Review: taking Methadone hydrochloride and Topiramate together


Summary

Drug interactions are reported among people who take Methadone hydrochloride and Topiramate together. This review analyzes the effectiveness and drug interactions between Methadone hydrochloride and Topiramate. It is created by eHealthMe based on reports of 287 people who take the same drugs from FDA and social media, and is updated regularly.

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Methadone Hydrochloride

Methadone hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from Methadone hydrochloride 2,744 users)

Topiramate

Topiramate has active ingredients of topiramate. It is often used in epilepsy. (latest outcomes from Topiramate 8,543 users)

On Jul, 27, 2016

287 people who take Methadone Hydrochloride, Topiramate are studied.


Number of reports submitted per year:

Methadone hydrochloride and Topiramate drug interactions.

Drug effectiveness over time:

Methadone Hydrochloride:
  • < 1 month: 0.0% - (0 of 2 people)
  • 1 - 6 months: 50.0% - (1 of 2 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 66.0% - (4 of 6 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 60.0% - (3 of 5 people)
  • 10+ years: 50.0% - (2 of 4 people)
  • not specified: 0.0% - (0 of 0 people)
Topiramate:
  • < 1 month: 0.0% - (0 of 2 people)
  • 1 - 6 months: 100.0% - (2 of 2 people)
  • 6 - 12 months: 0.0% - (0 of 2 people)
  • 1 - 2 years: 33.0% - (1 of 3 people)
  • 2 - 5 years: 50.0% - (2 of 4 people)
  • 5 - 10 years: 50.0% - (3 of 6 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Methadone Hydrochloride:
  • female: 46.0% - (7 of 15 people)
  • male: 66.0% - (4 of 6 people)
Topiramate:
  • female: 23.0% - (3 of 13 people)
  • male: 83.0% - (5 of 6 people)

Drug effectiveness by age:

Methadone Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 66.0% - (2 of 3 people)
  • 30-39: 71.0% - (5 of 7 people)
  • 40-49: 16.0% - (1 of 6 people)
  • 50-59: 33.0% - (1 of 3 people)
  • 60+: 100.0% - (2 of 2 people)
Topiramate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 42.0% - (3 of 7 people)
  • 40-49: 60.0% - (3 of 5 people)
  • 50-59: 0.0% - (0 of 3 people)
  • 60+: 100.0% - (2 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • disturbance in attention
  • urinary retention
  • amnesia
  • constipation
  • decreased appetite
  • drooling
  • drug effect decreased
  • drug withdrawal syndrome
  • dry mouth
  • dry skin
1 - 6 months:
  • depression
  • abnormal behaviour
  • dental caries
  • drug abuse
  • drug dependence
  • dysarthria
  • hypotension
  • partner stress
  • tooth abscess
  • dependence
6 - 12 months:
  • depression
  • abnormal behaviour
  • cardiac disorder
  • chest pain
  • dental caries
  • drug dependence
  • dysarthria
  • tooth abscess
  • abdominal pain
  • affective disorder
1 - 2 years:
  • abnormal behaviour
  • dental caries
  • depression
  • drug dependence
  • dysarthria
  • tooth abscess
  • drug abuse
  • overdose
  • partner stress
  • tooth loss
2 - 5 years:
  • anxiety
  • dizziness
  • impaired memory
  • nausea
  • stomach discomfort
  • agitation
  • alcohol withdrawal syndrome
  • alcoholism
  • angiopathy
  • ankle fracture
5 - 10 years:
  • convulsion
  • decreased appetite
  • depression
  • anxiety
  • anger
  • depression suicidal
  • insomnia
  • nausea
  • bipolar disorder
  • constipation
10+ years:
  • anger
  • depression suicidal
  • insomnia
not specified:
  • convulsion
  • pain
  • headache
  • depression
  • fatigue
  • anxiety
  • nausea
  • malaise
  • rash
  • drug toxicity

Most common drug interactions by gender *:

female:
  • depression
  • convulsion
  • fatigue
  • headache
  • pain
  • pneumonia
  • nausea
  • chest pain
  • anxiety
  • hypotension
male:
  • pain
  • malaise
  • vomiting
  • convulsion
  • rash
  • drug toxicity
  • confusional state
  • headache
  • loss of consciousness
  • anger

Most common drug interactions by age *:

2-9:
  • erythema multiforme
10-19:
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • congenital pancreatic anomaly
  • depression
  • multiple injuries
  • pancreatic pseudocyst
  • pancreatitis
20-29:
  • pulmonary embolism
  • anhedonia
  • anxiety
  • cholecystitis acute
  • increased tendency to bruise
  • injury
  • nephrolithiasis
  • pain
  • convulsion
  • disturbance in attention
30-39:
  • serotonin syndrome
  • completed suicide
  • drug toxicity
  • intentional overdose
  • loss of consciousness
  • neuropathy peripheral
  • type 2 diabetes mellitus
  • weight increased
  • anxiety
  • cardio-respiratory arrest
40-49:
  • pain
  • convulsion
  • malaise
  • headache
  • depression
  • rash
  • drug dependence
  • anger
  • back pain
  • anxiety
50-59:
  • depression
  • convulsion
  • tremor
  • headache
  • asthenia
  • nausea
  • balance disorder
  • central nervous system lesion
  • coronary artery disease
  • fatigue
60+:
  • myocardial infarction
  • chest pain
  • constipation
  • diarrhoea
  • fatigue
  • feeling abnormal
  • pneumonia
  • anger
  • blood creatine phosphokinase increased
  • fall

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Methadone hydrochloride (methadone hydrochloride) is often used to treat pain. Topiramate (topiramate) is often used to treat epilepsy. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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