Review: taking Nortriptyline hydrochloride and Zyban together


Summary

Drug interactions are reported among people who take Nortriptyline hydrochloride and Zyban together. This review analyzes the effectiveness and drug interactions between Nortriptyline hydrochloride and Zyban. It is created by eHealthMe based on reports of 680 people who take the same drugs from FDA and social media, and is updated regularly.

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Nortriptyline Hydrochloride

Nortriptyline hydrochloride has active ingredients of nortriptyline hydrochloride. It is often used in depression. (latest outcomes from Nortriptyline hydrochloride 1,707 users)

Zyban

Zyban has active ingredients of bupropion hydrochloride. It is often used in quit smoking. (latest outcomes from Zyban 7,308 users)

On Oct, 01, 2016

680 people who take Nortriptyline Hydrochloride, Zyban are studied.


Number of reports submitted per year:

Nortriptyline hydrochloride and Zyban drug interactions.

Drug effectiveness over time:

Nortriptyline Hydrochloride:
  • < 1 month: 0.0% - (0 of 4 people)
  • 1 - 6 months: 0.0% - (0 of 5 people)
  • 6 - 12 months: 33.0% - (2 of 6 people)
  • 1 - 2 years: 33.0% - (2 of 6 people)
  • 2 - 5 years: 28.0% - (2 of 7 people)
  • 5 - 10 years: 66.0% - (4 of 6 people)
  • 10+ years: 60.0% - (3 of 5 people)
  • not specified: 100.0% - (1 of 1 people)
Zyban:
  • < 1 month: 0.0% - (0 of 2 people)
  • 1 - 6 months: 28.0% - (2 of 7 people)
  • 6 - 12 months: 0.0% - (0 of 5 people)
  • 1 - 2 years: 18.0% - (2 of 11 people)
  • 2 - 5 years: 40.0% - (4 of 10 people)
  • 5 - 10 years: 66.0% - (4 of 6 people)
  • 10+ years: 100.0% - (2 of 2 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Nortriptyline Hydrochloride:
  • female: 40.0% - (12 of 30 people)
  • male: 20.0% - (2 of 10 people)
Zyban:
  • female: 31.0% - (10 of 32 people)
  • male: 33.0% - (4 of 12 people)

Drug effectiveness by age:

Nortriptyline Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 75.0% - (3 of 4 people)
  • 30-39: 25.0% - (2 of 8 people)
  • 40-49: 16.0% - (2 of 12 people)
  • 50-59: 57.0% - (4 of 7 people)
  • 60+: 33.0% - (3 of 9 people)
Zyban:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (3 of 6 people)
  • 30-39: 10.0% - (1 of 10 people)
  • 40-49: 18.0% - (2 of 11 people)
  • 50-59: 37.0% - (3 of 8 people)
  • 60+: 55.0% - (5 of 9 people)

Most common drug interactions over time *:

< 1 month:
  • dehydration
  • dysarthria
  • emotional distress
  • insomnia
  • cerebral ischaemia
  • electrocardiogram qrs complex prolonged
  • electrocardiogram t wave peaked
  • electroencephalogram abnormal
  • anorexia
  • family stress
1 - 6 months:
  • drug dependence
  • drug withdrawal syndrome
  • substance abuse
  • constipation
  • dry mouth
  • genital discharge
  • pain - joints
  • tiredness
  • drug ineffective
  • grand mal convulsion
6 - 12 months:
  • depression
  • anxiety
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • impaired healing
  • rash erythematous
  • scar
  • skin ulcer
  • diabetes mellitus
  • hepatic encephalopathy
  • hernia
1 - 2 years:
  • diabetes mellitus
  • suicidal ideation
  • memory loss
  • neuropathy peripheral
  • type 2 diabetes mellitus
  • breast cancer
  • hernia
  • hyperglycaemia
  • blurred vision
  • confusion
2 - 5 years:
  • acne
  • abdominal pain
  • abnormal weight gain
  • anxiety
  • breast cancer female
  • cholecystitis chronic
  • cholelithiasis
  • constipation aggravated
  • diabetes mellitus
  • diabetic ketoacidosis
5 - 10 years:
  • suicide attempt
  • amnesia
  • blood glucose increased
  • confusion
  • abnormal behaviour
  • aggression
  • anger
  • anxiety
  • depression
  • intentional overdose
10+ years:
  • vertigo
  • nausea
  • pruritus
  • tinnitus
not specified:
  • pain
  • depression
  • anxiety
  • drug ineffective
  • hypoaesthesia
  • fatigue
  • dyspnoea
  • arthralgia
  • back pain
  • nausea

Most common drug interactions by gender *:

female:
  • pain
  • depression
  • anxiety
  • fatigue
  • drug ineffective
  • diarrhoea
  • hypoaesthesia
  • dyspnoea
  • weight increased
  • arthralgia
male:
  • depression
  • pain
  • insomnia
  • anxiety
  • drug ineffective
  • fall
  • hypoaesthesia
  • neuropathy peripheral
  • pain in extremity
  • osteoarthritis

Most common drug interactions by age *:

0-1:
  • fall
  • haematochezia
  • hepatitis c
  • suicide attempt
  • type 2 diabetes mellitus
2-9:
  • sudden death
10-19:
  • agitation
  • somnolence
  • aggression
  • anger
  • constipation
  • deafness
  • disturbance in attention
  • drug ineffective
  • erection increased
  • fatigue
20-29:
  • anxiety
  • emotional distress
  • constipation
  • drug dependence
  • hypoaesthesia
  • weight increased
  • depression
  • fall
  • fatigue
  • muscle spasms
30-39:
  • depression
  • back pain
  • fatigue
  • pyrexia
  • pain
  • diarrhoea
  • sedation
  • weight increased
  • dyspnoea
  • hemiplegia
40-49:
  • depression
  • anxiety
  • pain
  • type 2 diabetes mellitus
  • chest pain
  • blood cholesterol increased
  • weight increased
  • fatigue
  • headache
  • hypertension
50-59:
  • pain
  • anxiety
  • paraesthesia
  • arthralgia
  • diarrhoea
  • hypoaesthesia
  • pain in extremity
  • back pain
  • lymphadenopathy
  • neuropathy peripheral
60+:
  • depression
  • drug ineffective
  • oedema peripheral
  • anxiety
  • dyspnoea
  • insomnia
  • nausea
  • thrombosis
  • neuropathy peripheral
  • arthralgia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Nortriptyline hydrochloride (nortriptyline hydrochloride) is often used to treat depression. Zyban (bupropion hydrochloride) is often used to treat quit smoking. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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