Review: taking Sertraline and Melatonin together


Summary

Drug interactions are reported among people who take Sertraline and Melatonin together. This review analyzes the effectiveness and drug interactions between Sertraline and Melatonin. It is created by eHealthMe based on reports of 579 people who take the same drugs from FDA and social media, and is updated regularly.

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Sertraline

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Sertraline 46,905 users)

Melatonin

Melatonin has active ingredients of melatonin. It is often used in insomnia. (latest outcomes from Melatonin 8,403 users)

On Sep, 20, 2016

579 people who take Sertraline, Melatonin are studied.


Number of reports submitted per year:

Sertraline and Melatonin drug interactions.

Drug effectiveness over time:

Sertraline:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 0.0% - (0 of 6 people)
  • 6 - 12 months: 16.0% - (1 of 6 people)
  • 1 - 2 years: 20.0% - (2 of 10 people)
  • 2 - 5 years: 37.0% - (3 of 8 people)
  • 5 - 10 years: 33.0% - (2 of 6 people)
  • 10+ years: 28.0% - (2 of 7 people)
  • not specified: 50.0% - (1 of 2 people)
Melatonin:
  • < 1 month: 14.0% - (1 of 7 people)
  • 1 - 6 months: 50.0% - (5 of 10 people)
  • 6 - 12 months: 20.0% - (2 of 10 people)
  • 1 - 2 years: 28.0% - (2 of 7 people)
  • 2 - 5 years: 55.0% - (5 of 9 people)
  • 5 - 10 years: 50.0% - (1 of 2 people)
  • 10+ years: 0.0% - (0 of 1 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Sertraline:
  • female: 22.0% - (7 of 31 people)
  • male: 26.0% - (4 of 15 people)
Melatonin:
  • female: 29.0% - (9 of 31 people)
  • male: 43.0% - (7 of 16 people)

Drug effectiveness by age:

Sertraline:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 3 people)
  • 10-19: 16.0% - (1 of 6 people)
  • 20-29: 30.0% - (3 of 10 people)
  • 30-39: 25.0% - (2 of 8 people)
  • 40-49: 20.0% - (1 of 5 people)
  • 50-59: 22.0% - (2 of 9 people)
  • 60+: 40.0% - (2 of 5 people)
Melatonin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 33.0% - (1 of 3 people)
  • 10-19: 14.0% - (1 of 7 people)
  • 20-29: 22.0% - (2 of 9 people)
  • 30-39: 71.0% - (5 of 7 people)
  • 40-49: 0.0% - (0 of 6 people)
  • 50-59: 33.0% - (3 of 9 people)
  • 60+: 66.0% - (4 of 6 people)

Most common drug interactions over time *:

< 1 month:
  • dysphagia
  • lip swelling
  • mouth ulceration
  • swelling face
  • stevens-johnson syndrome
  • dizziness
  • feeling drunk
  • gait disturbance
  • hypoaesthesia
  • paraesthesia oral
1 - 6 months:
  • restless legs syndrome
  • excessive hunger
  • heart palpitations
  • hypersexuality
  • pilonidal cyst
  • throat tightness
  • fatigue
  • insomnia
  • autism spectrum disorder
  • back pain
6 - 12 months:
  • depression
  • frequent or urgent urination
  • hyperlipidemia
  • hypertension
  • insomnia
  • restless leg syndrome
  • tachycardia
  • type 2 diabetes
  • alopecia
  • dermatillomania
1 - 2 years:
  • back pain
  • abdominal pain
  • diarrhoea
  • electrocardiogram t wave abnormal
  • fasciculations of muscle
  • fatigue - chronic
  • hallucination, visual
  • hallucinations aggravated
  • insomnia
  • lightheadedness - fainting
2 - 5 years:
  • depression
  • anxiety
  • fatigue
  • abdominal pain
  • frequent or urgent urination
  • hyperlipidemia
  • hypertension
  • hypomania
  • insomnia
  • night sweats
5 - 10 years:
  • inflammation localised
  • akathisia
  • arthritis
  • fear of weight gain
  • confusional state
  • fatigue
  • feeling abnormal
  • headache
  • insomnia
  • affect lability
10+ years:
  • diarrhoea
not specified:
  • fatigue
  • dizziness
  • anxiety
  • pain
  • gait disturbance
  • drug ineffective
  • pyrexia
  • headache
  • nausea
  • oedema peripheral

Most common drug interactions by gender *:

female:
  • fatigue
  • dizziness
  • gait disturbance
  • anxiety
  • pain
  • nausea
  • pyrexia
  • headache
  • depression
  • drug ineffective
male:
  • muscle spasms
  • diarrhoea
  • fall
  • drug ineffective
  • insomnia
  • confusional state
  • fatigue
  • ventricular tachycardia
  • dizziness
  • pain in extremity

Most common drug interactions by age *:

2-9:
  • anticholinergic syndrome
  • serotonin syndrome
  • vomiting
  • diarrhoea
  • nausea
  • agitation
  • hallucination, visual
  • muscle twitching
  • headache
  • mental status changes
10-19:
  • dizziness
  • dysphagia
  • lip swelling
  • mouth ulceration
  • swelling face
  • stevens-johnson syndrome
  • gait disturbance
  • feeling drunk
  • hypoaesthesia
  • paraesthesia oral
20-29:
  • irritability
  • anxiety
  • diarrhoea
  • eye movement disorder
  • fatigue
  • brain oedema
  • headache
  • muscle spasms
  • nausea
  • pulmonary oedema
30-39:
  • crohn's disease
  • headache
  • inflammation localised
  • anxiety
  • drug ineffective
  • muscle spasms
  • myalgia
  • pain in extremity
  • nausea
  • arthritis
40-49:
  • fatigue
  • drug ineffective
  • insomnia
  • blood pressure increased
  • dyspnoea
  • muscle spasms
  • musculoskeletal stiffness
  • abdominal distension
  • depression
  • performance status decreased
50-59:
  • confusional state
  • incontinence
  • lethargy
  • fatigue
  • fall
  • unresponsive to stimuli
  • insomnia
  • contusion
  • accidental exposure
  • depression
60+:
  • death
  • dizziness
  • gait disturbance
  • pain
  • anxiety
  • pyrexia
  • loss of consciousness
  • chronic obstructive pulmonary disease
  • constipation
  • heart rate increased

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Sertraline (sertraline hydrochloride) is often used to treat depression. Melatonin (melatonin) is often used to treat insomnia. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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