Review: taking Methotrexate and Oxycontin together


Summary

Drug interactions are reported among people who take Methotrexate and Oxycontin together. This review analyzes the effectiveness and drug interactions between Methotrexate and Oxycontin. It is created by eHealthMe based on reports of 1,800 people who take the same drugs from FDA and social media, and is updated regularly.

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Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 152,717 users)

Oxycontin

Oxycontin has active ingredients of oxycodone hydrochloride. It is often used in pain. (latest outcomes from Oxycontin 49,032 users)

On Aug, 21, 2016

1,800 people who take Methotrexate, Oxycontin are studied.


Number of reports submitted per year:

Methotrexate and Oxycontin drug interactions.

Drug effectiveness over time:

Methotrexate:
  • < 1 month: 100.0% - (1 of 1 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 0.0% - (0 of 2 people)
  • 2 - 5 years: 0.0% - (0 of 1 people)
  • 5 - 10 years: 50.0% - (1 of 2 people)
  • 10+ years: 0.0% - (0 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Oxycontin:
  • < 1 month: 100.0% - (1 of 1 people)
  • 1 - 6 months: 100.0% - (2 of 2 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 100.0% - (1 of 1 people)
  • 2 - 5 years: 28.0% - (2 of 7 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Methotrexate:
  • female: 28.0% - (2 of 7 people)
  • male: 0.0% - (0 of 2 people)
Oxycontin:
  • female: 50.0% - (5 of 10 people)
  • male: 100.0% - (2 of 2 people)

Drug effectiveness by age:

Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 2 people)
  • 40-49: 25.0% - (1 of 4 people)
  • 50-59: 0.0% - (0 of 1 people)
  • 60+: 50.0% - (1 of 2 people)
Oxycontin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 50.0% - (1 of 2 people)
  • 40-49: 60.0% - (3 of 5 people)
  • 50-59: 33.0% - (1 of 3 people)
  • 60+: 100.0% - (2 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • drug ineffective
  • hot flush
  • muscle twitching
  • withdrawal syndrome
  • anaemia
  • vomiting
  • rash
  • headache
  • dehydration
  • diarrhoea
1 - 6 months:
  • sepsis
  • renal failure acute
  • cellulitis
  • endocarditis bacterial
  • squamous cell carcinoma
  • anaemia
  • lung neoplasm
  • rheumatoid arthritis
  • convulsion
  • death
6 - 12 months:
  • pyrexia
  • squamous cell carcinoma
  • adverse event
  • conjunctivitis
  • metastases to mouth
  • nodule
  • pneumonia
  • swelling
  • visual impairment
  • abscess
1 - 2 years:
  • adverse event
  • anger
  • back pain
  • conjunctivitis
  • diarrhoea
  • drug ineffective
  • hostility
  • hypotension
  • nausea
  • nodule
2 - 5 years:
  • depression
  • pain
  • tremor
  • drug dependence
  • flatulence
  • mental disorder
  • suicidal ideation
  • arthralgia
  • drug withdrawal syndrome
  • abdominal pain
5 - 10 years:
  • fatigue
  • back pain aggravated
  • depression
  • dry eyes
  • lack of regular bowel movements
  • libido decreased
  • neck pain
  • neck stiffness
  • weight gain
  • pain - tooth or teeth
10+ years:
  • anaemia
  • arthritis bacterial
  • back pain
  • bacterial pyelonephritis
  • blood glucose abnormal
  • bronchopneumonia
  • cauda equina syndrome
  • empyema
  • hyponatraemia
  • intervertebral disc disorder
not specified:
  • pain
  • arthralgia
  • nausea
  • oedema peripheral
  • fatigue
  • pyrexia
  • back pain
  • dyspnoea
  • drug ineffective
  • rheumatoid arthritis

Most common drug interactions by gender *:

female:
  • pain
  • arthralgia
  • nausea
  • drug ineffective
  • fatigue
  • anxiety
  • vomiting
  • oedema peripheral
  • anaemia
  • back pain
male:
  • pain
  • weight decreased
  • arthralgia
  • oedema peripheral
  • depression
  • pyrexia
  • back pain
  • rheumatoid arthritis
  • headache
  • chest pain

Most common drug interactions by age *:

2-9:
  • anaemia
  • thrombocytopenia
  • hypokalaemia
  • leukopenia
  • neutropenia
  • stomatitis
  • febrile neutropenia
  • hypertension
  • abdominal pain
  • dehydration
10-19:
  • decreased appetite
  • pyrexia
  • neutrophil count decreased
  • acute monocytic leukaemia
  • headache
  • multi-organ failure
  • myeloid leukaemia
  • septic shock
  • transfusion reaction
  • pancytopenia
20-29:
  • nausea
  • completed suicide
  • dyspnoea
  • white blood cell count decreased
  • alopecia
  • cellulitis
  • endometriosis
  • pelvic inflammatory disease
  • catheter related infection
  • hyponatraemia
30-39:
  • drug ineffective
  • hot flush
  • muscle twitching
  • nausea
  • withdrawal syndrome
  • diarrhoea
  • fatigue
  • pain
  • arthralgia
  • vomiting
40-49:
  • pain
  • pyrexia
  • rheumatoid arthritis
  • depression
  • oedema peripheral
  • headache
  • weight decreased
  • anaemia
  • back pain
  • constipation
50-59:
  • fatigue
  • pain
  • arthralgia
  • nausea
  • pyrexia
  • headache
  • oedema peripheral
  • osteoarthritis
  • sinusitis
  • vomiting
60+:
  • pain
  • arthralgia
  • oedema peripheral
  • fatigue
  • fall
  • back pain
  • nausea
  • dyspnoea
  • drug ineffective
  • anxiety

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Oxycontin (oxycodone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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