Review: taking Plaquenil and Naproxen together


Summary

Drug interactions are reported among people who take Plaquenil and Naproxen together. This review analyzes the effectiveness and drug interactions between Plaquenil and Naproxen. It is created by eHealthMe based on reports of 1,268 people who take the same drugs from FDA and social media, and is updated regularly.

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Plaquenil

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in rheumatoid arthritis. (latest outcomes from Plaquenil 19,931 users)

Naproxen

Naproxen has active ingredients of naproxen. It is often used in pain. (latest outcomes from Naproxen 28,475 users)

On Aug, 26, 2016

1,268 people who take Plaquenil, Naproxen are studied.


Number of reports submitted per year:

Plaquenil and Naproxen drug interactions.

Drug effectiveness over time:

Plaquenil:
  • < 1 month: 0.0% - (0 of 2 people)
  • 1 - 6 months: 33.0% - (3 of 9 people)
  • 6 - 12 months: 0.0% - (0 of 4 people)
  • 1 - 2 years: 33.0% - (2 of 6 people)
  • 2 - 5 years: 22.0% - (2 of 9 people)
  • 5 - 10 years: 0.0% - (0 of 5 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 100.0% - (1 of 1 people)
Naproxen:
  • < 1 month: 0.0% - (0 of 4 people)
  • 1 - 6 months: 28.0% - (2 of 7 people)
  • 6 - 12 months: 0.0% - (0 of 4 people)
  • 1 - 2 years: 14.0% - (1 of 7 people)
  • 2 - 5 years: 16.0% - (1 of 6 people)
  • 5 - 10 years: 16.0% - (1 of 6 people)
  • 10+ years: 66.0% - (2 of 3 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Plaquenil:
  • female: 22.0% - (7 of 31 people)
  • male: 20.0% - (1 of 5 people)
Naproxen:
  • female: 20.0% - (7 of 34 people)
  • male: 0.0% - (0 of 4 people)

Drug effectiveness by age:

Plaquenil:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 3 people)
  • 20-29: 40.0% - (2 of 5 people)
  • 30-39: 28.0% - (2 of 7 people)
  • 40-49: 28.0% - (2 of 7 people)
  • 50-59: 11.0% - (1 of 9 people)
  • 60+: 20.0% - (1 of 5 people)
Naproxen:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 33.0% - (1 of 3 people)
  • 20-29: 14.0% - (1 of 7 people)
  • 30-39: 22.0% - (2 of 9 people)
  • 40-49: 25.0% - (2 of 8 people)
  • 50-59: 14.0% - (1 of 7 people)
  • 60+: 0.0% - (0 of 4 people)

Most common drug interactions over time *:

< 1 month:
  • palpitations
  • chest discomfort
  • vomiting
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • blood alkaline phosphatase increased
  • diarrhoea
  • headache
  • rash
  • sleeplessness
1 - 6 months:
  • dyspnoea
  • liver function test abnormal
  • atrial fibrillation
  • cardiac failure congestive
  • chest discomfort
  • palpitations
  • tachycardia
  • vomiting
  • blood creatinine increased
  • bone loss
6 - 12 months:
  • gastrointestinal haemorrhage
  • systemic lupus erythematosus
  • type 2 diabetes mellitus
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • autoimmune hepatitis
  • biliary dilatation
  • blood alkaline phosphatase increased
  • cholestasis
  • degenerative joint disease
1 - 2 years:
  • atrial fibrillation
  • coronary artery disease
  • thrombophlebitis
  • chest pain
  • dyspnoea
  • cardiac failure congestive
  • disease progression
  • infusion site abscess
  • infusion site induration
  • infusion site infection
2 - 5 years:
  • chronic fatigue syndrome
  • diabetes mellitus
  • fibromyalgia
  • immunosuppressant drug level decreased
  • lupus
  • mastalgia
  • miscarriage
  • mobility decreased
  • myoclonic jerks
  • pain - joints
5 - 10 years:
  • gallbladder injury
  • hidradenitis suppurativa
  • malaise
  • mouth ulceration
  • night sweats
  • polyp
  • retroperitoneal fibrosis
  • burning mouth syndrome
  • biliary dyskinesia
  • cough
10+ years:
  • deafness bilateral
  • fatigue
  • goiter
  • hyperlipidaemia
  • itching
  • proteinuria
  • shortness of breath
  • throat tightness
not specified:
  • arthralgia
  • pain
  • nausea
  • headache
  • fatigue
  • drug ineffective
  • dyspnoea
  • injection site pain
  • rheumatoid arthritis
  • pain in extremity

Most common drug interactions by gender *:

female:
  • pain
  • arthralgia
  • fatigue
  • headache
  • nausea
  • dyspnoea
  • injection site pain
  • urinary tract infection
  • drug ineffective
  • pain in extremity
male:
  • drug ineffective
  • dyspnoea
  • nausea
  • rheumatoid arthritis
  • atrial fibrillation
  • chest pain
  • arthralgia
  • headache
  • coronary artery disease
  • dizziness

Most common drug interactions by age *:

2-9:
  • autoimmune hepatitis
  • chest pain
  • muscle cramps
  • pyrexia
10-19:
  • arthralgia
  • chest pain
  • drug ineffective
  • fatigue
  • haematochezia
  • heart rate increased
  • hepatic failure
  • injection site bruising
  • injection site erythema
  • nausea
20-29:
  • cough
  • hepatic necrosis
  • pyrexia
  • anaemia
  • fatigue
  • pulmonary embolism
  • injection site pain
  • atelectasis
  • deep vein thrombosis
  • dizziness
30-39:
  • pain
  • headache
  • nausea
  • arthralgia
  • urinary tract infection
  • alopecia
  • depression
  • neck pain
  • convulsion
  • temporomandibular joint syndrome
40-49:
  • pain in extremity
  • anxiety
  • depression
  • headache
  • pain
  • drug ineffective
  • dyspnoea
  • arthralgia
  • nausea
  • back pain
50-59:
  • arthralgia
  • fatigue
  • nausea
  • rheumatoid arthritis
  • urinary tract infection
  • drug ineffective
  • vomiting
  • pain
  • headache
  • malaise
60+:
  • dyspnoea
  • arthralgia
  • drug ineffective
  • atrial fibrillation
  • pain
  • pneumonia
  • chest pain
  • nausea
  • headache
  • pain in extremity

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Plaquenil (hydroxychloroquine sulfate) is often used to treat rheumatoid arthritis. Naproxen (naproxen) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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