Review: taking Macrobid and Methotrexate together


Summary

Drug interactions are reported among people who take Macrobid and Methotrexate together. This review analyzes the effectiveness and drug interactions between Macrobid and Methotrexate. It is created by eHealthMe based on reports of 77 people who take the same drugs from FDA and social media, and is updated regularly.

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Macrobid

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. (latest outcomes from Macrobid 3,915 users)

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 160,929 users)

On Aug, 26, 2016

77 people who take Macrobid, Methotrexate are studied.


Number of reports submitted per year:

Macrobid and Methotrexate drug interactions.

Drug effectiveness over time:

Macrobid:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 0.0% - (0 of 0 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 0.0% - (0 of 0 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)
Methotrexate:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 0 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Macrobid:
  • female: 0.0% - (0 of 1 people)
  • male: 0.0% - (0 of 0 people)
Methotrexate:
  • female: 100.0% - (1 of 1 people)
  • male: 0.0% - (0 of 0 people)

Drug effectiveness by age:

Macrobid:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 0.0% - (0 of 1 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 0.0% - (0 of 0 people)
Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 100.0% - (1 of 1 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 0.0% - (0 of 0 people)

Most common drug interactions over time *:

< 1 month:
  • acute respiratory failure
  • atrial fibrillation
  • death
  • diverticular perforation
  • drug hypersensitivity
  • encephalopathy
  • femur fracture
  • peritonitis
  • pseudomonal sepsis
  • renal failure acute
1 - 6 months:
  • adverse event
  • conjunctivitis
  • nodule
  • pneumonia
  • swelling
  • visual impairment
  • acute respiratory failure
  • atrial fibrillation
  • death
  • diverticular perforation
6 - 12 months:
  • adverse event
  • conjunctivitis
  • nodule
  • pneumonia
  • swelling
  • visual impairment
1 - 2 years:
  • adverse event
  • conjunctivitis
  • nodule
  • pneumonia
  • swelling
  • visual impairment
  • bronchopneumonia
  • chest discomfort
  • coma
  • dizziness
2 - 5 years:
  • adverse event
  • conjunctivitis
  • nodule
  • pneumonia
  • shingles
  • swelling
  • visual impairment
5 - 10 years:
  • activities of daily living impaired
  • anxiety
  • asthenia
  • bladder disorder
  • chorea
  • confusional state
  • disorientation
  • dysgraphia
  • dyskinesia
  • dysphagia
10+ years:
  • arthralgia
  • cough
  • meningitis cryptococcal
  • nasal congestion
  • bacteria urine identified
  • blood culture positive
  • blood urine present
  • chest x-ray abnormal
  • fungus culture positive
  • hyperhidrosis
not specified:
  • nausea
  • arthralgia
  • urinary tract infection
  • pain
  • vomiting
  • dyspnoea
  • emotional distress
  • general physical health deterioration
  • osteomyelitis
  • pneumonia

Most common drug interactions by gender *:

female:
  • arthralgia
  • nausea
  • pneumonia
  • urinary tract infection
  • emotional distress
  • pain
  • vomiting
  • dyspnoea
  • general physical health deterioration
  • impaired healing
male:
  • constipation
  • fatigue
  • malaise
  • asthenia
  • blood alkaline phosphatase increased
  • bundle branch block right
  • candidiasis
  • diarrhoea
  • dyspnoea
  • gait disturbance

Most common drug interactions by age *:

2-9:
  • pruritus
  • scar
  • acute sinusitis
  • anaemia
  • angiopathy
  • anhedonia
  • anxiety
  • aortic arteriosclerosis
  • application site dryness
  • application site irritation
10-19:
  • ventricular septal defect
  • colitis
20-29:
  • fall
  • femur fracture
  • foot fracture
  • hepatic cirrhosis
  • joint dislocation
  • joint injury
  • lower limb fracture
  • nasopharyngitis
  • osteoporosis
  • patellofemoral pain syndrome
30-39:
  • arthralgia
  • back pain
  • cellulitis
  • diarrhoea
  • drug ineffective
  • feeling abnormal
  • feeling cold
  • fungal infection
  • gastric bypass
  • gastrointestinal stromal tumour
40-49:
  • arthralgia
  • emotional distress
  • general physical health deterioration
  • pain
  • abdominal pain
  • animal bite
  • benign neoplasm of thyroid gland
  • bone disorder
  • colon neoplasm
  • decreased interest
50-59:
  • adverse event
  • conjunctivitis
  • nodule
  • pneumonia
  • swelling
  • visual impairment
  • chest pain
  • cystitis
  • fatigue
  • nausea
60+:
  • urinary tract infection
  • arthralgia
  • nausea
  • urosepsis
  • abdominal pain
  • anaemia
  • anastomotic leak
  • animal bite
  • anxiety
  • atelectasis

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline) is often used to treat urinary tract infection. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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