Review: taking Methotrexate and Naproxen together


Summary

Drug interactions are reported among people who take Methotrexate and Naproxen together. This review analyzes the effectiveness and drug interactions between Methotrexate and Naproxen. It is created by eHealthMe based on reports of 4,473 people who take the same drugs from FDA and social media, and is updated regularly.

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Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 160,929 users)

Naproxen

Naproxen has active ingredients of naproxen. It is often used in pain. (latest outcomes from Naproxen 28,475 users)

On Aug, 26, 2016

4,473 people who take Methotrexate, Naproxen are studied.


Number of reports submitted per year:

Methotrexate and Naproxen drug interactions.

Drug effectiveness over time:

Methotrexate:
  • < 1 month: 100.0% - (1 of 1 people)
  • 1 - 6 months: 23.0% - (3 of 13 people)
  • 6 - 12 months: 25.0% - (1 of 4 people)
  • 1 - 2 years: 42.0% - (3 of 7 people)
  • 2 - 5 years: 33.0% - (2 of 6 people)
  • 5 - 10 years: 33.0% - (2 of 6 people)
  • 10+ years: 25.0% - (1 of 4 people)
  • not specified: 0.0% - (0 of 0 people)
Naproxen:
  • < 1 month: 0.0% - (0 of 4 people)
  • 1 - 6 months: 50.0% - (4 of 8 people)
  • 6 - 12 months: 0.0% - (0 of 5 people)
  • 1 - 2 years: 0.0% - (0 of 4 people)
  • 2 - 5 years: 37.0% - (3 of 8 people)
  • 5 - 10 years: 0.0% - (0 of 7 people)
  • 10+ years: 57.0% - (4 of 7 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Methotrexate:
  • female: 31.0% - (10 of 32 people)
  • male: 33.0% - (3 of 9 people)
Naproxen:
  • female: 26.0% - (9 of 34 people)
  • male: 22.0% - (2 of 9 people)

Drug effectiveness by age:

Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 40.0% - (2 of 5 people)
  • 40-49: 20.0% - (3 of 15 people)
  • 50-59: 50.0% - (7 of 14 people)
  • 60+: 25.0% - (1 of 4 people)
Naproxen:
  • 0-1: 0.0% - (0 of 1 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 33.0% - (1 of 3 people)
  • 30-39: 20.0% - (1 of 5 people)
  • 40-49: 30.0% - (4 of 13 people)
  • 50-59: 28.0% - (4 of 14 people)
  • 60+: 20.0% - (1 of 5 people)

Most common drug interactions over time *:

< 1 month:
  • autoimmune hepatitis
  • blood bilirubin increased
  • cholestasis
  • jaundice
  • prothrombin level decreased
  • transaminases increased
  • cytolytic hepatitis
  • open fracture
  • wound
  • arthralgia
1 - 6 months:
  • anaemia
  • gastroenteritis
  • diarrhoea
  • upper gastrointestinal haemorrhage
  • arthritis
  • anaemia megaloblastic
  • erosive oesophagitis
  • gastritis erosive
  • helicobacter infection
  • large intestinal ulcer
6 - 12 months:
  • renal impairment
  • arthritis
  • histiocytosis haematophagic
  • rash erythematous
  • vomiting
  • alanine aminotransferase increased
  • arthralgia
  • aspartate aminotransferase increased
  • cerebrovascular accident
  • diplopia
1 - 2 years:
  • pyrexia
  • nausea
  • pneumonia
  • abdominal pain
  • respiratory failure
  • gastroenteritis
  • oedema peripheral
  • sinusitis
  • urinary tract infection
  • convulsion
2 - 5 years:
  • pneumonia
  • clavicle fracture
  • device failure
  • femur fracture
  • gastric ulcer
  • impaired healing
  • vomiting
  • death
  • respiratory failure
  • small intestinal stenosis
5 - 10 years:
  • pulmonary fibrosis
  • pyrexia
  • diverticulitis
  • anxiety
  • fatigue
  • interstitial lung disease
  • respiratory failure
  • chest pain
  • enterococcal infection
  • general physical health deterioration
10+ years:
  • renal failure
  • genital ulceration
  • neutropenia
  • disseminated tuberculosis
  • immune reconstitution syndrome
  • lymph node tuberculosis
  • meningitis tuberculous
  • nephrolithiasis
  • tuberculosis of central nervous system
  • bronchiectasis
not specified:
  • arthralgia
  • drug ineffective
  • injection site pain
  • pyrexia
  • pain
  • nausea
  • headache
  • rheumatoid arthritis
  • pain in extremity
  • fatigue

Most common drug interactions by gender *:

female:
  • arthralgia
  • drug ineffective
  • pain
  • headache
  • injection site pain
  • pyrexia
  • nausea
  • pain in extremity
  • fatigue
  • rheumatoid arthritis
male:
  • arthralgia
  • drug ineffective
  • pyrexia
  • nausea
  • cough
  • rheumatoid arthritis
  • dyspnoea
  • chest pain
  • pneumonia
  • injection site pain

Most common drug interactions by age *:

2-9:
  • pyrexia
  • vomiting
  • arthralgia
  • drug ineffective
  • arthritis
  • histiocytosis haematophagic
  • cough
  • hepatitis
  • hodgkin's disease
  • hypoglycaemia
10-19:
  • pyrexia
  • arthralgia
  • injection site pain
  • arthritis
  • juvenile arthritis
  • disseminated intravascular coagulation
  • multi-organ failure
  • headache
  • diplopia
  • drug ineffective
20-29:
  • arthralgia
  • headache
  • pain
  • pyrexia
  • drug ineffective
  • atrophy
  • flushing
  • joint range of motion decreased
  • injection site pain
  • nausea
30-39:
  • nausea
  • oedema peripheral
  • pyrexia
  • diarrhoea
  • cough
  • dyspnoea
  • hypotension
  • injection site pain
  • hypocalcaemia
  • arthralgia
40-49:
  • uterine leiomyoma
  • arthralgia
  • pneumonia
  • injection site pain
  • headache
  • nausea
  • drug ineffective
  • pyrexia
  • rheumatoid arthritis
  • dysfunctional uterine bleeding
50-59:
  • arthralgia
  • headache
  • pyrexia
  • drug ineffective
  • pain
  • pain in extremity
  • injection site pain
  • nausea
  • dyspnoea
  • diarrhoea
60+:
  • drug ineffective
  • arthralgia
  • fatigue
  • rheumatoid arthritis
  • pneumonia
  • nausea
  • pain in extremity
  • cough
  • dyspnoea
  • fall

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Naproxen (naproxen) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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