Review: taking Mucinex and Benadryl together


Summary

Drug interactions are reported among people who take Mucinex and Benadryl together. This review analyzes the effectiveness and drug interactions between Mucinex and Benadryl. It is created by eHealthMe based on reports of 1,026 people who take the same drugs from FDA and social media, and is updated regularly.

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Mucinex

Mucinex has active ingredients of guaifenesin. It is often used in cough. (latest outcomes from Mucinex 9,449 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 43,259 users)

On Sep, 20, 2016

1,026 people who take Mucinex, Benadryl are studied.


Number of reports submitted per year:

Mucinex and Benadryl drug interactions.

Drug effectiveness over time:

Mucinex:
  • < 1 month: 25.0% - (4 of 16 people)
  • 1 - 6 months: 40.0% - (2 of 5 people)
  • 6 - 12 months: 0.0% - (0 of 3 people)
  • 1 - 2 years: 0.0% - (0 of 1 people)
  • 2 - 5 years: 33.0% - (1 of 3 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)
Benadryl:
  • < 1 month: 25.0% - (3 of 12 people)
  • 1 - 6 months: 50.0% - (1 of 2 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 40.0% - (2 of 5 people)
  • 2 - 5 years: 25.0% - (1 of 4 people)
  • 5 - 10 years: 50.0% - (1 of 2 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Mucinex:
  • female: 25.0% - (5 of 20 people)
  • male: 25.0% - (2 of 8 people)
Benadryl:
  • female: 35.0% - (7 of 20 people)
  • male: 37.0% - (3 of 8 people)

Drug effectiveness by age:

Mucinex:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 33.0% - (1 of 3 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 0.0% - (0 of 4 people)
  • 30-39: 55.0% - (5 of 9 people)
  • 40-49: 25.0% - (1 of 4 people)
  • 50-59: 0.0% - (0 of 4 people)
  • 60+: 0.0% - (0 of 3 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 3 people)
  • 10-19: 50.0% - (1 of 2 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 50.0% - (5 of 10 people)
  • 40-49: 75.0% - (3 of 4 people)
  • 50-59: 0.0% - (0 of 4 people)
  • 60+: 33.0% - (1 of 3 people)

Most common drug interactions over time *:

< 1 month:
  • pyrexia
  • anaemia
  • dyspnoea
  • asthenia
  • femur fracture
  • pleural effusion
  • thrombocytopenia
  • acute respiratory failure
  • atrial fibrillation
  • cardiomegaly
1 - 6 months:
  • sinusitis
  • insomnia
  • aggression
  • ammonia increased
  • cough
  • depressed mood
  • disorientation
  • drug ineffective
  • dysarthria
  • homicide
6 - 12 months:
  • blood potassium increased
  • bronchospasm
1 - 2 years:
  • allergic reactions
  • blood potassium increased
  • bronchospasm
  • diabetes mellitus
  • diabetes mellitus inadequate control
  • diabetic nephropathy
  • diplopia
  • glucose tolerance impaired
  • hypoglycaemia
  • muscle cramps
2 - 5 years:
  • blood creatinine increased
  • cardiomyopathy
  • dermatitis
  • erythema
  • abscess limb
  • breast inflammation
  • constipation
  • febrile neutropenia
  • ileus
  • anaemia
5 - 10 years:
  • carpal tunnel syndrome
  • endometriosis
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • fingernails - bluish
  • myoclonic jerks
  • weakness
not specified:
  • dyspnoea
  • nausea
  • pain
  • pneumonia
  • anxiety
  • cough
  • fatigue
  • diarrhoea
  • pyrexia
  • back pain

Most common drug interactions by gender *:

female:
  • dyspnoea
  • nausea
  • cough
  • pain
  • sinusitis
  • anxiety
  • fatigue
  • back pain
  • pneumonia
  • diarrhoea
male:
  • dyspnoea
  • pyrexia
  • pneumonia
  • dizziness
  • diarrhoea
  • chest pain
  • nausea
  • pain
  • asthenia
  • fatigue

Most common drug interactions by age *:

0-1:
  • cerebral infarction
  • convulsion
  • encephalomalacia
  • hyperparathyroidism secondary
  • hypertension
  • infection
  • respiratory distress
  • therapeutic response decreased
  • transplant rejection
  • orthostatic hypotension
2-9:
  • thrombocytopenia
  • adverse reaction
10-19:
  • depression
  • dysuria
  • hallucination
  • tremor
  • asthma
  • constipation
  • dizziness
  • drug abuse
  • drug dependence
  • drug eruption
20-29:
  • insomnia
  • upper respiratory tract infection
  • nausea
  • bronchitis
  • cardiac failure congestive
  • cholecystitis
  • influenza like illness
  • urinary tract infection
  • cardiomegaly
  • presyncope
30-39:
  • dyspnoea
  • pneumonia
  • pyrexia
  • chest pain
  • arthralgia
  • dizziness
  • dehydration
  • chills
  • hypoacusis
  • myalgia
40-49:
  • oedema peripheral
  • dyspnoea
  • insomnia
  • anaemia
  • nausea
  • pruritus
  • pain
  • pyrexia
  • abdominal pain upper
  • headache
50-59:
  • anxiety
  • atelectasis
  • pain
  • cough
  • gastritis
  • injury
  • osteoarthritis
  • diarrhoea
  • gait disturbance
  • tooth fracture
60+:
  • dyspnoea
  • pneumonia
  • nausea
  • asthenia
  • dizziness
  • anxiety
  • fatigue
  • pain
  • back pain
  • constipation

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Mucinex (guaifenesin) is often used to treat cough. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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