Review: taking Omeprazole and Metformin together


Summary

Drug interactions are reported among people who take Omeprazole and Metformin together. This review analyzes the effectiveness and drug interactions between Omeprazole and Metformin. It is created by eHealthMe based on reports of 8,884 people who take the same drugs from FDA and social media, and is updated regularly.

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Omeprazole

Omeprazole has active ingredients of omeprazole. It is often used in gastrooesophageal reflux disease. (latest outcomes from Omeprazole 94,634 users)

Metformin

Metformin has active ingredients of metformin. It is often used in diabetes. (latest outcomes from Metformin 99,379 users)

On Jul, 20, 2016

8,884 people who take Omeprazole, Metformin are studied.


Number of reports submitted per year:

Omeprazole and Metformin drug interactions.

Drug effectiveness over time:

Omeprazole:
  • < 1 month: 40.0% - (4 of 10 people)
  • 1 - 6 months: 57.0% - (16 of 28 people)
  • 6 - 12 months: 60.0% - (20 of 33 people)
  • 1 - 2 years: 82.0% - (37 of 45 people)
  • 2 - 5 years: 63.0% - (57 of 90 people)
  • 5 - 10 years: 81.0% - (57 of 70 people)
  • 10+ years: 82.0% - (32 of 39 people)
  • not specified: 0.0% - (0 of 4 people)
Metformin:
  • < 1 month: 20.0% - (4 of 20 people)
  • 1 - 6 months: 23.0% - (5 of 21 people)
  • 6 - 12 months: 44.0% - (13 of 29 people)
  • 1 - 2 years: 38.0% - (23 of 60 people)
  • 2 - 5 years: 44.0% - (34 of 77 people)
  • 5 - 10 years: 47.0% - (26 of 55 people)
  • 10+ years: 66.0% - (33 of 50 people)
  • not specified: 83.0% - (5 of 6 people)

Drug effectiveness by gender:

Omeprazole:
  • female: 69.0% - (127 of 184 people)
  • male: 71.0% - (96 of 135 people)
Metformin:
  • female: 41.0% - (75 of 181 people)
  • male: 49.0% - (68 of 137 people)

Drug effectiveness by age:

Omeprazole:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 87.0% - (7 of 8 people)
  • 30-39: 74.0% - (20 of 27 people)
  • 40-49: 73.0% - (42 of 57 people)
  • 50-59: 62.0% - (55 of 88 people)
  • 60+: 71.0% - (99 of 139 people)
Metformin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 22.0% - (2 of 9 people)
  • 30-39: 34.0% - (8 of 23 people)
  • 40-49: 48.0% - (26 of 54 people)
  • 50-59: 40.0% - (36 of 90 people)
  • 60+: 50.0% - (71 of 142 people)

Most common drug interactions over time *:

< 1 month:
  • pyrexia
  • renal failure acute
  • cholangitis
  • diarrhoea
  • stevens-johnson syndrome
  • insomnia
  • upper gastrointestinal haemorrhage
  • anaemia
  • back pain
  • alanine aminotransferase increased
1 - 6 months:
  • idiopathic thrombocytopenic purpura
  • respiratory distress
  • upper gastrointestinal haemorrhage
  • pneumonia
  • mucosal inflammation
  • neutropenia
  • gastrointestinal toxicity
  • haematotoxicity
  • nausea
  • stomatitis
6 - 12 months:
  • renal failure acute
  • diarrhoea
  • arteriosclerosis coronary artery
  • cardiac failure congestive
  • liver function test abnormal
  • myocardial infarction
  • rash
  • gas - flatulence
  • renal failure
  • blood creatinine increased
1 - 2 years:
  • erectile dysfunction
  • low platelet count
  • nausea
  • pain
  • cholelithiasis
  • insomnia
  • anaemia
  • deep vein thrombosis
  • dyspnoea
  • pancreatitis acute
2 - 5 years:
  • anxiety
  • myocardial infarction
  • diarrhoea
  • hypocalcaemia
  • pain
  • tetany
  • insomnia
  • renal failure acute
  • vomiting
  • anaemia
5 - 10 years:
  • diarrhoea
  • metabolic acidosis
  • hypomagnesaemia
  • tetany
  • renal failure acute
  • back pain
  • depression
  • hypocalcaemia
  • lactic acidosis
  • nausea
10+ years:
  • hyperkalaemia
  • renal tubular acidosis
  • low platelet count
  • gastric haemorrhage
  • high blood sugar
  • encephalopathy
  • itching
  • anaemia
  • acid reflux
  • diarrhoea
not specified:
  • nausea
  • dyspnoea
  • pain
  • diarrhoea
  • vomiting
  • fatigue
  • blood glucose increased
  • chest pain
  • weight decreased
  • dizziness

Most common drug interactions by gender *:

female:
  • nausea
  • dyspnoea
  • pain
  • diarrhoea
  • vomiting
  • headache
  • fatigue
  • weight decreased
  • chest pain
  • blood glucose increased
male:
  • nausea
  • dyspnoea
  • myocardial infarction
  • diarrhoea
  • renal failure acute
  • pain
  • asthenia
  • blood glucose increased
  • fatigue
  • chest pain

Most common drug interactions by age *:

0-1:
  • arthritis
  • blood cholesterol increased
  • cerebrovascular accident
  • convulsion
  • diabetic neuropathy
  • dyspnoea
  • foetal exposure during pregnancy
  • haematochezia
  • hypercalcaemia
  • hyperlipidaemia
2-9:
  • lactic acidosis
  • muscle spasms
10-19:
  • abdominal pain
  • cholecystitis chronic
  • gallbladder disorder
  • biliary dyskinesia
  • weight increased
  • pain
  • vomiting
  • gastric disorder
  • injury
  • irritable bowel syndrome
20-29:
  • cholecystitis chronic
  • cholelithiasis
  • abdominal distension
  • pain
  • diabetes mellitus inadequate control
  • abdominal pain upper
  • diabetes mellitus
  • rash
  • abdominal pain
  • injury
30-39:
  • agitation
  • white blood cell count increased
  • coma scale abnormal
  • neutrophil count increased
  • overdose
  • diabetes mellitus
  • nausea
  • type 2 diabetes mellitus
  • pain
  • diabetic neuropathy
40-49:
  • nausea
  • diabetes mellitus
  • chest pain
  • pain
  • myocardial infarction
  • diarrhoea
  • anxiety
  • headache
  • depression
  • fatigue
50-59:
  • nausea
  • pain
  • depression
  • anxiety
  • myocardial infarction
  • blood glucose increased
  • diarrhoea
  • back pain
  • fatigue
  • dyspnoea
60+:
  • nausea
  • dyspnoea
  • diarrhoea
  • asthenia
  • vomiting
  • renal failure acute
  • dizziness
  • pain
  • weight decreased
  • chest pain

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Omeprazole (omeprazole) is often used to treat gastrooesophageal reflux disease. Metformin (metformin) is often used to treat diabetes. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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