Review: taking Morphine sulfate and Methadone hydrochloride together


Summary

Drug interactions are reported among people who take Morphine sulfate and Methadone hydrochloride together. This review analyzes the effectiveness and drug interactions between Morphine sulfate and Methadone hydrochloride. It is created by eHealthMe based on reports of 2,442 people who take the same drugs from FDA and social media, and is updated regularly.

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Morphine Sulfate

Morphine sulfate has active ingredients of morphine sulfate. It is often used in pain. (latest outcomes from Morphine sulfate 27,565 users)

Methadone Hydrochloride

Methadone hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from Methadone hydrochloride 3,248 users)

On Sep, 17, 2016

2,442 people who take Morphine Sulfate, Methadone Hydrochloride are studied.


Number of reports submitted per year:

Morphine sulfate and Methadone hydrochloride drug interactions.

Drug effectiveness over time:

Morphine Sulfate:
  • < 1 month: 0.0% - (0 of 4 people)
  • 1 - 6 months: 20.0% - (1 of 5 people)
  • 6 - 12 months: 40.0% - (2 of 5 people)
  • 1 - 2 years: 33.0% - (1 of 3 people)
  • 2 - 5 years: 20.0% - (1 of 5 people)
  • 5 - 10 years: 75.0% - (3 of 4 people)
  • 10+ years: 0.0% - (0 of 1 people)
  • not specified: 0.0% - (0 of 1 people)
Methadone Hydrochloride:
  • < 1 month: 0.0% - (0 of 4 people)
  • 1 - 6 months: 33.0% - (2 of 6 people)
  • 6 - 12 months: 0.0% - (0 of 2 people)
  • 1 - 2 years: 50.0% - (1 of 2 people)
  • 2 - 5 years: 30.0% - (3 of 10 people)
  • 5 - 10 years: 60.0% - (3 of 5 people)
  • 10+ years: 33.0% - (1 of 3 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Morphine Sulfate:
  • female: 31.0% - (5 of 16 people)
  • male: 25.0% - (3 of 12 people)
Methadone Hydrochloride:
  • female: 33.0% - (6 of 18 people)
  • male: 28.0% - (4 of 14 people)

Drug effectiveness by age:

Morphine Sulfate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 25.0% - (1 of 4 people)
  • 30-39: 66.0% - (2 of 3 people)
  • 40-49: 14.0% - (1 of 7 people)
  • 50-59: 37.0% - (3 of 8 people)
  • 60+: 25.0% - (1 of 4 people)
Methadone Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 50.0% - (1 of 2 people)
  • 20-29: 0.0% - (0 of 5 people)
  • 30-39: 33.0% - (1 of 3 people)
  • 40-49: 33.0% - (3 of 9 people)
  • 50-59: 33.0% - (3 of 9 people)
  • 60+: 50.0% - (2 of 4 people)

Most common drug interactions over time *:

< 1 month:
  • somnolence
  • delirium
  • pyrexia
  • vomiting
  • nausea
  • dehydration
  • electrocardiogram qt prolonged
  • malaise
  • death
  • insomnia
1 - 6 months:
  • somnolence
  • drug dependence
  • constipation
  • pneumonia
  • acute respiratory distress syndrome
  • death
  • dental caries
  • drug abuse
  • coeliac artery compression syndrome
  • dysarthria
6 - 12 months:
  • vomiting
  • chest pain
  • dysarthria
  • dysuria
  • pain
  • pulmonary oedema
  • pyrexia
  • rectal haemorrhage
  • aggression
  • confusional state
1 - 2 years:
  • abnormal behaviour
  • dental caries
  • depression
  • drug dependence
  • dysarthria
  • tooth abscess
  • drug abuse
  • overdose
  • drug ineffective
  • partner stress
2 - 5 years:
  • depression
  • dental caries
  • pain
  • deep vein thrombosis
  • failed back surgery syndrome
  • heart injury
  • herniated intervertebral disk
  • high blood cholesterol
  • osteomyelitis
  • osteonecrosis of jaw
5 - 10 years:
  • depression
  • failed back surgery syndrome
  • heart injury
  • herniated intervertebral disk
  • high blood cholesterol
  • seasonal allergy
  • accidental death
  • cardiac disorder
  • decreased appetite
  • drug hypersensitivity
10+ years:
  • renal failure
  • anaemia
  • asthenia
  • constipation
  • disturbance in attention
  • flushing
  • sweating - excessive
  • accidental overdose
  • agitation
  • ammonia increased
not specified:
  • pain
  • anxiety
  • osteonecrosis of jaw
  • dyspnoea
  • back pain
  • nausea
  • arthralgia
  • vomiting
  • injury
  • osteoarthritis

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • osteonecrosis of jaw
  • nausea
  • dyspnoea
  • back pain
  • vomiting
  • emotional distress
  • injury
  • fall
male:
  • pain
  • anxiety
  • osteonecrosis of jaw
  • back pain
  • dyspnoea
  • asthenia
  • osteoarthritis
  • death
  • arthralgia
  • pyrexia

Most common drug interactions by age *:

0-1:
  • clonus
  • crying
  • accidental overdose
  • agitation
  • hypotension
  • akathisia
  • chorea
  • feeling jittery
  • insomnia
  • pyrexia
2-9:
  • apnoea
  • areflexia
  • asthenia
  • bulbar palsy
  • constipation
  • drooling
  • dysphagia
  • muscular weakness
  • overdose
  • tracheitis
10-19:
  • hypotension
  • pain
  • blood bilirubin increased
  • decreased appetite
  • pyrexia
  • seizure
  • vomiting
  • acute respiratory distress syndrome
  • hypertension
  • nausea
20-29:
  • drug abuse
  • drug toxicity
  • therapeutic agent toxicity
  • hyperaesthesia
  • pain
  • completed suicide
  • multiple drug overdose
  • overdose
  • back pain
  • cardiac arrest
30-39:
  • death
  • bone disorder
  • osteonecrosis of jaw
  • back pain
  • pain
  • headache
  • pain in extremity
  • asthenia
  • oedema peripheral
  • muscular weakness
40-49:
  • pain
  • dyspnoea
  • anxiety
  • depression
  • back pain
  • constipation
  • pneumonia
  • nausea
  • vomiting
  • osteonecrosis of jaw
50-59:
  • pain
  • anxiety
  • emotional distress
  • osteonecrosis of jaw
  • hypoaesthesia
  • dyspnoea
  • arthralgia
  • injury
  • back pain
  • nausea
60+:
  • pain
  • anxiety
  • osteomyelitis
  • dyspnoea
  • osteoarthritis
  • asthenia
  • back pain
  • osteonecrosis of jaw
  • dehydration
  • urinary tract infection

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Morphine sulfate (morphine sulfate) is often used to treat pain. Methadone hydrochloride (methadone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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