Review: taking Promethazine and Methadone hydrochloride together


Summary

Drug interactions are reported among people who take Promethazine and Methadone hydrochloride together. This review analyzes the effectiveness and drug interactions between Promethazine and Methadone hydrochloride. It is created by eHealthMe based on reports of 630 people who take the same drugs from FDA and social media, and is updated regularly.

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Promethazine

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. (latest outcomes from Promethazine 2,976 users)

Methadone Hydrochloride

Methadone hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from Methadone hydrochloride 2,951 users)

On Aug, 21, 2016

630 people who take Promethazine, Methadone Hydrochloride are studied.


Number of reports submitted per year:

Promethazine and Methadone hydrochloride drug interactions.

Drug effectiveness over time:

Promethazine:
  • < 1 month: 33.0% - (1 of 3 people)
  • 1 - 6 months: 50.0% - (2 of 4 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 33.0% - (1 of 3 people)
  • 2 - 5 years: 71.0% - (5 of 7 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 100.0% - (1 of 1 people)
Methadone Hydrochloride:
  • < 1 month: 50.0% - (3 of 6 people)
  • 1 - 6 months: 80.0% - (4 of 5 people)
  • 6 - 12 months: 50.0% - (1 of 2 people)
  • 1 - 2 years: 50.0% - (1 of 2 people)
  • 2 - 5 years: 50.0% - (1 of 2 people)
  • 5 - 10 years: 0.0% - (0 of 3 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 100.0% - (1 of 1 people)

Drug effectiveness by gender:

Promethazine:
  • female: 70.0% - (12 of 17 people)
  • male: 0.0% - (0 of 3 people)
Methadone Hydrochloride:
  • female: 50.0% - (9 of 18 people)
  • male: 66.0% - (2 of 3 people)

Drug effectiveness by age:

Promethazine:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (1 of 1 people)
  • 20-29: 100.0% - (1 of 1 people)
  • 30-39: 77.0% - (7 of 9 people)
  • 40-49: 33.0% - (2 of 6 people)
  • 50-59: 0.0% - (0 of 1 people)
  • 60+: 50.0% - (1 of 2 people)
Methadone Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 100.0% - (2 of 2 people)
  • 30-39: 55.0% - (5 of 9 people)
  • 40-49: 50.0% - (3 of 6 people)
  • 50-59: 0.0% - (0 of 1 people)
  • 60+: 50.0% - (1 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • acute respiratory distress syndrome
  • coeliac artery compression syndrome
  • drug dependence
  • hepatic necrosis
  • pneumonia
  • constipation
  • drug abuser
  • drug withdrawal syndrome
  • intentional overdose
  • pulmonary oedema
1 - 6 months:
  • acute respiratory distress syndrome
  • coeliac artery compression syndrome
  • drug dependence
  • hepatic necrosis
  • pneumonia
  • constipation
  • drug withdrawal syndrome
  • pulmonary oedema
  • withdrawal syndrome
  • anaemia
6 - 12 months:
  • acute respiratory distress syndrome
  • coeliac artery compression syndrome
  • drug dependence
  • hepatic necrosis
  • pneumonia
  • constipation
  • drug withdrawal syndrome
  • pulmonary oedema
  • withdrawal syndrome
  • anaemia
1 - 2 years:
  • headaches
2 - 5 years:
  • abdominal pain
  • calculus ureteric
  • anaemia
  • anhedonia
  • anxiety
  • arthritis
  • asthenia
  • blindness
  • bone disorder
  • breast mass
5 - 10 years:
  • headaches
not specified:
  • anxiety
  • pain
  • bone disorder
  • nausea
  • back pain
  • depression
  • pyrexia
  • anaemia
  • dental caries
  • pain in jaw

Most common drug interactions by gender *:

female:
  • anxiety
  • pain
  • back pain
  • depression
  • nausea
  • bone disorder
  • anaemia
  • dental caries
  • urinary tract infection
  • impaired healing
male:
  • pain
  • vomiting
  • anxiety
  • asthenia
  • bone disorder
  • injury
  • nausea
  • erythema
  • gastrooesophageal reflux disease
  • pyrexia

Most common drug interactions by age *:

0-1:
  • hypoxia
  • maternal drugs affecting foetus
  • neonatal hypoxia
  • neonatal respiratory depression
2-9:
  • cellulitis
  • formication
  • nausea
  • photophobia
  • visual acuity reduced
  • accidental exposure
  • blindness
  • crying
  • headache
  • herpes simplex
10-19:
  • pneumonitis
  • convulsion
  • pneumonia
  • renal disorder
  • affective disorder
  • anaemia
  • anxiety
  • autoimmune disorder
  • autoimmune hepatitis
  • cellulitis
20-29:
  • drug abuse
  • cardiomegaly
  • decubitus ulcer
  • depression
  • left ventricular hypertrophy
  • mental disorder
  • abscess jaw
  • anxiety
  • ataxia
  • back pain
30-39:
  • pneumonia
  • acute respiratory distress syndrome
  • drug dependence
  • coeliac artery compression syndrome
  • hepatic necrosis
  • constipation
  • drug abuse
  • drug withdrawal syndrome
  • cardiac arrest
  • death
40-49:
  • depression
  • anxiety
  • weight decreased
  • dyspnoea
  • pain
  • pyrexia
  • back pain
  • impaired healing
  • nausea
  • malnutrition
50-59:
  • nausea
  • pain
  • anxiety
  • arthralgia
  • depression
  • injury
  • abdominal pain
  • pain in jaw
  • bone disorder
  • pyrexia
60+:
  • pain
  • anxiety
  • bone disorder
  • dental caries
  • osteomyelitis
  • pain in jaw
  • osteoarthritis
  • anhedonia
  • asthenia
  • osteonecrosis of jaw

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Promethazine (promethazine hydrochloride) is often used to treat nausea. Methadone hydrochloride (methadone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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