Review: taking Lunesta and Benadryl together


Summary

Drug interactions are reported among people who take Lunesta and Benadryl together. This review analyzes the effectiveness and drug interactions between Lunesta and Benadryl. It is created by eHealthMe based on reports of 600 people who take the same drugs from FDA and social media, and is updated regularly.

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Lunesta

Lunesta has active ingredients of eszopiclone. It is often used in insomnia. (latest outcomes from Lunesta 18,765 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 43,259 users)

On Sep, 20, 2016

600 people who take Lunesta, Benadryl are studied.


Number of reports submitted per year:

Lunesta and Benadryl drug interactions.

Drug effectiveness over time:

Lunesta:
  • < 1 month: 20.0% - (1 of 5 people)
  • 1 - 6 months: 0.0% - (0 of 3 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 25.0% - (2 of 8 people)
  • 2 - 5 years: 50.0% - (2 of 4 people)
  • 5 - 10 years: 100.0% - (3 of 3 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)
Benadryl:
  • < 1 month: 16.0% - (1 of 6 people)
  • 1 - 6 months: 0.0% - (0 of 5 people)
  • 6 - 12 months: 50.0% - (1 of 2 people)
  • 1 - 2 years: 0.0% - (0 of 1 people)
  • 2 - 5 years: 0.0% - (0 of 1 people)
  • 5 - 10 years: 75.0% - (3 of 4 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Lunesta:
  • female: 23.0% - (4 of 17 people)
  • male: 57.0% - (4 of 7 people)
Benadryl:
  • female: 33.0% - (5 of 15 people)
  • male: 16.0% - (1 of 6 people)

Drug effectiveness by age:

Lunesta:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 5 people)
  • 30-39: 20.0% - (2 of 10 people)
  • 40-49: 83.0% - (5 of 6 people)
  • 50-59: 0.0% - (0 of 1 people)
  • 60+: 50.0% - (1 of 2 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 25.0% - (1 of 4 people)
  • 30-39: 25.0% - (2 of 8 people)
  • 40-49: 33.0% - (2 of 6 people)
  • 50-59: 100.0% - (1 of 1 people)
  • 60+: 0.0% - (0 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • pyrexia
  • infusion related reaction
  • bowen's disease
  • drug ineffective
  • basal cell carcinoma
  • dysgeusia
  • dyspnoea
  • gastroenteritis
  • insomnia
  • nasopharyngitis
1 - 6 months:
  • dementia
  • plasma cell myeloma
  • urticaria
  • abdominal pain
  • chills
  • chronic obstructive pulmonary disease
  • colitis
  • confusional state
  • dehydration
  • dysgeusia
6 - 12 months:
  • b-cell lymphoma
  • ureteric obstruction
  • insomnia
  • renal failure acute
  • abnormal dreams
  • arrhythmia
1 - 2 years:
  • b-cell lymphoma
  • ureteric obstruction
  • anorgasmia
  • atrial septal defect
  • cardiac failure congestive
  • cardiomegaly
  • congenital cardiovascular anomaly
  • drug exposure during pregnancy
  • pleural effusion
  • rash
2 - 5 years:
  • abdominal pain lower
  • b-cell lymphoma
  • ureteric obstruction
  • renal failure acute
  • accidental death
  • chronic graft versus host disease
  • coma
  • completed suicide
  • multiple drug overdose accidental
  • ovarian cysts
5 - 10 years:
  • anorgasmia
  • abdominal abscess
  • convulsion
  • drug ineffective
  • hangover
  • migraine
  • post procedural bile leak
  • pyrexia
10+ years:
  • abdominal pain lower
  • anger
  • anxiety
  • dizziness
  • irritability
  • nystagmus
  • ovarian cysts
  • panic attack
  • polycystic ovarian syndrome (pcos)
  • sweating - excessive
not specified:
  • pain
  • fatigue
  • nausea
  • arthralgia
  • pain in extremity
  • infusion related reaction
  • weight decreased
  • depression
  • anxiety
  • fall

Most common drug interactions by gender *:

female:
  • fatigue
  • infusion related reaction
  • arthralgia
  • nausea
  • pain
  • pain in extremity
  • insomnia
  • weight decreased
  • depression
  • headache
male:
  • pneumonia
  • anxiety
  • weight decreased
  • osteonecrosis of jaw
  • asthenia
  • back pain
  • fall
  • fatigue
  • pain in extremity
  • anaemia

Most common drug interactions by age *:

0-1:
  • abdominal discomfort
  • depression
  • insomnia
  • palpitations
  • panic disorder
  • weight decreased
10-19:
  • abdominal pain
  • abdominal pain upper
  • hypokinesia
  • initial insomnia
  • neck pain
  • pancreatitis
  • somnolence
  • suicide attempt
  • tardive dyskinesia
20-29:
  • abdominal pain
  • back pain
  • depression
  • headache
  • insomnia
  • pyrexia
  • anxiety
  • haemoglobin decreased
  • cardiomegaly
  • cardiomyopathy
30-39:
  • arthralgia
  • infusion related reaction
  • pain in extremity
  • contusion
  • fatigue
  • asthma
  • balance disorder
  • blood glucose decreased
  • blood potassium decreased
  • drug administration error
40-49:
  • pain
  • back pain
  • depression
  • pain in extremity
  • anxiety
  • diarrhoea
  • fatigue
  • weight decreased
  • infusion related reaction
  • intervertebral disc protrusion
50-59:
  • nausea
  • pain
  • pain in extremity
  • fatigue
  • infusion related reaction
  • hypotension
  • insomnia
  • drug ineffective
  • pyrexia
  • arthralgia
60+:
  • infusion related reaction
  • drug ineffective
  • fatigue
  • headache
  • nausea
  • arthralgia
  • hypertension
  • pain
  • pneumonia
  • rheumatoid arthritis

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Lunesta (eszopiclone) is often used to treat insomnia. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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