Review: taking Ritalin and Benadryl together


Summary

Drug interactions are reported among people who take Ritalin and Benadryl together. This review analyzes the effectiveness and drug interactions between Ritalin and Benadryl. It is created by eHealthMe based on reports of 335 people who take the same drugs from FDA and social media, and is updated regularly.

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Ritalin

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. (latest outcomes from Ritalin 11,167 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 29,242 users)

On Jul, 27, 2016

335 people who take Ritalin, Benadryl are studied.


Number of reports submitted per year:

Ritalin and Benadryl drug interactions.

Drug effectiveness over time:

Ritalin:
  • < 1 month: 50.0% - (2 of 4 people)
  • 1 - 6 months: 50.0% - (4 of 8 people)
  • 6 - 12 months: 100.0% - (2 of 2 people)
  • 1 - 2 years: 50.0% - (4 of 8 people)
  • 2 - 5 years: 80.0% - (4 of 5 people)
  • 5 - 10 years: 75.0% - (3 of 4 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 25.0% - (1 of 4 people)
Benadryl:
  • < 1 month: 25.0% - (3 of 12 people)
  • 1 - 6 months: 100.0% - (3 of 3 people)
  • 6 - 12 months: 0.0% - (0 of 5 people)
  • 1 - 2 years: 100.0% - (3 of 3 people)
  • 2 - 5 years: 0.0% - (0 of 1 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 0.0% - (0 of 2 people)
  • not specified: 100.0% - (4 of 4 people)

Drug effectiveness by gender:

Ritalin:
  • female: 64.0% - (11 of 17 people)
  • male: 52.0% - (10 of 19 people)
Benadryl:
  • female: 68.0% - (11 of 16 people)
  • male: 20.0% - (3 of 15 people)

Drug effectiveness by age:

Ritalin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 25.0% - (1 of 4 people)
  • 10-19: 75.0% - (6 of 8 people)
  • 20-29: 60.0% - (3 of 5 people)
  • 30-39: 42.0% - (3 of 7 people)
  • 40-49: 100.0% - (3 of 3 people)
  • 50-59: 33.0% - (2 of 6 people)
  • 60+: 100.0% - (3 of 3 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 25.0% - (1 of 4 people)
  • 10-19: 50.0% - (3 of 6 people)
  • 20-29: 0.0% - (0 of 4 people)
  • 30-39: 40.0% - (2 of 5 people)
  • 40-49: 33.0% - (1 of 3 people)
  • 50-59: 66.0% - (4 of 6 people)
  • 60+: 100.0% - (3 of 3 people)

Most common drug interactions over time *:

< 1 month:
  • aggression
  • convulsion
  • agitation
  • foaming at mouth
  • tardive dyskinesia
  • respiratory failure
  • diastolic hypertension
  • dizziness
  • extrapyramidal disorder
  • intentional overdose
1 - 6 months:
  • vomiting
  • abdominal pain
  • activated partial thromboplastin time prolonged
  • anal fissure
  • aortic valve incompetence
  • carpal tunnel syndrome
  • chest pain
  • confusional state
  • disease recurrence
  • dizziness
6 - 12 months:
  • anhedonia
  • depressed mood
  • depression
  • disorientation
  • dizziness
  • mania
  • nervousness
  • numbness and tingling
  • psychomotor hyperactivity
  • suicidal ideation
1 - 2 years:
  • abdominal distension
  • acute sinusitis
  • anhedonia
  • anxiety
  • arthralgia
  • atrophy
  • back pain
  • breast cancer
  • breast cancer in situ
  • breast cyst
2 - 5 years:
  • drug effect decreased
  • fatigue
  • alopecia
  • balance disorder
  • cough
  • decreased appetite
  • decreased interest
  • depression aggravated
  • diarrhoea
  • dizziness postural
5 - 10 years:
  • aortic valve stenosis
  • dizziness
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • headache
10+ years:
  • bipolar disorder
  • disability
  • feeling abnormal
  • hypertension
  • learning disability
  • mental disorder
  • mood swings
  • suicidal behaviour
  • depressed mood
  • crying
not specified:
  • chest pain
  • back pain
  • dyspnoea
  • osteonecrosis of jaw
  • pain in extremity
  • chronic obstructive pulmonary disease
  • fatigue
  • metastases to bone
  • fall
  • swelling

Most common drug interactions by gender *:

female:
  • fatigue
  • dyspnoea
  • chest pain
  • back pain
  • arthralgia
  • osteonecrosis of jaw
  • pain in extremity
  • anaemia
  • chronic obstructive pulmonary disease
  • metastases to bone
male:
  • bipolar disorder
  • agitation
  • disability
  • feeling abnormal
  • aggression
  • mental disorder
  • drug ineffective
  • learning disability
  • convulsion
  • suicidal ideation

Most common drug interactions by age *:

0-1:
  • convulsion
  • aggression
  • agitation
  • foaming at mouth
  • tardive dyskinesia
  • balance disorder
  • bradycardia
  • cholecystitis chronic
  • diabetic complication
  • dyspnoea
2-9:
  • drug ineffective
  • agitation
  • pyrexia
  • convulsion
  • abdominal pain
  • activated partial thromboplastin time prolonged
  • gastrointestinal haemorrhage
  • infusion related reaction
  • mastoiditis
  • urticaria
10-19:
  • weight increased
  • diabetes mellitus
  • suicidal ideation
  • aggression
  • agitation
  • anger
  • drug ineffective
  • dystonia
  • hepatic steatosis
  • convulsion
20-29:
  • deep vein thrombosis
  • diabetes mellitus
  • gastrooesophageal reflux disease
  • lactic acidosis
  • malaise
  • mouth ulceration
  • adnexa uteri mass
  • arthralgia
  • chest discomfort
  • depression
30-39:
  • memory impairment
  • asthenia
  • dyspnoea
  • fatigue
  • gait disturbance
  • hypoaesthesia
  • paraesthesia
  • confusional state
  • vision blurred
  • anxiety
40-49:
  • anxiety
  • depression
  • gastrooesophageal reflux disease
  • pain
  • fall
  • pain in extremity
  • balance disorder
  • bladder disorder
  • nausea
  • pyrexia
50-59:
  • depression
  • bipolar disorder
  • somnolence
  • suicidal ideation
  • anxiety
  • drug dependence
  • drug withdrawal syndrome
  • insomnia
  • mood swings
  • feeling abnormal
60+:
  • back pain
  • fatigue
  • arthralgia
  • arthritis
  • chest pain
  • chronic obstructive pulmonary disease
  • metastases to bone
  • osteonecrosis of jaw
  • osteoporosis
  • osteosclerosis

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Ritalin (methylphenidate hydrochloride) is often used to treat attention deficit hyperactivity disorder. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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