Review: taking Promethazine with codeine and Benadryl together


Summary

Drug interactions are reported among people who take Promethazine with codeine and Benadryl together. This review analyzes the effectiveness and drug interactions between Promethazine with codeine and Benadryl. It is created by eHealthMe based on reports of 69 people who take the same drugs from FDA and social media, and is updated regularly.

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Promethazine With Codeine

Promethazine with codeine has active ingredients of codeine phosphate; promethazine hydrochloride. It is often used in cough. (latest outcomes from Promethazine with codeine 65 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 33,627 users)

On Aug, 29, 2016

69 people who take Promethazine With Codeine, Benadryl are studied.


Number of reports submitted per year:

Promethazine with codeine and Benadryl drug interactions.

Drug effectiveness over time:

Promethazine With Codeine:
  • < 1 month: 100.0% - (1 of 1 people)
  • 1 - 6 months: 0.0% - (0 of 0 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 0.0% - (0 of 0 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)
Benadryl:
  • < 1 month: 100.0% - (1 of 1 people)
  • 1 - 6 months: 0.0% - (0 of 0 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 0.0% - (0 of 0 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Promethazine With Codeine:
  • female: 100.0% - (1 of 1 people)
  • male: 0.0% - (0 of 0 people)
Benadryl:
  • female: 100.0% - (1 of 1 people)
  • male: 0.0% - (0 of 0 people)

Drug effectiveness by age:

Promethazine With Codeine:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 0.0% - (0 of 0 people)
  • 50-59: 100.0% - (1 of 1 people)
  • 60+: 0.0% - (0 of 0 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 0.0% - (0 of 0 people)
  • 50-59: 100.0% - (1 of 1 people)
  • 60+: 0.0% - (0 of 0 people)

Most common drug interactions over time *:

< 1 month:
  • asthma
  • bronchiolitis
  • dyspnoea
  • ear pruritus
  • emphysema
  • infusion related reaction
  • leukoplakia
  • nausea
  • paraesthesia oral
  • throat lesion
1 - 6 months:
  • chest pain
  • death
  • stevens-johnson syndrome
  • blood creatine phosphokinase increased
5 - 10 years:
  • aggression
  • anxiety
  • depression
  • hallucination, auditory
  • intentional overdose
  • paranoia
  • suicide attempt
  • suicidal ideation
not specified:
  • nausea
  • back pain
  • insomnia
  • bronchitis
  • vomiting
  • fatigue
  • fall
  • pain
  • arthralgia
  • headache

Most common drug interactions by gender *:

female:
  • nausea
  • back pain
  • insomnia
  • vomiting
  • fatigue
  • pain
  • bronchitis
  • fall
  • amnesia
  • arthralgia
male:
  • back pain
  • nausea
  • arthralgia
  • bronchitis
  • fall
  • headache
  • aortic valve incompetence
  • arthritis
  • dysuria
  • pneumonia

Most common drug interactions by age *:

2-9:
  • abdominal pain
  • arrhythmia
  • drug level increased
  • dysuria
  • enterobiasis
  • headache
  • hyperhidrosis
  • malaise
  • otitis externa
  • otitis media
20-29:
  • insomnia
  • presyncope
  • back pain
  • nausea
  • vomiting
  • bronchitis
  • cardiac failure congestive
  • cholecystitis
  • hypertension
  • influenza like illness
30-39:
  • death
  • drug toxicity
  • glucose tolerance impaired
  • hyperglycaemia
  • insomnia
  • sleep disorder
  • type 2 diabetes mellitus
  • analgesic drug level above therapeutic
  • diabetes mellitus
  • drug abuse
40-49:
  • arthralgia
  • joint injury
  • muscle spasms
  • nausea
  • pain
  • amnesia
  • back pain
  • bursitis
  • cough
  • dependence
50-59:
  • nausea
  • anxiety
  • bronchitis
  • depression
  • gastrooesophageal reflux disease
  • hyperlipidaemia
  • pain
  • anaemia
  • chronic obstructive pulmonary disease
  • pain in extremity
60+:
  • nausea
  • back pain
  • fall
  • rotator cuff syndrome
  • aortic valve incompetence
  • arthralgia
  • bronchitis
  • diarrhoea
  • feeling abnormal
  • headache

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Promethazine with codeine (codeine phosphate; promethazine hydrochloride) is often used to treat cough. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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