Review: taking Prednisone and Methotrexate together


Summary

Drug interactions are reported among people who take Prednisone and Methotrexate together. This review analyzes the effectiveness and drug interactions between Prednisone and Methotrexate. It is created by eHealthMe based on reports of 25,968 people who take the same drugs from FDA and social media, and is updated regularly.

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Prednisone

Prednisone has active ingredients of prednisone. It is often used in rheumatoid arthritis. (latest outcomes from Prednisone 147,040 users)

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 129,047 users)

On Jul, 27, 2016

25,968 people who take Prednisone, Methotrexate are studied.


Number of reports submitted per year:

Prednisone and Methotrexate drug interactions.

Drug effectiveness over time:

Prednisone:
  • < 1 month: 32.0% - (13 of 40 people)
  • 1 - 6 months: 32.0% - (27 of 82 people)
  • 6 - 12 months: 29.0% - (13 of 44 people)
  • 1 - 2 years: 54.0% - (35 of 64 people)
  • 2 - 5 years: 48.0% - (25 of 52 people)
  • 5 - 10 years: 60.0% - (32 of 53 people)
  • 10+ years: 51.0% - (18 of 35 people)
  • not specified: 100.0% - (2 of 2 people)
Methotrexate:
  • < 1 month: 2.0% - (1 of 37 people)
  • 1 - 6 months: 16.0% - (15 of 89 people)
  • 6 - 12 months: 16.0% - (6 of 37 people)
  • 1 - 2 years: 33.0% - (20 of 59 people)
  • 2 - 5 years: 25.0% - (16 of 63 people)
  • 5 - 10 years: 38.0% - (16 of 42 people)
  • 10+ years: 34.0% - (10 of 29 people)
  • not specified: 0.0% - (0 of 2 people)

Drug effectiveness by gender:

Prednisone:
  • female: 44.0% - (131 of 296 people)
  • male: 44.0% - (34 of 76 people)
Methotrexate:
  • female: 21.0% - (61 of 289 people)
  • male: 33.0% - (23 of 69 people)

Drug effectiveness by age:

Prednisone:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 100.0% - (2 of 2 people)
  • 10-19: 22.0% - (2 of 9 people)
  • 20-29: 26.0% - (4 of 15 people)
  • 30-39: 37.0% - (15 of 40 people)
  • 40-49: 44.0% - (34 of 77 people)
  • 50-59: 46.0% - (60 of 129 people)
  • 60+: 48.0% - (48 of 100 people)
Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 100.0% - (2 of 2 people)
  • 10-19: 12.0% - (1 of 8 people)
  • 20-29: 18.0% - (3 of 16 people)
  • 30-39: 13.0% - (5 of 38 people)
  • 40-49: 16.0% - (13 of 77 people)
  • 50-59: 24.0% - (29 of 119 people)
  • 60+: 31.0% - (31 of 98 people)

Most common drug interactions over time *:

< 1 month:
  • pyrexia
  • post transplant lymphoproliferative disorder
  • ileus paralytic
  • pancreatic neoplasm
  • nausea
  • febrile neutropenia
  • pneumonia
  • hypotension
  • sepsis
  • proteus infection
1 - 6 months:
  • pyrexia
  • pneumonia
  • anaemia
  • febrile neutropenia
  • pain
  • sepsis
  • thrombocytopenia
  • cellulitis
  • headache
  • cardio-respiratory arrest
6 - 12 months:
  • pneumonia
  • pneumonitis
  • nausea
  • weight decreased
  • anaemia
  • cellulitis
  • death
  • drug ineffective
  • pulmonary fibrosis
  • asthenia
1 - 2 years:
  • pneumonia
  • nausea
  • fatigue
  • pyrexia
  • headache
  • rheumatoid arthritis
  • respiratory failure
  • hair loss
  • tuberculosis
  • arthralgia
2 - 5 years:
  • fatigue
  • diarrhoea
  • nausea
  • weight decreased
  • pneumonia
  • sepsis
  • impaired healing
  • insomnia
  • osteomyelitis
  • rheumatoid arthritis
5 - 10 years:
  • pyrexia
  • fatigue
  • weight decreased
  • death
  • nausea
  • pancytopenia
  • anaemia
  • asthenia
  • arthralgia
  • malaise
10+ years:
  • oedema peripheral
  • asthenia
  • arthralgia
  • pyrexia
  • cough
  • headache
  • cerebrovascular accident
  • vomiting
  • abdominal pain upper
  • agranulocytosis
not specified:
  • pyrexia
  • arthralgia
  • drug ineffective
  • nausea
  • pneumonia
  • fatigue
  • rheumatoid arthritis
  • pain
  • dyspnoea
  • headache

Most common drug interactions by gender *:

female:
  • arthralgia
  • pyrexia
  • nausea
  • drug ineffective
  • fatigue
  • pain
  • pneumonia
  • rheumatoid arthritis
  • dyspnoea
  • headache
male:
  • pyrexia
  • pneumonia
  • arthralgia
  • drug ineffective
  • rheumatoid arthritis
  • nausea
  • fatigue
  • asthenia
  • pain
  • dyspnoea

Most common drug interactions by age *:

0-1:
  • gamma-glutamyltransferase increased
  • neutropenia
  • diarrhoea
  • pyrexia
  • respiratory syncytial virus infection
  • stomatitis
  • thrombocytopenia
  • acute lymphocytic leukaemia
  • alopecia
  • arthropod bite
2-9:
  • pyrexia
  • pneumonia
  • drug toxicity
  • convulsion
  • febrile neutropenia
  • neutropenia
  • mucosal inflammation
  • alanine aminotransferase increased
  • lymphadenopathy
  • vomiting
10-19:
  • pyrexia
  • crohn's disease
  • hypotension
  • neutropenia
  • vomiting
  • abdominal pain
  • hyperglycaemia
  • headache
  • hyperbilirubinaemia
  • nausea
20-29:
  • pyrexia
  • arthralgia
  • drug ineffective
  • nausea
  • pain
  • dyspnoea
  • headache
  • rheumatoid arthritis
  • chest pain
  • weight decreased
30-39:
  • arthralgia
  • nausea
  • pyrexia
  • vomiting
  • headache
  • diarrhoea
  • fatigue
  • drug ineffective
  • dyspnoea
  • cough
40-49:
  • pyrexia
  • arthralgia
  • drug ineffective
  • nausea
  • rheumatoid arthritis
  • pain
  • fatigue
  • headache
  • oedema peripheral
  • dyspnoea
50-59:
  • arthralgia
  • pyrexia
  • nausea
  • fatigue
  • pain
  • drug ineffective
  • oedema peripheral
  • pain in extremity
  • headache
  • rheumatoid arthritis
60+:
  • pneumonia
  • arthralgia
  • pyrexia
  • drug ineffective
  • nausea
  • rheumatoid arthritis
  • asthenia
  • fatigue
  • dyspnoea
  • pain

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Prednisone (prednisone) is often used to treat rheumatoid arthritis. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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