Review: taking Nyquil and Benadryl together


Summary

Drug interactions are reported among people who take Nyquil and Benadryl together. This review analyzes the effectiveness and drug interactions between Nyquil and Benadryl. It is created by eHealthMe based on reports of 79 people who take the same drugs from FDA and social media, and is updated regularly.

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Nyquil

Nyquil has active ingredients of acetaminophen / dextromethorphan / doxylamine / pseudoephedrine. It is often used in nasopharyngitis. (latest outcomes from Nyquil 477 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 43,259 users)

On Sep, 16, 2016

79 people who take Nyquil, Benadryl are studied.


Number of reports submitted per year:

Nyquil and Benadryl drug interactions.

Most common drug interactions over time *:

< 1 month:
  • pneumonia
  • abdominal discomfort
  • acute myocardial infarction
  • alanine aminotransferase increased
  • arthritis
  • back disorder
  • constipation
  • diarrhoea
  • disorientation
  • disturbance in attention
6 - 12 months:
  • pre-existing condition improved
  • therapeutic response unexpected
  • urinary tract infection
  • weight decreased
  • back injury
  • carpal tunnel syndrome
  • hyponatraemia
  • nausea
2 - 5 years:
  • back injury
  • carpal tunnel syndrome
  • nausea
  • pre-existing condition improved
  • therapeutic response unexpected
  • weight decreased
not specified:
  • completed suicide
  • overdose
  • abdominal pain
  • serotonin syndrome
  • asthenia
  • cardiac failure
  • insomnia
  • vomiting
  • drug ineffective
  • accidental poisoning

Most common drug interactions by gender *:

female:
  • completed suicide
  • asthenia
  • overdose
  • abdominal pain
  • cerebrovascular accident
  • deep vein thrombosis
  • insomnia
  • pulmonary embolism
  • thrombosis
  • death
male:
  • pneumonia
  • serotonin syndrome
  • cardiac failure
  • completed suicide
  • accidental poisoning
  • abdominal pain
  • blood glucose decreased
  • bronchitis
  • delirium
  • drug screen positive

Most common drug interactions by age *:

10-19:
  • completed suicide
  • abdominal pain
  • intentional self-injury
  • overdose
  • vomiting
20-29:
  • abdominal pain
  • blood glucose decreased
  • delirium
  • electrocardiogram qt prolonged
  • hypertension
  • muscle spasms
  • rebound effect
  • sinus tachycardia
  • urinary incontinence
  • anomalous pulmonary venous connection
30-39:
  • completed suicide
  • abdominal pain
  • bronchitis
  • death
  • dyspnoea
  • intentional overdose
  • sputum increased
  • tinnitus
  • transaminases increased
  • upper respiratory tract infection
40-49:
  • activities of daily living impaired
  • adverse drug reaction
  • arthritis
  • back disorder
  • cerebrovascular accident
  • hypertension
  • insomnia
  • middle insomnia
  • migraine
  • sinusitis
50-59:
  • pneumonia
  • bruxism
  • discomfort
  • drug screen positive
  • fatigue
  • influenza
  • insomnia
  • nasopharyngitis
  • pyrexia
  • rash
60+:
  • serotonin syndrome
  • cardiac failure
  • overdose
  • accidental poisoning
  • hyponatraemia
  • somnolence
  • urinary tract infection
  • death
  • exposure to toxic agent
  • staphylococcal sepsis

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Nyquil (acetaminophen / dextromethorphan / doxylamine / pseudoephedrine) is often used to treat nasopharyngitis. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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