Review: taking Promethazine and Cyclobenzaprine hydrochloride together


Summary

Drug interactions are reported among people who take Promethazine and Cyclobenzaprine hydrochloride together. This review analyzes the effectiveness and drug interactions between Promethazine and Cyclobenzaprine hydrochloride. It is created by eHealthMe based on reports of 1,258 people who take the same drugs from FDA and social media, and is updated regularly.

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Promethazine

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. (latest outcomes from Promethazine 3,714 users)

Cyclobenzaprine Hydrochloride

Cyclobenzaprine hydrochloride has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Cyclobenzaprine hydrochloride 2,728 users)

On Aug, 27, 2016

1,258 people who take Promethazine, Cyclobenzaprine Hydrochloride are studied.


Number of reports submitted per year:

Promethazine and Cyclobenzaprine hydrochloride drug interactions.

Drug effectiveness over time:

Promethazine:
  • < 1 month: 20.0% - (2 of 10 people)
  • 1 - 6 months: 50.0% - (3 of 6 people)
  • 6 - 12 months: 100.0% - (2 of 2 people)
  • 1 - 2 years: 50.0% - (2 of 4 people)
  • 2 - 5 years: 62.0% - (5 of 8 people)
  • 5 - 10 years: 100.0% - (3 of 3 people)
  • 10+ years: 66.0% - (2 of 3 people)
  • not specified: 100.0% - (1 of 1 people)
Cyclobenzaprine Hydrochloride:
  • < 1 month: 30.0% - (3 of 10 people)
  • 1 - 6 months: 25.0% - (1 of 4 people)
  • 6 - 12 months: 0.0% - (0 of 2 people)
  • 1 - 2 years: 14.0% - (1 of 7 people)
  • 2 - 5 years: 0.0% - (0 of 5 people)
  • 5 - 10 years: 50.0% - (3 of 6 people)
  • 10+ years: 100.0% - (3 of 3 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Promethazine:
  • female: 51.0% - (16 of 31 people)
  • male: 66.0% - (4 of 6 people)
Cyclobenzaprine Hydrochloride:
  • female: 22.0% - (7 of 31 people)
  • male: 66.0% - (4 of 6 people)

Drug effectiveness by age:

Promethazine:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (1 of 1 people)
  • 20-29: 42.0% - (3 of 7 people)
  • 30-39: 55.0% - (5 of 9 people)
  • 40-49: 62.0% - (5 of 8 people)
  • 50-59: 50.0% - (5 of 10 people)
  • 60+: 50.0% - (1 of 2 people)
Cyclobenzaprine Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (1 of 1 people)
  • 20-29: 33.0% - (2 of 6 people)
  • 30-39: 22.0% - (2 of 9 people)
  • 40-49: 44.0% - (4 of 9 people)
  • 50-59: 20.0% - (2 of 10 people)
  • 60+: 0.0% - (0 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • pain
  • depression
  • nausea
  • constipation
  • death
  • pulmonary embolism
  • suicide attempt
  • cardiac arrest
  • cholecystitis chronic
  • injury
1 - 6 months:
  • migraine
  • nausea
  • pain
  • anxiety
  • blood pressure increased
  • breath holding
  • burning mouth syndrome
  • depression
  • heartburn - chronic
  • hormone level abnormal
6 - 12 months:
  • nausea
  • abdominal wall haematoma
  • acne
  • acute chest syndrome
  • arthralgia
  • atrioventricular block complete
  • back injury
  • back pain
  • bursitis
  • chest pain
1 - 2 years:
  • short-term memory loss
  • long-term memory loss
  • abdominal pain
  • back pain
  • breast tenderness
  • drowsiness
  • fatigue
  • fatigue - chronic
  • flatulence
  • insomnia
2 - 5 years:
  • acute chest syndrome
  • arthralgia
  • atrioventricular block complete
  • back injury
  • bursitis
  • nausea
  • back pain
  • pyrexia
  • abdominal wall haematoma
  • acne
5 - 10 years:
  • erection problems
  • skin striae
10+ years:
  • anxiety aggravated
  • heart rate increased
  • insomnia
not specified:
  • pain
  • anxiety
  • back pain
  • nausea
  • headache
  • pain in extremity
  • vomiting
  • osteonecrosis of jaw
  • chest pain
  • dyspnoea

Most common drug interactions by gender *:

female:
  • pain
  • back pain
  • anxiety
  • nausea
  • headache
  • pain in extremity
  • chest pain
  • fatigue
  • fall
  • dyspnoea
male:
  • nausea
  • pain
  • anxiety
  • osteoporosis
  • constipation
  • asthenia
  • pyrexia
  • osteoarthritis
  • vomiting
  • back pain

Most common drug interactions by age *:

2-9:
  • emotional disorder
  • tardive dyskinesia
  • alopecia
  • blindness
  • hypersensitivity
  • internal injury
  • mucous membrane disorder
  • nail disorder
  • oral disorder
  • pigmentation disorder
10-19:
  • nausea
  • weight decreased
  • cholecystitis
  • abdominal pain
  • acidosis
  • cholecystitis chronic
  • cholelithiasis
  • constipation
  • deep vein thrombosis
  • diarrhoea
20-29:
  • nausea
  • pulmonary embolism
  • pain
  • back pain
  • cholecystitis chronic
  • cholecystitis
  • deep vein thrombosis
  • anxiety
  • abdominal pain upper
  • depression
30-39:
  • nausea
  • deep vein thrombosis
  • pulmonary embolism
  • anxiety
  • pain
  • type 2 diabetes mellitus
  • vomiting
  • emotional distress
  • injury
  • constipation
40-49:
  • pain
  • depression
  • pain in extremity
  • nausea
  • chest pain
  • arthralgia
  • anxiety
  • abdominal pain
  • back pain
  • diarrhoea
50-59:
  • pain
  • anxiety
  • nausea
  • back pain
  • diarrhoea
  • headache
  • sinusitis
  • osteoarthritis
  • fatigue
  • depression
60+:
  • back pain
  • osteomyelitis
  • osteoarthritis
  • osteonecrosis of jaw
  • anxiety
  • dyspnoea
  • pain
  • weight decreased
  • anaemia
  • fall

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Promethazine (promethazine hydrochloride) is often used to treat nausea. Cyclobenzaprine hydrochloride (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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