • renal failure acute
  • anaemia
  • blood urea increased
  • chest pain
  • dizziness
  • atrioventricular block
  • cardiac arrest
  • blood creatinine increased
  • cough
6 - 12 months:
  • hyperkalaemia
  • asthenia
  • urinary tract infection
  • general physical health deterioration
  • renal failure acute
  • anorexia
  • sepsis
  • blood potassium decreased
  • bronchiectasis
  • dehydration
1 - 2 years:
  • anaemia
  • cardiac failure
  • chest pain
  • international normalised ratio increased
  • death
  • dehydration
  • hypotension
  • infection
  • renal failure acute
  • blood potassium decreased
2 - 5 years:
  • hyperkalaemia
  • hyponatraemia
  • dementia
  • palpitations
  • renal failure acute
  • cardiac failure
  • ascites
  • breath sounds abnormal
  • cardiac arrest
  • cardiogenic shock
5 - 10 years:
  • anaemia
  • eczema
  • myocardial infarction
  • xerosis
  • blood immunoglobulin e increased
  • bradycardia
  • cardiac disorder
  • cerebrovascular accident
  • eosinophil count increased
  • eosinophilic pneumonia
10+ years:
  • bradycardia
  • electrolyte imbalance
  • hyperkalaemia
  • syncope
  • electrocardiogram t wave abnormal
  • nodal rhythm
  • presyncope
  • blood potassium increased
  • electrocardiogram t wave peaked
  • nodal arrhythmia
not specified:
  • dyspnoea
  • fatigue
  • cardiac failure congestive
  • dizziness
  • pain
  • asthenia
  • nausea
  • fall
  • hypertension
  • diarrhoea

Most common drug interactions by gender *:

female:
  • dyspnoea
  • fatigue
  • pain
  • hypertension
  • cardiac failure congestive
  • dizziness
  • diarrhoea
  • asthenia
  • nausea
  • pneumonia
male:
  • dyspnoea
  • cardiac failure congestive
  • chest pain
  • fatigue
  • anaemia
  • dizziness
  • cough
  • asthenia
  • pain
  • hyperkalaemia

Most common drug interactions by age *:

0-1:
  • pulmonary embolism
  • proteinuria
  • seizure
  • haemolytic uraemic syndrome
  • blood pressure decreased
  • nephrotic syndrome
  • renal failure acute
  • abdominal mass
  • abdominal pain
  • cerebrovascular disorder
2-9:
  • pyrexia
  • renal failure acute
  • blood pressure systolic decreased
  • cyanosis
  • device related infection
  • hypotension
  • pneumonia
  • respiratory syncytial virus infection
  • pharyngitis streptococcal
  • appendicitis
10-19:
  • dehydration
  • diarrhoea
  • nausea
  • renal failure
  • vomiting
  • renal failure acute
  • blood alkaline phosphatase increased
  • blood lactate dehydrogenase increased
  • blood urea increased
  • dyspnoea
20-29:
  • anaemia
  • cardiac failure congestive
  • nausea
  • international normalised ratio increased
  • oedema
  • blood creatine phosphokinase increased
  • gastroenteritis
  • headache
  • hyperlipidaemia
  • hypertension
30-39:
  • pain
  • cardiac failure congestive
  • fatigue
  • abdominal distension
  • anxiety
  • weight increased
  • cough
  • feeling abnormal
  • dyspnoea
  • anhedonia
40-49:
  • fatigue
  • oedema peripheral
  • abdominal distension
  • urinary tract infection
  • fall
  • pain
  • chest pain
  • dizziness
  • back pain
  • constipation
50-59:
  • dyspnoea
  • fatigue
  • cardiac failure congestive
  • chest pain
  • pain
  • dizziness
  • hypertension
  • diarrhoea
  • pain in extremity
  • arthralgia
60+:
  • dyspnoea
  • asthenia
  • hyperkalaemia
  • dizziness
  • cardiac failure congestive
  • fatigue
  • fall
  • pain
  • diarrhoea
  • pneumonia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Losartan and Spironolactone?

Interactions between Losartan and drugs from A to Z

a b c d e f g h i j k l m n o p q r s t u v w x y z

Interactions between Spironolactone and drugs from A to Z

a b c d e f g h i j k l m n o p q r s t u v w x y z

On eHealthMe, Losartan (losartan potassium) is often used to treat high blood pressure. Spironolactone (spironolactone) is often used to treat high blood pressure. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:

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