Review: taking Ritalin and Zoloft together


Summary

Drug interactions are reported among people who take Ritalin and Zoloft together. This review analyzes the effectiveness and drug interactions between Ritalin and Zoloft. It is created by eHealthMe based on reports of 1,240 people who take the same drugs from FDA and social media, and is updated regularly.

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Ritalin

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. (latest outcomes from Ritalin 11,122 users)

Zoloft

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Zoloft 77,518 users)

On Jul, 29, 2016

1,240 people who take Ritalin, Zoloft are studied.


Number of reports submitted per year:

Ritalin and Zoloft drug interactions.

Drug effectiveness over time:

Ritalin:
  • < 1 month: 28.0% - (4 of 14 people)
  • 1 - 6 months: 34.0% - (11 of 32 people)
  • 6 - 12 months: 40.0% - (8 of 20 people)
  • 1 - 2 years: 61.0% - (13 of 21 people)
  • 2 - 5 years: 45.0% - (9 of 20 people)
  • 5 - 10 years: 58.0% - (7 of 12 people)
  • 10+ years: 78.0% - (15 of 19 people)
  • not specified: 42.0% - (3 of 7 people)
Zoloft:
  • < 1 month: 12.0% - (1 of 8 people)
  • 1 - 6 months: 41.0% - (12 of 29 people)
  • 6 - 12 months: 16.0% - (4 of 24 people)
  • 1 - 2 years: 36.0% - (8 of 22 people)
  • 2 - 5 years: 30.0% - (8 of 26 people)
  • 5 - 10 years: 55.0% - (10 of 18 people)
  • 10+ years: 60.0% - (6 of 10 people)
  • not specified: 50.0% - (2 of 4 people)

Drug effectiveness by gender:

Ritalin:
  • female: 49.0% - (51 of 103 people)
  • male: 45.0% - (19 of 42 people)
Zoloft:
  • female: 37.0% - (39 of 104 people)
  • male: 32.0% - (12 of 37 people)

Drug effectiveness by age:

Ritalin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 33.0% - (1 of 3 people)
  • 10-19: 29.0% - (10 of 34 people)
  • 20-29: 55.0% - (19 of 34 people)
  • 30-39: 37.0% - (10 of 27 people)
  • 40-49: 64.0% - (18 of 28 people)
  • 50-59: 62.0% - (10 of 16 people)
  • 60+: 66.0% - (2 of 3 people)
Zoloft:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 2 people)
  • 10-19: 25.0% - (8 of 32 people)
  • 20-29: 43.0% - (14 of 32 people)
  • 30-39: 50.0% - (13 of 26 people)
  • 40-49: 26.0% - (8 of 30 people)
  • 50-59: 37.0% - (6 of 16 people)
  • 60+: 66.0% - (2 of 3 people)

Most common drug interactions over time *:

< 1 month:
  • serotonin syndrome
  • alanine aminotransferase increased
  • blood pressure increased
  • body temperature increased
  • liver disorder
  • tachycardia
  • tachypnoea
  • hyperhidrosis
  • mydriasis
  • hyperreflexia
1 - 6 months:
  • abnormal behaviour
  • depression
  • aggression
  • agitation
  • anger
  • arthritis
  • euphoric mood
  • feeling abnormal
  • irritability
  • bruxism
6 - 12 months:
  • suicidal ideation
  • irritability
  • nausea
  • agitation
  • diabetes mellitus
  • extrapyramidal disorder
  • hallucinations
  • heart pounding
  • memory impairment
  • paranoia
1 - 2 years:
  • anxiety
  • disturbance in attention
  • sexual dysfunction
  • arthralgia
  • back pain
  • breast cancer
  • breast cancer in situ
  • breast cyst
  • breast dysplasia
  • breast mass
2 - 5 years:
  • depression
  • anxiety aggravated
  • anxiety
  • arthralgia
  • back pain
  • brain mass
  • breast cancer
  • breast cancer in situ
  • breast cyst
  • breast dysplasia
5 - 10 years:
  • anxiety aggravated
  • depression
  • diplopia
  • agitation
  • arthritis
  • bipolar disorder
  • chest pressure sensation
  • cognitive deterioration
  • confusional state
  • constipation
10+ years:
  • tinnitus
  • altered visual depth perception
  • aphasia
  • numbness and tingling
  • vertigo
  • bedwetting
  • excessive thirst
  • hallucinations
  • panic reaction
  • psychomotor hyperactivity
not specified:
  • depression
  • pain
  • fatigue
  • nausea
  • weight decreased
  • asthenia
  • anxiety
  • suicidal ideation
  • chest pain
  • anaemia

Most common drug interactions by gender *:

female:
  • pain
  • depression
  • nausea
  • fatigue
  • weight decreased
  • asthenia
  • back pain
  • fall
  • suicidal ideation
  • bone disorder
male:
  • depression
  • cellulitis
  • pain
  • anxiety
  • abnormal behaviour
  • aggression
  • hypertension
  • anaemia
  • chest pain
  • neck pain

Most common drug interactions by age *:

0-1:
  • pancreatitis acute
2-9:
  • dizziness
  • weight increased
  • dyspnoea
  • dysstasia
  • eye movement disorder
  • gastric dilatation
  • headache
  • papilloedema
  • aggression
  • compulsions
10-19:
  • abnormal behaviour
  • suicide attempt
  • weight increased
  • aggression
  • suicidal ideation
  • drug ineffective
  • depression
  • fatigue
  • anxiety
  • agitation
20-29:
  • aggression
  • drug dependence
  • drug withdrawal syndrome
  • mood swings
  • nausea
  • neck pain
  • weight increased
  • convulsion
  • pain in limb
  • suicidal ideation
30-39:
  • insomnia
  • fatigue
  • irritability
  • nausea
  • suicidal ideation
  • attention deficit/hyperactivity disorder
  • chest pain
  • dehydration
  • drug ineffective
  • memory impairment
40-49:
  • depression
  • cellulitis
  • asthenia
  • chest pain
  • pain
  • weight decreased
  • fall
  • neck pain
  • oedema peripheral
  • back pain
50-59:
  • pain
  • depression
  • anxiety
  • fatigue
  • arthralgia
  • weight decreased
  • anaemia
  • back pain
  • somnolence
  • fall
60+:
  • depression
  • pain
  • vomiting
  • anaemia
  • asthenia
  • nausea
  • back pain
  • contusion
  • infection
  • hypertension

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Ritalin (methylphenidate hydrochloride) is often used to treat attention deficit hyperactivity disorder. Zoloft (sertraline hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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