Review: taking Melatonin and Levothyroxine sodium together


Summary

Drug interactions are reported among people who take Melatonin and Levothyroxine sodium together. This review analyzes the effectiveness and drug interactions between Melatonin and Levothyroxine sodium. It is created by eHealthMe based on reports of 483 people who take the same drugs from FDA and social media, and is updated regularly.

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Melatonin

Melatonin has active ingredients of melatonin. It is often used in insomnia. (latest outcomes from Melatonin 3,072 users)

Levothyroxine Sodium

Levothyroxine sodium has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. (latest outcomes from Levothyroxine sodium 64,698 users)

On Jul, 21, 2016

483 people who take Melatonin, Levothyroxine Sodium are studied.


Number of reports submitted per year:

Melatonin and Levothyroxine sodium drug interactions.

Drug effectiveness over time:

Melatonin:
  • < 1 month: 0.0% - (0 of 5 people)
  • 1 - 6 months: 14.0% - (3 of 21 people)
  • 6 - 12 months: 0.0% - (0 of 5 people)
  • 1 - 2 years: 15.0% - (3 of 19 people)
  • 2 - 5 years: 52.0% - (9 of 17 people)
  • 5 - 10 years: 28.0% - (2 of 7 people)
  • 10+ years: 33.0% - (1 of 3 people)
  • not specified: 0.0% - (0 of 0 people)
Levothyroxine Sodium:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 50.0% - (1 of 2 people)
  • 6 - 12 months: 50.0% - (2 of 4 people)
  • 1 - 2 years: 12.0% - (1 of 8 people)
  • 2 - 5 years: 52.0% - (11 of 21 people)
  • 5 - 10 years: 58.0% - (7 of 12 people)
  • 10+ years: 77.0% - (28 of 36 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Melatonin:
  • female: 25.0% - (17 of 67 people)
  • male: 10.0% - (1 of 10 people)
Levothyroxine Sodium:
  • female: 59.0% - (43 of 72 people)
  • male: 63.0% - (7 of 11 people)

Drug effectiveness by age:

Melatonin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (1 of 1 people)
  • 20-29: 0.0% - (0 of 3 people)
  • 30-39: 0.0% - (0 of 4 people)
  • 40-49: 10.0% - (2 of 19 people)
  • 50-59: 45.0% - (9 of 20 people)
  • 60+: 20.0% - (6 of 30 people)
Levothyroxine Sodium:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 100.0% - (3 of 3 people)
  • 30-39: 100.0% - (4 of 4 people)
  • 40-49: 65.0% - (15 of 23 people)
  • 50-59: 50.0% - (10 of 20 people)
  • 60+: 56.0% - (18 of 32 people)

Most common drug interactions over time *:

< 1 month:
  • nosebleed
  • antepartum haemorrhage
  • nasopharyngitis
  • pruritus
  • rash maculo-papular
  • subchorionic haemorrhage
  • vitamin d deficiency
  • chest pain
  • depression
  • dysphagia
1 - 6 months:
  • bloating
  • weight gain
  • antepartum haemorrhage
  • diarrhoea
  • alopecia
  • anxiety
  • deja vu
  • dizziness
  • feeling abnormal
  • gastrointestinal discomfort
6 - 12 months:
  • cough
  • bipolar
  • blood thyroid stimulating hormone increased
  • cavities - tooth
  • drug ineffective
  • dry eyes
  • dry mouth
  • dystonia
  • high blood pressure
  • hot flashes
1 - 2 years:
  • constipation aggravated
  • heat intolerance
  • insomnia
  • dark circles under eyes
  • insomnia related to another mental condition
  • loss of taste
  • movement - uncoordinated
  • nightmares - repeated
  • supraventricular tachycardia
  • teeth grinding and clenching
2 - 5 years:
  • nosebleed
  • dark circles under eyes
  • insomnia related to another mental condition
  • loss of taste
  • movement - uncoordinated
  • nightmares - repeated
  • supraventricular tachycardia
  • teeth grinding and clenching
  • vision blurred
  • cough
5 - 10 years:
  • bone and joint pain
  • dry skin
  • earache
  • herpes simplex
  • itchiness
  • muscle pain
  • muscle spasms
  • skin blushing/flushing
  • stomach upset
  • sweating - excessive
10+ years:
  • insomnia
  • bloating
  • weight gain
  • constipation aggravated
  • depression
  • heat intolerance
  • frequent headaches
  • joint dislocation
  • postnasal drip
  • stomach upset
not specified:
  • nausea
  • headache
  • fatigue
  • pain
  • fall
  • dizziness
  • drug ineffective
  • malaise
  • anxiety
  • insomnia

Most common drug interactions by gender *:

female:
  • nausea
  • headache
  • fatigue
  • insomnia
  • pain
  • anxiety
  • malaise
  • dizziness
  • drug ineffective
  • cough
male:
  • nosebleed
  • myelodysplastic syndrome
  • respiratory failure
  • anal fistula
  • bloating
  • crohn's disease
  • metastases to bone
  • weight gain
  • asthenia
  • confusional state

Most common drug interactions by age *:

0-1:
  • respiratory distress
2-9:
  • abdominal pain
  • arterial occlusive disease
  • cerebrovascular accident
  • dehydration
  • diarrhoea
  • pulmonary oedema
  • radiation injury
  • skin hypertrophy
  • vasculitis
  • activated partial thromboplastin time prolonged
10-19:
  • anal fistula
  • crohn's disease
  • headache
  • confusional state
  • convulsion
  • haemorrhagic cerebral infarction
  • perirectal abscess
  • pneumonia aspiration
  • spastic diplegia
  • transverse sinus thrombosis
20-29:
  • diabetes mellitus
  • diarrhoea
  • diplopia
  • gastrooesophageal reflux disease
  • headache
  • hypocalcaemia
  • hyponatraemia
  • hypotension
  • hypothyroidism
  • lactic acidosis
30-39:
  • headache
  • convulsion
  • dark circles under eyes
  • epilepsy
  • insomnia related to another mental condition
  • movement - uncoordinated
  • nightmares - repeated
  • supraventricular tachycardia
  • teeth grinding and clenching
  • vision blurred
40-49:
  • pruritus
  • bloating
  • weight gain
  • fatigue
  • nasopharyngitis
  • rash maculo-papular
  • pyrexia
  • anxiety
  • weight increased
  • alanine aminotransferase increased
50-59:
  • drug ineffective
  • fatigue
  • headache
  • dyspnoea
  • rash
  • gastrooesophageal reflux disease
  • insomnia
  • nausea
  • paraesthesia
  • hypoaesthesia
60+:
  • nausea
  • fatigue
  • headache
  • fall
  • depression
  • anxiety
  • dry mouth
  • insomnia
  • hypertension
  • pain

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Melatonin (melatonin) is often used to treat insomnia. Levothyroxine sodium (levothyroxine sodium) is often used to treat hypothyroidism. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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