Review: taking Norco and Benadryl together


Summary

Drug interactions are reported among people who take Norco and Benadryl together. This review analyzes the effectiveness and drug interactions between Norco and Benadryl. It is created by eHealthMe based on reports of 3,417 people who take the same drugs from FDA and social media, and is updated regularly.

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Norco

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. (latest outcomes from Norco 9,270 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 33,627 users)

On Aug, 28, 2016

3,417 people who take Norco, Benadryl are studied.


Number of reports submitted per year:

Norco and Benadryl drug interactions.

Drug effectiveness over time:

Norco:
  • < 1 month: 44.0% - (11 of 25 people)
  • 1 - 6 months: 37.0% - (6 of 16 people)
  • 6 - 12 months: 28.0% - (2 of 7 people)
  • 1 - 2 years: 42.0% - (6 of 14 people)
  • 2 - 5 years: 38.0% - (5 of 13 people)
  • 5 - 10 years: 55.0% - (5 of 9 people)
  • 10+ years: 25.0% - (1 of 4 people)
  • not specified: 0.0% - (0 of 0 people)
Benadryl:
  • < 1 month: 20.0% - (6 of 29 people)
  • 1 - 6 months: 33.0% - (4 of 12 people)
  • 6 - 12 months: 60.0% - (3 of 5 people)
  • 1 - 2 years: 18.0% - (2 of 11 people)
  • 2 - 5 years: 25.0% - (3 of 12 people)
  • 5 - 10 years: 40.0% - (4 of 10 people)
  • 10+ years: 60.0% - (3 of 5 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Norco:
  • female: 40.0% - (27 of 67 people)
  • male: 42.0% - (9 of 21 people)
Benadryl:
  • female: 29.0% - (19 of 64 people)
  • male: 28.0% - (6 of 21 people)

Drug effectiveness by age:

Norco:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (8 of 16 people)
  • 30-39: 37.0% - (9 of 24 people)
  • 40-49: 41.0% - (10 of 24 people)
  • 50-59: 41.0% - (5 of 12 people)
  • 60+: 33.0% - (4 of 12 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 46.0% - (7 of 15 people)
  • 30-39: 25.0% - (6 of 24 people)
  • 40-49: 17.0% - (4 of 23 people)
  • 50-59: 45.0% - (5 of 11 people)
  • 60+: 25.0% - (3 of 12 people)

Most common drug interactions over time *:

< 1 month:
  • pain
  • anxiety
  • pruritus
  • injury
  • pain in extremity
  • burning sensation
  • emotional distress
  • oedema peripheral
  • erythema
  • dermatitis
1 - 6 months:
  • sepsis
  • haemorrhage intracranial
  • death
  • hypotension
  • pulmonary embolism
  • convulsion
  • failure to thrive
  • febrile neutropenia
  • gastrointestinal haemorrhage
  • abdominal pain
6 - 12 months:
  • constipation
  • ileus
  • pain
  • abdominal pain
  • abnormal dreams
  • adrenal insufficiency
  • anxiety
  • confusional state
  • dizziness postural
  • dry mouth
1 - 2 years:
  • iron deficiency anemia
  • flank pain
  • headache
  • arthritis
  • body overheating
  • chills
  • erection problems
  • febrile neutropenia
  • hallucinations, mixed
  • muscle twitching
2 - 5 years:
  • hematospermia
  • dizziness
  • abdominal distension
  • agitation aggravated
  • chest wall pain
  • crying
  • impaired memory
  • insomnia
  • stomach discomfort
  • arthritis
5 - 10 years:
  • anxiety
  • acid reflux
  • allergy to animal
  • allergy to chemicals
  • allergy to plants
  • back pain - low
  • eczema
  • excessive thirst
  • genital pain
  • high blood pressure
10+ years:
  • cough
  • decreased appetite
  • diarrhoea
  • fatigue
  • suicidal ideation
  • alopecia
  • balance disorder
  • decreased interest
  • depression aggravated
  • dizziness postural
not specified:
  • pain
  • anxiety
  • nausea
  • dyspnoea
  • back pain
  • arthralgia
  • fatigue
  • fall
  • anaemia
  • osteonecrosis of jaw

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • nausea
  • dyspnoea
  • fall
  • back pain
  • arthralgia
  • anaemia
  • fatigue
  • pain in extremity
male:
  • pain
  • anxiety
  • back pain
  • nausea
  • fatigue
  • dyspnoea
  • arthralgia
  • depression
  • asthenia
  • injury

Most common drug interactions by age *:

0-1:
  • antepartum haemorrhage
  • cleft palate
  • unwanted pregnancy
  • uterine haemorrhage
2-9:
  • heart rate increased
  • hypotension
  • overdose
  • respiratory depression
  • somnolence
  • anaemia
  • aortic disorder
  • apnoea
  • apnoeic attack
  • application site erythema
10-19:
  • hypotension
  • pain
  • blood bilirubin increased
  • pneumonitis
  • nausea
  • cholecystitis chronic
  • pulmonary embolism
  • acute respiratory distress syndrome
  • headache
  • cholelithiasis
20-29:
  • nausea
  • pain
  • back pain
  • vomiting
  • abdominal pain upper
  • fatigue
  • pulmonary embolism
  • headache
  • anxiety
  • dyspnoea
30-39:
  • pain
  • anaemia
  • depression
  • weight increased
  • drug abuse
  • fatigue
  • abdominal pain
  • haemorrhoids
  • arthralgia
  • acne
40-49:
  • pain
  • anxiety
  • nausea
  • back pain
  • dyspnoea
  • arthralgia
  • fatigue
  • injury
  • vomiting
  • chest pain
50-59:
  • pain
  • anxiety
  • injury
  • nausea
  • fall
  • osteoarthritis
  • osteonecrosis of jaw
  • emotional distress
  • pyrexia
  • pain in extremity
60+:
  • dyspnoea
  • pain
  • anaemia
  • fall
  • anxiety
  • fatigue
  • asthenia
  • back pain
  • arthralgia
  • constipation

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Norco (acetaminophen; hydrocodone bitartrate) is often used to treat pain. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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