Review: taking Plaquenil and Naproxen together


Summary

Drug interactions are reported among people who take Plaquenil and Naproxen together. This review analyzes the effectiveness and drug interactions between Plaquenil and Naproxen. It is created by eHealthMe based on reports of 921 people who take the same drugs from FDA and social media, and is updated regularly.

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Plaquenil

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in rheumatoid arthritis. (latest outcomes from Plaquenil 15,292 users)

Naproxen

Naproxen has active ingredients of naproxen. It is often used in pain. (latest outcomes from Naproxen 27,302 users)

On Jul, 27, 2016

921 people who take Plaquenil, Naproxen are studied.


Number of reports submitted per year:

Plaquenil and Naproxen drug interactions.

Drug effectiveness over time:

Plaquenil:
  • < 1 month: 0.0% - (0 of 2 people)
  • 1 - 6 months: 33.0% - (3 of 9 people)
  • 6 - 12 months: 0.0% - (0 of 4 people)
  • 1 - 2 years: 33.0% - (2 of 6 people)
  • 2 - 5 years: 27.0% - (3 of 11 people)
  • 5 - 10 years: 0.0% - (0 of 6 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 100.0% - (1 of 1 people)
Naproxen:
  • < 1 month: 0.0% - (0 of 4 people)
  • 1 - 6 months: 28.0% - (2 of 7 people)
  • 6 - 12 months: 0.0% - (0 of 4 people)
  • 1 - 2 years: 12.0% - (1 of 8 people)
  • 2 - 5 years: 16.0% - (1 of 6 people)
  • 5 - 10 years: 16.0% - (1 of 6 people)
  • 10+ years: 66.0% - (2 of 3 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Plaquenil:
  • female: 23.0% - (8 of 34 people)
  • male: 20.0% - (1 of 5 people)
Naproxen:
  • female: 20.0% - (7 of 35 people)
  • male: 0.0% - (0 of 4 people)

Drug effectiveness by age:

Plaquenil:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 3 people)
  • 20-29: 40.0% - (2 of 5 people)
  • 30-39: 37.0% - (3 of 8 people)
  • 40-49: 25.0% - (2 of 8 people)
  • 50-59: 10.0% - (1 of 10 people)
  • 60+: 20.0% - (1 of 5 people)
Naproxen:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 33.0% - (1 of 3 people)
  • 20-29: 14.0% - (1 of 7 people)
  • 30-39: 20.0% - (2 of 10 people)
  • 40-49: 25.0% - (2 of 8 people)
  • 50-59: 14.0% - (1 of 7 people)
  • 60+: 0.0% - (0 of 4 people)

Most common drug interactions over time *:

< 1 month:
  • sleeplessness
  • alanine aminotransferase increased
  • angioedema
  • anxiety
  • aspartate aminotransferase increased
  • blood alkaline phosphatase increased
  • chapped lips
  • constipation
  • diarrhoea
  • emotional distress
1 - 6 months:
  • atrial fibrillation
  • cardiac failure congestive
  • tachycardia
  • bone loss
  • cough
  • malaise
  • night sweats
  • polyp
  • retroperitoneal fibrosis
  • small cell lung cancer stage unspecified
6 - 12 months:
  • gastrointestinal haemorrhage
  • degenerative joint disease
  • fibromyalgia
  • muscle pain
  • osteoarthritis
  • ototoxicity
  • palpitations
  • reflux gastritis
  • skin reaction
  • spondylosis
1 - 2 years:
  • atrial fibrillation
  • coronary artery disease
  • thrombophlebitis
  • chest pain
  • dyspnoea
  • cardiac failure congestive
  • disease progression
  • infusion site abscess
  • infusion site induration
  • infusion site infection
2 - 5 years:
  • chronic fatigue syndrome
  • diabetes mellitus
  • fibromyalgia
  • immunosuppressant drug level decreased
  • lupus
  • mastalgia
  • miscarriage
  • mobility decreased
  • myoclonic jerks
  • pain - joints
5 - 10 years:
  • gallbladder injury
  • hidradenitis suppurativa
  • malaise
  • mouth ulceration
  • night sweats
  • polyp
  • retroperitoneal fibrosis
  • burning mouth syndrome
  • biliary dyskinesia
  • cough
10+ years:
  • deafness bilateral
  • fatigue
  • goiter
  • hyperlipidaemia
  • itching
  • proteinuria
  • shortness of breath
  • throat tightness
not specified:
  • nausea
  • pain
  • arthralgia
  • headache
  • drug ineffective
  • dyspnoea
  • fatigue
  • rheumatoid arthritis
  • urinary tract infection
  • vomiting

Most common drug interactions by gender *:

female:
  • nausea
  • pain
  • arthralgia
  • fatigue
  • headache
  • urinary tract infection
  • vomiting
  • dyspnoea
  • pain in extremity
  • drug ineffective
male:
  • drug ineffective
  • dyspnoea
  • atrial fibrillation
  • chest pain
  • rheumatoid arthritis
  • coronary artery disease
  • nausea
  • pyrexia
  • thrombophlebitis
  • headache

Most common drug interactions by age *:

2-9:
  • autoimmune hepatitis
  • chest pain
  • muscle cramps
  • pyrexia
10-19:
  • arthralgia
  • chest pain
  • drug ineffective
  • fatigue
  • haematochezia
  • hepatic failure
  • nausea
  • pleural effusion
  • polyuria
  • renal papillary necrosis
20-29:
  • cough
  • hepatic necrosis
  • pyrexia
  • anaemia
  • atelectasis
  • deep vein thrombosis
  • drug ineffective
  • dyspnoea
  • fatigue
  • haematochezia
30-39:
  • pain
  • headache
  • nausea
  • arthralgia
  • alopecia
  • neck pain
  • convulsion
  • depression
  • temporomandibular joint syndrome
  • therapeutic response decreased
40-49:
  • depression
  • anxiety
  • pain
  • drug ineffective
  • pain in extremity
  • headache
  • dyspnoea
  • rheumatoid arthritis
  • nausea
  • back pain
50-59:
  • nausea
  • urinary tract infection
  • rheumatoid arthritis
  • fatigue
  • vomiting
  • arthralgia
  • osteomyelitis
  • drug ineffective
  • fracture
  • pain
60+:
  • dyspnoea
  • atrial fibrillation
  • drug ineffective
  • arthralgia
  • pain
  • pneumonia
  • chest pain
  • coronary artery disease
  • thrombophlebitis
  • hypersensitivity

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Plaquenil (hydroxychloroquine sulfate) is often used to treat rheumatoid arthritis. Naproxen (naproxen) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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