Review: taking Lunesta and Benadryl together


Summary

Drug interactions are reported among people who take Lunesta and Benadryl together. This review analyzes the effectiveness and drug interactions between Lunesta and Benadryl. It is created by eHealthMe based on reports of 318 people who take the same drugs from FDA and social media, and is updated regularly.

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Lunesta

Lunesta has active ingredients of eszopiclone. It is often used in insomnia. (latest outcomes from Lunesta 16,088 users)

Benadryl

Benadryl has active ingredients of diphenhydramine. It is often used in hypersensitivity. (latest outcomes from Benadryl 29,241 users)

On Jul, 20, 2016

318 people who take Lunesta, Benadryl are studied.


Number of reports submitted per year:

Lunesta and Benadryl drug interactions.

Drug effectiveness over time:

Lunesta:
  • < 1 month: 16.0% - (1 of 6 people)
  • 1 - 6 months: 0.0% - (0 of 3 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 33.0% - (3 of 9 people)
  • 2 - 5 years: 33.0% - (2 of 6 people)
  • 5 - 10 years: 100.0% - (4 of 4 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)
Benadryl:
  • < 1 month: 14.0% - (1 of 7 people)
  • 1 - 6 months: 0.0% - (0 of 5 people)
  • 6 - 12 months: 50.0% - (1 of 2 people)
  • 1 - 2 years: 0.0% - (0 of 1 people)
  • 2 - 5 years: 0.0% - (0 of 1 people)
  • 5 - 10 years: 66.0% - (4 of 6 people)
  • 10+ years: 25.0% - (1 of 4 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Lunesta:
  • female: 25.0% - (5 of 20 people)
  • male: 55.0% - (5 of 9 people)
Benadryl:
  • female: 33.0% - (6 of 18 people)
  • male: 12.0% - (1 of 8 people)

Drug effectiveness by age:

Lunesta:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 5 people)
  • 30-39: 15.0% - (2 of 13 people)
  • 40-49: 85.0% - (6 of 7 people)
  • 50-59: 0.0% - (0 of 1 people)
  • 60+: 66.0% - (2 of 3 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 25.0% - (1 of 4 people)
  • 30-39: 18.0% - (2 of 11 people)
  • 40-49: 42.0% - (3 of 7 people)
  • 50-59: 100.0% - (1 of 1 people)
  • 60+: 0.0% - (0 of 3 people)

Most common drug interactions over time *:

< 1 month:
  • dysgeusia
  • drug ineffective
  • insomnia
  • dyspnoea
  • pneumonia
  • initial insomnia
  • nausea
  • vomiting
  • death
  • dehydration
1 - 6 months:
  • urticaria
  • dysgeusia
  • insomnia
6 - 12 months:
  • insomnia
1 - 2 years:
  • anorgasmia
  • atrial septal defect
  • cardiac failure congestive
  • cardiomegaly
  • congenital cardiovascular anomaly
  • drug exposure during pregnancy
  • pleural effusion
  • ventricular septal defect
  • accidental death
  • coma
2 - 5 years:
  • abdominal pain lower
  • accidental death
  • coma
  • completed suicide
  • multiple drug overdose accidental
  • ovarian cysts
  • polycystic ovarian syndrome (pcos)
  • pruritus
  • suicide attempt
  • urticaria
5 - 10 years:
  • anorgasmia
  • abdominal abscess
  • convulsion
  • post procedural bile leak
  • pyrexia
10+ years:
  • abdominal pain lower
  • anger
  • anxiety
  • dizziness
  • irritability
  • nystagmus
  • ovarian cysts
  • panic attack
  • polycystic ovarian syndrome (pcos)
  • sweating - excessive
not specified:
  • pain
  • weight decreased
  • nausea
  • osteonecrosis of jaw
  • dyspnoea
  • anxiety
  • constipation
  • pain in extremity
  • arthralgia
  • metastases to bone

Most common drug interactions by gender *:

female:
  • pain
  • weight decreased
  • nausea
  • dyspnoea
  • insomnia
  • arthralgia
  • fatigue
  • metastases to bone
  • osteonecrosis of jaw
  • constipation
male:
  • pneumonia
  • osteonecrosis of jaw
  • weight decreased
  • anaemia
  • anxiety
  • back pain
  • bone disorder
  • cardiomegaly
  • compression fracture
  • depression

Most common drug interactions by age *:

10-19:
  • abdominal pain
  • abdominal pain upper
  • initial insomnia
  • pancreatitis
  • somnolence
  • suicide attempt
20-29:
  • insomnia
  • vomiting
  • abdominal pain
  • asthenia
  • back pain
  • diarrhoea
  • nausea
  • overdose
  • palpitations
  • presyncope
30-39:
  • convulsion
  • excoriation
  • haemoglobin decreased
  • thrombophlebitis superficial
  • abscess jaw
  • anxiety
  • ataxia
  • blood alkaline phosphatase increased
  • blood immunoglobulin g increased
  • bone disorder
40-49:
  • back pain
  • depression
  • intervertebral disc protrusion
  • pain
  • anxiety
  • pain in extremity
  • bone disorder
  • constipation
  • osteonecrosis of jaw
  • spinal osteoarthritis
50-59:
  • insomnia
  • pain
  • nausea
  • pain in extremity
  • anaemia
  • fatigue
  • anxiety
  • arthralgia
  • dyspnoea
  • gait disturbance
60+:
  • pneumonia
  • fatigue
  • weight decreased
  • fall
  • arthralgia
  • hyponatraemia
  • nausea
  • osteoarthritis
  • pain
  • anaemia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Lunesta (eszopiclone) is often used to treat insomnia. Benadryl (diphenhydramine) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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