Review: taking Lunesta and Benadryl together


Summary

Drug interactions are reported among people who take Lunesta and Benadryl together. This review analyzes the effectiveness and drug interactions between Lunesta and Benadryl. It is created by eHealthMe based on reports of 413 people who take the same drugs from FDA and social media, and is updated regularly.

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Lunesta

Lunesta has active ingredients of eszopiclone. It is often used in insomnia. (latest outcomes from Lunesta 16,937 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 32,636 users)

On Aug, 24, 2016

413 people who take Lunesta, Benadryl are studied.


Number of reports submitted per year:

Lunesta and Benadryl drug interactions.

Drug effectiveness over time:

Lunesta:
  • < 1 month: 20.0% - (1 of 5 people)
  • 1 - 6 months: 0.0% - (0 of 3 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 25.0% - (2 of 8 people)
  • 2 - 5 years: 50.0% - (2 of 4 people)
  • 5 - 10 years: 100.0% - (3 of 3 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)
Benadryl:
  • < 1 month: 16.0% - (1 of 6 people)
  • 1 - 6 months: 0.0% - (0 of 5 people)
  • 6 - 12 months: 50.0% - (1 of 2 people)
  • 1 - 2 years: 0.0% - (0 of 1 people)
  • 2 - 5 years: 0.0% - (0 of 1 people)
  • 5 - 10 years: 75.0% - (3 of 4 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Lunesta:
  • female: 23.0% - (4 of 17 people)
  • male: 57.0% - (4 of 7 people)
Benadryl:
  • female: 33.0% - (5 of 15 people)
  • male: 16.0% - (1 of 6 people)

Drug effectiveness by age:

Lunesta:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 5 people)
  • 30-39: 20.0% - (2 of 10 people)
  • 40-49: 83.0% - (5 of 6 people)
  • 50-59: 0.0% - (0 of 1 people)
  • 60+: 50.0% - (1 of 2 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 25.0% - (1 of 4 people)
  • 30-39: 25.0% - (2 of 8 people)
  • 40-49: 33.0% - (2 of 6 people)
  • 50-59: 100.0% - (1 of 1 people)
  • 60+: 0.0% - (0 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • dysgeusia
  • insomnia
  • drug ineffective
  • dyspnoea
  • nausea
  • pyrexia
  • pneumonia
  • death
  • dehydration
  • depression
1 - 6 months:
  • urticaria
  • chronic obstructive pulmonary disease
  • confusional state
  • dehydration
  • dementia
  • dysgeusia
  • headache
  • insomnia
  • nausea
  • plasma cell myeloma
6 - 12 months:
  • b-cell lymphoma
  • renal failure acute
  • ureteric obstruction
  • insomnia
1 - 2 years:
  • anorgasmia
  • atrial septal defect
  • b-cell lymphoma
  • cardiac failure congestive
  • cardiomegaly
  • congenital cardiovascular anomaly
  • drug exposure during pregnancy
  • pleural effusion
  • renal failure acute
  • ureteric obstruction
2 - 5 years:
  • abdominal pain lower
  • b-cell lymphoma
  • renal failure acute
  • ureteric obstruction
  • accidental death
  • chronic graft versus host disease
  • coma
  • completed suicide
  • multiple drug overdose accidental
  • ovarian cysts
5 - 10 years:
  • anorgasmia
  • abdominal abscess
  • convulsion
  • post procedural bile leak
  • pyrexia
10+ years:
  • abdominal pain lower
  • anger
  • anxiety
  • dizziness
  • irritability
  • nystagmus
  • ovarian cysts
  • panic attack
  • polycystic ovarian syndrome (pcos)
  • sweating - excessive
not specified:
  • pain
  • weight decreased
  • osteonecrosis of jaw
  • nausea
  • anxiety
  • depression
  • dyspnoea
  • back pain
  • pain in extremity
  • fatigue

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • weight decreased
  • insomnia
  • dyspnoea
  • fatigue
  • arthralgia
  • osteonecrosis of jaw
  • depression
  • pain in extremity
male:
  • pneumonia
  • osteonecrosis of jaw
  • weight decreased
  • anaemia
  • anxiety
  • pain
  • asthenia
  • depression
  • fall
  • hepatic steatosis

Most common drug interactions by age *:

10-19:
  • abdominal pain
  • abdominal pain upper
  • initial insomnia
  • pancreatitis
  • somnolence
  • suicide attempt
20-29:
  • back pain
  • insomnia
  • pyrexia
  • headache
  • abdominal pain
  • anxiety
  • cardiomegaly
  • cardiomyopathy
  • depression
  • influenza like illness
30-39:
  • convulsion
  • excoriation
  • flushing
  • haemoglobin decreased
  • abscess jaw
  • anxiety
  • ataxia
  • blood alkaline phosphatase increased
  • blood immunoglobulin g increased
  • bone disorder
40-49:
  • back pain
  • depression
  • intervertebral disc protrusion
  • pain
  • anxiety
  • pain in extremity
  • bone disorder
  • constipation
  • nausea
  • osteonecrosis of jaw
50-59:
  • pain
  • insomnia
  • anaemia
  • nausea
  • pain in extremity
  • weight decreased
  • fatigue
  • anxiety
  • gait disturbance
  • pyrexia
60+:
  • pneumonia
  • nausea
  • weight decreased
  • fatigue
  • headache
  • fall
  • anaemia
  • arthralgia
  • hypertension
  • back pain

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Lunesta (eszopiclone) is often used to treat insomnia. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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