Review: taking Methotrexate and Tylenol together


Summary

Drug interactions are reported among people who take Methotrexate and Tylenol together. This review analyzes the effectiveness and drug interactions between Methotrexate and Tylenol. It is created by eHealthMe based on reports of 6,235 people who take the same drugs from FDA and social media, and is updated regularly.

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Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 152,717 users)

Tylenol

Tylenol has active ingredients of acetaminophen. It is often used in pain. (latest outcomes from Tylenol 61,244 users)

On Aug, 19, 2016

6,235 people who take Methotrexate, Tylenol are studied.


Number of reports submitted per year:

Methotrexate and Tylenol drug interactions.

Drug effectiveness over time:

Methotrexate:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 9 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 25.0% - (1 of 4 people)
  • 2 - 5 years: 16.0% - (1 of 6 people)
  • 5 - 10 years: 14.0% - (1 of 7 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Tylenol:
  • < 1 month: 33.0% - (1 of 3 people)
  • 1 - 6 months: 0.0% - (0 of 0 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 14.0% - (1 of 7 people)
  • 2 - 5 years: 20.0% - (1 of 5 people)
  • 5 - 10 years: 50.0% - (2 of 4 people)
  • 10+ years: 0.0% - (0 of 5 people)
  • not specified: 100.0% - (1 of 1 people)

Drug effectiveness by gender:

Methotrexate:
  • female: 23.0% - (5 of 21 people)
  • male: 0.0% - (0 of 7 people)
Tylenol:
  • female: 25.0% - (5 of 20 people)
  • male: 16.0% - (1 of 6 people)

Drug effectiveness by age:

Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 0.0% - (0 of 4 people)
  • 40-49: 50.0% - (1 of 2 people)
  • 50-59: 30.0% - (3 of 10 people)
  • 60+: 10.0% - (1 of 10 people)
Tylenol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 0.0% - (0 of 4 people)
  • 40-49: 0.0% - (0 of 2 people)
  • 50-59: 40.0% - (4 of 10 people)
  • 60+: 25.0% - (2 of 8 people)

Most common drug interactions over time *:

< 1 month:
  • pyrexia
  • febrile neutropenia
  • pneumonia
  • neutropenia
  • platelet count decreased
  • diarrhoea
  • hypotension
  • white blood cell count decreased
  • nausea
  • respiratory failure
1 - 6 months:
  • pyrexia
  • nausea
  • pneumonia
  • dyspnoea
  • interstitial lung disease
  • rheumatoid arthritis
  • fatigue
  • headache
  • arthralgia
  • colitis
6 - 12 months:
  • drug ineffective
  • nausea
  • pneumonitis
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • pneumonia
  • pyrexia
  • vomiting
  • weight decreased
  • dehydration
1 - 2 years:
  • pyrexia
  • pneumonia
  • respiratory failure
  • fatigue
  • lung disorder
  • multi-organ failure
  • sepsis
  • general physical health deterioration
  • vomiting
  • cholestasis
2 - 5 years:
  • pneumonia
  • pyrexia
  • nausea
  • dyspnoea
  • erysipelas
  • fatigue
  • herpes zoster
  • pharyngitis streptococcal
  • rheumatoid arthritis
  • alanine aminotransferase increased
5 - 10 years:
  • thrombocytopenia
  • headache
  • chills
  • pyrexia
  • asthenia
  • nausea
  • chest pain
  • staphylococcal infection
  • weight decreased
  • angina pectoris
10+ years:
  • asthenia
  • agranulocytosis
  • headache
  • oedema peripheral
  • chills
  • chest pain
  • myocardial infarction
  • pancreatitis acute
  • sepsis
  • candidiasis
not specified:
  • arthralgia
  • pyrexia
  • nausea
  • pain
  • headache
  • dyspnoea
  • fatigue
  • pneumonia
  • vomiting
  • fall

Most common drug interactions by gender *:

female:
  • arthralgia
  • nausea
  • headache
  • pain
  • pyrexia
  • dyspnoea
  • fatigue
  • pneumonia
  • vomiting
  • diarrhoea
male:
  • pyrexia
  • nausea
  • pneumonia
  • pain
  • arthralgia
  • dyspnoea
  • fatigue
  • vomiting
  • oedema peripheral
  • drug ineffective

Most common drug interactions by age *:

0-1:
  • oesophageal squamous cell carcinoma
  • pyrexia
  • febrile neutropenia
  • respiratory failure
  • ascites
  • staphylococcal infection
  • abdominal distension
  • acute respiratory distress syndrome
  • bile output abnormal
  • blood lactate dehydrogenase abnormal
2-9:
  • pyrexia
  • diarrhoea
  • vomiting
  • mucosal inflammation
  • nausea
  • neutropenia
  • tremor
  • anaemia
  • febrile neutropenia
  • somnolence
10-19:
  • mucosal inflammation
  • pyrexia
  • febrile neutropenia
  • arthralgia
  • crohn's disease
  • nausea
  • pain
  • vomiting
  • abdominal pain
  • headache
20-29:
  • pyrexia
  • hepatic function abnormal
  • pain
  • behcet's syndrome
  • headache
  • pain in extremity
  • arthralgia
  • nausea
  • dizziness
  • dyspnoea
30-39:
  • headache
  • pyrexia
  • dyspnoea
  • cough
  • pruritus
  • infusion related reaction
  • vomiting
  • nausea
  • dehydration
  • diarrhoea
40-49:
  • lung neoplasm
  • nausea
  • headache
  • pyrexia
  • arthralgia
  • thyroid cancer
  • fatigue
  • pain
  • dyspnoea
  • vomiting
50-59:
  • headache
  • arthralgia
  • pain
  • nausea
  • pyrexia
  • back pain
  • dyspnoea
  • diarrhoea
  • fatigue
  • vomiting
60+:
  • pneumonia
  • pyrexia
  • arthralgia
  • dyspnoea
  • pain
  • nausea
  • atrial fibrillation
  • oedema peripheral
  • fatigue
  • fall

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Tylenol (acetaminophen) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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