Review: taking Ritalin and Benadryl together


Summary

Drug interactions are reported among people who take Ritalin and Benadryl together. This review analyzes the effectiveness and drug interactions between Ritalin and Benadryl. It is created by eHealthMe based on reports of 603 people who take the same drugs from FDA and social media, and is updated regularly.

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Ritalin

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. (latest outcomes from Ritalin 14,979 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 43,259 users)

On Sep, 18, 2016

603 people who take Ritalin, Benadryl are studied.


Number of reports submitted per year:

Ritalin and Benadryl drug interactions.

Drug effectiveness over time:

Ritalin:
  • < 1 month: 50.0% - (2 of 4 people)
  • 1 - 6 months: 55.0% - (5 of 9 people)
  • 6 - 12 months: 100.0% - (2 of 2 people)
  • 1 - 2 years: 50.0% - (4 of 8 people)
  • 2 - 5 years: 66.0% - (4 of 6 people)
  • 5 - 10 years: 60.0% - (3 of 5 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 50.0% - (1 of 2 people)
Benadryl:
  • < 1 month: 25.0% - (3 of 12 people)
  • 1 - 6 months: 100.0% - (3 of 3 people)
  • 6 - 12 months: 16.0% - (1 of 6 people)
  • 1 - 2 years: 100.0% - (3 of 3 people)
  • 2 - 5 years: 0.0% - (0 of 1 people)
  • 5 - 10 years: 66.0% - (2 of 3 people)
  • 10+ years: 0.0% - (0 of 2 people)
  • not specified: 100.0% - (2 of 2 people)

Drug effectiveness by gender:

Ritalin:
  • female: 68.0% - (11 of 16 people)
  • male: 52.0% - (11 of 21 people)
Benadryl:
  • female: 66.0% - (10 of 15 people)
  • male: 23.0% - (4 of 17 people)

Drug effectiveness by age:

Ritalin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 25.0% - (1 of 4 people)
  • 10-19: 75.0% - (6 of 8 people)
  • 20-29: 60.0% - (3 of 5 people)
  • 30-39: 37.0% - (3 of 8 people)
  • 40-49: 100.0% - (4 of 4 people)
  • 50-59: 40.0% - (2 of 5 people)
  • 60+: 100.0% - (3 of 3 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 25.0% - (1 of 4 people)
  • 10-19: 50.0% - (3 of 6 people)
  • 20-29: 0.0% - (0 of 4 people)
  • 30-39: 33.0% - (2 of 6 people)
  • 40-49: 50.0% - (2 of 4 people)
  • 50-59: 60.0% - (3 of 5 people)
  • 60+: 100.0% - (3 of 3 people)

Most common drug interactions over time *:

< 1 month:
  • convulsion
  • aggression
  • insomnia
  • agitation
  • dyspnoea
  • foaming at mouth
  • headache
  • tardive dyskinesia
  • cough
  • drug ineffective
1 - 6 months:
  • pain
  • allergy to metals
  • application site erythema
  • atrial septal defect
  • cleft lip and palate
  • disease progression
  • drug effect decreased
  • drug hypersensitivity
  • drug ineffective
  • failure to thrive
6 - 12 months:
  • insomnia
  • abnormal dreams
  • arrhythmia
  • sinusitis
  • ammonia increased
  • anhedonia
  • cough
  • depressed mood
  • depression
  • disorientation
1 - 2 years:
  • basal cell carcinoma
  • abdominal distension
  • acute sinusitis
  • anaemia
  • anhedonia
  • anxiety
  • arthralgia
  • atrophy
  • back pain
  • breast cancer
2 - 5 years:
  • pain
  • allergy to metals
  • drug effect decreased
  • drug hypersensitivity
  • fatigue
  • obesity
  • seasonal allergy
  • alopecia
  • balance disorder
  • cerebrovascular accident
5 - 10 years:
  • aortic valve stenosis
  • dizziness
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • headache
  • nasopharyngitis
10+ years:
  • bipolar disorder
  • feeling abnormal
  • hypertension
  • learning disability
  • mental disorder
  • mood swings
  • suicidal behaviour
  • depressed mood
  • disability
  • crying
not specified:
  • fatigue
  • headache
  • dyspnoea
  • back pain
  • chest pain
  • nausea
  • fall
  • arthralgia
  • osteonecrosis of jaw
  • metastases to bone

Most common drug interactions by gender *:

female:
  • headache
  • fatigue
  • dyspnoea
  • back pain
  • chest pain
  • arthralgia
  • weight decreased
  • anaemia
  • fall
  • nausea
male:
  • drug ineffective
  • fatigue
  • mental status changes
  • bipolar disorder
  • anxiety
  • convulsion
  • death
  • pyrexia
  • agitation
  • mood swings

Most common drug interactions by age *:

0-1:
  • convulsion
  • aggression
  • agitation
  • foaming at mouth
  • tardive dyskinesia
  • balance disorder
  • bradycardia
  • cholecystitis chronic
  • diabetic complication
  • dyspnoea
2-9:
  • drug ineffective
  • convulsion
  • agitation
  • pyrexia
  • headache
  • abdominal pain
  • activated partial thromboplastin time prolonged
  • blood glucose increased
  • gastrointestinal haemorrhage
  • infusion related reaction
10-19:
  • weight increased
  • diabetes mellitus
  • drug ineffective
  • suicidal ideation
  • aggression
  • agitation
  • cardio-respiratory arrest
  • depression
  • hepatic steatosis
  • asthma
20-29:
  • headache
  • nausea
  • dyspnoea
  • malaise
  • diarrhoea
  • fatigue
  • anxiety
  • arthralgia
  • convulsion
  • hepatic steatosis
30-39:
  • dyspnoea
  • fatigue
  • memory impairment
  • asthenia
  • gait disturbance
  • hypoaesthesia
  • paraesthesia
  • vomiting
  • confusional state
  • vision blurred
40-49:
  • pain
  • drug abuse
  • anxiety
  • nausea
  • pyrexia
  • depression
  • gastrooesophageal reflux disease
  • pain in extremity
  • decreased appetite
  • diarrhoea
50-59:
  • depression
  • insomnia
  • somnolence
  • bipolar disorder
  • headache
  • suicidal ideation
  • anxiety
  • drug dependence
  • drug withdrawal syndrome
  • fatigue
60+:
  • fatigue
  • back pain
  • weight decreased
  • osteosclerosis
  • arthralgia
  • chest pain
  • dyspnoea
  • headache
  • arthritis
  • chronic obstructive pulmonary disease

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Ritalin (methylphenidate hydrochloride) is often used to treat attention deficit hyperactivity disorder. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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