Review: taking Ritalin and Zoloft together


Summary

Drug interactions are reported among people who take Ritalin and Zoloft together. This review analyzes the effectiveness and drug interactions between Ritalin and Zoloft. It is created by eHealthMe based on reports of 1,871 people who take the same drugs from FDA and social media, and is updated regularly.

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Ritalin

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. (latest outcomes from Ritalin 14,979 users)

Zoloft

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Zoloft 97,228 users)

On Sep, 17, 2016

1,871 people who take Ritalin, Zoloft are studied.


Number of reports submitted per year:

Ritalin and Zoloft drug interactions.

Drug effectiveness over time:

Ritalin:
  • < 1 month: 23.0% - (3 of 13 people)
  • 1 - 6 months: 33.0% - (11 of 33 people)
  • 6 - 12 months: 44.0% - (8 of 18 people)
  • 1 - 2 years: 57.0% - (11 of 19 people)
  • 2 - 5 years: 47.0% - (8 of 17 people)
  • 5 - 10 years: 44.0% - (4 of 9 people)
  • 10+ years: 69.0% - (9 of 13 people)
  • not specified: 60.0% - (3 of 5 people)
Zoloft:
  • < 1 month: 20.0% - (1 of 5 people)
  • 1 - 6 months: 46.0% - (12 of 26 people)
  • 6 - 12 months: 19.0% - (4 of 21 people)
  • 1 - 2 years: 39.0% - (9 of 23 people)
  • 2 - 5 years: 29.0% - (7 of 24 people)
  • 5 - 10 years: 55.0% - (10 of 18 people)
  • 10+ years: 42.0% - (3 of 7 people)
  • not specified: 50.0% - (2 of 4 people)

Drug effectiveness by gender:

Ritalin:
  • female: 45.0% - (39 of 86 people)
  • male: 43.0% - (18 of 41 people)
Zoloft:
  • female: 39.0% - (36 of 91 people)
  • male: 32.0% - (12 of 37 people)

Drug effectiveness by age:

Ritalin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 50.0% - (2 of 4 people)
  • 10-19: 28.0% - (8 of 28 people)
  • 20-29: 53.0% - (15 of 28 people)
  • 30-39: 34.0% - (8 of 23 people)
  • 40-49: 57.0% - (15 of 26 people)
  • 50-59: 46.0% - (7 of 15 people)
  • 60+: 66.0% - (2 of 3 people)
Zoloft:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 33.0% - (1 of 3 people)
  • 10-19: 25.0% - (7 of 28 people)
  • 20-29: 46.0% - (13 of 28 people)
  • 30-39: 52.0% - (12 of 23 people)
  • 40-49: 28.0% - (8 of 28 people)
  • 50-59: 33.0% - (5 of 15 people)
  • 60+: 66.0% - (2 of 3 people)

Most common drug interactions over time *:

< 1 month:
  • serotonin syndrome
  • tachycardia
  • blood pressure increased
  • alanine aminotransferase increased
  • body temperature increased
  • liver disorder
  • tachypnoea
  • mydriasis
  • hyperhidrosis
  • drug ineffective
1 - 6 months:
  • abnormal behaviour
  • depression
  • drug ineffective
  • aggression
  • agitation
  • anger
  • arthritis
  • chest pain
  • euphoric mood
  • feeling abnormal
6 - 12 months:
  • disturbance in attention
  • drug ineffective
  • memory impairment
  • nausea
  • suicidal ideation
  • application site erythema
  • irritability
  • aggression
  • agitation
  • asthenia
1 - 2 years:
  • anxiety
  • disturbance in attention
  • depression
  • headache
  • sexual dysfunction
  • somnolence
  • arthralgia
  • back pain
  • breast cancer
  • breast cancer in situ
2 - 5 years:
  • anxiety aggravated
  • depression
  • anxiety
  • arthralgia
  • back pain
  • brain mass
  • breast cancer
  • breast cancer in situ
  • breast cyst
  • breast dysplasia
5 - 10 years:
  • anxiety aggravated
  • abnormal weight gain
  • depression
  • diplopia
  • drug ineffective
  • emotional disorder
  • gynaecomastia
  • agitation
  • arthritis
  • bipolar disorder
10+ years:
  • tinnitus
  • altered visual depth perception
  • aphasia
  • numbness and tingling
  • vertigo
  • bedwetting
  • excessive thirst
  • hallucinations
  • panic reaction
  • psychomotor hyperactivity
not specified:
  • depression
  • pain
  • drug ineffective
  • nausea
  • fatigue
  • weight decreased
  • asthenia
  • headache
  • suicidal ideation
  • fall

Most common drug interactions by gender *:

female:
  • depression
  • pain
  • fatigue
  • headache
  • nausea
  • weight decreased
  • asthenia
  • drug ineffective
  • fall
  • back pain
male:
  • depression
  • drug ineffective
  • abnormal behaviour
  • pain
  • aggression
  • dizziness
  • suicide attempt
  • nausea
  • anxiety
  • cellulitis

Most common drug interactions by age *:

0-1:
  • abnormal behaviour
  • anxiety
  • attention deficit/hyperactivity disorder
  • depression
  • oppositional defiant disorder
  • pancreatitis acute
2-9:
  • application site erythema
  • drug ineffective
  • dizziness
  • dyspnoea
  • decreased appetite
  • abnormal behaviour
  • weight increased
  • drug administration error
  • dysstasia
  • eye movement disorder
10-19:
  • abnormal behaviour
  • drug ineffective
  • suicidal ideation
  • suicide attempt
  • aggression
  • somnolence
  • weight increased
  • depression
  • decreased appetite
  • fatigue
20-29:
  • nausea
  • suicidal ideation
  • aggression
  • anxiety
  • depression
  • feeling abnormal
  • mood swings
  • tachycardia
  • convulsion
  • drug dependence
30-39:
  • fatigue
  • insomnia
  • drug ineffective
  • asthenia
  • dyspnoea
  • back pain
  • diarrhoea
  • palpitations
  • weight decreased
  • nausea
40-49:
  • depression
  • weight decreased
  • fall
  • pain
  • asthenia
  • cellulitis
  • hyperhidrosis
  • headache
  • chest pain
  • oedema peripheral
50-59:
  • pain
  • depression
  • nausea
  • fatigue
  • anxiety
  • arthralgia
  • asthenia
  • vomiting
  • weight decreased
  • anaemia
60+:
  • depression
  • asthenia
  • pain
  • fall
  • nausea
  • vomiting
  • diarrhoea
  • back pain
  • anaemia
  • decreased appetite

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Ritalin (methylphenidate hydrochloride) is often used to treat attention deficit hyperactivity disorder. Zoloft (sertraline hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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