Review: taking Oxycodone hydrochloride and Benadryl together


Summary

Drug interactions are reported among people who take Oxycodone hydrochloride and Benadryl together. This review analyzes the effectiveness and drug interactions between Oxycodone hydrochloride and Benadryl. It is created by eHealthMe based on reports of 1,771 people who take the same drugs from FDA and social media, and is updated regularly.

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Oxycodone Hydrochloride

Oxycodone hydrochloride has active ingredients of oxycodone hydrochloride. It is often used in pain. (latest outcomes from Oxycodone hydrochloride 827 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 29,242 users)

On Jul, 22, 2016

1,771 people who take Oxycodone Hydrochloride, Benadryl are studied.


Number of reports submitted per year:

Oxycodone hydrochloride and Benadryl drug interactions.

Drug effectiveness over time:

Oxycodone Hydrochloride:
  • < 1 month: 20.0% - (1 of 5 people)
  • 1 - 6 months: 100.0% - (2 of 2 people)
  • 6 - 12 months: 50.0% - (1 of 2 people)
  • 1 - 2 years: 100.0% - (3 of 3 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 100.0% - (2 of 2 people)
  • 10+ years: 0.0% - (0 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Benadryl:
  • < 1 month: 25.0% - (1 of 4 people)
  • 1 - 6 months: 25.0% - (1 of 4 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 33.0% - (1 of 3 people)
  • 5 - 10 years: 66.0% - (2 of 3 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Oxycodone Hydrochloride:
  • female: 66.0% - (6 of 9 people)
  • male: 57.0% - (4 of 7 people)
Benadryl:
  • female: 37.0% - (3 of 8 people)
  • male: 37.0% - (3 of 8 people)

Drug effectiveness by age:

Oxycodone Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 75.0% - (3 of 4 people)
  • 30-39: 50.0% - (3 of 6 people)
  • 40-49: 100.0% - (3 of 3 people)
  • 50-59: 100.0% - (1 of 1 people)
  • 60+: 0.0% - (0 of 2 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 50.0% - (2 of 4 people)
  • 30-39: 33.0% - (2 of 6 people)
  • 40-49: 66.0% - (2 of 3 people)
  • 50-59: 0.0% - (0 of 1 people)
  • 60+: 0.0% - (0 of 1 people)

Most common drug interactions over time *:

< 1 month:
  • constipation
  • nausea
  • febrile neutropenia
  • renal failure
  • respiratory failure
  • death
  • hyperkalaemia
  • diarrhoea
  • malaise
  • neutrophil count decreased
1 - 6 months:
  • anxiety
  • pain
  • constipation
  • depression
  • drug dependence
  • drug withdrawal syndrome
  • atelectasis
  • haemangioma of liver
  • haemorrhage
  • pneumonia
6 - 12 months:
  • anxiety
  • drug withdrawal syndrome
  • fall
  • headache
  • memory impairment
  • nausea
  • somnolence
  • coma
  • drug ineffective
  • head injury
1 - 2 years:
  • drug dependence
  • coma
  • cardiac arrest
  • contusion
  • coronary artery atherosclerosis
  • hepatic fibrosis
  • hepatic steatosis
  • nausea
  • pyrexia
  • respiratory failure
2 - 5 years:
  • drug dependence
  • drug withdrawal syndrome
  • depression
  • insomnia
  • asthenia
  • fall
  • anxiety
  • headache
  • constipation
  • nausea
5 - 10 years:
  • irritability
  • nausea
  • nervousness
  • oedema peripheral
  • pain in extremity
  • depression
  • drug withdrawal syndrome
  • headache
  • hyperhidrosis
  • insomnia
10+ years:
  • dermatitis acneiform
  • hot flashes
  • itching
  • low blood pressure
  • sweating increased
not specified:
  • pain
  • anxiety
  • nausea
  • back pain
  • vomiting
  • arthralgia
  • osteonecrosis of jaw
  • pyrexia
  • dyspnoea
  • fall

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • nausea
  • arthralgia
  • osteonecrosis of jaw
  • back pain
  • vomiting
  • diarrhoea
  • fall
  • dyspnoea
male:
  • pain
  • anxiety
  • back pain
  • nausea
  • vomiting
  • depression
  • pneumonia
  • pyrexia
  • arthralgia
  • fatigue

Most common drug interactions by age *:

2-9:
  • respiratory arrest
  • accidental drug intake by child
  • cardiac arrest
  • drug toxicity
  • anorexia
  • bone pain
  • death
  • cough
  • febrile neutropenia
  • neck pain
10-19:
  • vomiting
  • blood culture positive
  • pain
  • pyrexia
  • staphylococcal infection
  • gastrointestinal haemorrhage
  • chills
  • device related infection
  • heart rate increased
  • infection
20-29:
  • accidental overdose
  • multiple drug overdose
  • nausea
  • pain
  • cardiac arrest
  • pulmonary embolism
  • vomiting
  • diarrhoea
  • respiratory arrest
  • abdominal pain upper
30-39:
  • fatigue
  • pain
  • back pain
  • diarrhoea
  • pyrexia
  • arthralgia
  • dyspnoea
  • vomiting
  • depression
  • anxiety
40-49:
  • pain
  • anxiety
  • back pain
  • depression
  • asthenia
  • nausea
  • headache
  • vomiting
  • fall
  • pain in jaw
50-59:
  • pain
  • anxiety
  • fall
  • nausea
  • osteoarthritis
  • osteonecrosis of jaw
  • vomiting
  • pyrexia
  • injury
  • insomnia
60+:
  • nausea
  • vomiting
  • pain
  • osteoarthritis
  • pneumonia
  • osteonecrosis of jaw
  • fall
  • anaemia
  • bone disorder
  • arthralgia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Oxycodone hydrochloride (oxycodone hydrochloride) is often used to treat pain. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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