Review: taking Lyrica and Keppra together


Summary

Drug interactions are reported among people who take Lyrica and Keppra together. This review analyzes the effectiveness and drug interactions between Lyrica and Keppra. It is created by eHealthMe based on reports of 1,396 people who take the same drugs from FDA and social media, and is updated regularly.

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Lyrica

Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. (latest outcomes from Lyrica 121,583 users)

Keppra

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. (latest outcomes from Keppra 36,047 users)

On Sep, 17, 2016

1,396 people who take Lyrica, Keppra are studied.


Number of reports submitted per year:

Lyrica and Keppra drug interactions.

Drug effectiveness over time:

Lyrica:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 75.0% - (3 of 4 people)
  • 6 - 12 months: 0.0% - (0 of 4 people)
  • 1 - 2 years: 20.0% - (1 of 5 people)
  • 2 - 5 years: 80.0% - (4 of 5 people)
  • 5 - 10 years: 0.0% - (0 of 1 people)
  • 10+ years: 0.0% - (0 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Keppra:
  • < 1 month: 100.0% - (1 of 1 people)
  • 1 - 6 months: 25.0% - (1 of 4 people)
  • 6 - 12 months: 0.0% - (0 of 3 people)
  • 1 - 2 years: 60.0% - (3 of 5 people)
  • 2 - 5 years: 25.0% - (1 of 4 people)
  • 5 - 10 years: 50.0% - (1 of 2 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Lyrica:
  • female: 33.0% - (5 of 15 people)
  • male: 60.0% - (3 of 5 people)
Keppra:
  • female: 31.0% - (5 of 16 people)
  • male: 60.0% - (3 of 5 people)

Drug effectiveness by age:

Lyrica:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 25.0% - (1 of 4 people)
  • 40-49: 60.0% - (3 of 5 people)
  • 50-59: 60.0% - (3 of 5 people)
  • 60+: 50.0% - (1 of 2 people)
Keppra:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 75.0% - (3 of 4 people)
  • 40-49: 33.0% - (2 of 6 people)
  • 50-59: 40.0% - (2 of 5 people)
  • 60+: 50.0% - (1 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • somnolence
  • coma
  • posterior reversible encephalopathy syndrome
  • suicide attempt
  • convulsion
  • dizziness
  • nausea
  • feeling abnormal
  • vertigo
  • agranulocytosis
1 - 6 months:
  • agitation
  • convulsion
  • onychophagia
  • self injurious behaviour
  • dizziness
  • fatigue
  • headache
  • depression
  • epilepsy
  • pneumonia
6 - 12 months:
  • foetal exposure during pregnancy
  • premature baby
  • abnormal palmar/plantar creases
  • dysmorphism
  • somnolence
  • fall
  • confusional state
  • convulsion
  • disturbance in attention
  • loss of consciousness
1 - 2 years:
  • fatigue
  • drug ineffective
  • drug hypersensitivity
  • malaise
  • nausea
  • burning sensation
  • convulsion
  • depression
  • depression suicidal
  • headache
2 - 5 years:
  • convulsion
  • insomnia
  • somnolence
  • mouth dry aggravated
  • muscular weakness
  • pain
  • abortion spontaneous
  • adrenal insufficiency
  • anuria
  • balance disorder
5 - 10 years:
  • pain
  • back pain
  • accidental overdose
  • brain injury
  • kidney stones
  • pulmonary venous thrombosis
  • seizures
  • supraventricular tachycardia
  • asthenia
  • back injury
10+ years:
  • cough
not specified:
  • convulsion
  • drug ineffective
  • fatigue
  • somnolence
  • weight increased
  • dizziness
  • fall
  • seizure
  • nausea
  • insomnia

Most common drug interactions by gender *:

female:
  • convulsion
  • fatigue
  • somnolence
  • weight increased
  • drug ineffective
  • dizziness
  • nausea
  • pain
  • headache
  • fall
male:
  • convulsion
  • drug ineffective
  • fall
  • somnolence
  • seizure
  • fatigue
  • dizziness
  • insomnia
  • overdose
  • pain

Most common drug interactions by age *:

0-1:
  • foetal exposure during pregnancy
  • low birth weight baby
  • premature baby
  • cyanosis
  • epilepsy
  • drug ineffective
  • metabolic acidosis
  • status epilepticus
  • anxiety
  • bradyphrenia
2-9:
  • metabolic acidosis
  • convulsion
  • drug ineffective
  • acidosis hyperchloraemic
  • calculus urinary
  • haemodynamic instability
  • rash
  • rebound effect
  • therapeutic response decreased
10-19:
  • convulsion
  • irritability
  • nausea
  • back pain
  • cervical vertebral fracture
  • abdominal wall haematoma
  • aggression
  • bacterial infection
  • blood pressure increased
  • bone marrow reticulin fibrosis
20-29:
  • convulsion
  • drug ineffective
  • pyrexia
  • epilepsy
  • coma
  • suicide attempt
  • drug exposure during pregnancy
  • pneumonia
  • somnolence
  • acute respiratory distress syndrome
30-39:
  • convulsion
  • weight increased
  • fatigue
  • dizziness
  • drug ineffective
  • cardiac arrest
  • overdose
  • memory impairment
  • accidental poisoning
  • fall
40-49:
  • convulsion
  • dizziness
  • drug ineffective
  • somnolence
  • fatigue
  • pain
  • ataxia
  • headache
  • tremor
  • muscular weakness
50-59:
  • convulsion
  • fatigue
  • epilepsy
  • drug ineffective
  • weight increased
  • pain
  • headache
  • fall
  • nausea
  • somnolence
60+:
  • convulsion
  • fatigue
  • drug ineffective
  • fall
  • weight increased
  • somnolence
  • nausea
  • confusional state
  • hypotension
  • grand mal convulsion

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Lyrica (pregabalin) is often used to treat fibromyalgia. Keppra (levetiracetam) is often used to treat epilepsy. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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