Review: taking Methotrexate and Tylenol together


Summary

Drug interactions are reported among people who take Methotrexate and Tylenol together. This review analyzes the effectiveness and drug interactions between Methotrexate and Tylenol. It is created by eHealthMe based on reports of 7,853 people who take the same drugs from FDA and social media, and is updated regularly.

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Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 205,730 users)

Tylenol

Tylenol has active ingredients of acetaminophen. It is often used in pain. (latest outcomes from Tylenol 81,872 users)

On Sep, 17, 2016

7,853 people who take Methotrexate, Tylenol are studied.


Number of reports submitted per year:

Methotrexate and Tylenol drug interactions.

Drug effectiveness over time:

Methotrexate:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 9 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 25.0% - (1 of 4 people)
  • 2 - 5 years: 14.0% - (1 of 7 people)
  • 5 - 10 years: 14.0% - (1 of 7 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Tylenol:
  • < 1 month: 33.0% - (1 of 3 people)
  • 1 - 6 months: 0.0% - (0 of 0 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 14.0% - (1 of 7 people)
  • 2 - 5 years: 20.0% - (1 of 5 people)
  • 5 - 10 years: 50.0% - (2 of 4 people)
  • 10+ years: 16.0% - (1 of 6 people)
  • not specified: 100.0% - (1 of 1 people)

Drug effectiveness by gender:

Methotrexate:
  • female: 22.0% - (5 of 22 people)
  • male: 0.0% - (0 of 7 people)
Tylenol:
  • female: 28.0% - (6 of 21 people)
  • male: 16.0% - (1 of 6 people)

Drug effectiveness by age:

Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 0.0% - (0 of 4 people)
  • 40-49: 50.0% - (1 of 2 people)
  • 50-59: 27.0% - (3 of 11 people)
  • 60+: 10.0% - (1 of 10 people)
Tylenol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 0.0% - (0 of 4 people)
  • 40-49: 0.0% - (0 of 2 people)
  • 50-59: 45.0% - (5 of 11 people)
  • 60+: 25.0% - (2 of 8 people)

Most common drug interactions over time *:

< 1 month:
  • pyrexia
  • febrile neutropenia
  • neutropenia
  • pneumonia
  • diarrhoea
  • sepsis
  • platelet count decreased
  • nausea
  • rash
  • hypotension
1 - 6 months:
  • pyrexia
  • nausea
  • pneumonia
  • interstitial lung disease
  • dyspnoea
  • rheumatoid arthritis
  • fatigue
  • vomiting
  • headache
  • diarrhoea
6 - 12 months:
  • rheumatoid arthritis
  • nausea
  • drug ineffective
  • pneumonitis
  • pneumonia
  • alanine aminotransferase increased
  • pyrexia
  • vomiting
  • weight decreased
  • arthralgia
1 - 2 years:
  • pyrexia
  • fatigue
  • pneumonia
  • respiratory failure
  • arthralgia
  • constipation
  • diarrhoea
  • dyspnoea
  • vomiting
  • gastroenteritis
2 - 5 years:
  • pneumonia
  • pyrexia
  • alanine aminotransferase increased
  • hepatitis
  • nausea
  • pancreatitis acute
  • dyspnoea
  • injection site erythema
  • injection site pruritus
  • erysipelas
5 - 10 years:
  • thrombocytopenia
  • headache
  • pyrexia
  • chills
  • nausea
  • asthenia
  • hepatitis
  • basal cell carcinoma
  • chest pain
  • fatigue
10+ years:
  • asthenia
  • headache
  • agranulocytosis
  • chills
  • oedema peripheral
  • pancreatitis acute
  • hepatitis
  • alanine aminotransferase increased
  • injection site erythema
  • injection site pruritus
not specified:
  • arthralgia
  • pain
  • nausea
  • pyrexia
  • headache
  • fatigue
  • dyspnoea
  • drug ineffective
  • pneumonia
  • rheumatoid arthritis

Most common drug interactions by gender *:

female:
  • arthralgia
  • pain
  • nausea
  • headache
  • pyrexia
  • dyspnoea
  • fatigue
  • pneumonia
  • drug ineffective
  • rheumatoid arthritis
male:
  • pyrexia
  • arthralgia
  • pneumonia
  • nausea
  • pain
  • dyspnoea
  • fatigue
  • drug ineffective
  • diarrhoea
  • headache

Most common drug interactions by age *:

0-1:
  • oesophageal squamous cell carcinoma
  • pyrexia
  • febrile neutropenia
  • respiratory failure
  • ascites
  • staphylococcal infection
  • abdominal distension
  • acute respiratory distress syndrome
  • bile output abnormal
  • blood lactate dehydrogenase abnormal
2-9:
  • pyrexia
  • diarrhoea
  • febrile neutropenia
  • mucosal inflammation
  • vomiting
  • nausea
  • tachycardia
  • neutropenia
  • tremor
  • anaemia
10-19:
  • nausea
  • febrile neutropenia
  • vomiting
  • pyrexia
  • crohn's disease
  • mucosal inflammation
  • pain
  • abdominal pain
  • arthralgia
  • pain in extremity
20-29:
  • pyrexia
  • pain
  • hepatic function abnormal
  • behcet's syndrome
  • infusion related reaction
  • nausea
  • drug ineffective
  • pain in extremity
  • arthralgia
  • headache
30-39:
  • headache
  • pyrexia
  • dyspnoea
  • pain
  • infusion related reaction
  • fatigue
  • vomiting
  • pruritus
  • dehydration
  • nausea
40-49:
  • nausea
  • headache
  • arthralgia
  • fatigue
  • lung neoplasm
  • pain
  • pyrexia
  • dyspnoea
  • pneumonia
  • rheumatoid arthritis
50-59:
  • arthralgia
  • headache
  • pain
  • nausea
  • fatigue
  • pyrexia
  • drug ineffective
  • pain in extremity
  • diarrhoea
  • pneumonia
60+:
  • arthralgia
  • pneumonia
  • pyrexia
  • pain
  • dyspnoea
  • nausea
  • fatigue
  • fall
  • rheumatoid arthritis
  • atrial fibrillation

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Tylenol (acetaminophen) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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