Review: taking Methotrexate and Milk thistle together


Summary

Drug interactions are reported among people who take Methotrexate and Milk thistle together. This review analyzes the effectiveness and drug interactions between Methotrexate and Milk thistle. It is created by eHealthMe based on reports of 44 people who take the same drugs from FDA and social media, and is updated regularly.

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Methotrexate

Methotrexate has active ingredients of methotrexate. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 129,243 users)

Milk Thistle

Milk thistle has active ingredients of milk thistle. It is often used in fatty liver. (latest outcomes from Milk thistle 583 users)

On Jul, 20, 2016

44 people who take Methotrexate, Milk Thistle are studied.


Number of reports submitted per year:

Methotrexate and Milk thistle drug interactions.

Drug effectiveness over time:

Methotrexate:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 0.0% - (0 of 2 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 0.0% - (0 of 0 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 0 people)
Milk Thistle:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 0 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Methotrexate:
  • female: 20.0% - (1 of 5 people)
  • male: 0.0% - (0 of 0 people)
Milk Thistle:
  • female: 100.0% - (1 of 1 people)
  • male: 0.0% - (0 of 0 people)

Drug effectiveness by age:

Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 1 people)
  • 40-49: 0.0% - (0 of 1 people)
  • 50-59: 0.0% - (0 of 2 people)
  • 60+: 100.0% - (1 of 1 people)
Milk Thistle:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 0.0% - (0 of 0 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 100.0% - (1 of 1 people)

Most common drug interactions over time *:

< 1 month:
  • hypotension
  • lung infiltration
  • meningitis cryptococcal
  • pneumonia bacterial
  • pneumonia cryptococcal
  • respiratory acidosis
  • pulmonary mass
  • pulmonary oedema
  • blood creatinine increased
  • disseminated intravascular coagulation
1 - 6 months:
  • liver function test abnormal
  • hepatotoxicity
  • pulmonary tuberculosis
  • dry eyes aggravated
2 - 5 years:
  • haematuria
10+ years:
  • haematuria
not specified:
  • blood alkaline phosphatase increased
  • escherichia sepsis
  • pyrexia
  • uterine polyp
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • blood bilirubin increased
  • blood potassium decreased
  • endometrial hyperplasia
  • pulmonary tuberculosis

Most common drug interactions by gender *:

female:
  • blood alkaline phosphatase increased
  • escherichia sepsis
  • pulmonary tuberculosis
  • uterine polyp
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • blood bilirubin increased
  • blood potassium decreased
  • endometrial hyperplasia
  • haematocrit decreased
male:
  • pulmonary mass
  • pulmonary oedema
  • blood creatinine increased
  • c-reactive protein increased
  • disseminated intravascular coagulation
  • hypotension
  • lung infiltration
  • lymphadenitis
  • meningitis cryptococcal
  • pneumonia bacterial

Most common drug interactions by age *:

40-49:
  • disorientation
  • euphoric mood
50-59:
  • pulmonary mass
  • pulmonary oedema
  • blood creatinine increased
  • c-reactive protein increased
  • disseminated intravascular coagulation
  • hypotension
  • liver function test abnormal
  • lung infiltration
  • lymphadenitis
  • meningitis cryptococcal
60+:
  • uterine polyp
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • blood bilirubin increased
  • blood potassium decreased
  • endometrial hyperplasia
  • haematocrit decreased
  • blood alkaline phosphatase increased
  • escherichia sepsis
  • pulmonary tuberculosis

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Methotrexate (methotrexate) is often used to treat rheumatoid arthritis. Milk thistle (milk thistle) is often used to treat fatty liver. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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