Review: taking Oxycodone hydrochloride and Benadryl together


Summary

Drug interactions are reported among people who take Oxycodone hydrochloride and Benadryl together. This review analyzes the effectiveness and drug interactions between Oxycodone hydrochloride and Benadryl. It is created by eHealthMe based on reports of 2,444 people who take the same drugs from FDA and social media, and is updated regularly.

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Oxycodone Hydrochloride

Oxycodone hydrochloride has active ingredients of oxycodone hydrochloride. It is often used in pain. (latest outcomes from Oxycodone hydrochloride 1,363 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 32,636 users)

On Aug, 23, 2016

2,444 people who take Oxycodone Hydrochloride, Benadryl are studied.


Number of reports submitted per year:

Oxycodone hydrochloride and Benadryl drug interactions.

Drug effectiveness over time:

Oxycodone Hydrochloride:
  • < 1 month: 20.0% - (1 of 5 people)
  • 1 - 6 months: 100.0% - (2 of 2 people)
  • 6 - 12 months: 50.0% - (1 of 2 people)
  • 1 - 2 years: 100.0% - (3 of 3 people)
  • 2 - 5 years: 60.0% - (3 of 5 people)
  • 5 - 10 years: 100.0% - (2 of 2 people)
  • 10+ years: 25.0% - (1 of 4 people)
  • not specified: 0.0% - (0 of 0 people)
Benadryl:
  • < 1 month: 25.0% - (1 of 4 people)
  • 1 - 6 months: 20.0% - (1 of 5 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 16.0% - (1 of 6 people)
  • 5 - 10 years: 60.0% - (3 of 5 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Oxycodone Hydrochloride:
  • female: 64.0% - (9 of 14 people)
  • male: 44.0% - (4 of 9 people)
Benadryl:
  • female: 30.0% - (4 of 13 people)
  • male: 30.0% - (3 of 10 people)

Drug effectiveness by age:

Oxycodone Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 75.0% - (3 of 4 people)
  • 30-39: 57.0% - (4 of 7 people)
  • 40-49: 80.0% - (4 of 5 people)
  • 50-59: 40.0% - (2 of 5 people)
  • 60+: 0.0% - (0 of 2 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 50.0% - (2 of 4 people)
  • 30-39: 28.0% - (2 of 7 people)
  • 40-49: 60.0% - (3 of 5 people)
  • 50-59: 0.0% - (0 of 5 people)
  • 60+: 0.0% - (0 of 1 people)

Most common drug interactions over time *:

< 1 month:
  • diarrhoea
  • nausea
  • pyrexia
  • febrile neutropenia
  • malaise
  • constipation
  • pruritus
  • pain
  • musculoskeletal stiffness
  • urticaria
1 - 6 months:
  • pain
  • anxiety
  • constipation
  • drug dependence
  • drug withdrawal syndrome
  • depression
  • atelectasis
  • febrile neutropenia
  • haemangioma of liver
  • haemorrhage
6 - 12 months:
  • anxiety
  • drug withdrawal syndrome
  • fall
  • headache
  • memory impairment
  • nausea
  • somnolence
  • coma
  • drug ineffective
  • head injury
1 - 2 years:
  • drug dependence
  • coma
  • cardiac arrest
  • contusion
  • coronary artery atherosclerosis
  • hepatic fibrosis
  • hepatic steatosis
  • nausea
  • pyrexia
  • respiratory failure
2 - 5 years:
  • depression
  • drug dependence
  • drug withdrawal syndrome
  • headache
  • insomnia
  • nausea
  • constipation
  • anxiety
  • pain
  • asthenia
5 - 10 years:
  • anger
  • depression
  • drug withdrawal syndrome
  • headache
  • hyperhidrosis
  • insomnia
  • irritability
  • nausea
  • nervousness
  • oedema peripheral
10+ years:
  • stress
  • anger
  • pain exacerbated
  • abdominal pain
  • accidental overdose
  • agitation
  • anxiety
  • azotaemia
  • cellulitis
  • cholecystitis
not specified:
  • pain
  • anxiety
  • nausea
  • vomiting
  • back pain
  • arthralgia
  • dyspnoea
  • osteonecrosis of jaw
  • pyrexia
  • diarrhoea

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • nausea
  • vomiting
  • arthralgia
  • back pain
  • dyspnoea
  • diarrhoea
  • osteonecrosis of jaw
  • fall
male:
  • pain
  • nausea
  • anxiety
  • vomiting
  • back pain
  • depression
  • fatigue
  • pneumonia
  • arthralgia
  • pyrexia

Most common drug interactions by age *:

0-1:
  • constipation
  • decreased appetite
  • diabetes insipidus
  • hyponatraemia
  • muscle spasms
  • myoclonic epilepsy
  • pain
  • dehydration
  • hypernatraemia
  • vomiting
2-9:
  • respiratory arrest
  • accidental drug intake by child
  • cardiac arrest
  • febrile neutropenia
  • hypokalaemia
  • anaemia
  • leukopenia
  • neutropenia
  • thrombocytopenia
  • drug toxicity
10-19:
  • pyrexia
  • pain
  • vomiting
  • blood culture positive
  • disease progression
  • alanine aminotransferase increased
  • chills
  • paraesthesia
  • blood alkaline phosphatase increased
  • staphylococcal infection
20-29:
  • death
  • drug abuse
  • completed suicide
  • cardiac arrest
  • nausea
  • pain
  • diarrhoea
  • respiratory arrest
  • anxiety
  • accidental overdose
30-39:
  • fatigue
  • pain
  • pyrexia
  • back pain
  • diarrhoea
  • vomiting
  • dyspnoea
  • arthralgia
  • headache
  • nausea
40-49:
  • pain
  • anxiety
  • back pain
  • depression
  • nausea
  • vomiting
  • asthenia
  • headache
  • dyspnoea
  • pain in jaw
50-59:
  • pain
  • anxiety
  • nausea
  • fall
  • osteoarthritis
  • osteonecrosis of jaw
  • vomiting
  • injury
  • diarrhoea
  • pyrexia
60+:
  • nausea
  • pain
  • vomiting
  • arthralgia
  • osteoarthritis
  • diarrhoea
  • pneumonia
  • pyrexia
  • osteonecrosis of jaw
  • fall

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Oxycodone hydrochloride (oxycodone hydrochloride) is often used to treat pain. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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