Review: taking Prednisone and Methotrexate together


Summary

Drug interactions are reported among people who take Prednisone and Methotrexate together. This review analyzes the effectiveness and drug interactions between Prednisone and Methotrexate. It is created by eHealthMe based on reports of 39,773 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information

On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 86 million people have used us. 300+ peer-reviewed medical journals have referenced our original studies. Start now >>>


Prednisone

Prednisone has active ingredients of prednisone. It is often used in rheumatoid arthritis. (latest outcomes from Prednisone 224,214 users)

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 205,730 users)

On Sep, 17, 2016

39,773 people who take Prednisone, Methotrexate are studied.


Number of reports submitted per year:

Prednisone and Methotrexate drug interactions.

Drug effectiveness over time:

Prednisone:
  • < 1 month: 28.0% - (9 of 32 people)
  • 1 - 6 months: 35.0% - (22 of 62 people)
  • 6 - 12 months: 32.0% - (11 of 34 people)
  • 1 - 2 years: 54.0% - (25 of 46 people)
  • 2 - 5 years: 50.0% - (23 of 46 people)
  • 5 - 10 years: 53.0% - (23 of 43 people)
  • 10+ years: 59.0% - (16 of 27 people)
  • not specified: 100.0% - (2 of 2 people)
Methotrexate:
  • < 1 month: 3.0% - (1 of 26 people)
  • 1 - 6 months: 18.0% - (14 of 74 people)
  • 6 - 12 months: 19.0% - (6 of 31 people)
  • 1 - 2 years: 41.0% - (18 of 43 people)
  • 2 - 5 years: 26.0% - (13 of 50 people)
  • 5 - 10 years: 36.0% - (12 of 33 people)
  • 10+ years: 39.0% - (9 of 23 people)
  • not specified: 0.0% - (0 of 2 people)

Drug effectiveness by gender:

Prednisone:
  • female: 45.0% - (104 of 230 people)
  • male: 43.0% - (27 of 62 people)
Methotrexate:
  • female: 23.0% - (53 of 226 people)
  • male: 35.0% - (20 of 56 people)

Drug effectiveness by age:

Prednisone:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 100.0% - (2 of 2 people)
  • 10-19: 25.0% - (2 of 8 people)
  • 20-29: 30.0% - (4 of 13 people)
  • 30-39: 38.0% - (14 of 36 people)
  • 40-49: 45.0% - (28 of 61 people)
  • 50-59: 47.0% - (45 of 95 people)
  • 60+: 46.0% - (36 of 77 people)
Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 100.0% - (2 of 2 people)
  • 10-19: 14.0% - (1 of 7 people)
  • 20-29: 21.0% - (3 of 14 people)
  • 30-39: 14.0% - (5 of 35 people)
  • 40-49: 19.0% - (12 of 63 people)
  • 50-59: 32.0% - (28 of 87 people)
  • 60+: 29.0% - (22 of 74 people)

Most common drug interactions over time *:

< 1 month:
  • pyrexia
  • post transplant lymphoproliferative disorder
  • pneumonia
  • sepsis
  • nausea
  • febrile neutropenia
  • headache
  • ileus paralytic
  • vomiting
  • mucosal inflammation
1 - 6 months:
  • pyrexia
  • pneumonia
  • pain
  • anaemia
  • sepsis
  • febrile neutropenia
  • nausea
  • headache
  • thrombocytopenia
  • dyspnoea
6 - 12 months:
  • pneumonia
  • nausea
  • drug ineffective
  • rheumatoid arthritis
  • dyspnoea
  • alanine aminotransferase increased
  • weight decreased
  • pneumonitis
  • anaemia
  • pyrexia
1 - 2 years:
  • nausea
  • pneumonia
  • drug ineffective
  • fatigue
  • pyrexia
  • rheumatoid arthritis
  • arthralgia
  • headache
  • vomiting
  • dyspnoea
2 - 5 years:
  • fatigue
  • diarrhoea
  • nausea
  • pneumonia
  • weight decreased
  • pain
  • sepsis
  • impaired healing
  • rheumatoid arthritis
  • drug ineffective
5 - 10 years:
  • pyrexia
  • fatigue
  • drug ineffective
  • nausea
  • weight decreased
  • arthralgia
  • rheumatoid arthritis
  • death
  • asthenia
  • pneumonia
10+ years:
  • oedema peripheral
  • asthenia
  • pyrexia
  • vomiting
  • arthralgia
  • headache
  • pain
  • arthropathy
  • cough
  • diarrhoea
not specified:
  • arthralgia
  • drug ineffective
  • pain
  • rheumatoid arthritis
  • fatigue
  • pyrexia
  • nausea
  • headache
  • pain in extremity
  • injection site pain

Most common drug interactions by gender *:

female:
  • arthralgia
  • drug ineffective
  • pain
  • fatigue
  • nausea
  • rheumatoid arthritis
  • pyrexia
  • headache
  • injection site pain
  • pain in extremity
male:
  • drug ineffective
  • arthralgia
  • pyrexia
  • rheumatoid arthritis
  • pain
  • pneumonia
  • fatigue
  • nausea
  • dyspnoea
  • diarrhoea

Most common drug interactions by age *:

0-1:
  • diarrhoea
  • pyrexia
  • febrile neutropenia
  • dyspnoea
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • vomiting
  • drug ineffective
  • gamma-glutamyltransferase increased
  • nausea
2-9:
  • pyrexia
  • neutropenia
  • febrile neutropenia
  • pneumonia
  • convulsion
  • mucosal inflammation
  • drug toxicity
  • vomiting
  • cough
  • abdominal pain
10-19:
  • crohn's disease
  • pyrexia
  • febrile neutropenia
  • hypotension
  • neutropenia
  • vomiting
  • abdominal pain
  • headache
  • sepsis
  • nausea
20-29:
  • arthralgia
  • drug ineffective
  • pyrexia
  • nausea
  • headache
  • pain
  • febrile neutropenia
  • dyspnoea
  • haematotoxicity
  • injection site pain
30-39:
  • arthralgia
  • drug ineffective
  • headache
  • pyrexia
  • nausea
  • vomiting
  • fatigue
  • diarrhoea
  • pain
  • injection site pain
40-49:
  • arthralgia
  • drug ineffective
  • pyrexia
  • pain
  • headache
  • rheumatoid arthritis
  • fatigue
  • nausea
  • injection site pain
  • dyspnoea
50-59:
  • arthralgia
  • drug ineffective
  • pain
  • fatigue
  • nausea
  • rheumatoid arthritis
  • headache
  • pyrexia
  • pain in extremity
  • injection site pain
60+:
  • arthralgia
  • drug ineffective
  • pneumonia
  • rheumatoid arthritis
  • pain
  • fatigue
  • nausea
  • pyrexia
  • dyspnoea
  • pain in extremity

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Prednisone and Methotrexate?

Can you answer these questions?

More questions for: Prednisone, Methotrexate

You may be interested in these reviews

More reviews for: Prednisone, Methotrexate

On eHealthMe, Prednisone (prednisone) is often used to treat rheumatoid arthritis. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.