Review: taking Neurontin and Methadone hydrochloride together


Summary

Drug interactions are reported among people who take Neurontin and Methadone hydrochloride together. This review analyzes the effectiveness and drug interactions between Neurontin and Methadone hydrochloride. It is created by eHealthMe based on reports of 2,043 people who take the same drugs from FDA and social media, and is updated regularly.

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Neurontin

Neurontin has active ingredients of gabapentin. It is often used in pain. (latest outcomes from Neurontin 56,882 users)

Methadone Hydrochloride

Methadone hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from Methadone hydrochloride 2,744 users)

On Jul, 22, 2016

2,043 people who take Neurontin, Methadone Hydrochloride are studied.


Number of reports submitted per year:

Neurontin and Methadone hydrochloride drug interactions.

Drug effectiveness over time:

Neurontin:
  • < 1 month: 25.0% - (3 of 12 people)
  • 1 - 6 months: 0.0% - (0 of 5 people)
  • 6 - 12 months: 30.0% - (3 of 10 people)
  • 1 - 2 years: 33.0% - (5 of 15 people)
  • 2 - 5 years: 23.0% - (4 of 17 people)
  • 5 - 10 years: 47.0% - (10 of 21 people)
  • 10+ years: 62.0% - (5 of 8 people)
  • not specified: 0.0% - (0 of 0 people)
Methadone Hydrochloride:
  • < 1 month: 46.0% - (7 of 15 people)
  • 1 - 6 months: 52.0% - (9 of 17 people)
  • 6 - 12 months: 0.0% - (0 of 3 people)
  • 1 - 2 years: 71.0% - (5 of 7 people)
  • 2 - 5 years: 50.0% - (7 of 14 people)
  • 5 - 10 years: 66.0% - (10 of 15 people)
  • 10+ years: 43.0% - (7 of 16 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Neurontin:
  • female: 33.0% - (19 of 56 people)
  • male: 34.0% - (11 of 32 people)
Methadone Hydrochloride:
  • female: 53.0% - (33 of 62 people)
  • male: 46.0% - (12 of 26 people)

Drug effectiveness by age:

Neurontin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (5 of 10 people)
  • 30-39: 45.0% - (9 of 20 people)
  • 40-49: 26.0% - (7 of 26 people)
  • 50-59: 18.0% - (4 of 22 people)
  • 60+: 50.0% - (5 of 10 people)
Methadone Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 80.0% - (8 of 10 people)
  • 30-39: 54.0% - (13 of 24 people)
  • 40-49: 50.0% - (12 of 24 people)
  • 50-59: 43.0% - (10 of 23 people)
  • 60+: 28.0% - (2 of 7 people)

Most common drug interactions over time *:

< 1 month:
  • pneumonia
  • drug withdrawal syndrome
  • overdose
  • dehydration
  • nausea
  • vomiting
  • bone pain
  • dizziness
  • dysarthria
  • electrocardiogram qt prolonged
1 - 6 months:
  • depressed level of consciousness
  • hepatic encephalopathy
  • ascites
  • cognitive disorder
  • completed suicide
  • constipation
  • drug abuse
  • drug dependence
  • loss of consciousness
  • musculoskeletal stiffness
6 - 12 months:
  • vomiting
  • drug ineffective
  • depression
  • drug dependence
  • intentional overdose
  • nausea
  • suicide attempt
  • tremor
  • blood creatinine increased
  • blood urea increased
1 - 2 years:
  • depression
  • abnormal behaviour
  • dental caries
  • drug dependence
  • dysarthria
  • tooth abscess
  • drug abuse
  • drug ineffective
  • overdose
  • partner stress
2 - 5 years:
  • drug ineffective
  • diarrhoea
  • hallucination
  • oedema peripheral
  • angiopathy
  • cerebrovascular accident
  • chest pain
  • constipation
  • coordination abnormal
  • dental caries
5 - 10 years:
  • chronic pain
  • diarrhoea
  • dehydration
  • hypotension
  • neutropenia
  • arthritis
  • haematocrit decreased
  • haemoglobin decreased
  • pain in extremity
10+ years:
  • renal failure
  • anxiety disorder
  • back pain
  • bone pain
  • sleepiness - during the day
  • edema
  • insomnia
  • weight gain
  • anxiety
  • bipolar disorder
not specified:
  • pain
  • anxiety
  • dyspnoea
  • osteonecrosis of jaw
  • back pain
  • nausea
  • oedema peripheral
  • arthralgia
  • bone disorder
  • hypoaesthesia

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • dyspnoea
  • nausea
  • osteonecrosis of jaw
  • back pain
  • oedema peripheral
  • emotional distress
  • hypoaesthesia
  • bone disorder
male:
  • pain
  • anxiety
  • arthralgia
  • back pain
  • osteonecrosis of jaw
  • dyspnoea
  • oedema peripheral
  • asthenia
  • headache
  • depression

Most common drug interactions by age *:

2-9:
  • respiratory distress
  • bone pain
  • convulsion
  • disease progression
  • febrile neutropenia
  • hepatomegaly
  • jaundice
  • metastases to kidney
  • metastases to liver
  • neoplasm progression
10-19:
  • hypotension
  • haematocrit decreased
  • cardiac arrest
  • completed suicide
  • pyrexia
  • caecitis
  • pneumonitis
  • acute respiratory distress syndrome
  • febrile neutropenia
  • haemoglobin decreased
20-29:
  • vomiting
  • deep vein thrombosis
  • hypokalaemia
  • oedema peripheral
  • pain
  • weight decreased
  • asthenia
  • constipation
  • paraesthesia
  • pneumonia
30-39:
  • osteonecrosis of jaw
  • back pain
  • bone disorder
  • anxiety
  • pain in extremity
  • oedema peripheral
  • pain
  • nausea
  • deep vein thrombosis
  • hypoaesthesia
40-49:
  • pain
  • dyspnoea
  • fatigue
  • anxiety
  • oedema peripheral
  • nausea
  • depression
  • insomnia
  • back pain
  • vomiting
50-59:
  • pain
  • anxiety
  • emotional distress
  • arthralgia
  • osteonecrosis of jaw
  • pyrexia
  • injury
  • back pain
  • dyspnoea
  • fall
60+:
  • pain
  • pneumonia
  • dyspnoea
  • back pain
  • weight decreased
  • osteonecrosis of jaw
  • osteomyelitis
  • impaired healing
  • anxiety
  • osteoarthritis

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Neurontin (gabapentin) is often used to treat pain. Methadone hydrochloride (methadone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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