Review: taking Methotrexate and Naproxen together


Summary

Drug interactions are reported among people who take Methotrexate and Naproxen together. This review analyzes the effectiveness and drug interactions between Methotrexate and Naproxen. It is created by eHealthMe based on reports of 3,447 people who take the same drugs from FDA and social media, and is updated regularly.

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Methotrexate

Methotrexate has active ingredients of methotrexate. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 129,243 users)

Naproxen

Naproxen has active ingredients of naproxen. It is often used in pain. (latest outcomes from Naproxen 27,298 users)

On Jul, 20, 2016

3,447 people who take Methotrexate, Naproxen are studied.


Number of reports submitted per year:

Methotrexate and Naproxen drug interactions.

Drug effectiveness over time:

Methotrexate:
  • < 1 month: 100.0% - (1 of 1 people)
  • 1 - 6 months: 20.0% - (3 of 15 people)
  • 6 - 12 months: 25.0% - (1 of 4 people)
  • 1 - 2 years: 27.0% - (3 of 11 people)
  • 2 - 5 years: 33.0% - (2 of 6 people)
  • 5 - 10 years: 33.0% - (2 of 6 people)
  • 10+ years: 25.0% - (1 of 4 people)
  • not specified: 0.0% - (0 of 0 people)
Naproxen:
  • < 1 month: 0.0% - (0 of 5 people)
  • 1 - 6 months: 44.0% - (4 of 9 people)
  • 6 - 12 months: 0.0% - (0 of 5 people)
  • 1 - 2 years: 0.0% - (0 of 4 people)
  • 2 - 5 years: 37.0% - (3 of 8 people)
  • 5 - 10 years: 0.0% - (0 of 7 people)
  • 10+ years: 36.0% - (4 of 11 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Methotrexate:
  • female: 26.0% - (10 of 38 people)
  • male: 33.0% - (3 of 9 people)
Naproxen:
  • female: 22.0% - (9 of 40 people)
  • male: 22.0% - (2 of 9 people)

Drug effectiveness by age:

Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 40.0% - (2 of 5 people)
  • 40-49: 15.0% - (3 of 19 people)
  • 50-59: 46.0% - (7 of 15 people)
  • 60+: 25.0% - (1 of 4 people)
Naproxen:
  • 0-1: 0.0% - (0 of 1 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 3 people)
  • 20-29: 33.0% - (1 of 3 people)
  • 30-39: 20.0% - (1 of 5 people)
  • 40-49: 23.0% - (4 of 17 people)
  • 50-59: 26.0% - (4 of 15 people)
  • 60+: 20.0% - (1 of 5 people)

Most common drug interactions over time *:

< 1 month:
  • autoimmune hepatitis
  • blood bilirubin increased
  • cholestasis
  • cytolytic hepatitis
  • jaundice
  • open fracture
  • prothrombin level decreased
  • transaminases increased
  • wound
  • amnesia
1 - 6 months:
  • anaemia
  • gastroenteritis
  • upper gastrointestinal haemorrhage
  • anaemia megaloblastic
  • diarrhoea
  • erosive oesophagitis
  • gastritis erosive
  • helicobacter infection
  • large intestinal ulcer
  • pain
6 - 12 months:
  • renal impairment
  • arthritis
  • histiocytosis haematophagic
  • rash erythematous
  • aspartate aminotransferase increased
  • cerebrovascular accident
  • respiratory arrest
  • vomiting
  • alanine aminotransferase increased
  • atelectasis
1 - 2 years:
  • nausea
  • abdominal pain
  • oedema peripheral
  • dizziness
  • liver function test abnormal
  • malaise
  • night sweats
  • abdominal mass
  • arthritis
  • autoimmune hepatitis
2 - 5 years:
  • pneumonia
  • clavicle fracture
  • device failure
  • femur fracture
  • gastric ulcer
  • impaired healing
  • vomiting
  • death
  • respiratory failure
  • small intestinal stenosis
5 - 10 years:
  • pulmonary fibrosis
  • diverticulitis
  • pyrexia
  • anxiety
  • enterococcal infection
  • fatigue
  • general physical health deterioration
  • klebsiella infection
  • polyneuropathy
  • candidiasis
10+ years:
  • renal failure
  • genital ulceration
  • neutropenia
  • disseminated tuberculosis
  • immune reconstitution syndrome
  • lymph node tuberculosis
  • meningitis tuberculous
  • nephrolithiasis
  • tuberculosis of central nervous system
  • bronchiectasis
not specified:
  • arthralgia
  • pyrexia
  • drug ineffective
  • nausea
  • headache
  • pain
  • dyspnoea
  • rheumatoid arthritis
  • pneumonia
  • oedema peripheral

Most common drug interactions by gender *:

female:
  • arthralgia
  • nausea
  • drug ineffective
  • pyrexia
  • headache
  • pain
  • fatigue
  • pneumonia
  • pain in extremity
  • vomiting
male:
  • pyrexia
  • arthralgia
  • dyspnoea
  • nausea
  • cough
  • drug ineffective
  • chest pain
  • oedema peripheral
  • rheumatoid arthritis
  • pneumonia

Most common drug interactions by age *:

2-9:
  • pyrexia
  • vomiting
  • hepatitis
  • hodgkin's disease
  • hypoglycaemia
  • juvenile arthritis
  • arthralgia
  • headache
  • hyperammonaemia
  • arthritis
10-19:
  • pyrexia
  • arthralgia
  • arthritis
  • juvenile arthritis
  • injection site pain
  • disseminated intravascular coagulation
  • multi-organ failure
  • diplopia
  • balance disorder
  • brain oedema
20-29:
  • arthralgia
  • pyrexia
  • atrophy
  • drug ineffective
  • joint range of motion decreased
  • pain
  • flushing
  • headache
  • hepatic failure
  • hepatic necrosis
30-39:
  • oedema peripheral
  • dyspnoea
  • nausea
  • cough
  • diarrhoea
  • injection site pain
  • dehydration
  • gastrointestinal haemorrhage
  • hypotension
  • pyrexia
40-49:
  • uterine leiomyoma
  • arthralgia
  • pneumonia
  • dysfunctional uterine bleeding
  • rheumatoid arthritis
  • nausea
  • pyrexia
  • injection site erythema
  • drug ineffective
  • chest pain
50-59:
  • arthralgia
  • pyrexia
  • headache
  • drug ineffective
  • dyspnoea
  • pain
  • nausea
  • diarrhoea
  • oedema peripheral
  • anaemia
60+:
  • drug ineffective
  • nausea
  • arthralgia
  • pneumonia
  • fatigue
  • dyspnoea
  • cough
  • anaemia
  • chest pain
  • pyrexia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Methotrexate (methotrexate) is often used to treat rheumatoid arthritis. Naproxen (naproxen) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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