Review: taking Sertraline hydrochloride and Donepezil together


Summary

Drug interactions are reported among people who take Sertraline hydrochloride and Donepezil together. This review analyzes the effectiveness and drug interactions between Sertraline hydrochloride and Donepezil. It is created by eHealthMe based on reports of 1,485 people who take the same drugs from FDA and social media, and is updated regularly.

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Sertraline Hydrochloride

Sertraline hydrochloride has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Sertraline hydrochloride 13,356 users)

Donepezil

Donepezil has active ingredients of donepezil hydrochloride. It is often used in dementia alzheimer's type. (latest outcomes from Donepezil 6,115 users)

On Sep, 16, 2016

1,485 people who take Sertraline Hydrochloride, Donepezil are studied.


Number of reports submitted per year:

Sertraline hydrochloride and Donepezil drug interactions.

Drug effectiveness over time:

Sertraline Hydrochloride:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 42.0% - (3 of 7 people)
  • 6 - 12 months: 25.0% - (1 of 4 people)
  • 1 - 2 years: 40.0% - (2 of 5 people)
  • 2 - 5 years: 25.0% - (1 of 4 people)
  • 5 - 10 years: 50.0% - (1 of 2 people)
  • 10+ years: 0.0% - (0 of 2 people)
  • not specified: 0.0% - (0 of 0 people)
Donepezil:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 7.0% - (1 of 13 people)
  • 6 - 12 months: 0.0% - (0 of 2 people)
  • 1 - 2 years: 16.0% - (1 of 6 people)
  • 2 - 5 years: 25.0% - (1 of 4 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Sertraline Hydrochloride:
  • female: 38.0% - (7 of 18 people)
  • male: 16.0% - (1 of 6 people)
Donepezil:
  • female: 16.0% - (3 of 18 people)
  • male: 0.0% - (0 of 8 people)

Drug effectiveness by age:

Sertraline Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 33.0% - (1 of 3 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 33.0% - (7 of 21 people)
Donepezil:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 0.0% - (0 of 3 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 13.0% - (3 of 22 people)

Most common drug interactions over time *:

< 1 month:
  • circulatory collapse
  • hypernatraemia
  • liver disorder
  • shock
  • delusional disorder, persecutory type
  • general physical health deterioration
  • syncope
  • atrial fibrillation
  • dehydration
  • tremor
1 - 6 months:
  • general physical health deterioration
  • depressed level of consciousness
  • somnolence
  • dyskinesia
  • rhabdomyolysis
  • serotonin syndrome
  • diarrhoea
  • headache
  • respiratory distress
  • disturbance in attention
6 - 12 months:
  • dry mouth
  • eye swelling
  • itching
  • sleepiness
  • anaemia
  • dizziness
  • femoral neck fracture
  • atrioventricular block complete
  • depression
  • syncope
1 - 2 years:
  • rhabdomyolysis
  • hyperthermia malignant
  • diarrhoea
  • hypoproteinaemia
  • subdural haematoma
  • weight decreased
  • dehydration
  • dizziness
  • gait disturbance
  • general physical health deterioration
2 - 5 years:
  • diarrhoea
  • fall
  • confusional state
  • hypernatraemia
  • disorientation
  • hypothyroidism
  • malnutrition
  • gallbladder cancer metastatic
  • hypoproteinaemia
  • subdural haematoma
5 - 10 years:
  • gallbladder cancer
  • gallbladder cancer metastatic
  • activated partial thromboplastin time prolonged
  • alanine aminotransferase increased
  • ascites
  • blood chloride increased
  • blood potassium decreased
  • cerebral haemorrhage
  • colitis
  • diarrhoea
10+ years:
  • urinary incontinence aggravated
  • agitation
  • anger
  • confusion aggravated
  • dementia alzheimer's type
  • depression
  • memory impairment
  • mood swings
  • muscle rigidity
not specified:
  • fall
  • nausea
  • confusional state
  • depression
  • asthenia
  • agitation
  • diarrhoea
  • dehydration
  • fatigue
  • dyspnoea

Most common drug interactions by gender *:

female:
  • fall
  • confusional state
  • depression
  • diarrhoea
  • nausea
  • memory impairment
  • dyspnoea
  • anxiety
  • agitation
  • fatigue
male:
  • fall
  • nausea
  • dehydration
  • asthenia
  • agitation
  • vomiting
  • diarrhoea
  • syncope
  • confusional state
  • fatigue

Most common drug interactions by age *:

2-9:
  • acute psychosis
  • anxiety
  • hallucination
  • paranoia
  • sleep disorder
10-19:
  • gastrointestinal haemorrhage
  • anaemia
  • pyrexia
  • anaemia macrocytic
  • angioplasty
  • arthralgia
  • bacteraemia
  • blood glucose increased
  • blood lactate dehydrogenase increased
  • catheter site erythema
20-29:
  • anticonvulsant drug level decreased
  • drug withdrawal convulsions
  • headache
  • nausea
  • status epilepticus
  • vision blurred
30-39:
  • cushing's syndrome
  • diabetes mellitus
  • emotional disorder
  • hepatic enzyme increased
  • weight increased
40-49:
  • dyspnoea
  • depressed mood
  • muscle spasms
  • oedema peripheral
  • cognitive disorder
  • fall
  • abdominal distension
  • bladder dilatation
  • blood cholesterol increased
  • blood pressure increased
50-59:
  • fall
  • nausea
  • confusional state
  • mental status changes
  • convulsion
  • pancytopenia
  • fatigue
  • vomiting
  • asthenia
  • contusion
60+:
  • fall
  • confusional state
  • diarrhoea
  • nausea
  • dehydration
  • agitation
  • depression
  • asthenia
  • dizziness
  • pneumonia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Sertraline hydrochloride (sertraline hydrochloride) is often used to treat depression. Donepezil (donepezil hydrochloride) is often used to treat dementia alzheimer's type. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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