Review: taking Methotrexate and Milk thistle together


Summary

Drug interactions are reported among people who take Methotrexate and Milk thistle together. This review analyzes the effectiveness and drug interactions between Methotrexate and Milk thistle. It is created by eHealthMe based on reports of 104 people who take the same drugs from FDA and social media, and is updated regularly.

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Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 205,730 users)

Milk Thistle

Milk thistle has active ingredients of milk thistle. It is often used in liver disorder. (latest outcomes from Milk thistle 1,490 users)

On Sep, 19, 2016

104 people who take Methotrexate, Milk Thistle are studied.


Number of reports submitted per year:

Methotrexate and Milk thistle drug interactions.

Drug effectiveness over time:

Methotrexate:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 0.0% - (0 of 2 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 0.0% - (0 of 0 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 0 people)
Milk Thistle:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 0 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Methotrexate:
  • female: 20.0% - (1 of 5 people)
  • male: 0.0% - (0 of 0 people)
Milk Thistle:
  • female: 100.0% - (1 of 1 people)
  • male: 0.0% - (0 of 0 people)

Drug effectiveness by age:

Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 1 people)
  • 40-49: 0.0% - (0 of 1 people)
  • 50-59: 0.0% - (0 of 2 people)
  • 60+: 100.0% - (1 of 1 people)
Milk Thistle:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 0.0% - (0 of 0 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 100.0% - (1 of 1 people)

Most common drug interactions over time *:

< 1 month:
  • pulmonary mass
  • pulmonary oedema
  • blood creatinine increased
  • disseminated intravascular coagulation
  • hypotension
  • lung infiltration
  • meningitis cryptococcal
  • pneumonia bacterial
  • pneumonia cryptococcal
  • respiratory acidosis
1 - 6 months:
  • liver function test abnormal
  • hepatotoxicity
  • pulmonary tuberculosis
  • acute coronary syndrome
  • acute myocardial infarction
  • dry eyes aggravated
6 - 12 months:
  • death
  • mycobacterium tuberculosis complex test positive
1 - 2 years:
  • adverse reaction
  • death
  • mycobacterium tuberculosis complex test positive
  • pneumonia
  • pulmonary mass
  • stomatitis
2 - 5 years:
  • haematuria
5 - 10 years:
  • acute coronary syndrome
  • acute myocardial infarction
10+ years:
  • haematuria
not specified:
  • nausea
  • injection site pain
  • pyrexia
  • fatigue
  • arthralgia
  • pain in extremity
  • vomiting
  • headache
  • insomnia
  • blood alkaline phosphatase increased

Most common drug interactions by gender *:

female:
  • nausea
  • injection site pain
  • blood alkaline phosphatase increased
  • escherichia sepsis
  • pain in extremity
  • pulmonary tuberculosis
  • uterine polyp
  • vomiting
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
male:
  • headache
  • pulmonary mass
  • pulmonary oedema
  • pyrexia
  • fatigue
  • arthralgia
  • blood creatinine increased
  • c-reactive protein increased
  • disseminated intravascular coagulation
  • drug ineffective

Most common drug interactions by age *:

30-39:
  • injection site pain
40-49:
  • headache
  • fatigue
  • autoimmune neutropenia
  • neutrophil count decreased
  • blood testosterone decreased
  • burns third degree
  • desmoid tumour
  • pulmonary embolism
  • radiation injury
  • arthralgia
50-59:
  • pneumonia
  • pulmonary mass
  • pulmonary oedema
  • pyrexia
  • blood creatinine increased
  • c-reactive protein increased
  • disseminated intravascular coagulation
  • hypotension
  • liver function test abnormal
  • lung infiltration
60+:
  • nausea
  • blood alkaline phosphatase increased
  • escherichia sepsis
  • pulmonary tuberculosis
  • uterine polyp
  • vomiting
  • insomnia
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • blood bilirubin increased

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Milk thistle (milk thistle) is often used to treat liver disorder. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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