Review: taking Metformin and Aspirin together


Summary

Drug interactions are reported among people who take Metformin and Aspirin together. This review analyzes the effectiveness and drug interactions between Metformin and Aspirin. It is created by eHealthMe based on reports of 18,891 people who take the same drugs from FDA and social media, and is updated regularly.

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Metformin

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 99,381 users)

Aspirin

Aspirin has active ingredients of aspirin. It is often used in preventive health care. (latest outcomes from Aspirin 160,694 users)

On Jul, 27, 2016

18,891 people who take Metformin, Aspirin are studied.


Number of reports submitted per year:

Metformin and Aspirin drug interactions.

Drug effectiveness over time:

Metformin:
  • < 1 month: 42.0% - (6 of 14 people)
  • 1 - 6 months: 28.0% - (12 of 42 people)
  • 6 - 12 months: 51.0% - (17 of 33 people)
  • 1 - 2 years: 33.0% - (35 of 106 people)
  • 2 - 5 years: 44.0% - (56 of 125 people)
  • 5 - 10 years: 53.0% - (71 of 132 people)
  • 10+ years: 45.0% - (28 of 61 people)
  • not specified: 100.0% - (3 of 3 people)
Aspirin:
  • < 1 month: 43.0% - (7 of 16 people)
  • 1 - 6 months: 52.0% - (18 of 34 people)
  • 6 - 12 months: 27.0% - (6 of 22 people)
  • 1 - 2 years: 43.0% - (22 of 51 people)
  • 2 - 5 years: 41.0% - (48 of 115 people)
  • 5 - 10 years: 44.0% - (57 of 128 people)
  • 10+ years: 54.0% - (37 of 68 people)
  • not specified: 0.0% - (0 of 2 people)

Drug effectiveness by gender:

Metformin:
  • female: 42.0% - (111 of 261 people)
  • male: 45.0% - (117 of 255 people)
Aspirin:
  • female: 43.0% - (88 of 204 people)
  • male: 46.0% - (107 of 232 people)

Drug effectiveness by age:

Metformin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 42.0% - (8 of 19 people)
  • 40-49: 28.0% - (24 of 84 people)
  • 50-59: 53.0% - (89 of 167 people)
  • 60+: 43.0% - (106 of 244 people)
Aspirin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 38.0% - (5 of 13 people)
  • 40-49: 40.0% - (29 of 72 people)
  • 50-59: 46.0% - (66 of 143 people)
  • 60+: 45.0% - (94 of 206 people)

Most common drug interactions over time *:

< 1 month:
  • vomiting
  • renal failure acute
  • diarrhoea
  • hypotension
  • hypoglycaemia
  • hyperkalaemia
  • hyponatraemia
  • dehydration
  • headache
  • nausea
1 - 6 months:
  • lactic acidosis
  • renal failure acute
  • asthenia
  • confusional state
  • liver function test abnormal
  • nausea
  • respiratory failure
  • hypoglycaemia
  • pneumonia
  • blood glucose increased
6 - 12 months:
  • encephalopathy
  • hepatic failure
  • hepatitis cholestatic
  • duodenal ulcer
  • jaundice cholestatic
  • lactic acidosis
  • renal failure acute
  • hepatic neoplasm malignant
  • portal vein thrombosis
  • malaise
1 - 2 years:
  • renal failure acute
  • hypoglycaemia
  • nausea
  • rhabdomyolysis
  • vomiting
  • hyperkalaemia
  • constipation
  • rash
  • breast tenderness
  • cellulitis
2 - 5 years:
  • renal failure acute
  • dehydration
  • lactic acidosis
  • diabetic ketoacidosis
  • staphylococcal sepsis
  • vomiting
  • diarrhoea
  • nausea
  • anaemia
  • fatigue
5 - 10 years:
  • renal failure acute
  • nausea
  • weight decreased
  • diarrhoea
  • constipation
  • muscle spasms
  • hypoglycaemia
  • dizziness
  • dystonia
  • bladder cancer
10+ years:
  • erectile dysfunction
  • impotence
  • intracranial pressure increased
  • hyperkalaemia
  • fatigue
  • renal failure acute
  • death
  • dizziness
  • renal failure
  • vomiting
not specified:
  • nausea
  • blood glucose increased
  • dyspnoea
  • pain
  • vomiting
  • renal failure acute
  • dizziness
  • diarrhoea
  • weight decreased
  • fatigue

Most common drug interactions by gender *:

female:
  • nausea
  • blood glucose increased
  • vomiting
  • dyspnoea
  • pain
  • dizziness
  • diarrhoea
  • renal failure acute
  • weight decreased
  • asthenia
male:
  • blood glucose increased
  • dyspnoea
  • nausea
  • renal failure acute
  • myocardial infarction
  • pain
  • dizziness
  • flushing
  • fatigue
  • diarrhoea

Most common drug interactions by age *:

0-1:
  • neonatal respiratory distress syndrome
  • cerebrovascular accident
  • chest pain
  • congenital teratoma
  • conjunctival haemorrhage
  • cryptorchism
  • facial paresis
  • foetal cerebrovascular disorder
  • foetal growth restriction
  • hypoglycaemia neonatal
2-9:
  • accidental exposure
  • abdominal pain
  • accidental drug intake by child
  • adrenal mass
  • diarrhoea
  • duodenal ulcer haemorrhage
  • faeces discoloured
  • gastrointestinal haemorrhage
  • influenza like illness
  • loss of consciousness
10-19:
  • cholecystitis chronic
  • cholelithiasis
  • deep vein thrombosis
  • hypercoagulation
  • oedema peripheral
  • pain in extremity
  • pulmonary embolism
  • abortion spontaneous
  • acidosis
  • astrocytoma
20-29:
  • deep vein thrombosis
  • pain
  • nausea
  • pulmonary embolism
  • anxiety
  • vomiting
  • dizziness
  • type 2 diabetes mellitus
  • abortion spontaneous
  • blood glucose increased
30-39:
  • pain
  • type 2 diabetes mellitus
  • deep vein thrombosis
  • nausea
  • vomiting
  • abdominal pain
  • headache
  • cholelithiasis
  • diabetes mellitus
  • gallbladder disorder
40-49:
  • nausea
  • diabetes mellitus
  • pain
  • dizziness
  • vomiting
  • dyspnoea
  • blood glucose increased
  • chest pain
  • diarrhoea
  • myocardial infarction
50-59:
  • nausea
  • blood glucose increased
  • pain
  • vomiting
  • dizziness
  • renal failure acute
  • weight decreased
  • anxiety
  • myocardial infarction
  • dyspnoea
60+:
  • nausea
  • renal failure acute
  • dyspnoea
  • blood glucose increased
  • vomiting
  • diarrhoea
  • asthenia
  • pain
  • weight decreased
  • fatigue

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Metformin (metformin hydrochloride) is often used to treat diabetes. Aspirin (aspirin) is often used to treat preventive health care. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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