Review: taking Promethazine and Methadone hydrochloride together


Summary

Drug interactions are reported among people who take Promethazine and Methadone hydrochloride together. This review analyzes the effectiveness and drug interactions between Promethazine and Methadone hydrochloride. It is created by eHealthMe based on reports of 843 people who take the same drugs from FDA and social media, and is updated regularly.

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Promethazine

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. (latest outcomes from Promethazine 7,296 users)

Methadone Hydrochloride

Methadone hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from Methadone hydrochloride 3,246 users)

On Sep, 21, 2016

843 people who take Promethazine, Methadone Hydrochloride are studied.


Number of reports submitted per year:

Promethazine and Methadone hydrochloride drug interactions.

Drug effectiveness over time:

Promethazine:
  • < 1 month: 33.0% - (1 of 3 people)
  • 1 - 6 months: 50.0% - (2 of 4 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 33.0% - (1 of 3 people)
  • 2 - 5 years: 71.0% - (5 of 7 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 100.0% - (1 of 1 people)
Methadone Hydrochloride:
  • < 1 month: 50.0% - (3 of 6 people)
  • 1 - 6 months: 80.0% - (4 of 5 people)
  • 6 - 12 months: 50.0% - (1 of 2 people)
  • 1 - 2 years: 50.0% - (1 of 2 people)
  • 2 - 5 years: 50.0% - (1 of 2 people)
  • 5 - 10 years: 0.0% - (0 of 3 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 100.0% - (1 of 1 people)

Drug effectiveness by gender:

Promethazine:
  • female: 70.0% - (12 of 17 people)
  • male: 0.0% - (0 of 3 people)
Methadone Hydrochloride:
  • female: 50.0% - (9 of 18 people)
  • male: 66.0% - (2 of 3 people)

Drug effectiveness by age:

Promethazine:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (1 of 1 people)
  • 20-29: 100.0% - (1 of 1 people)
  • 30-39: 77.0% - (7 of 9 people)
  • 40-49: 33.0% - (2 of 6 people)
  • 50-59: 0.0% - (0 of 1 people)
  • 60+: 50.0% - (1 of 2 people)
Methadone Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 100.0% - (2 of 2 people)
  • 30-39: 55.0% - (5 of 9 people)
  • 40-49: 50.0% - (3 of 6 people)
  • 50-59: 0.0% - (0 of 1 people)
  • 60+: 50.0% - (1 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • acute respiratory distress syndrome
  • coeliac artery compression syndrome
  • drug dependence
  • hepatic necrosis
  • pneumonia
  • constipation
  • drug abuser
  • drug withdrawal syndrome
  • intentional overdose
  • pulmonary oedema
1 - 6 months:
  • acute respiratory distress syndrome
  • coeliac artery compression syndrome
  • drug dependence
  • hepatic necrosis
  • pneumonia
  • constipation
  • drug withdrawal syndrome
  • pulmonary oedema
  • anaemia
  • withdrawal syndrome
6 - 12 months:
  • acute respiratory distress syndrome
  • coeliac artery compression syndrome
  • drug dependence
  • hepatic necrosis
  • pneumonia
  • constipation
  • drug withdrawal syndrome
  • pulmonary oedema
  • withdrawal syndrome
  • anaemia
1 - 2 years:
  • abdominal wall haematoma
  • anaemia
  • pelvic haematoma
  • diarrhoea
  • dizziness
  • headaches
  • vertigo
2 - 5 years:
  • abdominal pain
  • anaemia
  • anhedonia
  • anxiety
  • arthritis
  • asthenia
  • blindness
  • bone disorder
  • breast mass
  • calculus ureteric
5 - 10 years:
  • headaches
10+ years:
  • back pain
  • electrocardiogram qt prolonged
  • gastric ph decreased
  • insomnia
  • malaise
  • myocardial infarction
  • platelet count increased
  • presyncope
  • sedation
not specified:
  • pain
  • anxiety
  • nausea
  • back pain
  • bone disorder
  • drug abuse
  • pyrexia
  • anaemia
  • depression
  • dental caries

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • back pain
  • nausea
  • depression
  • anaemia
  • bone disorder
  • urinary tract infection
  • dental caries
  • drug abuse
male:
  • pain
  • nausea
  • anxiety
  • death
  • pyrexia
  • drug abuse
  • gastrooesophageal reflux disease
  • bone disorder
  • erythema
  • pain in jaw

Most common drug interactions by age *:

0-1:
  • neonatal hypoxia
  • foetal exposure during pregnancy
  • cleft palate
  • hypoxia
  • maternal drugs affecting foetus
  • micrognathia
  • neonatal respiratory depression
  • premature baby
  • sudden infant death syndrome
2-9:
  • cellulitis
  • formication
  • nausea
  • photophobia
  • pyrexia
  • visual acuity reduced
  • accidental exposure
  • blindness
  • crying
  • headache
10-19:
  • pneumonitis
  • convulsion
  • pneumonia
  • renal disorder
  • affective disorder
  • anaemia
  • anxiety
  • autoimmune disorder
  • autoimmune hepatitis
  • cellulitis
20-29:
  • drug abuse
  • depression
  • anxiety
  • cardiomegaly
  • decubitus ulcer
  • haematocrit decreased
  • hallucination
  • hypoglycaemia
  • left ventricular hypertrophy
  • mental disorder
30-39:
  • death
  • pneumonia
  • acute respiratory distress syndrome
  • drug dependence
  • coeliac artery compression syndrome
  • hepatic necrosis
  • constipation
  • drug abuse
  • drug withdrawal syndrome
  • cardiac arrest
40-49:
  • depression
  • anxiety
  • weight decreased
  • pain
  • dyspnoea
  • nausea
  • pyrexia
  • back pain
  • vomiting
  • drug abuse
50-59:
  • drug abuse
  • nausea
  • pain
  • anxiety
  • arthralgia
  • depression
  • injury
  • pyrexia
  • headache
  • abdominal pain
60+:
  • pain
  • anxiety
  • dental caries
  • osteomyelitis
  • pain in jaw
  • bone disorder
  • osteoarthritis
  • anhedonia
  • back pain
  • osteonecrosis of jaw

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Promethazine (promethazine hydrochloride) is often used to treat nausea. Methadone hydrochloride (methadone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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