Review: taking Metformin and Aspirin together


Summary

Drug interactions are reported among people who take Metformin and Aspirin together. This review analyzes the effectiveness and drug interactions between Metformin and Aspirin. It is created by eHealthMe based on reports of 34,257 people who take the same drugs from FDA and social media, and is updated regularly.

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Metformin

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 174,670 users)

Aspirin

Aspirin has active ingredients of aspirin. It is often used in preventive health care. (latest outcomes from Aspirin 272,197 users)

On Sep, 16, 2016

34,257 people who take Metformin, Aspirin are studied.


Number of reports submitted per year:

Metformin and Aspirin drug interactions.

Drug effectiveness over time:

Metformin:
  • < 1 month: 42.0% - (6 of 14 people)
  • 1 - 6 months: 25.0% - (8 of 31 people)
  • 6 - 12 months: 50.0% - (15 of 30 people)
  • 1 - 2 years: 39.0% - (29 of 74 people)
  • 2 - 5 years: 48.0% - (49 of 101 people)
  • 5 - 10 years: 46.0% - (46 of 98 people)
  • 10+ years: 39.0% - (19 of 48 people)
  • not specified: 100.0% - (1 of 1 people)
Aspirin:
  • < 1 month: 42.0% - (6 of 14 people)
  • 1 - 6 months: 40.0% - (9 of 22 people)
  • 6 - 12 months: 23.0% - (4 of 17 people)
  • 1 - 2 years: 45.0% - (19 of 42 people)
  • 2 - 5 years: 43.0% - (40 of 93 people)
  • 5 - 10 years: 51.0% - (47 of 92 people)
  • 10+ years: 57.0% - (30 of 52 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Metformin:
  • female: 39.0% - (71 of 180 people)
  • male: 47.0% - (102 of 217 people)
Aspirin:
  • female: 45.0% - (64 of 140 people)
  • male: 47.0% - (91 of 193 people)

Drug effectiveness by age:

Metformin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 38.0% - (7 of 18 people)
  • 40-49: 31.0% - (19 of 61 people)
  • 50-59: 53.0% - (72 of 134 people)
  • 60+: 40.0% - (74 of 182 people)
Aspirin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 41.0% - (5 of 12 people)
  • 40-49: 37.0% - (20 of 53 people)
  • 50-59: 49.0% - (56 of 114 people)
  • 60+: 48.0% - (73 of 152 people)

Most common drug interactions over time *:

< 1 month:
  • diarrhoea
  • vomiting
  • renal failure acute
  • hypoglycaemia
  • headache
  • hypotension
  • overdose
  • hyponatraemia
  • dehydration
  • nausea
1 - 6 months:
  • asthenia
  • nausea
  • renal failure acute
  • malaise
  • hypoglycaemia
  • confusional state
  • lactic acidosis
  • dizziness
  • pain
  • syncope
6 - 12 months:
  • lactic acidosis
  • hypoglycaemia
  • encephalopathy
  • nausea
  • renal failure acute
  • hepatic failure
  • hepatitis cholestatic
  • duodenal ulcer
  • jaundice cholestatic
  • malaise
1 - 2 years:
  • renal failure acute
  • hypoglycaemia
  • lactic acidosis
  • vomiting
  • nausea
  • rhabdomyolysis
  • chest pain
  • fatigue
  • dizziness
  • hyperkalaemia
2 - 5 years:
  • lactic acidosis
  • renal failure acute
  • dehydration
  • vomiting
  • anaemia
  • dizziness
  • nausea
  • diabetic ketoacidosis
  • gastrointestinal haemorrhage
  • staphylococcal sepsis
5 - 10 years:
  • weight decreased
  • nausea
  • renal failure acute
  • diarrhoea
  • hypoglycaemia
  • dizziness
  • gastrointestinal haemorrhage
  • vomiting
  • anaemia
  • constipation
10+ years:
  • diarrhoea
  • metabolic acidosis
  • renal failure acute
  • hypotension
  • syncope
  • erectile dysfunction
  • renal impairment
  • hyperkalaemia
  • lactic acidosis
  • vomiting
not specified:
  • nausea
  • dyspnoea
  • blood glucose increased
  • fatigue
  • diarrhoea
  • dizziness
  • pain
  • vomiting
  • weight decreased
  • drug ineffective

Most common drug interactions by gender *:

female:
  • nausea
  • blood glucose increased
  • diarrhoea
  • dyspnoea
  • vomiting
  • pain
  • fatigue
  • dizziness
  • weight decreased
  • headache
male:
  • dyspnoea
  • blood glucose increased
  • nausea
  • fatigue
  • diarrhoea
  • dizziness
  • myocardial infarction
  • weight decreased
  • pain
  • renal failure acute

Most common drug interactions by age *:

0-1:
  • neonatal respiratory distress syndrome
  • cerebrovascular accident
  • chest pain
  • congenital teratoma
  • conjunctival haemorrhage
  • cryptorchism
  • facial paresis
  • foetal cerebrovascular disorder
  • foetal growth restriction
  • hypoglycaemia neonatal
2-9:
  • myocardial infarction
  • accidental exposure
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • diarrhoea
  • nausea
  • abdominal distension
  • abdominal pain
  • abdominal pain upper
  • accident at work
10-19:
  • pain in extremity
  • dizziness
  • pruritus
  • cardiac disorder
  • weight decreased
  • erythema
  • body height decreased
  • diabetes mellitus
  • fatigue
  • headache
20-29:
  • deep vein thrombosis
  • pain
  • vomiting
  • anxiety
  • nausea
  • pulmonary embolism
  • confusional state
  • abdominal pain
  • cerebrovascular accident
  • dizziness
30-39:
  • nausea
  • pain
  • vomiting
  • headache
  • diabetes mellitus
  • fatigue
  • abdominal pain
  • deep vein thrombosis
  • arthralgia
  • diarrhoea
40-49:
  • nausea
  • pain
  • dizziness
  • dyspnoea
  • chest pain
  • fatigue
  • diabetes mellitus
  • diarrhoea
  • vomiting
  • myocardial infarction
50-59:
  • nausea
  • blood glucose increased
  • dizziness
  • vomiting
  • pain
  • diarrhoea
  • dyspnoea
  • weight decreased
  • renal failure acute
  • headache
60+:
  • nausea
  • dyspnoea
  • diarrhoea
  • fatigue
  • blood glucose increased
  • renal failure acute
  • vomiting
  • dizziness
  • asthenia
  • weight decreased

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Metformin (metformin hydrochloride) is often used to treat diabetes. Aspirin (aspirin) is often used to treat preventive health care. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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