Review: taking Macrobid and Methotrexate together


Summary

Drug interactions are reported among people who take Macrobid and Methotrexate together. This review analyzes the effectiveness and drug interactions between Macrobid and Methotrexate. It is created by eHealthMe based on reports of 155 people who take the same drugs from FDA and social media, and is updated regularly.

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Macrobid

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. (latest outcomes from Macrobid 3,402 users)

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 129,243 users)

On Jul, 24, 2016

155 people who take Macrobid, Methotrexate are studied.


Number of reports submitted per year:

Macrobid and Methotrexate drug interactions.

Drug effectiveness over time:

Macrobid:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 0.0% - (0 of 1 people)
  • 2 - 5 years: 0.0% - (0 of 0 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)
Methotrexate:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 0 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 50.0% - (1 of 2 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Macrobid:
  • female: 0.0% - (0 of 4 people)
  • male: 0.0% - (0 of 0 people)
Methotrexate:
  • female: 50.0% - (2 of 4 people)
  • male: 0.0% - (0 of 0 people)

Drug effectiveness by age:

Macrobid:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 0.0% - (0 of 1 people)
  • 50-59: 0.0% - (0 of 2 people)
  • 60+: 0.0% - (0 of 1 people)
Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 100.0% - (1 of 1 people)
  • 50-59: 50.0% - (1 of 2 people)
  • 60+: 0.0% - (0 of 1 people)

Most common drug interactions over time *:

< 1 month:
  • mucosal inflammation
  • neutropenia
  • platelet disorder
  • renal failure acute
  • infection
  • pancreatitis acute
  • oedematous pancreatitis
  • pancytopenia
  • shingles
1 - 6 months:
  • abdominal pain upper
  • chest pain
  • mouth ulceration
  • akinesia
  • immobile
  • oedema peripheral
  • peripheral swelling
  • rash
  • shortness of breath
6 - 12 months:
  • pancreatitis acute
  • oedematous pancreatitis
  • sinus disorder
  • urinary tract infection bacterial
1 - 2 years:
  • bronchopneumonia
  • chest discomfort
  • coma
  • dizziness
  • fatigue
  • hypoxia
  • lower blood pressure
  • pneumonia
  • pneumonitis
  • pulmonary fibrosis
2 - 5 years:
  • cardiac arrest
  • gastroenteritis
  • pyrexia
  • sepsis
  • anastomotic complication
  • arthralgia
  • culture urine positive
  • enterococcal infection
  • escherichia infection
  • escherichia urinary tract infection
10+ years:
  • meningitis cryptococcal
  • arthralgia
  • cough
  • nasal congestion
  • bacteria urine identified
  • blood culture positive
  • blood urine present
  • chest x-ray abnormal
  • fatigue
  • fungus culture positive
not specified:
  • arthralgia
  • pain
  • transient ischaemic attack
  • urinary tract infection
  • dyspnoea
  • pyrexia
  • oedema peripheral
  • pneumonia
  • general physical health deterioration
  • anxiety

Most common drug interactions by gender *:

female:
  • arthralgia
  • pain
  • transient ischaemic attack
  • urinary tract infection
  • dyspnoea
  • general physical health deterioration
  • pyrexia
  • anxiety
  • chest pain
  • oedema peripheral
male:
  • oral pain
  • pneumonia
  • anastomotic complication
  • asthenia
  • blood alkaline phosphatase increased
  • bundle branch block right
  • constipation
  • fatigue
  • hypersensitivity
  • impaired healing

Most common drug interactions by age *:

2-9:
  • gastroenteritis
  • pyrexia
  • cardiac arrest
  • sepsis
  • haemoglobin decreased
  • sudden death
  • arthralgia
  • blood phosphorus increased
  • c-reactive protein increased
  • culture urine positive
20-29:
  • oedematous pancreatitis
  • pancreatitis acute
30-39:
  • pain
  • cervical dysplasia
  • diarrhoea
  • discomfort
  • drug exposure before pregnancy
  • fatigue
  • feeling cold
  • hyperhidrosis
  • pelvic venous thrombosis
  • premature labour
40-49:
  • arthralgia
  • meningitis cryptococcal
  • abdominal pain
  • animal bite
  • benign neoplasm of thyroid gland
  • bone disorder
  • colon neoplasm
  • decreased interest
  • defaecation urgency
  • depression
50-59:
  • chest pain
  • alanine aminotransferase increased
  • diabetes mellitus
  • drug ineffective
  • fall
  • hypercholesterolaemia
  • nipple pain
  • sinusitis
  • appendicitis
  • arthralgia
60+:
  • arthralgia
  • transient ischaemic attack
  • urinary tract infection
  • oedema peripheral
  • fatigue
  • pain
  • chest pain
  • dizziness
  • dyspnoea
  • fall

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline) is often used to treat urinary tract infection. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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