Review: taking Metformin and Aspirin together


Summary

Drug interactions are reported among people who take Metformin and Aspirin together. This review analyzes the effectiveness and drug interactions between Metformin and Aspirin. It is created by eHealthMe based on reports of 24,185 people who take the same drugs from FDA and social media, and is updated regularly.

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Metformin

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 117,555 users)

Aspirin

Aspirin has active ingredients of aspirin. It is often used in preventive health care. (latest outcomes from Aspirin 184,887 users)

On Aug, 19, 2016

24,185 people who take Metformin, Aspirin are studied.


Number of reports submitted per year:

Metformin and Aspirin drug interactions.

Drug effectiveness over time:

Metformin:
  • < 1 month: 42.0% - (6 of 14 people)
  • 1 - 6 months: 25.0% - (8 of 31 people)
  • 6 - 12 months: 50.0% - (15 of 30 people)
  • 1 - 2 years: 39.0% - (29 of 74 people)
  • 2 - 5 years: 48.0% - (49 of 101 people)
  • 5 - 10 years: 46.0% - (46 of 98 people)
  • 10+ years: 40.0% - (19 of 47 people)
  • not specified: 100.0% - (1 of 1 people)
Aspirin:
  • < 1 month: 42.0% - (6 of 14 people)
  • 1 - 6 months: 40.0% - (9 of 22 people)
  • 6 - 12 months: 23.0% - (4 of 17 people)
  • 1 - 2 years: 45.0% - (19 of 42 people)
  • 2 - 5 years: 43.0% - (40 of 93 people)
  • 5 - 10 years: 51.0% - (47 of 92 people)
  • 10+ years: 57.0% - (30 of 52 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Metformin:
  • female: 39.0% - (71 of 179 people)
  • male: 47.0% - (102 of 217 people)
Aspirin:
  • female: 45.0% - (64 of 140 people)
  • male: 47.0% - (91 of 193 people)

Drug effectiveness by age:

Metformin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 38.0% - (7 of 18 people)
  • 40-49: 31.0% - (19 of 61 people)
  • 50-59: 53.0% - (72 of 134 people)
  • 60+: 40.0% - (74 of 181 people)
Aspirin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 41.0% - (5 of 12 people)
  • 40-49: 37.0% - (20 of 53 people)
  • 50-59: 49.0% - (56 of 114 people)
  • 60+: 48.0% - (73 of 152 people)

Most common drug interactions over time *:

< 1 month:
  • renal failure acute
  • vomiting
  • diarrhoea
  • overdose
  • hyponatraemia
  • hypotension
  • hypoglycaemia
  • headache
  • hyperkalaemia
  • nausea
1 - 6 months:
  • renal failure acute
  • lactic acidosis
  • confusional state
  • hypoglycaemia
  • nausea
  • asthenia
  • dizziness
  • headache
  • liver function test abnormal
  • respiratory failure
6 - 12 months:
  • renal failure acute
  • encephalopathy
  • hepatic failure
  • hepatitis cholestatic
  • lactic acidosis
  • duodenal ulcer
  • jaundice cholestatic
  • malaise
  • nausea
  • hepatic neoplasm malignant
1 - 2 years:
  • renal failure acute
  • hypoglycaemia
  • lactic acidosis
  • nausea
  • vomiting
  • rhabdomyolysis
  • dizziness
  • hyperkalaemia
  • cellulitis
  • constipation
2 - 5 years:
  • lactic acidosis
  • renal failure acute
  • dehydration
  • vomiting
  • diabetic ketoacidosis
  • staphylococcal sepsis
  • dizziness
  • anaemia
  • diarrhoea
  • nausea
5 - 10 years:
  • weight decreased
  • nausea
  • renal failure acute
  • diarrhoea
  • constipation
  • dizziness
  • hypoglycaemia
  • muscle spasms
  • anaemia
  • hiatus hernia
10+ years:
  • diarrhoea
  • metabolic acidosis
  • hypotension
  • renal failure acute
  • erectile dysfunction
  • syncope
  • renal impairment
  • lactic acidosis
  • impotence
  • vomiting
not specified:
  • nausea
  • blood glucose increased
  • dyspnoea
  • pain
  • vomiting
  • dizziness
  • renal failure acute
  • diarrhoea
  • fatigue
  • weight decreased

Most common drug interactions by gender *:

female:
  • nausea
  • blood glucose increased
  • vomiting
  • dyspnoea
  • pain
  • diarrhoea
  • dizziness
  • renal failure acute
  • fatigue
  • weight decreased
male:
  • blood glucose increased
  • dyspnoea
  • nausea
  • renal failure acute
  • myocardial infarction
  • pain
  • dizziness
  • fatigue
  • diarrhoea
  • flushing

Most common drug interactions by age *:

0-1:
  • neonatal respiratory distress syndrome
  • cerebrovascular accident
  • chest pain
  • congenital teratoma
  • conjunctival haemorrhage
  • cryptorchism
  • facial paresis
  • foetal cerebrovascular disorder
  • foetal growth restriction
  • hypoglycaemia neonatal
2-9:
  • myocardial infarction
  • accidental exposure
  • diarrhoea
  • abdominal distension
  • abdominal pain
  • abdominal pain upper
  • accident at work
  • accidental drug intake by child
  • acute graft versus host disease
  • adrenal mass
10-19:
  • nausea
  • cholecystitis chronic
  • pain in extremity
  • vomiting
  • abdominal pain upper
  • deep vein thrombosis
  • diarrhoea
  • dizziness
  • pancreatitis acute
  • pruritus
20-29:
  • deep vein thrombosis
  • pain
  • pulmonary embolism
  • anxiety
  • vomiting
  • nausea
  • dizziness
  • cholecystitis chronic
  • blood cholesterol increased
  • confusional state
30-39:
  • pain
  • nausea
  • vomiting
  • deep vein thrombosis
  • headache
  • type 2 diabetes mellitus
  • abdominal pain
  • diabetes mellitus
  • cholelithiasis
  • arthralgia
40-49:
  • nausea
  • pain
  • dizziness
  • dyspnoea
  • chest pain
  • diabetes mellitus
  • fatigue
  • vomiting
  • diarrhoea
  • myocardial infarction
50-59:
  • nausea
  • blood glucose increased
  • vomiting
  • dizziness
  • pain
  • renal failure acute
  • dyspnoea
  • diarrhoea
  • weight decreased
  • myocardial infarction
60+:
  • nausea
  • renal failure acute
  • dyspnoea
  • blood glucose increased
  • diarrhoea
  • vomiting
  • asthenia
  • fatigue
  • dizziness
  • pain

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Metformin (metformin hydrochloride) is often used to treat diabetes. Aspirin (aspirin) is often used to treat preventive health care. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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