Review: taking Methotrexate and Tylenol together


Summary

Drug interactions are reported among people who take Methotrexate and Tylenol together. This review analyzes the effectiveness and drug interactions between Methotrexate and Tylenol. It is created by eHealthMe based on reports of 4,766 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone

Join a support group for people who take Methotrexate and Tylenol >>>

Personalized health information

On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 86 million people have used us. 300+ peer-reviewed medical journals have referenced our original studies. Start now >>>


Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 129,047 users)

Tylenol

Tylenol has active ingredients of acetaminophen. It is often used in pain. (latest outcomes from Tylenol 53,038 users)

On Jul, 29, 2016

4,766 people who take Methotrexate, Tylenol are studied.


Number of reports submitted per year:

Methotrexate and Tylenol drug interactions.

Drug effectiveness over time:

Methotrexate:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 14 people)
  • 6 - 12 months: 100.0% - (2 of 2 people)
  • 1 - 2 years: 40.0% - (2 of 5 people)
  • 2 - 5 years: 18.0% - (2 of 11 people)
  • 5 - 10 years: 14.0% - (1 of 7 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Tylenol:
  • < 1 month: 40.0% - (2 of 5 people)
  • 1 - 6 months: 0.0% - (0 of 0 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 36.0% - (4 of 11 people)
  • 2 - 5 years: 16.0% - (1 of 6 people)
  • 5 - 10 years: 60.0% - (3 of 5 people)
  • 10+ years: 0.0% - (0 of 6 people)
  • not specified: 100.0% - (1 of 1 people)

Drug effectiveness by gender:

Methotrexate:
  • female: 26.0% - (8 of 30 people)
  • male: 0.0% - (0 of 10 people)
Tylenol:
  • female: 34.0% - (10 of 29 people)
  • male: 16.0% - (1 of 6 people)

Drug effectiveness by age:

Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 0.0% - (0 of 4 people)
  • 40-49: 66.0% - (2 of 3 people)
  • 50-59: 25.0% - (4 of 16 people)
  • 60+: 13.0% - (2 of 15 people)
Tylenol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 0.0% - (0 of 4 people)
  • 40-49: 0.0% - (0 of 3 people)
  • 50-59: 50.0% - (8 of 16 people)
  • 60+: 30.0% - (3 of 10 people)

Most common drug interactions over time *:

< 1 month:
  • febrile neutropenia
  • pyrexia
  • hypotension
  • nausea
  • respiratory failure
  • dehydration
  • diarrhoea
  • hyperglycaemia
  • vomiting
  • hypoalbuminaemia
1 - 6 months:
  • nausea
  • pneumonia
  • pyrexia
  • interstitial lung disease
  • colitis
  • dyspnoea
  • rheumatoid arthritis
  • diarrhoea
  • rash
  • vomiting
6 - 12 months:
  • pneumonitis
  • alanine aminotransferase increased
  • pneumonia
  • aspartate aminotransferase increased
  • dehydration
  • infection
  • liver function test abnormal
  • sepsis
  • tuberculosis
  • nausea
1 - 2 years:
  • pneumonia
  • pyrexia
  • respiratory failure
  • multi-organ failure
  • fatigue
  • sepsis
  • general physical health deterioration
  • lung disorder
  • vomiting
  • disseminated tuberculosis
2 - 5 years:
  • pneumonia
  • erysipelas
  • herpes zoster
  • pharyngitis streptococcal
  • pyrexia
  • fatigue
  • rheumatoid arthritis
  • cough
  • dyspnoea
  • nausea
5 - 10 years:
  • thrombocytopenia
  • headache
  • nausea
  • chills
  • hepatic failure
  • non-small cell lung cancer stage iiib
  • pyrexia
  • renal failure
  • abdominal pain upper
  • asthenia
10+ years:
  • asthenia
  • agranulocytosis
  • headache
  • chills
  • oedema peripheral
  • chest pain
  • myocardial infarction
  • candidiasis
  • dehydration
  • hypotension
not specified:
  • pyrexia
  • nausea
  • arthralgia
  • pain
  • dyspnoea
  • headache
  • vomiting
  • fatigue
  • pneumonia
  • diarrhoea

Most common drug interactions by gender *:

female:
  • nausea
  • pyrexia
  • headache
  • arthralgia
  • pain
  • dyspnoea
  • vomiting
  • fatigue
  • pneumonia
  • diarrhoea
male:
  • pyrexia
  • nausea
  • dyspnoea
  • pneumonia
  • vomiting
  • fatigue
  • pain
  • arthralgia
  • hypotension
  • cough

Most common drug interactions by age *:

0-1:
  • ascites
  • staphylococcal infection
  • bronchial hyperreactivity
  • central line infection
  • catheter related infection
  • acute circulatory failure
  • angioneurotic oedema
  • bacteria stool identified
  • blister
  • graft versus host disease
2-9:
  • pyrexia
  • diarrhoea
  • nausea
  • vomiting
  • tremor
  • somnolence
  • tachycardia
  • abdominal pain
  • headache
  • hypotension
10-19:
  • febrile neutropenia
  • arthralgia
  • mucosal inflammation
  • vomiting
  • crohn's disease
  • pain
  • multi-organ failure
  • pyrexia
  • febrile bone marrow aplasia
  • muscular weakness
20-29:
  • pyrexia
  • hepatic function abnormal
  • behcet's syndrome
  • pain
  • headache
  • arthralgia
  • nausea
  • dizziness
  • dyspnoea
  • crohn's disease
30-39:
  • dyspnoea
  • pruritus
  • dehydration
  • vomiting
  • cough
  • hyperglycaemia
  • headache
  • pyrexia
  • oedema peripheral
  • diarrhoea
40-49:
  • lung neoplasm
  • nausea
  • thyroid cancer
  • pyrexia
  • headache
  • arthralgia
  • pain
  • dyspnoea
  • fatigue
  • vomiting
50-59:
  • headache
  • arthralgia
  • pain
  • nausea
  • pyrexia
  • back pain
  • pneumonia
  • vomiting
  • diarrhoea
  • dyspnoea
60+:
  • pyrexia
  • dyspnoea
  • pneumonia
  • nausea
  • atrial fibrillation
  • oedema peripheral
  • arthralgia
  • pain
  • fatigue
  • asthenia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Methotrexate and Tylenol?

Can you answer these questions?

More questions for: Methotrexate, Tylenol

You may be interested in these reviews

More reviews for: Methotrexate, Tylenol

On eHealthMe, Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Tylenol (acetaminophen) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.