Review: taking Plaquenil and Naproxen together


Summary

Drug interactions are reported among people who take Plaquenil and Naproxen together. This review analyzes the effectiveness and drug interactions between Plaquenil and Naproxen. It is created by eHealthMe based on reports of 1,895 people who take the same drugs from FDA and social media, and is updated regularly.

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Plaquenil

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in rheumatoid arthritis. (latest outcomes from Plaquenil 26,923 users)

Naproxen

Naproxen has active ingredients of naproxen. It is often used in pain. (latest outcomes from Naproxen 36,950 users)

On Sep, 16, 2016

1,895 people who take Plaquenil, Naproxen are studied.


Number of reports submitted per year:

Plaquenil and Naproxen drug interactions.

Drug effectiveness over time:

Plaquenil:
  • < 1 month: 0.0% - (0 of 2 people)
  • 1 - 6 months: 33.0% - (3 of 9 people)
  • 6 - 12 months: 0.0% - (0 of 4 people)
  • 1 - 2 years: 33.0% - (2 of 6 people)
  • 2 - 5 years: 22.0% - (2 of 9 people)
  • 5 - 10 years: 0.0% - (0 of 5 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 100.0% - (1 of 1 people)
Naproxen:
  • < 1 month: 0.0% - (0 of 4 people)
  • 1 - 6 months: 28.0% - (2 of 7 people)
  • 6 - 12 months: 0.0% - (0 of 4 people)
  • 1 - 2 years: 14.0% - (1 of 7 people)
  • 2 - 5 years: 16.0% - (1 of 6 people)
  • 5 - 10 years: 16.0% - (1 of 6 people)
  • 10+ years: 66.0% - (2 of 3 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Plaquenil:
  • female: 22.0% - (7 of 31 people)
  • male: 20.0% - (1 of 5 people)
Naproxen:
  • female: 20.0% - (7 of 34 people)
  • male: 0.0% - (0 of 4 people)

Drug effectiveness by age:

Plaquenil:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 3 people)
  • 20-29: 40.0% - (2 of 5 people)
  • 30-39: 28.0% - (2 of 7 people)
  • 40-49: 28.0% - (2 of 7 people)
  • 50-59: 11.0% - (1 of 9 people)
  • 60+: 20.0% - (1 of 5 people)
Naproxen:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 33.0% - (1 of 3 people)
  • 20-29: 14.0% - (1 of 7 people)
  • 30-39: 22.0% - (2 of 9 people)
  • 40-49: 25.0% - (2 of 8 people)
  • 50-59: 14.0% - (1 of 7 people)
  • 60+: 0.0% - (0 of 4 people)

Most common drug interactions over time *:

< 1 month:
  • palpitations
  • rash
  • chest discomfort
  • vomiting
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • blood alkaline phosphatase increased
  • diarrhoea
  • headache
  • lower respiratory tract infection
1 - 6 months:
  • dyspnoea
  • liver function test abnormal
  • arthritis
  • drug ineffective
  • impaired work ability
  • atrial fibrillation
  • cardiac failure congestive
  • chest discomfort
  • malaise
  • palpitations
6 - 12 months:
  • gastrointestinal haemorrhage
  • systemic lupus erythematosus
  • type 2 diabetes mellitus
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • autoimmune hepatitis
  • biliary dilatation
  • blood alkaline phosphatase increased
  • cholestasis
  • colonoscopy
1 - 2 years:
  • atrial fibrillation
  • coronary artery disease
  • thrombophlebitis
  • chest pain
  • dyspnoea
  • cardiac failure congestive
  • disease progression
  • infusion site abscess
  • infusion site induration
  • infusion site infection
2 - 5 years:
  • acute myocardial infarction
  • cardiac failure congestive
  • chronic fatigue syndrome
  • deep vein thrombosis
  • diabetes mellitus
  • fibromyalgia
  • immunosuppressant drug level decreased
  • lupus
  • mastalgia
  • miscarriage
5 - 10 years:
  • drug ineffective
  • impaired work ability
  • interstitial lung disease
  • red blood cell sedimentation rate abnormal
  • rheumatoid arthritis
  • drug effect decreased
  • biliary dyskinesia
  • cough
  • gallbladder injury
  • hidradenitis suppurativa
10+ years:
  • blindness
  • carpal tunnel syndrome
  • cataract
  • deafness bilateral
  • drug ineffective
  • fasciitis
  • fatigue
  • foot deformity
  • gait disturbance
  • gastric disorder
not specified:
  • pain
  • drug ineffective
  • arthralgia
  • fatigue
  • nausea
  • headache
  • rheumatoid arthritis
  • vomiting
  • pain in extremity
  • dyspnoea

Most common drug interactions by gender *:

female:
  • pain
  • drug ineffective
  • arthralgia
  • fatigue
  • headache
  • nausea
  • rheumatoid arthritis
  • vomiting
  • pain in extremity
  • injection site pain
male:
  • drug ineffective
  • arthralgia
  • dyspnoea
  • pain
  • rheumatoid arthritis
  • nausea
  • pneumonia
  • chest pain
  • fatigue
  • joint swelling

Most common drug interactions by age *:

0-1:
  • adrenal insufficiency
  • antibody test positive
  • arthritis
  • body height below normal
  • bone density decreased
  • c-reactive protein increased
  • diarrhoea
  • dizziness
  • drug ineffective
  • drug intolerance
2-9:
  • abdominal pain upper
  • alopecia
  • asthenia
  • cough
  • rhinorrhoea
  • sneezing
  • c-reactive protein increased
  • pyrexia
  • abdominal pain
  • eating disorder
10-19:
  • nausea
  • drug ineffective
  • pain
  • fatigue
  • heart rate increased
  • vomiting
  • arthralgia
  • arthritis
  • back pain
  • chest pain
20-29:
  • cough
  • pyrexia
  • dizziness
  • fatigue
  • injection site pain
  • diarrhoea
  • hepatic necrosis
  • injection site erythema
  • joint swelling
  • vomiting
30-39:
  • pain
  • arthralgia
  • headache
  • nausea
  • fatigue
  • alopecia
  • depression
  • infusion related reaction
  • malaise
  • pain in extremity
40-49:
  • pain
  • headache
  • drug ineffective
  • pain in extremity
  • rheumatoid arthritis
  • injection site pain
  • anxiety
  • arthralgia
  • fatigue
  • back pain
50-59:
  • drug ineffective
  • rheumatoid arthritis
  • arthralgia
  • pain
  • fatigue
  • nausea
  • vomiting
  • pneumonia
  • malaise
  • urinary tract infection
60+:
  • pain
  • arthralgia
  • drug ineffective
  • fatigue
  • dyspnoea
  • nausea
  • rheumatoid arthritis
  • headache
  • fall
  • pain in extremity

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Plaquenil (hydroxychloroquine sulfate) is often used to treat rheumatoid arthritis. Naproxen (naproxen) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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