Review: taking Omeprazole and Metformin together


Summary

Drug interactions are reported among people who take Omeprazole and Metformin together. This review analyzes the effectiveness and drug interactions between Omeprazole and Metformin. It is created by eHealthMe based on reports of 16,745 people who take the same drugs from FDA and social media, and is updated regularly.

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Omeprazole

Omeprazole has active ingredients of omeprazole. It is often used in gastrooesophageal reflux disease. (latest outcomes from Omeprazole 154,416 users)

Metformin

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 174,670 users)

On Sep, 16, 2016

16,745 people who take Omeprazole, Metformin are studied.


Number of reports submitted per year:

Omeprazole and Metformin drug interactions.

Drug effectiveness over time:

Omeprazole:
  • < 1 month: 25.0% - (2 of 8 people)
  • 1 - 6 months: 54.0% - (13 of 24 people)
  • 6 - 12 months: 53.0% - (14 of 26 people)
  • 1 - 2 years: 75.0% - (25 of 33 people)
  • 2 - 5 years: 65.0% - (47 of 72 people)
  • 5 - 10 years: 79.0% - (49 of 62 people)
  • 10+ years: 83.0% - (26 of 31 people)
  • not specified: 0.0% - (0 of 1 people)
Metformin:
  • < 1 month: 30.0% - (4 of 13 people)
  • 1 - 6 months: 25.0% - (5 of 20 people)
  • 6 - 12 months: 37.0% - (9 of 24 people)
  • 1 - 2 years: 39.0% - (21 of 53 people)
  • 2 - 5 years: 45.0% - (30 of 66 people)
  • 5 - 10 years: 46.0% - (22 of 47 people)
  • 10+ years: 50.0% - (16 of 32 people)
  • not specified: 66.0% - (2 of 3 people)

Drug effectiveness by gender:

Omeprazole:
  • female: 67.0% - (97 of 143 people)
  • male: 69.0% - (79 of 114 people)
Metformin:
  • female: 41.0% - (59 of 142 people)
  • male: 43.0% - (50 of 116 people)

Drug effectiveness by age:

Omeprazole:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 75.0% - (3 of 4 people)
  • 30-39: 73.0% - (19 of 26 people)
  • 40-49: 73.0% - (33 of 45 people)
  • 50-59: 59.0% - (48 of 81 people)
  • 60+: 72.0% - (73 of 101 people)
Metformin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 40.0% - (2 of 5 people)
  • 30-39: 31.0% - (7 of 22 people)
  • 40-49: 47.0% - (21 of 44 people)
  • 50-59: 38.0% - (32 of 83 people)
  • 60+: 45.0% - (47 of 104 people)

Most common drug interactions over time *:

< 1 month:
  • nausea
  • diarrhoea
  • malaise
  • pyrexia
  • weight decreased
  • alanine aminotransferase increased
  • dyspnoea
  • general physical health deterioration
  • insomnia
  • renal failure acute
1 - 6 months:
  • vomiting
  • nausea
  • renal failure acute
  • diabetes mellitus
  • constipation
  • pneumonia
  • upper gastrointestinal haemorrhage
  • abdominal pain
  • chest pain
  • renal failure
6 - 12 months:
  • renal failure acute
  • diarrhoea
  • lactic acidosis
  • tubulointerstitial nephritis
  • dyspnoea
  • liver function test abnormal
  • rash
  • arteriosclerosis coronary artery
  • cardiac failure congestive
  • myocardial infarction
1 - 2 years:
  • erectile dysfunction
  • low platelet count
  • pain
  • drug ineffective
  • fatigue
  • nausea
  • pancreatitis acute
  • vomiting
  • anaemia
  • cholelithiasis
2 - 5 years:
  • anxiety
  • diarrhoea
  • myocardial infarction
  • renal failure acute
  • depression
  • lactic acidosis
  • pain
  • anaemia
  • hypocalcaemia
  • hypoglycaemia
5 - 10 years:
  • diarrhoea
  • metabolic acidosis
  • renal failure acute
  • hypomagnesaemia
  • cardiac failure congestive
  • depression
  • malaise
  • tetany
  • nausea
  • back pain
10+ years:
  • hyperkalaemia
  • renal tubular acidosis
  • diarrhoea
  • lactic acidosis
  • syncope
  • hypotension
  • metabolic acidosis
  • renal impairment
  • low platelet count
  • renal failure acute
not specified:
  • nausea
  • dyspnoea
  • diarrhoea
  • pain
  • fatigue
  • vomiting
  • dizziness
  • blood glucose increased
  • headache
  • drug ineffective

Most common drug interactions by gender *:

female:
  • nausea
  • dyspnoea
  • diarrhoea
  • pain
  • vomiting
  • fatigue
  • headache
  • drug ineffective
  • dizziness
  • weight decreased
male:
  • diarrhoea
  • dyspnoea
  • nausea
  • fatigue
  • dizziness
  • pain
  • blood glucose increased
  • asthenia
  • myocardial infarction
  • weight decreased

Most common drug interactions by age *:

0-1:
  • foetal exposure during pregnancy
  • arthritis
  • hypertension
  • premature baby
  • blood cholesterol increased
  • cerebrovascular accident
  • convulsion
  • diabetic neuropathy
  • dyspnoea
  • haematochezia
2-9:
  • lactic acidosis
  • abdominal pain
  • abdominal rigidity
  • abdominal tenderness
  • abnormal behaviour
  • acidosis
  • blood creatinine increased
  • blood glucose increased
  • blood urea increased
  • drug ineffective
10-19:
  • abdominal pain
  • hypoglycaemia
  • cholecystitis chronic
  • acidosis
  • gallbladder disorder
  • hyperlactacidaemia
  • hypotension
  • biliary dyskinesia
  • vomiting
  • weight increased
20-29:
  • pain
  • injury
  • nausea
  • completed suicide
  • cholelithiasis
  • cholecystitis chronic
  • vomiting
  • anxiety
  • dyspnoea
  • deep vein thrombosis
30-39:
  • agitation
  • neutrophil count increased
  • white blood cell count increased
  • coma scale abnormal
  • overdose
  • nausea
  • diabetes mellitus
  • pain
  • dyspnoea
  • abdominal pain
40-49:
  • nausea
  • diabetes mellitus
  • pain
  • diarrhoea
  • chest pain
  • fatigue
  • headache
  • dyspnoea
  • vomiting
  • dizziness
50-59:
  • nausea
  • pain
  • dyspnoea
  • fatigue
  • diarrhoea
  • anxiety
  • depression
  • vomiting
  • arthralgia
  • headache
60+:
  • diarrhoea
  • nausea
  • dyspnoea
  • vomiting
  • fatigue
  • dizziness
  • asthenia
  • pain
  • weight decreased
  • renal failure acute

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Omeprazole (omeprazole) is often used to treat gastrooesophageal reflux disease. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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